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P48751 (B3A3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 124. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Anion exchange protein 3

Short name=AE 3
Short name=Anion exchanger 3
Alternative name(s):
CAE3/BAE3
Cardiac/brain band 3-like protein
Neuronal band 3-like protein
Solute carrier family 4 member 3
Gene names
Name:SLC4A3
Synonyms:AE3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1232 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Plasma membrane anion exchange protein of wide distribution. Mediates at least a part of the Cl-/HCO3- exchange in cardiac myocytes. Both BAE3 and CAE3 forms transport Cl-.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Both BAE3 and CAE3 are expressed in failing ventricle.

Sequence similarities

Belongs to the anion exchanger (TC 2.A.31) family. [View classification]

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.
Isoform BAE3 (identifier: P48751-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform CAE3 (identifier: P48751-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-296: Missing.
     297-299: SPS → MPA
Isoform 3 (identifier: P48751-3)

The sequence of this isoform differs from the canonical sequence as follows:
     203-203: S → SRPCSELRDGDGTTDLALSSPRLLCCLP

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12321232Anion exchange protein 3
PRO_0000079219

Regions

Topological domain1 – 708708Cytoplasmic
Transmembrane709 – 73123Helical; Potential
Transmembrane737 – 77438Helical; Potential
Transmembrane794 – 81623Helical; Potential
Transmembrane826 – 84722Helical; Potential
Transmembrane893 – 91018Helical; Potential
Topological domain911 – 92515Cytoplasmic Potential
Transmembrane926 – 94621Helical; Potential
Transmembrane980 – 100223Helical; Potential
Transmembrane1028 – 104922Helical; Potential
Transmembrane1083 – 112846Helical; Potential
Transmembrane1155 – 119137Helical; Potential
Region709 – 1232524Membrane (anion exchange)
Compositional bias136 – 14914Poly-Glu
Compositional bias152 – 16110Pro-rich
Compositional bias202 – 2076Poly-Ser
Compositional bias308 – 3136Poly-Lys
Compositional bias442 – 4454Poly-Ser
Compositional bias1184 – 11874Poly-Leu

Amino acid modifications

Lipidation11651S-palmitoyl cysteine By similarity

Natural variations

Alternative sequence1 – 296296Missing in isoform CAE3.
VSP_000462
Alternative sequence2031S → SRPCSELRDGDGTTDLALSS PRLLCCLP in isoform 3.
VSP_038184
Alternative sequence297 – 2993SPS → MPA in isoform CAE3.
VSP_000463
Natural variant1571H → P. Ref.1 Ref.3 Ref.4 Ref.6 Ref.7
Corresponds to variant rs597306 [ dbSNP | Ensembl ].
VAR_059081
Natural variant2261S → L.
Corresponds to variant rs36068948 [ dbSNP | Ensembl ].
VAR_055536
Natural variant8671D → A. Ref.1 Ref.4 Ref.6 Ref.7
Corresponds to variant rs635311 [ dbSNP | Ensembl ].
VAR_059082

Experimental info

Sequence conflict1181P → S in AAI46657. Ref.7
Sequence conflict2431N → S in AAI71760. Ref.7
Sequence conflict2501Q → H in AAI46657. Ref.7
Sequence conflict3041I → V in AAB05850. Ref.2
Sequence conflict3431R → P in AAB05850. Ref.2
Sequence conflict4661P → S in AAB05850. Ref.2
Sequence conflict5901Q → K in AAN34939. Ref.3
Sequence conflict6081S → G in AAB05850. Ref.2
Sequence conflict7021D → A in AAB05850. Ref.2
Sequence conflict812 – 8132GS → FI in AAB05850. Ref.2
Sequence conflict8221F → L in AAB05850. Ref.2
Sequence conflict8501H → R in AAN34939. Ref.3
Sequence conflict860 – 8634Missing in AAB05850. Ref.2
Sequence conflict8751S → C in AAB05850. Ref.2
Sequence conflict885 – 8873SPR → GPE in AAB05850. Ref.2
Sequence conflict8991L → P in AAB05850. Ref.2
Sequence conflict9531K → N in BAF82663. Ref.4
Sequence conflict9831P → L in AAI71760. Ref.7
Sequence conflict10521R → H in BAF82663. Ref.4
Sequence conflict10541V → I in AAN34939. Ref.3
Sequence conflict10961I → M in AAB05850. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform BAE3 [UniParc].

Last modified October 5, 2010. Version 2.
Checksum: BA0B360E9D30030A

FASTA1,232135,791
        10         20         30         40         50         60 
MANGVIPPPG GASPLPQVRV PLEEPPLSPD VEEEDDDLGK TLAVSRFGDL ISKPPAWDPE 

        70         80         90        100        110        120 
KPSRSYSERD FEFHRHTSHH THHPLSARLP PPHKLRRLPP TSARHTRRKR KKEKTSAPPS 

       130        140        150        160        170        180 
EGTPPIQEEG GAGVDEEEEE EEEEEGESEA EPVEPPHSGT PQKAKFSIGS DEDDSPGLPG 

       190        200        210        220        230        240 
RAAVTKPLPS VGPHTDKSPQ HSSSSPSPRA RASRLAGEKS RPWSPSASYD LRERLCPGSA 

       250        260        270        280        290        300 
LGNPGGPEQQ VPTDEAEAQM LGSADLDDMK SHRLEDNPGV RRHLVKKPSR TQGGRGSPSG 

       310        320        330        340        350        360 
LAPILRRKKK KKKLDRRPHE VFVELNELML DRSQEPHWRE TARWIKFEED VEEETERWGK 

       370        380        390        400        410        420 
PHVASLSFRS LLELRRTIAH GAALLDLEQT TLPGIAHLVV ETMIVSDQIR PEDRASVLRT 

       430        440        450        460        470        480 
LLLKHSHPND DKDSGFFPRN PSSSSMNSVL GNHHPTPSHG PDGAVPTMAD DLGEPAPLWP 

       490        500        510        520        530        540 
HDPDAKEKPL HMPGGDGHRG KSLKLLEKIP EDAEATVVLV GCVPFLEQPA AAFVRLNEAV 

       550        560        570        580        590        600 
LLESVLEVPV PVRFLFVMLG PSHTSTDYHE LGRSIATLMS DKLFHEAAYQ ADDRQDLLSA 

       610        620        630        640        650        660 
ISEFLDGSIV IPPSEVEGRD LLRSVAAFQR ELLRKRRERE QTKVEMTTRG GYTAPGKELS 

       670        680        690        700        710        720 
LELGGSEATP EDDPLLRTGS VFGGLVRDVR RRYPHYPSDL RDALHSQCVA AVLFIYFAAL 

       730        740        750        760        770        780 
SPAITFGGLL GEKTEGLMGV SELIVSTAVL GVLFSLLGAQ PLLVVGFSGP LLVFEEAFFK 

       790        800        810        820        830        840 
FCRAQDLEYL TGRVWVGLWL VVFVLALVAA EGSFLVRYIS PFTQEIFAFL ISLIFIYETF 

       850        860        870        880        890        900 
YKLYKVFTEH PLLPFYPPEG ALEGSLDAGL EPNGSALPPT EGPPSPRNQP NTALLSLILM 

       910        920        930        940        950        960 
LGTFFIAFFL RKFRNSRFLG GKARRIIGDF GIPISILVMV LVDYSITDTY TQKLTVPTGL 

       970        980        990       1000       1010       1020 
SVTSPDKRSW FIPPLGSARP FPPWMMVAAA VPALLVLILI FMETQITALI VSQKARRLLK 

      1030       1040       1050       1060       1070       1080 
GSGFHLDLLL IGSLGGLCGL FGLPWLTAAT VRSVTHVNAL TVMRTAIAPG DKPQIQEVRE 

      1090       1100       1110       1120       1130       1140 
QRVTGVLIAS LVGLSIVMGA VLRRIPLAVL FGIFLYMGVT SLSGIQLSQR LLLILMPAKH 

      1150       1160       1170       1180       1190       1200 
HPEQPYVTKV KTWRMHLFTC IQLGCIALLW VVKSTAASLA FPFLLLLTVP LRHCLLPRLF 

      1210       1220       1230 
QDRELQALDS EDAEPNFDED GQDEYNELHM PV 

« Hide

Isoform CAE3 [UniParc].

Checksum: 0C028134284DD31B
Show »

FASTA936103,737
Isoform 3 [UniParc].

Checksum: C175EF6C771E31A5
Show »

FASTA1,259138,662

References

« Hide 'large scale' references
[1]"Molecular cloning, expression, and chromosomal localization of two isoforms of the AE3 anion exchanger from human heart."
Yannoukakos D., Stuart-Tilley A., Fernandez H., Fey P., Duyk G., Alper S.L.
Circ. Res. 75:603-614(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BAE3), VARIANTS PRO-157 AND ALA-867.
Tissue: Heart.
[2]"Cloning of the characterization of the human cardiac anion exchanger gene."
Kudo S., Mattei M.-G., Bloor C.M., Fukuda M., Ranney H.M., Xu A.
Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CAE3).
Tissue: Heart.
[3]"Sequence of an alternative splice form of brain AE3."
Mount D.B.
Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), VARIANT PRO-157.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BAE3), VARIANTS PRO-157 AND ALA-867.
Tissue: Hippocampus.
[5]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS PRO-157 AND ALA-867.
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BAE3), VARIANTS PRO-157 AND ALA-867.
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U05596 mRNA. Translation: AAA50748.1.
L27213 mRNA. Translation: AAB05850.1.
AY142112 mRNA. Translation: AAN34939.1.
AK289974 mRNA. Translation: BAF82663.1.
AC009955 Genomic DNA. No translation available.
CH471063 Genomic DNA. Translation: EAW70778.1.
BC136384 mRNA. Translation: AAI36385.1.
BC146656 mRNA. Translation: AAI46657.1.
BC171760 mRNA. Translation: AAI71760.1.
PIRI38496.
RefSeqNP_005061.2. NM_005070.3.
NP_963868.2. NM_201574.2.
XP_005246846.1. XM_005246789.2.
UniGeneHs.1176.
Hs.684906.

3D structure databases

ProteinModelPortalP48751.
SMRP48751. Positions 320-638, 692-733.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112399. 2 interactions.
STRING9606.ENSP00000273063.

Protein family/group databases

TCDB2.A.31.1.3. the anion exchanger (ae) family.

PTM databases

PhosphoSiteP48751.

Polymorphism databases

DMDM308153414.

Proteomic databases

PaxDbP48751.
PRIDEP48751.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000273063; ENSP00000273063; ENSG00000114923. [P48751-3]
ENST00000317151; ENSP00000314006; ENSG00000114923. [P48751-1]
ENST00000358055; ENSP00000350756; ENSG00000114923. [P48751-1]
ENST00000373760; ENSP00000362865; ENSG00000114923. [P48751-1]
ENST00000373762; ENSP00000362867; ENSG00000114923. [P48751-3]
GeneID6508.
KEGGhsa:6508.
UCSCuc002vmo.4. human. [P48751-3]
uc002vmp.4. human. [P48751-1]

Organism-specific databases

CTD6508.
GeneCardsGC02P220492.
HGNCHGNC:11029. SLC4A3.
HPAHPA040315.
MIM106195. gene.
neXtProtNX_P48751.
PharmGKBPA35897.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG268067.
HOGENOMHOG000280683.
HOVERGENHBG004326.
KOK13856.
OMAGDSHRGK.
OrthoDBEOG7TMZR0.
PhylomeDBP48751.
TreeFamTF313630.

Enzyme and pathway databases

ReactomeREACT_15518. Transmembrane transport of small molecules.

Gene expression databases

ArrayExpressP48751.
BgeeP48751.
CleanExHS_SLC4A3.
GenevestigatorP48751.

Family and domain databases

Gene3D3.40.1100.10. 1 hit.
InterProIPR001717. Anion_exchange.
IPR002979. Anion_exchange_3.
IPR018241. Anion_exchange_CS.
IPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERPTHR11453. PTHR11453. 1 hit.
PTHR11453:SF15. PTHR11453:SF15. 1 hit.
PfamPF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view]
PRINTSPR00165. ANIONEXCHNGR.
PR01189. ANIONEXHNGR3.
PR01231. HCO3TRNSPORT.
SUPFAMSSF55804. SSF55804. 2 hits.
TIGRFAMsTIGR00834. ae. 1 hit.
PROSITEPS00219. ANION_EXCHANGER_1. 1 hit.
PS00220. ANION_EXCHANGER_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSLC4A3. human.
GeneWikiSLC4A3.
GenomeRNAi6508.
NextBio25305.
PROP48751.
SOURCESearch...

Entry information

Entry nameB3A3_HUMAN
AccessionPrimary (citable) accession number: P48751
Secondary accession number(s): A6H8L2 expand/collapse secondary AC list , A8K1Q9, B7ZVX6, B9EGD1, Q6YIQ9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: October 5, 2010
Last modified: April 16, 2014
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM