Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Gastric inhibitory polypeptide

Gene

Gip

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-MMU-400511. Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP).
R-MMU-418555. G alpha (s) signalling events.
R-MMU-420092. Glucagon-type ligand receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Gastric inhibitory polypeptide
Short name:
GIP
Alternative name(s):
Glucose-dependent insulinotropic polypeptide
Gene namesi
Name:Gip
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:107504. Gip.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121By similarityAdd
BLAST
Propeptidei22 – 4221PRO_0000011217Add
BLAST
Peptidei44 – 8542Gastric inhibitory polypeptidePRO_0000011218Add
BLAST
Propeptidei87 – 14458PRO_0000011219Add
BLAST

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

PaxDbiP48756.
PRIDEiP48756.

PTM databases

PhosphoSiteiP48756.

Expressioni

Gene expression databases

CleanExiMM_GIP.
GenevisibleiP48756. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099445.

Structurei

3D structure databases

ProteinModelPortaliP48756.
SMRiP48756. Positions 44-75.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glucagon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JC1A. Eukaryota.
ENOG4111BXQ. LUCA.
GeneTreeiENSGT00390000005121.
HOGENOMiHOG000112725.
HOVERGENiHBG005839.
InParanoidiP48756.
KOiK05258.
OMAiLAWMVDQ.
OrthoDBiEOG7C8GKZ.
TreeFamiTF332333.

Family and domain databases

InterProiIPR000532. Glucagon_GIP_secretin_VIP.
[Graphical view]
PfamiPF00123. Hormone_2. 1 hit.
[Graphical view]
SMARTiSM00070. GLUCA. 1 hit.
[Graphical view]
PROSITEiPS00260. GLUCAGON. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48756-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVALKTCSLL LVLLFLAVGL GEKEEVEFRS HAKFAGPRPR GPRYAEGTFI
60 70 80 90 100
SDYSIAMDKI RQQDFVNWLL AQRGKKSDWK HNITQREARA LVLAGQSQGK
110 120 130 140
EDKEAQESSL PKSLSDDDVL RDLLIQELLA WMVDQTELCR LRSQ
Length:144
Mass (Da):16,389
Last modified:October 3, 2012 - v2
Checksum:i36E618665D4DA8C3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti136 – 1361T → A in AAC52731 (PubMed:8764827).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34295 mRNA. Translation: AAC52731.1.
AK008308 mRNA. Translation: BAB25592.1.
AL603682 Genomic DNA. Translation: CAM18267.1.
CH466556 Genomic DNA. Translation: EDL16005.1.
CCDSiCCDS25287.1.
PIRiS71426.
RefSeqiNP_032145.2. NM_008119.2.
XP_006532287.1. XM_006532224.2.
XP_006532288.1. XM_006532225.2.
UniGeneiMm.248452.

Genome annotation databases

EnsembliENSMUST00000103156; ENSMUSP00000099445; ENSMUSG00000014351.
ENSMUST00000103157; ENSMUSP00000099446; ENSMUSG00000014351.
GeneIDi14607.
KEGGimmu:14607.
UCSCiuc007lba.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34295 mRNA. Translation: AAC52731.1.
AK008308 mRNA. Translation: BAB25592.1.
AL603682 Genomic DNA. Translation: CAM18267.1.
CH466556 Genomic DNA. Translation: EDL16005.1.
CCDSiCCDS25287.1.
PIRiS71426.
RefSeqiNP_032145.2. NM_008119.2.
XP_006532287.1. XM_006532224.2.
XP_006532288.1. XM_006532225.2.
UniGeneiMm.248452.

3D structure databases

ProteinModelPortaliP48756.
SMRiP48756. Positions 44-75.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099445.

PTM databases

PhosphoSiteiP48756.

Proteomic databases

PaxDbiP48756.
PRIDEiP48756.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000103156; ENSMUSP00000099445; ENSMUSG00000014351.
ENSMUST00000103157; ENSMUSP00000099446; ENSMUSG00000014351.
GeneIDi14607.
KEGGimmu:14607.
UCSCiuc007lba.1. mouse.

Organism-specific databases

CTDi2695.
MGIiMGI:107504. Gip.

Phylogenomic databases

eggNOGiENOG410JC1A. Eukaryota.
ENOG4111BXQ. LUCA.
GeneTreeiENSGT00390000005121.
HOGENOMiHOG000112725.
HOVERGENiHBG005839.
InParanoidiP48756.
KOiK05258.
OMAiLAWMVDQ.
OrthoDBiEOG7C8GKZ.
TreeFamiTF332333.

Enzyme and pathway databases

ReactomeiR-MMU-400511. Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP).
R-MMU-418555. G alpha (s) signalling events.
R-MMU-420092. Glucagon-type ligand receptors.

Miscellaneous databases

PROiP48756.
SOURCEiSearch...

Gene expression databases

CleanExiMM_GIP.
GenevisibleiP48756. MM.

Family and domain databases

InterProiIPR000532. Glucagon_GIP_secretin_VIP.
[Graphical view]
PfamiPF00123. Hormone_2. 1 hit.
[Graphical view]
SMARTiSM00070. GLUCA. 1 hit.
[Graphical view]
PROSITEiPS00260. GLUCAGON. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of a murine glucose-dependent insulinotropic polypeptide (GIP) cDNA from a tumor cell line (STC6-14) and quantification of glucose-induced increases in GIP mRNA."
    Schieldrop P.J., Gelling R.W., Elliot R., Hewitt J., Kieffer T.J., McIntosh C.H.S., Pederson R.A.
    Biochim. Biophys. Acta 1308:111-113(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Small intestine.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiGIP_MOUSE
AccessioniPrimary (citable) accession number: P48756
Secondary accession number(s): Q9D887
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: October 3, 2012
Last modified: June 8, 2016
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.