P48755 (FOSL1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fos-related antigen 1
Short name=FRA-1

Gene names

Name:	Fosl1
Synonyms:	Fra1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	273 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subunit structure	Heterodimer By similarity.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the bZIP family. Fos subfamily. Contains 1 bZIP (basic-leucine zipper) domain.

Ontologies

Keywords
Cellular component	Nucleus
Ligand	DNA-binding
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular response to extracellular stimulus Inferred from direct assay Ref.2. Source: MGI female pregnancy Inferred from electronic annotation. Source: Compara in utero embryonic development Inferred from mutant phenotype PubMed 11044407. Source: MGI learning Inferred from electronic annotation. Source: Compara negative regulation of cell proliferation Inferred from electronic annotation. Source: Compara placenta blood vessel development Inferred from mutant phenotype PubMed 11044407. Source: MGI positive regulation of apoptotic process Inferred from electronic annotation. Source: Compara positive regulation of cell cycle Inferred from electronic annotation. Source: Compara positive regulation of sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: Compara response to cAMP Inferred from electronic annotation. Source: Compara response to corticosterone stimulus Inferred from electronic annotation. Source: Compara response to cytokine stimulus Inferred from electronic annotation. Source: Compara response to drug Inferred from electronic annotation. Source: Compara response to gravity Inferred from electronic annotation. Source: Compara response to hydrogen peroxide Inferred from electronic annotation. Source: Compara response to mechanical stimulus Inferred from electronic annotation. Source: Compara response to progesterone stimulus Inferred from electronic annotation. Source: Compara vitellogenesis Inferred from mutant phenotype PubMed 11044407. Source: MGI
Cellular_component	cytosol Inferred from electronic annotation. Source: Compara neuron projection Inferred from electronic annotation. Source: Compara nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell presynaptic membrane Inferred from electronic annotation. Source: Compara
Molecular_function	RNA polymerase II regulatory region sequence-specific DNA binding Inferred from direct assay PubMed 19289495. Source: MGI sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 273	273	Fos-related antigen 1		PRO_0000076480
Regions
	Domain	105 – 168	64	bZIP
	Region	107 – 127	21	Basic motif By similarity
	Region	133 – 161	29	Leucine-zipper By similarity
	Compositional bias	103 – 106	4	Poly-Glu
	Compositional bias	253 – 257	5	Poly-Ser
Amino acid modifications
	Modified residue	267	1	Phosphoserine By similarity
Experimental info
	Sequence conflict	17	1	P → A in AAC52888. Ref.1
	Sequence conflict	39	1	L → F in AAC52888. Ref.1
	Sequence conflict	170	1	P → L in AAC52888. Ref.1
	Sequence conflict	249	1	A → T in AAC52888. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P48755 [UniParc]. Last modified May 30, 2000. Version 2. Checksum: 4B068B0259866805	FASTA	273	29,800
	10 20 30 40 50 60 MYRDYGEPGP SSGAGSPYGR PAQPPQAQAQ TAQQQKFHLV PSIDSSSQEL HWMVQPHFLG 70 80 90 100 110 120 PTGYPRPLAY PQYSPPQPRP GVIRALGPPP GVRRRPCEQI SPEEEERRRV RRERNKLAAA 130 140 150 160 170 180 KCRNRRKELT DFLQAETDKL EDEKSGLQRE IEELQKQKER LELVLEAHRP ICKIPEGDKK 190 200 210 220 230 240 DPGGSGSTSG ASSPPAPGRP VPCISLSPGP VLEPEALHTP TLMTTPSLTP FTPSLVFTYP 250 260 270 STPEPCSSAH RKSSSSSGDP SSDPLGSPTL LAL

References

[1]	"Isolation and characterization of murine fra-1: induction mediated by CD40 and surface Ig is protein kinase C dependent." Huo L., Rothstein T.L. J. Immunol. 157:3812-3818(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: BALB/cByJ. Tissue: Spleen.
[2]	"Structure and chromosomal assignment of the mouse fra-1 gene, and its exclusion as a candidate gene for oc (osteosclerosis)." Schreiber M., Poirier C., Franchi A., Kurzbauer R., Guenet J.-L., Carle G.F., Wagner E.F. Oncogene 15:1171-1178(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129/Sv.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U34245 mRNA. Translation: AAC52888.1. AF017128 Genomic DNA. Translation: AAB71369.1.
IPI	IPI00114353.
RefSeq	NP_034365.1. NM_010235.2.
UniGene	Mm.6215.
3D structure databases
ProteinModelPortal	P48755.
SMR	P48755. Positions 108-160.
ModBase	Search...
PTM databases
PhosphoSite	P48755.
Proteomic databases
PRIDE	P48755.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000025850; ENSMUSP00000025850; ENSMUSG00000024912.
GeneID	14283.
KEGG	mmu:14283.
Organism-specific databases
CTD	8061.
MGI	MGI:107179. Fosl1.
Phylogenomic databases
eggNOG	NOG252534.
HOGENOM	HOG000234334.
HOVERGEN	HBG005743.
InParanoid	P48755.
KO	K04502.
OMA	CASAHRK.
OrthoDB	EOG41C6XG.
Gene expression databases
ArrayExpress	P48755.
Bgee	P48755.
CleanEx	MM_FOSL1.
Genevestigator	P48755.
GermOnline	ENSMUSG00000024912. Mus musculus.
Family and domain databases
InterPro	IPR004827. bZIP. IPR000837. Leuzip_Fos. [Graphical view]
Pfam	PF00170. bZIP_1. 1 hit. [Graphical view]
PRINTS	PR00042. LEUZIPPRFOS.
SMART	SM00338. BRLZ. 1 hit. [Graphical view]
PROSITE	PS50217. BZIP. 1 hit. PS00036. BZIP_BASIC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	285665.
SOURCE	Search...

Entry information

Entry name

FOSL1_MOUSE

Accession

Primary (citable) accession number: P48755
Secondary accession number(s): O35285

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	May 30, 2000
Last modified:	April 3, 2013
This is version 93 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program