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P48746

- B3A2_RABIT

UniProt

P48746 - B3A2_RABIT

Protein

Anion exchange protein 2

Gene

SLC4A2

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Plasma membrane anion exchange protein of wide distribution.

    GO - Molecular functioni

    1. inorganic anion exchanger activity Source: InterPro

    Keywords - Biological processi

    Anion exchange, Antiport, Ion transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Anion exchange protein 2
    Short name:
    AE 2
    Short name:
    Anion exchanger 2
    Alternative name(s):
    Band 3-related protein
    Short name:
    B3RP
    Solute carrier family 4 member 2
    Gene namesi
    Name:SLC4A2
    Synonyms:AE2
    OrganismiOryctolagus cuniculus (Rabbit)
    Taxonomic identifieri9986 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
    ProteomesiUP000001811: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12371237Anion exchange protein 2PRO_0000079217Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei113 – 1131PhosphoserineBy similarity
    Modified residuei144 – 1441PhosphoserineBy similarity
    Modified residuei170 – 1701PhosphoserineBy similarity
    Modified residuei172 – 1721PhosphoserineBy similarity
    Modified residuei253 – 2531PhosphothreonineBy similarity
    Modified residuei439 – 4391PhosphoserineBy similarity
    Glycosylationi855 – 8551N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi864 – 8641N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi878 – 8781N-linked (GlcNAc...)Sequence Analysis
    Lipidationi1169 – 11691S-palmitoyl cysteineBy similarity

    Keywords - PTMi

    Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliP48746.
    SMRiP48746. Positions 688-729, 1129-1161.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 703703CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini844 – 89653ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini915 – 92915CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei704 – 72724HelicalSequence AnalysisAdd
    BLAST
    Transmembranei733 – 77038HelicalSequence AnalysisAdd
    BLAST
    Transmembranei790 – 81223HelicalSequence AnalysisAdd
    BLAST
    Transmembranei822 – 84322HelicalSequence AnalysisAdd
    BLAST
    Transmembranei897 – 91418HelicalSequence AnalysisAdd
    BLAST
    Transmembranei930 – 95021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei984 – 100623HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1032 – 105322HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1087 – 113246HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1159 – 119537HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni704 – 1237534Membrane (anion exchange)Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi5 – 316312Pro-richAdd
    BLAST
    Compositional biasi74 – 8815His-richAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG004326.

    Family and domain databases

    Gene3Di3.40.1100.10. 1 hit.
    InterProiIPR001717. Anion_exchange.
    IPR002978. Anion_exchange_2.
    IPR018241. Anion_exchange_CS.
    IPR013769. Band3_cytoplasmic_dom.
    IPR011531. HCO3_transpt_C.
    IPR003020. HCO3_transpt_euk.
    IPR016152. PTrfase/Anion_transptr.
    [Graphical view]
    PANTHERiPTHR11453. PTHR11453. 1 hit.
    PTHR11453:SF14. PTHR11453:SF14. 1 hit.
    PfamiPF07565. Band_3_cyto. 1 hit.
    PF00955. HCO3_cotransp. 1 hit.
    [Graphical view]
    PRINTSiPR00165. ANIONEXCHNGR.
    PR01188. ANIONEXHNGR2.
    PR01231. HCO3TRNSPORT.
    SUPFAMiSSF55804. SSF55804. 2 hits.
    TIGRFAMsiTIGR00834. ae. 1 hit.
    PROSITEiPS00219. ANION_EXCHANGER_1. 1 hit.
    PS00220. ANION_EXCHANGER_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P48746-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSAPRRPAS GADSFRTPEP ESLGPGTPGF PEQEEDELHR TLGVERFEEI     50
    LQEAGSRGGE EPGRSYGEED FEYHRQSSHH IHHPLSTHLP PDARRRKTPQ 100
    GPGRKPRRRP GASPTGATPT IEEGEEDEEE ANEAEGARAP TEPSPASTPS 150
    SVQFFLQEDE GAERKAERTS PSPPTLLPHQ EAAPWATEGA QTGVPVEEVA 200
    VVASGTAGGD NGGASGRPLT KAQPGHRSYN LQERRRIGSM TGAEQALLPR 250
    VPTDESEAQT LATADLDLMK SHRFEDVPGV RRHLVRKNAK GSAQSSREGR 300
    EPGPTPRSRP RAPHKPHEVF VELNELLLDK NQEPQWRETA RWIKFEEDVE 350
    EETERWGKPH VASLSFRSLL ELRRTLAHGA VLLDLDQQTL PGVAHQVVEQ 400
    MVISDQIKAE DRANVLRALL LKHSHPSDEK DFSFPRNISA GSLGSLLGHH 450
    HGQGAESDPH VTEPLIGGIP ETRLDVERER DVPPSAPPAG ITRSKSKHEL 500
    KLLEKIPENA EATVVLVGCV EFLSRPTMAF VRLREAVELD AVLEVPVPVR 550
    FLFLLLGPSS ANMDYHEIGR SISTLMSDKQ FHEAAYLADE REDLLTAINA 600
    FLDCSVVLPP SEVQGEELLR SVAHFQRQML KKREEQGRLL PPGLGLEPKS 650
    AQDKALLQMV EAAGAAEDDP LRRTGRPFGG LIRDVRRRYP HYLSDFRDAL 700
    DPQCVAAVIF IYFAALSPAI TFGGLLGEKT QDLIGVSELI MSTALQGVIF 750
    CLLGAQPLLV IGFSGPLLVF EEAFFTFCSS NQLEYLVGRV WIGFWLVLLA 800
    LLMVALEGSF LVRFVSRFTQ EIFAFLISLI FIYETFYKLI KIFQEHPLHG 850
    CSVSNSSETD SSENATWAGA GSTLGPANRS SAGQAGQGRP RGQPNTALLS 900
    LVLMAGTFFI AFFLRKFKNS RFFPGRIRRV IGDFGVPIAI LIMVLVDYSI 950
    EDTYTQKLSV PSGFSVTAPD KRGWVINPLG EKSPFPVWMM VASLLPAILV 1000
    FILIFMETQI TTLIISKKER MLQKGSGFHL DLLLIVAMGG ICALFGLPWL 1050
    AAATVRSVTH ANALTVMSKA VAPGDKPKIQ EVKEQRVTGL LVALLVGLSI 1100
    VIGDLLRQIP LAVLFGIFLY MGVTSLNGIQ FYERLHLLLM PPKHHPDVTY 1150
    VKKVRTLRMH LFTALQLLCL ALLWAVMSTA ASLAFPFILI LTVPLRMVVL 1200
    TRIFTEREMK CLDANEAEPV FDEREGVDEY NEMPMPV 1237
    Length:1,237
    Mass (Da):136,536
    Last modified:February 1, 1996 - v1
    Checksum:i2811D11051552BB2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S45791 mRNA. Translation: AAB23488.1.
    PIRiA56764.
    RefSeqiNP_001075788.1. NM_001082319.1.
    UniGeneiOcu.3310.

    Genome annotation databases

    GeneIDi100009159.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S45791 mRNA. Translation: AAB23488.1 .
    PIRi A56764.
    RefSeqi NP_001075788.1. NM_001082319.1.
    UniGenei Ocu.3310.

    3D structure databases

    ProteinModelPortali P48746.
    SMRi P48746. Positions 688-729, 1129-1161.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100009159.

    Organism-specific databases

    CTDi 6522.

    Phylogenomic databases

    HOVERGENi HBG004326.

    Family and domain databases

    Gene3Di 3.40.1100.10. 1 hit.
    InterProi IPR001717. Anion_exchange.
    IPR002978. Anion_exchange_2.
    IPR018241. Anion_exchange_CS.
    IPR013769. Band3_cytoplasmic_dom.
    IPR011531. HCO3_transpt_C.
    IPR003020. HCO3_transpt_euk.
    IPR016152. PTrfase/Anion_transptr.
    [Graphical view ]
    PANTHERi PTHR11453. PTHR11453. 1 hit.
    PTHR11453:SF14. PTHR11453:SF14. 1 hit.
    Pfami PF07565. Band_3_cyto. 1 hit.
    PF00955. HCO3_cotransp. 1 hit.
    [Graphical view ]
    PRINTSi PR00165. ANIONEXCHNGR.
    PR01188. ANIONEXHNGR2.
    PR01231. HCO3TRNSPORT.
    SUPFAMi SSF55804. SSF55804. 2 hits.
    TIGRFAMsi TIGR00834. ae. 1 hit.
    PROSITEi PS00219. ANION_EXCHANGER_1. 1 hit.
    PS00220. ANION_EXCHANGER_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning and localization of a band 3-related protein from ileum."
      Chow A., Dobbins J.W., Aronson P.S., Igarashi P.
      Am. J. Physiol. 263:G345-G352(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: New Zealand white.

    Entry informationi

    Entry nameiB3A2_RABIT
    AccessioniPrimary (citable) accession number: P48746
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3