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P48746 (B3A2_RABIT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Anion exchange protein 2

Short name=AE 2
Short name=Anion exchanger 2
Alternative name(s):
Band 3-related protein
Short name=B3RP
Solute carrier family 4 member 2
Gene names
Name:SLC4A2
Synonyms:AE2
OrganismOryctolagus cuniculus (Rabbit) [Reference proteome]
Taxonomic identifier9986 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus

Protein attributes

Sequence length1237 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Plasma membrane anion exchange protein of wide distribution.

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the anion exchanger (TC 2.A.31) family. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12371237Anion exchange protein 2
PRO_0000079217

Regions

Topological domain1 – 703703Cytoplasmic Potential
Transmembrane704 – 72724Helical; Potential
Transmembrane733 – 77038Helical; Potential
Transmembrane790 – 81223Helical; Potential
Transmembrane822 – 84322Helical; Potential
Topological domain844 – 89653Extracellular Potential
Transmembrane897 – 91418Helical; Potential
Topological domain915 – 92915Cytoplasmic Potential
Transmembrane930 – 95021Helical; Potential
Transmembrane984 – 100623Helical; Potential
Transmembrane1032 – 105322Helical; Potential
Transmembrane1087 – 113246Helical; Potential
Transmembrane1159 – 119537Helical; Potential
Region704 – 1237534Membrane (anion exchange)
Compositional bias5 – 316312Pro-rich
Compositional bias74 – 8815His-rich

Amino acid modifications

Modified residue1131Phosphoserine By similarity
Modified residue1441Phosphoserine By similarity
Modified residue1701Phosphoserine By similarity
Modified residue1721Phosphoserine By similarity
Modified residue2531Phosphothreonine By similarity
Modified residue4391Phosphoserine By similarity
Lipidation11691S-palmitoyl cysteine By similarity
Glycosylation8551N-linked (GlcNAc...) Potential
Glycosylation8641N-linked (GlcNAc...) Potential
Glycosylation8781N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P48746 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 2811D11051552BB2

FASTA1,237136,536
        10         20         30         40         50         60 
MSSAPRRPAS GADSFRTPEP ESLGPGTPGF PEQEEDELHR TLGVERFEEI LQEAGSRGGE 

        70         80         90        100        110        120 
EPGRSYGEED FEYHRQSSHH IHHPLSTHLP PDARRRKTPQ GPGRKPRRRP GASPTGATPT 

       130        140        150        160        170        180 
IEEGEEDEEE ANEAEGARAP TEPSPASTPS SVQFFLQEDE GAERKAERTS PSPPTLLPHQ 

       190        200        210        220        230        240 
EAAPWATEGA QTGVPVEEVA VVASGTAGGD NGGASGRPLT KAQPGHRSYN LQERRRIGSM 

       250        260        270        280        290        300 
TGAEQALLPR VPTDESEAQT LATADLDLMK SHRFEDVPGV RRHLVRKNAK GSAQSSREGR 

       310        320        330        340        350        360 
EPGPTPRSRP RAPHKPHEVF VELNELLLDK NQEPQWRETA RWIKFEEDVE EETERWGKPH 

       370        380        390        400        410        420 
VASLSFRSLL ELRRTLAHGA VLLDLDQQTL PGVAHQVVEQ MVISDQIKAE DRANVLRALL 

       430        440        450        460        470        480 
LKHSHPSDEK DFSFPRNISA GSLGSLLGHH HGQGAESDPH VTEPLIGGIP ETRLDVERER 

       490        500        510        520        530        540 
DVPPSAPPAG ITRSKSKHEL KLLEKIPENA EATVVLVGCV EFLSRPTMAF VRLREAVELD 

       550        560        570        580        590        600 
AVLEVPVPVR FLFLLLGPSS ANMDYHEIGR SISTLMSDKQ FHEAAYLADE REDLLTAINA 

       610        620        630        640        650        660 
FLDCSVVLPP SEVQGEELLR SVAHFQRQML KKREEQGRLL PPGLGLEPKS AQDKALLQMV 

       670        680        690        700        710        720 
EAAGAAEDDP LRRTGRPFGG LIRDVRRRYP HYLSDFRDAL DPQCVAAVIF IYFAALSPAI 

       730        740        750        760        770        780 
TFGGLLGEKT QDLIGVSELI MSTALQGVIF CLLGAQPLLV IGFSGPLLVF EEAFFTFCSS 

       790        800        810        820        830        840 
NQLEYLVGRV WIGFWLVLLA LLMVALEGSF LVRFVSRFTQ EIFAFLISLI FIYETFYKLI 

       850        860        870        880        890        900 
KIFQEHPLHG CSVSNSSETD SSENATWAGA GSTLGPANRS SAGQAGQGRP RGQPNTALLS 

       910        920        930        940        950        960 
LVLMAGTFFI AFFLRKFKNS RFFPGRIRRV IGDFGVPIAI LIMVLVDYSI EDTYTQKLSV 

       970        980        990       1000       1010       1020 
PSGFSVTAPD KRGWVINPLG EKSPFPVWMM VASLLPAILV FILIFMETQI TTLIISKKER 

      1030       1040       1050       1060       1070       1080 
MLQKGSGFHL DLLLIVAMGG ICALFGLPWL AAATVRSVTH ANALTVMSKA VAPGDKPKIQ 

      1090       1100       1110       1120       1130       1140 
EVKEQRVTGL LVALLVGLSI VIGDLLRQIP LAVLFGIFLY MGVTSLNGIQ FYERLHLLLM 

      1150       1160       1170       1180       1190       1200 
PPKHHPDVTY VKKVRTLRMH LFTALQLLCL ALLWAVMSTA ASLAFPFILI LTVPLRMVVL 

      1210       1220       1230 
TRIFTEREMK CLDANEAEPV FDEREGVDEY NEMPMPV 

« Hide

References

[1]"cDNA cloning and localization of a band 3-related protein from ileum."
Chow A., Dobbins J.W., Aronson P.S., Igarashi P.
Am. J. Physiol. 263:G345-G352(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: New Zealand white.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S45791 mRNA. Translation: AAB23488.1.
PIRA56764.
RefSeqNP_001075788.1. NM_001082319.1.
UniGeneOcu.3310.

3D structure databases

ProteinModelPortalP48746.
SMRP48746. Positions 688-729, 1129-1161.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100009159.

Organism-specific databases

CTD6522.

Phylogenomic databases

HOVERGENHBG004326.

Family and domain databases

Gene3D3.40.1100.10. 1 hit.
InterProIPR001717. Anion_exchange.
IPR002978. Anion_exchange_2.
IPR018241. Anion_exchange_CS.
IPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERPTHR11453. PTHR11453. 1 hit.
PTHR11453:SF14. PTHR11453:SF14. 1 hit.
PfamPF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view]
PRINTSPR00165. ANIONEXCHNGR.
PR01188. ANIONEXHNGR2.
PR01231. HCO3TRNSPORT.
SUPFAMSSF55804. SSF55804. 2 hits.
TIGRFAMsTIGR00834. ae. 1 hit.
PROSITEPS00219. ANION_EXCHANGER_1. 1 hit.
PS00220. ANION_EXCHANGER_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB3A2_RABIT
AccessionPrimary (citable) accession number: P48746
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: April 16, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families