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P48751

- B3A3_HUMAN

UniProt

P48751 - B3A3_HUMAN

Protein

Anion exchange protein 3

Gene

SLC4A3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
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    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 2 (05 Oct 2010)
      Previous versions | rss
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    Functioni

    Plasma membrane anion exchange protein of wide distribution. Mediates at least a part of the Cl-/HCO3- exchange in cardiac myocytes. Both BAE3 and CAE3 forms transport Cl-.

    GO - Molecular functioni

    1. inorganic anion exchanger activity Source: ProtInc

    GO - Biological processi

    1. bicarbonate transport Source: Reactome
    2. ion transport Source: Reactome
    3. regulation of intracellular pH Source: Ensembl
    4. transmembrane transport Source: Reactome
    5. transport Source: ProtInc

    Keywords - Biological processi

    Anion exchange, Antiport, Ion transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_19298. Bicarbonate transporters.

    Protein family/group databases

    TCDBi2.A.31.1.3. the anion exchanger (ae) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Anion exchange protein 3
    Short name:
    AE 3
    Short name:
    Anion exchanger 3
    Alternative name(s):
    CAE3/BAE3
    Cardiac/brain band 3-like protein
    Neuronal band 3-like protein
    Solute carrier family 4 member 3
    Gene namesi
    Name:SLC4A3
    Synonyms:AE3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:11029. SLC4A3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. membrane Source: ProtInc
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35897.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12321232Anion exchange protein 3PRO_0000079219Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi1165 – 11651S-palmitoyl cysteineBy similarity

    Keywords - PTMi

    Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiP48751.
    PRIDEiP48751.

    PTM databases

    PhosphoSiteiP48751.

    Expressioni

    Tissue specificityi

    Both BAE3 and CAE3 are expressed in failing ventricle.

    Gene expression databases

    ArrayExpressiP48751.
    BgeeiP48751.
    CleanExiHS_SLC4A3.
    GenevestigatoriP48751.

    Organism-specific databases

    HPAiHPA040315.

    Interactioni

    Protein-protein interaction databases

    BioGridi112399. 2 interactions.
    STRINGi9606.ENSP00000273063.

    Structurei

    3D structure databases

    ProteinModelPortaliP48751.
    SMRiP48751. Positions 320-638, 692-733.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 708708CytoplasmicAdd
    BLAST
    Topological domaini911 – 92515CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei709 – 73123HelicalSequence AnalysisAdd
    BLAST
    Transmembranei737 – 77438HelicalSequence AnalysisAdd
    BLAST
    Transmembranei794 – 81623HelicalSequence AnalysisAdd
    BLAST
    Transmembranei826 – 84722HelicalSequence AnalysisAdd
    BLAST
    Transmembranei893 – 91018HelicalSequence AnalysisAdd
    BLAST
    Transmembranei926 – 94621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei980 – 100223HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1028 – 104922HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1083 – 112846HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1155 – 119137HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni709 – 1232524Membrane (anion exchange)Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi136 – 14914Poly-GluAdd
    BLAST
    Compositional biasi152 – 16110Pro-rich
    Compositional biasi202 – 2076Poly-Ser
    Compositional biasi308 – 3136Poly-Lys
    Compositional biasi442 – 4454Poly-Ser
    Compositional biasi1184 – 11874Poly-Leu

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG268067.
    HOGENOMiHOG000280683.
    HOVERGENiHBG004326.
    KOiK13856.
    OMAiGDSHRGK.
    OrthoDBiEOG7TMZR0.
    PhylomeDBiP48751.
    TreeFamiTF313630.

    Family and domain databases

    Gene3Di3.40.1100.10. 1 hit.
    InterProiIPR001717. Anion_exchange.
    IPR002979. Anion_exchange_3.
    IPR018241. Anion_exchange_CS.
    IPR013769. Band3_cytoplasmic_dom.
    IPR011531. HCO3_transpt_C.
    IPR003020. HCO3_transpt_euk.
    IPR016152. PTrfase/Anion_transptr.
    [Graphical view]
    PANTHERiPTHR11453. PTHR11453. 1 hit.
    PTHR11453:SF15. PTHR11453:SF15. 1 hit.
    PfamiPF07565. Band_3_cyto. 1 hit.
    PF00955. HCO3_cotransp. 1 hit.
    [Graphical view]
    PRINTSiPR00165. ANIONEXCHNGR.
    PR01189. ANIONEXHNGR3.
    PR01231. HCO3TRNSPORT.
    SUPFAMiSSF55804. SSF55804. 2 hits.
    TIGRFAMsiTIGR00834. ae. 1 hit.
    PROSITEiPS00219. ANION_EXCHANGER_1. 1 hit.
    PS00220. ANION_EXCHANGER_2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.

    Isoform BAE3 (identifier: P48751-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MANGVIPPPG GASPLPQVRV PLEEPPLSPD VEEEDDDLGK TLAVSRFGDL     50
    ISKPPAWDPE KPSRSYSERD FEFHRHTSHH THHPLSARLP PPHKLRRLPP 100
    TSARHTRRKR KKEKTSAPPS EGTPPIQEEG GAGVDEEEEE EEEEEGESEA 150
    EPVEPPHSGT PQKAKFSIGS DEDDSPGLPG RAAVTKPLPS VGPHTDKSPQ 200
    HSSSSPSPRA RASRLAGEKS RPWSPSASYD LRERLCPGSA LGNPGGPEQQ 250
    VPTDEAEAQM LGSADLDDMK SHRLEDNPGV RRHLVKKPSR TQGGRGSPSG 300
    LAPILRRKKK KKKLDRRPHE VFVELNELML DRSQEPHWRE TARWIKFEED 350
    VEEETERWGK PHVASLSFRS LLELRRTIAH GAALLDLEQT TLPGIAHLVV 400
    ETMIVSDQIR PEDRASVLRT LLLKHSHPND DKDSGFFPRN PSSSSMNSVL 450
    GNHHPTPSHG PDGAVPTMAD DLGEPAPLWP HDPDAKEKPL HMPGGDGHRG 500
    KSLKLLEKIP EDAEATVVLV GCVPFLEQPA AAFVRLNEAV LLESVLEVPV 550
    PVRFLFVMLG PSHTSTDYHE LGRSIATLMS DKLFHEAAYQ ADDRQDLLSA 600
    ISEFLDGSIV IPPSEVEGRD LLRSVAAFQR ELLRKRRERE QTKVEMTTRG 650
    GYTAPGKELS LELGGSEATP EDDPLLRTGS VFGGLVRDVR RRYPHYPSDL 700
    RDALHSQCVA AVLFIYFAAL SPAITFGGLL GEKTEGLMGV SELIVSTAVL 750
    GVLFSLLGAQ PLLVVGFSGP LLVFEEAFFK FCRAQDLEYL TGRVWVGLWL 800
    VVFVLALVAA EGSFLVRYIS PFTQEIFAFL ISLIFIYETF YKLYKVFTEH 850
    PLLPFYPPEG ALEGSLDAGL EPNGSALPPT EGPPSPRNQP NTALLSLILM 900
    LGTFFIAFFL RKFRNSRFLG GKARRIIGDF GIPISILVMV LVDYSITDTY 950
    TQKLTVPTGL SVTSPDKRSW FIPPLGSARP FPPWMMVAAA VPALLVLILI 1000
    FMETQITALI VSQKARRLLK GSGFHLDLLL IGSLGGLCGL FGLPWLTAAT 1050
    VRSVTHVNAL TVMRTAIAPG DKPQIQEVRE QRVTGVLIAS LVGLSIVMGA 1100
    VLRRIPLAVL FGIFLYMGVT SLSGIQLSQR LLLILMPAKH HPEQPYVTKV 1150
    KTWRMHLFTC IQLGCIALLW VVKSTAASLA FPFLLLLTVP LRHCLLPRLF 1200
    QDRELQALDS EDAEPNFDED GQDEYNELHM PV 1232
    Length:1,232
    Mass (Da):135,791
    Last modified:October 5, 2010 - v2
    Checksum:iBA0B360E9D30030A
    GO
    Isoform CAE3 (identifier: P48751-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-296: Missing.
         297-299: SPS → MPA

    Show »
    Length:936
    Mass (Da):103,737
    Checksum:i0C028134284DD31B
    GO
    Isoform 3 (identifier: P48751-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         203-203: S → SRPCSELRDGDGTTDLALSSPRLLCCLP

    Show »
    Length:1,259
    Mass (Da):138,662
    Checksum:iC175EF6C771E31A5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti118 – 1181P → S in AAI46657. (PubMed:15489334)Curated
    Sequence conflicti243 – 2431N → S in AAI71760. (PubMed:15489334)Curated
    Sequence conflicti250 – 2501Q → H in AAI46657. (PubMed:15489334)Curated
    Sequence conflicti304 – 3041I → V in AAB05850. 1 PublicationCurated
    Sequence conflicti343 – 3431R → P in AAB05850. 1 PublicationCurated
    Sequence conflicti466 – 4661P → S in AAB05850. 1 PublicationCurated
    Sequence conflicti590 – 5901Q → K in AAN34939. 1 PublicationCurated
    Sequence conflicti608 – 6081S → G in AAB05850. 1 PublicationCurated
    Sequence conflicti702 – 7021D → A in AAB05850. 1 PublicationCurated
    Sequence conflicti812 – 8132GS → FI in AAB05850. 1 PublicationCurated
    Sequence conflicti822 – 8221F → L in AAB05850. 1 PublicationCurated
    Sequence conflicti850 – 8501H → R in AAN34939. 1 PublicationCurated
    Sequence conflicti860 – 8634Missing in AAB05850. 1 PublicationCurated
    Sequence conflicti875 – 8751S → C in AAB05850. 1 PublicationCurated
    Sequence conflicti885 – 8873SPR → GPE in AAB05850. 1 PublicationCurated
    Sequence conflicti899 – 8991L → P in AAB05850. 1 PublicationCurated
    Sequence conflicti953 – 9531K → N in BAF82663. (PubMed:14702039)Curated
    Sequence conflicti983 – 9831P → L in AAI71760. (PubMed:15489334)Curated
    Sequence conflicti1052 – 10521R → H in BAF82663. (PubMed:14702039)Curated
    Sequence conflicti1054 – 10541V → I in AAN34939. 1 PublicationCurated
    Sequence conflicti1096 – 10961I → M in AAB05850. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti157 – 1571H → P.5 Publications
    Corresponds to variant rs597306 [ dbSNP | Ensembl ].
    VAR_059081
    Natural varianti226 – 2261S → L.
    Corresponds to variant rs36068948 [ dbSNP | Ensembl ].
    VAR_055536
    Natural varianti867 – 8671D → A.4 Publications
    Corresponds to variant rs635311 [ dbSNP | Ensembl ].
    VAR_059082

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 296296Missing in isoform CAE3. 1 PublicationVSP_000462Add
    BLAST
    Alternative sequencei203 – 2031S → SRPCSELRDGDGTTDLALSS PRLLCCLP in isoform 3. 1 PublicationVSP_038184
    Alternative sequencei297 – 2993SPS → MPA in isoform CAE3. 1 PublicationVSP_000463

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U05596 mRNA. Translation: AAA50748.1.
    L27213 mRNA. Translation: AAB05850.1.
    AY142112 mRNA. Translation: AAN34939.1.
    AK289974 mRNA. Translation: BAF82663.1.
    AC009955 Genomic DNA. No translation available.
    CH471063 Genomic DNA. Translation: EAW70778.1.
    BC136384 mRNA. Translation: AAI36385.1.
    BC146656 mRNA. Translation: AAI46657.1.
    BC171760 mRNA. Translation: AAI71760.1.
    CCDSiCCDS2445.1. [P48751-1]
    CCDS2446.1. [P48751-3]
    PIRiI38496.
    RefSeqiNP_005061.2. NM_005070.3.
    NP_963868.2. NM_201574.2.
    XP_005246846.1. XM_005246789.2. [P48751-3]
    UniGeneiHs.1176.
    Hs.684906.

    Genome annotation databases

    EnsembliENST00000273063; ENSP00000273063; ENSG00000114923. [P48751-3]
    ENST00000317151; ENSP00000314006; ENSG00000114923. [P48751-1]
    ENST00000358055; ENSP00000350756; ENSG00000114923. [P48751-1]
    ENST00000373760; ENSP00000362865; ENSG00000114923. [P48751-1]
    GeneIDi6508.
    KEGGihsa:6508.
    UCSCiuc002vmo.4. human. [P48751-3]
    uc002vmp.4. human. [P48751-1]

    Polymorphism databases

    DMDMi308153414.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U05596 mRNA. Translation: AAA50748.1 .
    L27213 mRNA. Translation: AAB05850.1 .
    AY142112 mRNA. Translation: AAN34939.1 .
    AK289974 mRNA. Translation: BAF82663.1 .
    AC009955 Genomic DNA. No translation available.
    CH471063 Genomic DNA. Translation: EAW70778.1 .
    BC136384 mRNA. Translation: AAI36385.1 .
    BC146656 mRNA. Translation: AAI46657.1 .
    BC171760 mRNA. Translation: AAI71760.1 .
    CCDSi CCDS2445.1. [P48751-1 ]
    CCDS2446.1. [P48751-3 ]
    PIRi I38496.
    RefSeqi NP_005061.2. NM_005070.3.
    NP_963868.2. NM_201574.2.
    XP_005246846.1. XM_005246789.2. [P48751-3 ]
    UniGenei Hs.1176.
    Hs.684906.

    3D structure databases

    ProteinModelPortali P48751.
    SMRi P48751. Positions 320-638, 692-733.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112399. 2 interactions.
    STRINGi 9606.ENSP00000273063.

    Protein family/group databases

    TCDBi 2.A.31.1.3. the anion exchanger (ae) family.

    PTM databases

    PhosphoSitei P48751.

    Polymorphism databases

    DMDMi 308153414.

    Proteomic databases

    PaxDbi P48751.
    PRIDEi P48751.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000273063 ; ENSP00000273063 ; ENSG00000114923 . [P48751-3 ]
    ENST00000317151 ; ENSP00000314006 ; ENSG00000114923 . [P48751-1 ]
    ENST00000358055 ; ENSP00000350756 ; ENSG00000114923 . [P48751-1 ]
    ENST00000373760 ; ENSP00000362865 ; ENSG00000114923 . [P48751-1 ]
    GeneIDi 6508.
    KEGGi hsa:6508.
    UCSCi uc002vmo.4. human. [P48751-3 ]
    uc002vmp.4. human. [P48751-1 ]

    Organism-specific databases

    CTDi 6508.
    GeneCardsi GC02P220492.
    HGNCi HGNC:11029. SLC4A3.
    HPAi HPA040315.
    MIMi 106195. gene.
    neXtProti NX_P48751.
    PharmGKBi PA35897.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG268067.
    HOGENOMi HOG000280683.
    HOVERGENi HBG004326.
    KOi K13856.
    OMAi GDSHRGK.
    OrthoDBi EOG7TMZR0.
    PhylomeDBi P48751.
    TreeFami TF313630.

    Enzyme and pathway databases

    Reactomei REACT_19298. Bicarbonate transporters.

    Miscellaneous databases

    ChiTaRSi SLC4A3. human.
    GeneWikii SLC4A3.
    GenomeRNAii 6508.
    NextBioi 25305.
    PROi P48751.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P48751.
    Bgeei P48751.
    CleanExi HS_SLC4A3.
    Genevestigatori P48751.

    Family and domain databases

    Gene3Di 3.40.1100.10. 1 hit.
    InterProi IPR001717. Anion_exchange.
    IPR002979. Anion_exchange_3.
    IPR018241. Anion_exchange_CS.
    IPR013769. Band3_cytoplasmic_dom.
    IPR011531. HCO3_transpt_C.
    IPR003020. HCO3_transpt_euk.
    IPR016152. PTrfase/Anion_transptr.
    [Graphical view ]
    PANTHERi PTHR11453. PTHR11453. 1 hit.
    PTHR11453:SF15. PTHR11453:SF15. 1 hit.
    Pfami PF07565. Band_3_cyto. 1 hit.
    PF00955. HCO3_cotransp. 1 hit.
    [Graphical view ]
    PRINTSi PR00165. ANIONEXCHNGR.
    PR01189. ANIONEXHNGR3.
    PR01231. HCO3TRNSPORT.
    SUPFAMi SSF55804. SSF55804. 2 hits.
    TIGRFAMsi TIGR00834. ae. 1 hit.
    PROSITEi PS00219. ANION_EXCHANGER_1. 1 hit.
    PS00220. ANION_EXCHANGER_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning, expression, and chromosomal localization of two isoforms of the AE3 anion exchanger from human heart."
      Yannoukakos D., Stuart-Tilley A., Fernandez H., Fey P., Duyk G., Alper S.L.
      Circ. Res. 75:603-614(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BAE3), VARIANTS PRO-157 AND ALA-867.
      Tissue: Heart.
    2. "Cloning of the characterization of the human cardiac anion exchanger gene."
      Kudo S., Mattei M.-G., Bloor C.M., Fukuda M., Ranney H.M., Xu A.
      Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CAE3).
      Tissue: Heart.
    3. "Sequence of an alternative splice form of brain AE3."
      Mount D.B.
      Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), VARIANT PRO-157.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BAE3), VARIANTS PRO-157 AND ALA-867.
      Tissue: Hippocampus.
    5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS PRO-157 AND ALA-867.
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BAE3), VARIANTS PRO-157 AND ALA-867.
      Tissue: Testis.

    Entry informationi

    Entry nameiB3A3_HUMAN
    AccessioniPrimary (citable) accession number: P48751
    Secondary accession number(s): A6H8L2
    , A8K1Q9, B7ZVX6, B9EGD1, Q6YIQ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 128 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3