Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Fos-related antigen 1

Gene

Fosl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Fos-related antigen 1
Short name:
FRA-1
Gene namesi
Name:Fosl1
Synonyms:Fra1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:107179. Fosl1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 273273Fos-related antigen 1PRO_0000076480Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei267 – 2671PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP48755.
PeptideAtlasiP48755.
PRIDEiP48755.

PTM databases

iPTMnetiP48755.
PhosphoSiteiP48755.

Expressioni

Gene expression databases

BgeeiENSMUSG00000024912.
CleanExiMM_FOSL1.
ExpressionAtlasiP48755. baseline and differential.
GenevisibleiP48755. MM.

Interactioni

Subunit structurei

Heterodimer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025850.

Structurei

3D structure databases

ProteinModelPortaliP48755.
SMRiP48755. Positions 108-160.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini105 – 16864bZIPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni107 – 12721Basic motifPROSITE-ProRule annotationAdd
BLAST
Regioni133 – 16129Leucine-zipperPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi103 – 1064Poly-Glu
Compositional biasi253 – 2575Poly-Ser

Sequence similaritiesi

Belongs to the bZIP family. Fos subfamily.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1414. Eukaryota.
ENOG4111CH5. LUCA.
HOGENOMiHOG000234334.
HOVERGENiHBG005743.
InParanoidiP48755.
KOiK04502.
OMAiPCEQISP.
OrthoDBiEOG091G0GGW.
PhylomeDBiP48755.
TreeFamiTF326301.

Family and domain databases

InterProiIPR000837. AP-1.
IPR004827. bZIP.
[Graphical view]
PANTHERiPTHR23351. PTHR23351. 1 hit.
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
PRINTSiPR00042. LEUZIPPRFOS.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48755-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYRDYGEPGP SSGAGSPYGR PAQPPQAQAQ TAQQQKFHLV PSIDSSSQEL
60 70 80 90 100
HWMVQPHFLG PTGYPRPLAY PQYSPPQPRP GVIRALGPPP GVRRRPCEQI
110 120 130 140 150
SPEEEERRRV RRERNKLAAA KCRNRRKELT DFLQAETDKL EDEKSGLQRE
160 170 180 190 200
IEELQKQKER LELVLEAHRP ICKIPEGDKK DPGGSGSTSG ASSPPAPGRP
210 220 230 240 250
VPCISLSPGP VLEPEALHTP TLMTTPSLTP FTPSLVFTYP STPEPCSSAH
260 270
RKSSSSSGDP SSDPLGSPTL LAL
Length:273
Mass (Da):29,800
Last modified:May 30, 2000 - v2
Checksum:i4B068B0259866805
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti17 – 171P → A in AAC52888 (PubMed:8892610).Curated
Sequence conflicti39 – 391L → F in AAC52888 (PubMed:8892610).Curated
Sequence conflicti170 – 1701P → L in AAC52888 (PubMed:8892610).Curated
Sequence conflicti249 – 2491A → T in AAC52888 (PubMed:8892610).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34245 mRNA. Translation: AAC52888.1.
AF017128 Genomic DNA. Translation: AAB71369.1.
CCDSiCCDS29464.1.
RefSeqiNP_034365.1. NM_010235.2.
UniGeneiMm.6215.

Genome annotation databases

EnsembliENSMUST00000025850; ENSMUSP00000025850; ENSMUSG00000024912.
GeneIDi14283.
KEGGimmu:14283.
UCSCiuc008gdc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34245 mRNA. Translation: AAC52888.1.
AF017128 Genomic DNA. Translation: AAB71369.1.
CCDSiCCDS29464.1.
RefSeqiNP_034365.1. NM_010235.2.
UniGeneiMm.6215.

3D structure databases

ProteinModelPortaliP48755.
SMRiP48755. Positions 108-160.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025850.

PTM databases

iPTMnetiP48755.
PhosphoSiteiP48755.

Proteomic databases

PaxDbiP48755.
PeptideAtlasiP48755.
PRIDEiP48755.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025850; ENSMUSP00000025850; ENSMUSG00000024912.
GeneIDi14283.
KEGGimmu:14283.
UCSCiuc008gdc.1. mouse.

Organism-specific databases

CTDi8061.
MGIiMGI:107179. Fosl1.

Phylogenomic databases

eggNOGiKOG1414. Eukaryota.
ENOG4111CH5. LUCA.
HOGENOMiHOG000234334.
HOVERGENiHBG005743.
InParanoidiP48755.
KOiK04502.
OMAiPCEQISP.
OrthoDBiEOG091G0GGW.
PhylomeDBiP48755.
TreeFamiTF326301.

Miscellaneous databases

PROiP48755.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024912.
CleanExiMM_FOSL1.
ExpressionAtlasiP48755. baseline and differential.
GenevisibleiP48755. MM.

Family and domain databases

InterProiIPR000837. AP-1.
IPR004827. bZIP.
[Graphical view]
PANTHERiPTHR23351. PTHR23351. 1 hit.
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
PRINTSiPR00042. LEUZIPPRFOS.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFOSL1_MOUSE
AccessioniPrimary (citable) accession number: P48755
Secondary accession number(s): O35285
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: May 30, 2000
Last modified: September 7, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.