Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Fos-related antigen 1

Gene

Fosl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Fos-related antigen 1
Short name:
FRA-1
Gene namesi
Name:Fosl1
Synonyms:Fra1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:107179. Fosl1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000764801 – 273Fos-related antigen 1Add BLAST273

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei267PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP48755.
PeptideAtlasiP48755.
PRIDEiP48755.

PTM databases

iPTMnetiP48755.
PhosphoSitePlusiP48755.

Expressioni

Gene expression databases

BgeeiENSMUSG00000024912.
CleanExiMM_FOSL1.
ExpressionAtlasiP48755. baseline and differential.
GenevisibleiP48755. MM.

Interactioni

Subunit structurei

Heterodimer.By similarity

Protein-protein interaction databases

ELMiP48755.
STRINGi10090.ENSMUSP00000025850.

Structurei

3D structure databases

ProteinModelPortaliP48755.
SMRiP48755.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini105 – 168bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni107 – 127Basic motifPROSITE-ProRule annotationAdd BLAST21
Regioni133 – 161Leucine-zipperPROSITE-ProRule annotationAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi103 – 106Poly-Glu4
Compositional biasi253 – 257Poly-Ser5

Sequence similaritiesi

Belongs to the bZIP family. Fos subfamily.Curated

Phylogenomic databases

eggNOGiKOG1414. Eukaryota.
ENOG4111CH5. LUCA.
GeneTreeiENSGT00730000110541.
HOGENOMiHOG000234334.
HOVERGENiHBG005743.
InParanoidiP48755.
KOiK04502.
OMAiPCEQISP.
OrthoDBiEOG091G0GGW.
PhylomeDBiP48755.
TreeFamiTF326301.

Family and domain databases

InterProiView protein in InterPro
IPR000837. AP-1.
IPR004827. bZIP.
IPR029815. Fra1.
PANTHERiPTHR23351. PTHR23351. 1 hit.
PTHR23351:SF6. PTHR23351:SF6. 1 hit.
PfamiView protein in Pfam
PF00170. bZIP_1. 1 hit.
PRINTSiPR00042. LEUZIPPRFOS.
SMARTiView protein in SMART
SM00338. BRLZ. 1 hit.
PROSITEiView protein in PROSITE
PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.

Sequencei

Sequence statusi: Complete.

P48755-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYRDYGEPGP SSGAGSPYGR PAQPPQAQAQ TAQQQKFHLV PSIDSSSQEL
60 70 80 90 100
HWMVQPHFLG PTGYPRPLAY PQYSPPQPRP GVIRALGPPP GVRRRPCEQI
110 120 130 140 150
SPEEEERRRV RRERNKLAAA KCRNRRKELT DFLQAETDKL EDEKSGLQRE
160 170 180 190 200
IEELQKQKER LELVLEAHRP ICKIPEGDKK DPGGSGSTSG ASSPPAPGRP
210 220 230 240 250
VPCISLSPGP VLEPEALHTP TLMTTPSLTP FTPSLVFTYP STPEPCSSAH
260 270
RKSSSSSGDP SSDPLGSPTL LAL
Length:273
Mass (Da):29,800
Last modified:May 30, 2000 - v2
Checksum:i4B068B0259866805
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti17P → A in AAC52888 (PubMed:8892610).Curated1
Sequence conflicti39L → F in AAC52888 (PubMed:8892610).Curated1
Sequence conflicti170P → L in AAC52888 (PubMed:8892610).Curated1
Sequence conflicti249A → T in AAC52888 (PubMed:8892610).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34245 mRNA. Translation: AAC52888.1.
AF017128 Genomic DNA. Translation: AAB71369.1.
CCDSiCCDS29464.1.
RefSeqiNP_034365.1. NM_010235.2.
UniGeneiMm.6215.

Genome annotation databases

EnsembliENSMUST00000025850; ENSMUSP00000025850; ENSMUSG00000024912.
GeneIDi14283.
KEGGimmu:14283.
UCSCiuc008gdc.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiFOSL1_MOUSE
AccessioniPrimary (citable) accession number: P48755
Secondary accession number(s): O35285
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: May 30, 2000
Last modified: October 25, 2017
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families