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P48746

- B3A2_RABIT

UniProt

P48746 - B3A2_RABIT

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Protein

Anion exchange protein 2

Gene
SLC4A2, AE2
Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Plasma membrane anion exchange protein of wide distribution.

GO - Molecular functioni

  1. inorganic anion exchanger activity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Anion exchange, Antiport, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Anion exchange protein 2
Short name:
AE 2
Short name:
Anion exchanger 2
Alternative name(s):
Band 3-related protein
Short name:
B3RP
Solute carrier family 4 member 2
Gene namesi
Name:SLC4A2
Synonyms:AE2
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 703703Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei704 – 72724Helical; Reviewed predictionAdd
BLAST
Transmembranei733 – 77038Helical; Reviewed predictionAdd
BLAST
Transmembranei790 – 81223Helical; Reviewed predictionAdd
BLAST
Transmembranei822 – 84322Helical; Reviewed predictionAdd
BLAST
Topological domaini844 – 89653Extracellular Reviewed predictionAdd
BLAST
Transmembranei897 – 91418Helical; Reviewed predictionAdd
BLAST
Topological domaini915 – 92915Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei930 – 95021Helical; Reviewed predictionAdd
BLAST
Transmembranei984 – 100623Helical; Reviewed predictionAdd
BLAST
Transmembranei1032 – 105322Helical; Reviewed predictionAdd
BLAST
Transmembranei1087 – 113246Helical; Reviewed predictionAdd
BLAST
Transmembranei1159 – 119537Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12371237Anion exchange protein 2PRO_0000079217Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei113 – 1131Phosphoserine By similarity
Modified residuei144 – 1441Phosphoserine By similarity
Modified residuei170 – 1701Phosphoserine By similarity
Modified residuei172 – 1721Phosphoserine By similarity
Modified residuei253 – 2531Phosphothreonine By similarity
Modified residuei439 – 4391Phosphoserine By similarity
Glycosylationi855 – 8551N-linked (GlcNAc...) Reviewed prediction
Glycosylationi864 – 8641N-linked (GlcNAc...) Reviewed prediction
Glycosylationi878 – 8781N-linked (GlcNAc...) Reviewed prediction
Lipidationi1169 – 11691S-palmitoyl cysteine By similarity

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliP48746.
SMRiP48746. Positions 688-729, 1129-1161.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni704 – 1237534Membrane (anion exchange)Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi5 – 316312Pro-richAdd
BLAST
Compositional biasi74 – 8815His-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG004326.

Family and domain databases

Gene3Di3.40.1100.10. 1 hit.
InterProiIPR001717. Anion_exchange.
IPR002978. Anion_exchange_2.
IPR018241. Anion_exchange_CS.
IPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 1 hit.
PTHR11453:SF14. PTHR11453:SF14. 1 hit.
PfamiPF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view]
PRINTSiPR00165. ANIONEXCHNGR.
PR01188. ANIONEXHNGR2.
PR01231. HCO3TRNSPORT.
SUPFAMiSSF55804. SSF55804. 2 hits.
TIGRFAMsiTIGR00834. ae. 1 hit.
PROSITEiPS00219. ANION_EXCHANGER_1. 1 hit.
PS00220. ANION_EXCHANGER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48746-1 [UniParc]FASTAAdd to Basket

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MSSAPRRPAS GADSFRTPEP ESLGPGTPGF PEQEEDELHR TLGVERFEEI     50
LQEAGSRGGE EPGRSYGEED FEYHRQSSHH IHHPLSTHLP PDARRRKTPQ 100
GPGRKPRRRP GASPTGATPT IEEGEEDEEE ANEAEGARAP TEPSPASTPS 150
SVQFFLQEDE GAERKAERTS PSPPTLLPHQ EAAPWATEGA QTGVPVEEVA 200
VVASGTAGGD NGGASGRPLT KAQPGHRSYN LQERRRIGSM TGAEQALLPR 250
VPTDESEAQT LATADLDLMK SHRFEDVPGV RRHLVRKNAK GSAQSSREGR 300
EPGPTPRSRP RAPHKPHEVF VELNELLLDK NQEPQWRETA RWIKFEEDVE 350
EETERWGKPH VASLSFRSLL ELRRTLAHGA VLLDLDQQTL PGVAHQVVEQ 400
MVISDQIKAE DRANVLRALL LKHSHPSDEK DFSFPRNISA GSLGSLLGHH 450
HGQGAESDPH VTEPLIGGIP ETRLDVERER DVPPSAPPAG ITRSKSKHEL 500
KLLEKIPENA EATVVLVGCV EFLSRPTMAF VRLREAVELD AVLEVPVPVR 550
FLFLLLGPSS ANMDYHEIGR SISTLMSDKQ FHEAAYLADE REDLLTAINA 600
FLDCSVVLPP SEVQGEELLR SVAHFQRQML KKREEQGRLL PPGLGLEPKS 650
AQDKALLQMV EAAGAAEDDP LRRTGRPFGG LIRDVRRRYP HYLSDFRDAL 700
DPQCVAAVIF IYFAALSPAI TFGGLLGEKT QDLIGVSELI MSTALQGVIF 750
CLLGAQPLLV IGFSGPLLVF EEAFFTFCSS NQLEYLVGRV WIGFWLVLLA 800
LLMVALEGSF LVRFVSRFTQ EIFAFLISLI FIYETFYKLI KIFQEHPLHG 850
CSVSNSSETD SSENATWAGA GSTLGPANRS SAGQAGQGRP RGQPNTALLS 900
LVLMAGTFFI AFFLRKFKNS RFFPGRIRRV IGDFGVPIAI LIMVLVDYSI 950
EDTYTQKLSV PSGFSVTAPD KRGWVINPLG EKSPFPVWMM VASLLPAILV 1000
FILIFMETQI TTLIISKKER MLQKGSGFHL DLLLIVAMGG ICALFGLPWL 1050
AAATVRSVTH ANALTVMSKA VAPGDKPKIQ EVKEQRVTGL LVALLVGLSI 1100
VIGDLLRQIP LAVLFGIFLY MGVTSLNGIQ FYERLHLLLM PPKHHPDVTY 1150
VKKVRTLRMH LFTALQLLCL ALLWAVMSTA ASLAFPFILI LTVPLRMVVL 1200
TRIFTEREMK CLDANEAEPV FDEREGVDEY NEMPMPV 1237
Length:1,237
Mass (Da):136,536
Last modified:February 1, 1996 - v1
Checksum:i2811D11051552BB2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S45791 mRNA. Translation: AAB23488.1.
PIRiA56764.
RefSeqiNP_001075788.1. NM_001082319.1.
UniGeneiOcu.3310.

Genome annotation databases

GeneIDi100009159.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S45791 mRNA. Translation: AAB23488.1 .
PIRi A56764.
RefSeqi NP_001075788.1. NM_001082319.1.
UniGenei Ocu.3310.

3D structure databases

ProteinModelPortali P48746.
SMRi P48746. Positions 688-729, 1129-1161.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100009159.

Organism-specific databases

CTDi 6522.

Phylogenomic databases

HOVERGENi HBG004326.

Family and domain databases

Gene3Di 3.40.1100.10. 1 hit.
InterProi IPR001717. Anion_exchange.
IPR002978. Anion_exchange_2.
IPR018241. Anion_exchange_CS.
IPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR016152. PTrfase/Anion_transptr.
[Graphical view ]
PANTHERi PTHR11453. PTHR11453. 1 hit.
PTHR11453:SF14. PTHR11453:SF14. 1 hit.
Pfami PF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view ]
PRINTSi PR00165. ANIONEXCHNGR.
PR01188. ANIONEXHNGR2.
PR01231. HCO3TRNSPORT.
SUPFAMi SSF55804. SSF55804. 2 hits.
TIGRFAMsi TIGR00834. ae. 1 hit.
PROSITEi PS00219. ANION_EXCHANGER_1. 1 hit.
PS00220. ANION_EXCHANGER_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "cDNA cloning and localization of a band 3-related protein from ileum."
    Chow A., Dobbins J.W., Aronson P.S., Igarashi P.
    Am. J. Physiol. 263:G345-G352(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: New Zealand white.

Entry informationi

Entry nameiB3A2_RABIT
AccessioniPrimary (citable) accession number: P48746
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: April 16, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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