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Protein

Gastric inhibitory polypeptide

Gene

Gip

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-MMU-400511. Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP).
R-MMU-418555. G alpha (s) signalling events.
R-MMU-420092. Glucagon-type ligand receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Gastric inhibitory polypeptide
Short name:
GIP
Alternative name(s):
Glucose-dependent insulinotropic polypeptide
Gene namesi
Name:Gip
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:107504. Gip.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
PropeptideiPRO_000001121722 – 42Add BLAST21
PeptideiPRO_000001121844 – 85Gastric inhibitory polypeptideAdd BLAST42
PropeptideiPRO_000001121987 – 144Add BLAST58

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

PaxDbiP48756.
PeptideAtlasiP48756.
PRIDEiP48756.

PTM databases

PhosphoSitePlusiP48756.

Expressioni

Gene expression databases

BgeeiENSMUSG00000014351.
CleanExiMM_GIP.
GenevisibleiP48756. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099445.

Structurei

3D structure databases

ProteinModelPortaliP48756.
SMRiP48756.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glucagon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JC1A. Eukaryota.
ENOG4111BXQ. LUCA.
GeneTreeiENSGT00390000005121.
HOGENOMiHOG000112725.
HOVERGENiHBG005839.
InParanoidiP48756.
KOiK05258.
OMAiLAWMVDQ.
OrthoDBiEOG091G153X.
TreeFamiTF332333.

Family and domain databases

InterProiView protein in InterPro
IPR000532. Glucagon_GIP_secretin_VIP.
PfamiView protein in Pfam
PF00123. Hormone_2. 1 hit.
SMARTiView protein in SMART
SM00070. GLUCA. 1 hit.
PROSITEiView protein in PROSITE
PS00260. GLUCAGON. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48756-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVALKTCSLL LVLLFLAVGL GEKEEVEFRS HAKFAGPRPR GPRYAEGTFI
60 70 80 90 100
SDYSIAMDKI RQQDFVNWLL AQRGKKSDWK HNITQREARA LVLAGQSQGK
110 120 130 140
EDKEAQESSL PKSLSDDDVL RDLLIQELLA WMVDQTELCR LRSQ
Length:144
Mass (Da):16,389
Last modified:October 3, 2012 - v2
Checksum:i36E618665D4DA8C3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti136T → A in AAC52731 (PubMed:8764827).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34295 mRNA. Translation: AAC52731.1.
AK008308 mRNA. Translation: BAB25592.1.
AL603682 Genomic DNA. Translation: CAM18267.1.
CH466556 Genomic DNA. Translation: EDL16005.1.
CCDSiCCDS25287.1.
PIRiS71426.
RefSeqiNP_032145.2. NM_008119.2.
XP_006532287.1. XM_006532224.3.
XP_006532288.1. XM_006532225.3.
UniGeneiMm.248452.

Genome annotation databases

EnsembliENSMUST00000103156; ENSMUSP00000099445; ENSMUSG00000014351.
ENSMUST00000103157; ENSMUSP00000099446; ENSMUSG00000014351.
GeneIDi14607.
KEGGimmu:14607.
UCSCiuc007lba.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiGIP_MOUSE
AccessioniPrimary (citable) accession number: P48756
Secondary accession number(s): Q9D887
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: October 3, 2012
Last modified: May 10, 2017
This is version 107 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families