P48751 (B3A3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Anion exchange protein 3
Short name=AE 3
Short name=Anion exchanger 3

Alternative name(s):
CAE3/BAE3
Cardiac/brain band 3-like protein
Neuronal band 3-like protein
Solute carrier family 4 member 3

Gene names

Name:	SLC4A3
Synonyms:	AE3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1232 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Plasma membrane anion exchange protein of wide distribution. Mediates at least a part of the Cl-/HCO3- exchange in cardiac myocytes. Both BAE3 and CAE3 forms transport Cl-.
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Both BAE3 and CAE3 are expressed in failing ventricle.
Sequence similarities	Belongs to the anion exchanger (TC 2.A.31) family. [View classification]

Ontologies

Keywords
Biological process	Anion exchange Antiport Ion transport Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
PTM	Lipoprotein Palmitate Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	bicarbonate transport Traceable author statement. Source: Reactome regulation of intracellular pH Inferred from electronic annotation. Source: Compara
Cellular_component	integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc
Molecular_function	inorganic anion exchanger activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.

Isoform BAE3 (identifier: P48751-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform CAE3 (identifier: P48751-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-296: Missing.
     297-299: SPS → MPA

Isoform 3 (identifier: P48751-3)

The sequence of this isoform differs from the canonical sequence as follows:
     203-203: S → SRPCSELRDGDGTTDLALSSPRLLCCLP

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1232	1232	Anion exchange protein 3		PRO_0000079219
Regions
	Topological domain	1 – 708	708	Cytoplasmic
	Transmembrane	709 – 731	23	Helical; Potential
	Transmembrane	737 – 774	38	Helical; Potential
	Transmembrane	794 – 816	23	Helical; Potential
	Transmembrane	826 – 847	22	Helical; Potential
	Transmembrane	893 – 910	18	Helical; Potential
	Topological domain	911 – 925	15	Cytoplasmic Potential
	Transmembrane	926 – 946	21	Helical; Potential
	Transmembrane	980 – 1002	23	Helical; Potential
	Transmembrane	1028 – 1049	22	Helical; Potential
	Transmembrane	1083 – 1128	46	Helical; Potential
	Transmembrane	1155 – 1191	37	Helical; Potential
	Region	709 – 1232	524	Membrane (anion exchange)
	Compositional bias	136 – 149	14	Poly-Glu
	Compositional bias	152 – 161	10	Pro-rich
	Compositional bias	202 – 207	6	Poly-Ser
	Compositional bias	308 – 313	6	Poly-Lys
	Compositional bias	442 – 445	4	Poly-Ser
	Compositional bias	1184 – 1187	4	Poly-Leu
Amino acid modifications
	Modified residue	170	1	Phosphoserine By similarity
	Modified residue	198	1	Phosphoserine By similarity
	Modified residue	297	1	Phosphoserine By similarity
	Lipidation	1165	1	S-palmitoyl cysteine By similarity
Natural variations
	Alternative sequence	1 – 296	296	Missing in isoform CAE3.		VSP_000462
	Alternative sequence	203	1	S → SRPCSELRDGDGTTDLALSS PRLLCCLP in isoform 3.		VSP_038184
	Alternative sequence	297 – 299	3	SPS → MPA in isoform CAE3.		VSP_000463
	Natural variant	157	1	H → P. Ref.1 Ref.3 Ref.4 Ref.6 Ref.7 Corresponds to variant rs597306 [ dbSNP | Ensembl ].		VAR_059081
	Natural variant	226	1	S → L. Corresponds to variant rs36068948 [ dbSNP | Ensembl ].		VAR_055536
	Natural variant	867	1	D → A. Ref.1 Ref.4 Ref.6 Ref.7 Corresponds to variant rs635311 [ dbSNP | Ensembl ].		VAR_059082
Experimental info
	Sequence conflict	118	1	P → S in AAI46657. Ref.7
	Sequence conflict	243	1	N → S in AAI71760. Ref.7
	Sequence conflict	250	1	Q → H in AAI46657. Ref.7
	Sequence conflict	304	1	I → V in AAB05850. Ref.2
	Sequence conflict	343	1	R → P in AAB05850. Ref.2
	Sequence conflict	466	1	P → S in AAB05850. Ref.2
	Sequence conflict	590	1	Q → K in AAN34939. Ref.3
	Sequence conflict	608	1	S → G in AAB05850. Ref.2
	Sequence conflict	702	1	D → A in AAB05850. Ref.2
	Sequence conflict	812 – 813	2	GS → FI in AAB05850. Ref.2
	Sequence conflict	822	1	F → L in AAB05850. Ref.2
	Sequence conflict	850	1	H → R in AAN34939. Ref.3
	Sequence conflict	860 – 863	4	Missing in AAB05850. Ref.2
	Sequence conflict	875	1	S → C in AAB05850. Ref.2
	Sequence conflict	885 – 887	3	SPR → GPE in AAB05850. Ref.2
	Sequence conflict	899	1	L → P in AAB05850. Ref.2
	Sequence conflict	953	1	K → N in BAF82663. Ref.4
	Sequence conflict	983	1	P → L in AAI71760. Ref.7
	Sequence conflict	1052	1	R → H in BAF82663. Ref.4
	Sequence conflict	1054	1	V → I in AAN34939. Ref.3
	Sequence conflict	1096	1	I → M in AAB05850. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform BAE3 [UniParc]. Last modified October 5, 2010. Version 2. Checksum: BA0B360E9D30030A	FASTA	1,232	135,791
	10 20 30 40 50 60 MANGVIPPPG GASPLPQVRV PLEEPPLSPD VEEEDDDLGK TLAVSRFGDL ISKPPAWDPE 70 80 90 100 110 120 KPSRSYSERD FEFHRHTSHH THHPLSARLP PPHKLRRLPP TSARHTRRKR KKEKTSAPPS 130 140 150 160 170 180 EGTPPIQEEG GAGVDEEEEE EEEEEGESEA EPVEPPHSGT PQKAKFSIGS DEDDSPGLPG 190 200 210 220 230 240 RAAVTKPLPS VGPHTDKSPQ HSSSSPSPRA RASRLAGEKS RPWSPSASYD LRERLCPGSA 250 260 270 280 290 300 LGNPGGPEQQ VPTDEAEAQM LGSADLDDMK SHRLEDNPGV RRHLVKKPSR TQGGRGSPSG 310 320 330 340 350 360 LAPILRRKKK KKKLDRRPHE VFVELNELML DRSQEPHWRE TARWIKFEED VEEETERWGK 370 380 390 400 410 420 PHVASLSFRS LLELRRTIAH GAALLDLEQT TLPGIAHLVV ETMIVSDQIR PEDRASVLRT 430 440 450 460 470 480 LLLKHSHPND DKDSGFFPRN PSSSSMNSVL GNHHPTPSHG PDGAVPTMAD DLGEPAPLWP 490 500 510 520 530 540 HDPDAKEKPL HMPGGDGHRG KSLKLLEKIP EDAEATVVLV GCVPFLEQPA AAFVRLNEAV 550 560 570 580 590 600 LLESVLEVPV PVRFLFVMLG PSHTSTDYHE LGRSIATLMS DKLFHEAAYQ ADDRQDLLSA 610 620 630 640 650 660 ISEFLDGSIV IPPSEVEGRD LLRSVAAFQR ELLRKRRERE QTKVEMTTRG GYTAPGKELS 670 680 690 700 710 720 LELGGSEATP EDDPLLRTGS VFGGLVRDVR RRYPHYPSDL RDALHSQCVA AVLFIYFAAL 730 740 750 760 770 780 SPAITFGGLL GEKTEGLMGV SELIVSTAVL GVLFSLLGAQ PLLVVGFSGP LLVFEEAFFK 790 800 810 820 830 840 FCRAQDLEYL TGRVWVGLWL VVFVLALVAA EGSFLVRYIS PFTQEIFAFL ISLIFIYETF 850 860 870 880 890 900 YKLYKVFTEH PLLPFYPPEG ALEGSLDAGL EPNGSALPPT EGPPSPRNQP NTALLSLILM 910 920 930 940 950 960 LGTFFIAFFL RKFRNSRFLG GKARRIIGDF GIPISILVMV LVDYSITDTY TQKLTVPTGL 970 980 990 1000 1010 1020 SVTSPDKRSW FIPPLGSARP FPPWMMVAAA VPALLVLILI FMETQITALI VSQKARRLLK 1030 1040 1050 1060 1070 1080 GSGFHLDLLL IGSLGGLCGL FGLPWLTAAT VRSVTHVNAL TVMRTAIAPG DKPQIQEVRE 1090 1100 1110 1120 1130 1140 QRVTGVLIAS LVGLSIVMGA VLRRIPLAVL FGIFLYMGVT SLSGIQLSQR LLLILMPAKH 1150 1160 1170 1180 1190 1200 HPEQPYVTKV KTWRMHLFTC IQLGCIALLW VVKSTAASLA FPFLLLLTVP LRHCLLPRLF 1210 1220 1230 QDRELQALDS EDAEPNFDED GQDEYNELHM PV
	Isoform CAE3 [UniParc]. Checksum: 0C028134284DD31B	FASTA	936	103,737
	10 20 30 40 50 60 MPAGLAPILR RKKKKKKLDR RPHEVFVELN ELMLDRSQEP HWRETARWIK FEEDVEEETE 70 80 90 100 110 120 RWGKPHVASL SFRSLLELRR TIAHGAALLD LEQTTLPGIA HLVVETMIVS DQIRPEDRAS 130 140 150 160 170 180 VLRTLLLKHS HPNDDKDSGF FPRNPSSSSM NSVLGNHHPT PSHGPDGAVP TMADDLGEPA 190 200 210 220 230 240 PLWPHDPDAK EKPLHMPGGD GHRGKSLKLL EKIPEDAEAT VVLVGCVPFL EQPAAAFVRL 250 260 270 280 290 300 NEAVLLESVL EVPVPVRFLF VMLGPSHTST DYHELGRSIA TLMSDKLFHE AAYQADDRQD 310 320 330 340 350 360 LLSAISEFLD GSIVIPPSEV EGRDLLRSVA AFQRELLRKR REREQTKVEM TTRGGYTAPG 370 380 390 400 410 420 KELSLELGGS EATPEDDPLL RTGSVFGGLV RDVRRRYPHY PSDLRDALHS QCVAAVLFIY 430 440 450 460 470 480 FAALSPAITF GGLLGEKTEG LMGVSELIVS TAVLGVLFSL LGAQPLLVVG FSGPLLVFEE 490 500 510 520 530 540 AFFKFCRAQD LEYLTGRVWV GLWLVVFVLA LVAAEGSFLV RYISPFTQEI FAFLISLIFI 550 560 570 580 590 600 YETFYKLYKV FTEHPLLPFY PPEGALEGSL DAGLEPNGSA LPPTEGPPSP RNQPNTALLS 610 620 630 640 650 660 LILMLGTFFI AFFLRKFRNS RFLGGKARRI IGDFGIPISI LVMVLVDYSI TDTYTQKLTV 670 680 690 700 710 720 PTGLSVTSPD KRSWFIPPLG SARPFPPWMM VAAAVPALLV LILIFMETQI TALIVSQKAR 730 740 750 760 770 780 RLLKGSGFHL DLLLIGSLGG LCGLFGLPWL TAATVRSVTH VNALTVMRTA IAPGDKPQIQ 790 800 810 820 830 840 EVREQRVTGV LIASLVGLSI VMGAVLRRIP LAVLFGIFLY MGVTSLSGIQ LSQRLLLILM 850 860 870 880 890 900 PAKHHPEQPY VTKVKTWRMH LFTCIQLGCI ALLWVVKSTA ASLAFPFLLL LTVPLRHCLL 910 920 930 PRLFQDRELQ ALDSEDAEPN FDEDGQDEYN ELHMPV
	Isoform 3 [UniParc]. Checksum: C175EF6C771E31A5	FASTA	1,259	138,662
	10 20 30 40 50 60 MANGVIPPPG GASPLPQVRV PLEEPPLSPD VEEEDDDLGK TLAVSRFGDL ISKPPAWDPE 70 80 90 100 110 120 KPSRSYSERD FEFHRHTSHH THHPLSARLP PPHKLRRLPP TSARHTRRKR KKEKTSAPPS 130 140 150 160 170 180 EGTPPIQEEG GAGVDEEEEE EEEEEGESEA EPVEPPHSGT PQKAKFSIGS DEDDSPGLPG 190 200 210 220 230 240 RAAVTKPLPS VGPHTDKSPQ HSSRPCSELR DGDGTTDLAL SSPRLLCCLP SSPSPRARAS 250 260 270 280 290 300 RLAGEKSRPW SPSASYDLRE RLCPGSALGN PGGPEQQVPT DEAEAQMLGS ADLDDMKSHR 310 320 330 340 350 360 LEDNPGVRRH LVKKPSRTQG GRGSPSGLAP ILRRKKKKKK LDRRPHEVFV ELNELMLDRS 370 380 390 400 410 420 QEPHWRETAR WIKFEEDVEE ETERWGKPHV ASLSFRSLLE LRRTIAHGAA LLDLEQTTLP 430 440 450 460 470 480 GIAHLVVETM IVSDQIRPED RASVLRTLLL KHSHPNDDKD SGFFPRNPSS SSMNSVLGNH 490 500 510 520 530 540 HPTPSHGPDG AVPTMADDLG EPAPLWPHDP DAKEKPLHMP GGDGHRGKSL KLLEKIPEDA 550 560 570 580 590 600 EATVVLVGCV PFLEQPAAAF VRLNEAVLLE SVLEVPVPVR FLFVMLGPSH TSTDYHELGR 610 620 630 640 650 660 SIATLMSDKL FHEAAYQADD RQDLLSAISE FLDGSIVIPP SEVEGRDLLR SVAAFQRELL 670 680 690 700 710 720 RKRREREQTK VEMTTRGGYT APGKELSLEL GGSEATPEDD PLLRTGSVFG GLVRDVRRRY 730 740 750 760 770 780 PHYPSDLRDA LHSQCVAAVL FIYFAALSPA ITFGGLLGEK TEGLMGVSEL IVSTAVLGVL 790 800 810 820 830 840 FSLLGAQPLL VVGFSGPLLV FEEAFFKFCR AQDLEYLTGR VWVGLWLVVF VLALVAAEGS 850 860 870 880 890 900 FLVRYISPFT QEIFAFLISL IFIYETFYKL YKVFTEHPLL PFYPPEGALE GSLDAGLEPN 910 920 930 940 950 960 GSALPPTEGP PSPRNQPNTA LLSLILMLGT FFIAFFLRKF RNSRFLGGKA RRIIGDFGIP 970 980 990 1000 1010 1020 ISILVMVLVD YSITDTYTQK LTVPTGLSVT SPDKRSWFIP PLGSARPFPP WMMVAAAVPA 1030 1040 1050 1060 1070 1080 LLVLILIFME TQITALIVSQ KARRLLKGSG FHLDLLLIGS LGGLCGLFGL PWLTAATVRS 1090 1100 1110 1120 1130 1140 VTHVNALTVM RTAIAPGDKP QIQEVREQRV TGVLIASLVG LSIVMGAVLR RIPLAVLFGI 1150 1160 1170 1180 1190 1200 FLYMGVTSLS GIQLSQRLLL ILMPAKHHPE QPYVTKVKTW RMHLFTCIQL GCIALLWVVK 1210 1220 1230 1240 1250 STAASLAFPF LLLLTVPLRH CLLPRLFQDR ELQALDSEDA EPNFDEDGQD EYNELHMPV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning, expression, and chromosomal localization of two isoforms of the AE3 anion exchanger from human heart." Yannoukakos D., Stuart-Tilley A., Fernandez H., Fey P., Duyk G., Alper S.L. Circ. Res. 75:603-614(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BAE3), VARIANTS PRO-157 AND ALA-867. Tissue: Heart.
[2]	"Cloning of the characterization of the human cardiac anion exchanger gene." Kudo S., Mattei M.-G., Bloor C.M., Fukuda M., Ranney H.M., Xu A. Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CAE3). Tissue: Heart.
[3]	"Sequence of an alternative splice form of brain AE3." Mount D.B. Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), VARIANT PRO-157.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BAE3), VARIANTS PRO-157 AND ALA-867. Tissue: Hippocampus.
[5]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS PRO-157 AND ALA-867.
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BAE3), VARIANTS PRO-157 AND ALA-867. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U05596 mRNA. Translation: AAA50748.1. L27213 mRNA. Translation: AAB05850.1. AY142112 mRNA. Translation: AAN34939.1. AK289974 mRNA. Translation: BAF82663.1. AC009955 Genomic DNA. No translation available. CH471063 Genomic DNA. Translation: EAW70778.1. BC136384 mRNA. Translation: AAI36385.1. BC146656 mRNA. Translation: AAI46657.1. BC171760 mRNA. Translation: AAI71760.1.
IPI	IPI00011159. IPI00401785. IPI00473049.
PIR	I38496.
RefSeq	NP_005061.2. NM_005070.3. NP_963868.2. NM_201574.2.
UniGene	Hs.1176.
3D structure databases
ProteinModelPortal	P48751.
SMR	P48751. Positions 692-733.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000273063.
PTM databases
PhosphoSite	P48751.
Polymorphism databases
DMDM	308153414.
Proteomic databases
PaxDb	P48751.
PRIDE	P48751.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000273063; ENSP00000273063; ENSG00000114923. ENST00000317151; ENSP00000314006; ENSG00000114923. ENST00000358055; ENSP00000350756; ENSG00000114923. ENST00000373760; ENSP00000362865; ENSG00000114923. ENST00000373762; ENSP00000362867; ENSG00000114923.
GeneID	6508.
KEGG	hsa:6508.
UCSC	uc002vmo.4. human. uc002vmp.4. human.
Organism-specific databases
CTD	6508.
GeneCards	GC02P220492.
HGNC	HGNC:11029. SLC4A3.
HPA	HPA040315.
MIM	106195. gene.
neXtProt	NX_P48751.
PharmGKB	PA35897.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG268067.
HOGENOM	HOG000280683.
HOVERGEN	HBG004326.
KO	K13856.
OMA	GRAAFTK.
OrthoDB	EOG4WDDB2.
Enzyme and pathway databases
Reactome	REACT_15518. Transmembrane transport of small molecules.
Gene expression databases
ArrayExpress	P48751.
Bgee	P48751.
CleanEx	HS_SLC4A3.
Genevestigator	P48751.
GermOnline	ENSG00000114923. Homo sapiens.
Family and domain databases
Gene3D	3.40.1100.10. 1 hit.
InterPro	IPR001717. Anion_exchange. IPR002979. Anion_exchange_3. IPR018241. Anion_exchange_CS. IPR013769. Band3_cytoplasmic_dom. IPR011531. HCO3_transpt_C. IPR003020. HCO3_transpt_euk. IPR016152. PTrfase/Anion_transptr. [Graphical view]
PANTHER	PTHR11453. PTHR11453. 1 hit. PTHR11453:SF15. PTHR11453:SF15. 1 hit.
Pfam	PF07565. Band_3_cyto. 1 hit. PF00955. HCO3_cotransp. 1 hit. [Graphical view]
PRINTS	PR00165. ANIONEXCHNGR. PR01189. ANIONEXHNGR3. PR01231. HCO3TRNSPORT.
SUPFAM	SSF55804. PTrfase/Anion_transptr. 1 hit.
TIGRFAMs	TIGR00834. ae. 1 hit.
PROSITE	PS00219. ANION_EXCHANGER_1. 1 hit. PS00220. ANION_EXCHANGER_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SLC4A3. human.
GenomeRNAi	6508.
NextBio	25305.
SOURCE	Search...

Entry information

Entry name

B3A3_HUMAN

Accession

Primary (citable) accession number: P48751
Secondary accession number(s): A6H8L2 , A8K1Q9, B7ZVX6, B9EGD1, Q6YIQ9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	October 5, 2010
Last modified:	May 1, 2013
This is version 115 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.