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Protein

B1 bradykinin receptor

Gene

BDKRB1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
B1 bradykinin receptor
Short name:
B1R
Short name:
BK-1 receptor
Gene namesi
Name:BDKRB1
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 39ExtracellularSequence analysisAdd BLAST39
Transmembranei40 – 63Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini64 – 72CytoplasmicSequence analysis9
Transmembranei73 – 97Helical; Name=2Sequence analysisAdd BLAST25
Topological domaini98 – 110ExtracellularSequence analysisAdd BLAST13
Transmembranei111 – 132Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini133 – 154CytoplasmicSequence analysisAdd BLAST22
Transmembranei155 – 177Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini178 – 198ExtracellularSequence analysisAdd BLAST21
Transmembranei199 – 225Helical; Name=5Sequence analysisAdd BLAST27
Topological domaini226 – 246CytoplasmicSequence analysisAdd BLAST21
Transmembranei247 – 271Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini272 – 290ExtracellularSequence analysisAdd BLAST19
Transmembranei291 – 314Helical; Name=7Sequence analysisAdd BLAST24
Topological domaini315 – 352CytoplasmicSequence analysisAdd BLAST38

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4087.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000691861 – 352B1 bradykinin receptorAdd BLAST352

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi13N-linked (GlcNAc...)Sequence analysis1
Glycosylationi21N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi109 ↔ 188PROSITE-ProRule annotation
Glycosylationi184N-linked (GlcNAc...)Sequence analysis1
Lipidationi329S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Expressioni

Inductioni

In response to tissue injury.

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000022849.

Chemistry databases

BindingDBiP48748.

Structurei

3D structure databases

ProteinModelPortaliP48748.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB1 sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000010314.
HOVERGENiHBG103183.
InParanoidiP48748.
KOiK03915.

Family and domain databases

InterProiView protein in InterPro
IPR001186. Brdyknn_1_rcpt.
IPR000496. Brdyknn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00425. BRADYKININR.
PR00993. BRADYKINNB1R.
PR00237. GPCRRHODOPSN.
PROSITEiView protein in PROSITE
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P48748-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASQGPLELQ PSNQSQLAPP NATSCSGAPD AWDLLHRLLP TFIIAIFTLG
60 70 80 90 100
LLGNSFVLSV FLLARRRLSV AEIYLANLAA SDLVFVLGLP FWAENVRNQF
110 120 130 140 150
DWPFGAALCR IVNGVIKANL FISIFLVVAI SQDRYSVLVH PMASRRGRRR
160 170 180 190 200
RQAQATCALI WLAGGLLSTP TFVLRSVRAV PELNVSACIL LLPHEAWHWL
210 220 230 240 250
RMVELNLLGF LLPLAAILFF NCHILASLRR RGERVPSRCG GPRDSKSTAL
260 270 280 290 300
ILTLVASFLV CWAPYHFFAF LECLWQVHAI GGCFWEEFTD LGLQLSNFSA
310 320 330 340 350
FVNSCLNPVI YVFVGRLFRT KVWELCQQCS PRSLAPVSSS RRKEMLWGFW

RN
Length:352
Mass (Da):39,503
Last modified:February 1, 1996 - v1
Checksum:i492AD177258853CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20507 mRNA. Translation: AAC48482.1.
PIRiS60024.
RefSeqiNP_001075816.1. NM_001082347.1.
UniGeneiOcu.2280.

Genome annotation databases

GeneIDi100009198.
KEGGiocu:100009198.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20507 mRNA. Translation: AAC48482.1.
PIRiS60024.
RefSeqiNP_001075816.1. NM_001082347.1.
UniGeneiOcu.2280.

3D structure databases

ProteinModelPortaliP48748.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000022849.

Chemistry databases

BindingDBiP48748.
ChEMBLiCHEMBL4087.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100009198.
KEGGiocu:100009198.

Organism-specific databases

CTDi623.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000010314.
HOVERGENiHBG103183.
InParanoidiP48748.
KOiK03915.

Miscellaneous databases

PROiPR:P48748.

Family and domain databases

InterProiView protein in InterPro
IPR001186. Brdyknn_1_rcpt.
IPR000496. Brdyknn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00425. BRADYKININR.
PR00993. BRADYKINNB1R.
PR00237. GPCRRHODOPSN.
PROSITEiView protein in PROSITE
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiBKRB1_RABIT
AccessioniPrimary (citable) accession number: P48748
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 8, 2016
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.