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Protein

Anion exchange protein 3

Gene

SLC4A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Plasma membrane anion exchange protein of wide distribution. Mediates at least a part of the Cl-/HCO3- exchange in cardiac myocytes. Both BAE3 and CAE3 forms transport Cl-.

GO - Molecular functioni

GO - Biological processi

  • bicarbonate transport Source: Reactome
  • chloride transmembrane transport Source: GO_Central
  • regulation of intracellular pH Source: GO_Central
  • transport Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Anion exchange, Antiport, Ion transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000114923-MONOMER.
ReactomeiR-HSA-425381. Bicarbonate transporters.
SIGNORiP48751.

Protein family/group databases

TCDBi2.A.31.1.3. the anion exchanger (ae) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Anion exchange protein 3
Short name:
AE 3
Short name:
Anion exchanger 3
Alternative name(s):
CAE3/BAE3
Cardiac/brain band 3-like protein
Neuronal band 3-like protein
Solute carrier family 4 member 3
Gene namesi
Name:SLC4A3
Synonyms:AE3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:11029. SLC4A3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 708CytoplasmicAdd BLAST708
Transmembranei709 – 731HelicalSequence analysisAdd BLAST23
Transmembranei737 – 774HelicalSequence analysisAdd BLAST38
Transmembranei794 – 816HelicalSequence analysisAdd BLAST23
Transmembranei826 – 847HelicalSequence analysisAdd BLAST22
Transmembranei893 – 910HelicalSequence analysisAdd BLAST18
Topological domaini911 – 925CytoplasmicSequence analysisAdd BLAST15
Transmembranei926 – 946HelicalSequence analysisAdd BLAST21
Transmembranei980 – 1002HelicalSequence analysisAdd BLAST23
Transmembranei1028 – 1049HelicalSequence analysisAdd BLAST22
Transmembranei1083 – 1128HelicalSequence analysisAdd BLAST46
Transmembranei1155 – 1191HelicalSequence analysisAdd BLAST37

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi6508.
OpenTargetsiENSG00000114923.
PharmGKBiPA35897.

Polymorphism and mutation databases

BioMutaiSLC4A3.
DMDMi308153414.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000792191 – 1232Anion exchange protein 3Add BLAST1232

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei167PhosphoserineBy similarity1
Modified residuei170PhosphoserineBy similarity1
Modified residuei175PhosphoserineBy similarity1
Modified residuei198PhosphoserineBy similarity1
Modified residuei295Omega-N-methylarginineBy similarity1
Lipidationi1165S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Palmitate, Phosphoprotein

Proteomic databases

MaxQBiP48751.
PaxDbiP48751.
PeptideAtlasiP48751.
PRIDEiP48751.

PTM databases

iPTMnetiP48751.
PhosphoSitePlusiP48751.

Expressioni

Tissue specificityi

Both BAE3 and CAE3 are expressed in failing ventricle.

Gene expression databases

BgeeiENSG00000114923.
CleanExiHS_SLC4A3.
ExpressionAtlasiP48751. baseline and differential.
GenevisibleiP48751. HS.

Organism-specific databases

HPAiHPA040315.

Interactioni

Protein-protein interaction databases

BioGridi112399. 1 interactor.
STRINGi9606.ENSP00000273063.

Structurei

3D structure databases

ProteinModelPortaliP48751.
SMRiP48751.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni709 – 1232Membrane (anion exchange)Add BLAST524

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi136 – 149Poly-GluAdd BLAST14
Compositional biasi152 – 161Pro-rich10
Compositional biasi202 – 207Poly-Ser6
Compositional biasi308 – 313Poly-Lys6
Compositional biasi442 – 445Poly-Ser4
Compositional biasi1184 – 1187Poly-Leu4

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1172. Eukaryota.
ENOG410XPHD. LUCA.
GeneTreeiENSGT00760000119021.
HOGENOMiHOG000280683.
HOVERGENiHBG004326.
InParanoidiP48751.
KOiK13856.
OMAiKSPQHSV.
OrthoDBiEOG091G01FT.
PhylomeDBiP48751.
TreeFamiTF313630.

Family and domain databases

Gene3Di3.40.1100.10. 1 hit.
InterProiIPR001717. Anion_exchange.
IPR002979. Anion_exchange_3.
IPR018241. Anion_exchange_CS.
IPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 2 hits.
PTHR11453:SF15. PTHR11453:SF15. 2 hits.
PfamiPF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view]
PRINTSiPR00165. ANIONEXCHNGR.
PR01189. ANIONEXHNGR3.
PR01231. HCO3TRNSPORT.
SUPFAMiSSF55804. SSF55804. 2 hits.
TIGRFAMsiTIGR00834. ae. 1 hit.
PROSITEiPS00219. ANION_EXCHANGER_1. 1 hit.
PS00220. ANION_EXCHANGER_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform BAE3 (identifier: P48751-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MANGVIPPPG GASPLPQVRV PLEEPPLSPD VEEEDDDLGK TLAVSRFGDL
60 70 80 90 100
ISKPPAWDPE KPSRSYSERD FEFHRHTSHH THHPLSARLP PPHKLRRLPP
110 120 130 140 150
TSARHTRRKR KKEKTSAPPS EGTPPIQEEG GAGVDEEEEE EEEEEGESEA
160 170 180 190 200
EPVEPPHSGT PQKAKFSIGS DEDDSPGLPG RAAVTKPLPS VGPHTDKSPQ
210 220 230 240 250
HSSSSPSPRA RASRLAGEKS RPWSPSASYD LRERLCPGSA LGNPGGPEQQ
260 270 280 290 300
VPTDEAEAQM LGSADLDDMK SHRLEDNPGV RRHLVKKPSR TQGGRGSPSG
310 320 330 340 350
LAPILRRKKK KKKLDRRPHE VFVELNELML DRSQEPHWRE TARWIKFEED
360 370 380 390 400
VEEETERWGK PHVASLSFRS LLELRRTIAH GAALLDLEQT TLPGIAHLVV
410 420 430 440 450
ETMIVSDQIR PEDRASVLRT LLLKHSHPND DKDSGFFPRN PSSSSMNSVL
460 470 480 490 500
GNHHPTPSHG PDGAVPTMAD DLGEPAPLWP HDPDAKEKPL HMPGGDGHRG
510 520 530 540 550
KSLKLLEKIP EDAEATVVLV GCVPFLEQPA AAFVRLNEAV LLESVLEVPV
560 570 580 590 600
PVRFLFVMLG PSHTSTDYHE LGRSIATLMS DKLFHEAAYQ ADDRQDLLSA
610 620 630 640 650
ISEFLDGSIV IPPSEVEGRD LLRSVAAFQR ELLRKRRERE QTKVEMTTRG
660 670 680 690 700
GYTAPGKELS LELGGSEATP EDDPLLRTGS VFGGLVRDVR RRYPHYPSDL
710 720 730 740 750
RDALHSQCVA AVLFIYFAAL SPAITFGGLL GEKTEGLMGV SELIVSTAVL
760 770 780 790 800
GVLFSLLGAQ PLLVVGFSGP LLVFEEAFFK FCRAQDLEYL TGRVWVGLWL
810 820 830 840 850
VVFVLALVAA EGSFLVRYIS PFTQEIFAFL ISLIFIYETF YKLYKVFTEH
860 870 880 890 900
PLLPFYPPEG ALEGSLDAGL EPNGSALPPT EGPPSPRNQP NTALLSLILM
910 920 930 940 950
LGTFFIAFFL RKFRNSRFLG GKARRIIGDF GIPISILVMV LVDYSITDTY
960 970 980 990 1000
TQKLTVPTGL SVTSPDKRSW FIPPLGSARP FPPWMMVAAA VPALLVLILI
1010 1020 1030 1040 1050
FMETQITALI VSQKARRLLK GSGFHLDLLL IGSLGGLCGL FGLPWLTAAT
1060 1070 1080 1090 1100
VRSVTHVNAL TVMRTAIAPG DKPQIQEVRE QRVTGVLIAS LVGLSIVMGA
1110 1120 1130 1140 1150
VLRRIPLAVL FGIFLYMGVT SLSGIQLSQR LLLILMPAKH HPEQPYVTKV
1160 1170 1180 1190 1200
KTWRMHLFTC IQLGCIALLW VVKSTAASLA FPFLLLLTVP LRHCLLPRLF
1210 1220 1230
QDRELQALDS EDAEPNFDED GQDEYNELHM PV
Length:1,232
Mass (Da):135,791
Last modified:October 5, 2010 - v2
Checksum:iBA0B360E9D30030A
GO
Isoform CAE3 (identifier: P48751-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-296: Missing.
     297-299: SPS → MPA

Show »
Length:936
Mass (Da):103,737
Checksum:i0C028134284DD31B
GO
Isoform 3 (identifier: P48751-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     203-203: S → SRPCSELRDGDGTTDLALSSPRLLCCLP

Show »
Length:1,259
Mass (Da):138,662
Checksum:iC175EF6C771E31A5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti118P → S in AAI46657 (PubMed:15489334).Curated1
Sequence conflicti243N → S in AAI71760 (PubMed:15489334).Curated1
Sequence conflicti250Q → H in AAI46657 (PubMed:15489334).Curated1
Sequence conflicti304I → V in AAB05850 (Ref. 2) Curated1
Sequence conflicti343R → P in AAB05850 (Ref. 2) Curated1
Sequence conflicti466P → S in AAB05850 (Ref. 2) Curated1
Sequence conflicti590Q → K in AAN34939 (Ref. 3) Curated1
Sequence conflicti608S → G in AAB05850 (Ref. 2) Curated1
Sequence conflicti702D → A in AAB05850 (Ref. 2) Curated1
Sequence conflicti812 – 813GS → FI in AAB05850 (Ref. 2) Curated2
Sequence conflicti822F → L in AAB05850 (Ref. 2) Curated1
Sequence conflicti850H → R in AAN34939 (Ref. 3) Curated1
Sequence conflicti860 – 863Missing in AAB05850 (Ref. 2) Curated4
Sequence conflicti875S → C in AAB05850 (Ref. 2) Curated1
Sequence conflicti885 – 887SPR → GPE in AAB05850 (Ref. 2) Curated3
Sequence conflicti899L → P in AAB05850 (Ref. 2) Curated1
Sequence conflicti953K → N in BAF82663 (PubMed:14702039).Curated1
Sequence conflicti983P → L in AAI71760 (PubMed:15489334).Curated1
Sequence conflicti1052R → H in BAF82663 (PubMed:14702039).Curated1
Sequence conflicti1054V → I in AAN34939 (Ref. 3) Curated1
Sequence conflicti1096I → M in AAB05850 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059081157H → P.5 PublicationsCorresponds to variant rs597306dbSNPEnsembl.1
Natural variantiVAR_055536226S → L.Corresponds to variant rs36068948dbSNPEnsembl.1
Natural variantiVAR_059082867D → A.4 PublicationsCorresponds to variant rs635311dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0004621 – 296Missing in isoform CAE3. 1 PublicationAdd BLAST296
Alternative sequenceiVSP_038184203S → SRPCSELRDGDGTTDLALSS PRLLCCLP in isoform 3. 1 Publication1
Alternative sequenceiVSP_000463297 – 299SPS → MPA in isoform CAE3. 1 Publication3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U05596 mRNA. Translation: AAA50748.1.
L27213 mRNA. Translation: AAB05850.1.
AY142112 mRNA. Translation: AAN34939.1.
AK289974 mRNA. Translation: BAF82663.1.
AC009955 Genomic DNA. No translation available.
CH471063 Genomic DNA. Translation: EAW70778.1.
BC136384 mRNA. Translation: AAI36385.1.
BC146656 mRNA. Translation: AAI46657.1.
BC171760 mRNA. Translation: AAI71760.1.
CCDSiCCDS2445.1. [P48751-1]
CCDS2446.1. [P48751-3]
PIRiI38496.
RefSeqiNP_001313488.1. NM_001326559.1.
NP_005061.2. NM_005070.3.
NP_963868.2. NM_201574.2.
XP_005246846.1. XM_005246789.4. [P48751-3]
UniGeneiHs.1176.
Hs.684906.

Genome annotation databases

EnsembliENST00000273063; ENSP00000273063; ENSG00000114923. [P48751-3]
ENST00000317151; ENSP00000314006; ENSG00000114923. [P48751-1]
ENST00000358055; ENSP00000350756; ENSG00000114923. [P48751-1]
ENST00000373760; ENSP00000362865; ENSG00000114923. [P48751-1]
GeneIDi6508.
KEGGihsa:6508.
UCSCiuc002vmo.5. human. [P48751-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U05596 mRNA. Translation: AAA50748.1.
L27213 mRNA. Translation: AAB05850.1.
AY142112 mRNA. Translation: AAN34939.1.
AK289974 mRNA. Translation: BAF82663.1.
AC009955 Genomic DNA. No translation available.
CH471063 Genomic DNA. Translation: EAW70778.1.
BC136384 mRNA. Translation: AAI36385.1.
BC146656 mRNA. Translation: AAI46657.1.
BC171760 mRNA. Translation: AAI71760.1.
CCDSiCCDS2445.1. [P48751-1]
CCDS2446.1. [P48751-3]
PIRiI38496.
RefSeqiNP_001313488.1. NM_001326559.1.
NP_005061.2. NM_005070.3.
NP_963868.2. NM_201574.2.
XP_005246846.1. XM_005246789.4. [P48751-3]
UniGeneiHs.1176.
Hs.684906.

3D structure databases

ProteinModelPortaliP48751.
SMRiP48751.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112399. 1 interactor.
STRINGi9606.ENSP00000273063.

Protein family/group databases

TCDBi2.A.31.1.3. the anion exchanger (ae) family.

PTM databases

iPTMnetiP48751.
PhosphoSitePlusiP48751.

Polymorphism and mutation databases

BioMutaiSLC4A3.
DMDMi308153414.

Proteomic databases

MaxQBiP48751.
PaxDbiP48751.
PeptideAtlasiP48751.
PRIDEiP48751.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000273063; ENSP00000273063; ENSG00000114923. [P48751-3]
ENST00000317151; ENSP00000314006; ENSG00000114923. [P48751-1]
ENST00000358055; ENSP00000350756; ENSG00000114923. [P48751-1]
ENST00000373760; ENSP00000362865; ENSG00000114923. [P48751-1]
GeneIDi6508.
KEGGihsa:6508.
UCSCiuc002vmo.5. human. [P48751-1]

Organism-specific databases

CTDi6508.
DisGeNETi6508.
GeneCardsiSLC4A3.
HGNCiHGNC:11029. SLC4A3.
HPAiHPA040315.
MIMi106195. gene.
neXtProtiNX_P48751.
OpenTargetsiENSG00000114923.
PharmGKBiPA35897.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1172. Eukaryota.
ENOG410XPHD. LUCA.
GeneTreeiENSGT00760000119021.
HOGENOMiHOG000280683.
HOVERGENiHBG004326.
InParanoidiP48751.
KOiK13856.
OMAiKSPQHSV.
OrthoDBiEOG091G01FT.
PhylomeDBiP48751.
TreeFamiTF313630.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000114923-MONOMER.
ReactomeiR-HSA-425381. Bicarbonate transporters.
SIGNORiP48751.

Miscellaneous databases

ChiTaRSiSLC4A3. human.
GeneWikiiSLC4A3.
GenomeRNAii6508.
PROiP48751.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000114923.
CleanExiHS_SLC4A3.
ExpressionAtlasiP48751. baseline and differential.
GenevisibleiP48751. HS.

Family and domain databases

Gene3Di3.40.1100.10. 1 hit.
InterProiIPR001717. Anion_exchange.
IPR002979. Anion_exchange_3.
IPR018241. Anion_exchange_CS.
IPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 2 hits.
PTHR11453:SF15. PTHR11453:SF15. 2 hits.
PfamiPF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view]
PRINTSiPR00165. ANIONEXCHNGR.
PR01189. ANIONEXHNGR3.
PR01231. HCO3TRNSPORT.
SUPFAMiSSF55804. SSF55804. 2 hits.
TIGRFAMsiTIGR00834. ae. 1 hit.
PROSITEiPS00219. ANION_EXCHANGER_1. 1 hit.
PS00220. ANION_EXCHANGER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB3A3_HUMAN
AccessioniPrimary (citable) accession number: P48751
Secondary accession number(s): A6H8L2
, A8K1Q9, B7ZVX6, B9EGD1, Q6YIQ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: October 5, 2010
Last modified: November 2, 2016
This is version 146 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.