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Protein

Anion exchange protein 2

Gene

SLC4A2

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Plasma membrane anion exchange protein of wide distribution.

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Anion exchange, Antiport, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Anion exchange protein 2
Short name:
AE 2
Short name:
Anion exchanger 2
Alternative name(s):
Band 3-related protein
Short name:
B3RP
Solute carrier family 4 member 2
Gene namesi
Name:SLC4A2
Synonyms:AE2
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 703703CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei704 – 72724HelicalSequence AnalysisAdd
BLAST
Transmembranei733 – 77038HelicalSequence AnalysisAdd
BLAST
Transmembranei790 – 81223HelicalSequence AnalysisAdd
BLAST
Transmembranei822 – 84322HelicalSequence AnalysisAdd
BLAST
Topological domaini844 – 89653ExtracellularSequence AnalysisAdd
BLAST
Transmembranei897 – 91418HelicalSequence AnalysisAdd
BLAST
Topological domaini915 – 92915CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei930 – 95021HelicalSequence AnalysisAdd
BLAST
Transmembranei984 – 100623HelicalSequence AnalysisAdd
BLAST
Transmembranei1032 – 105322HelicalSequence AnalysisAdd
BLAST
Transmembranei1087 – 113246HelicalSequence AnalysisAdd
BLAST
Transmembranei1159 – 119537HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12371237Anion exchange protein 2PRO_0000079217Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei113 – 1131PhosphoserineBy similarity
Modified residuei144 – 1441PhosphoserineBy similarity
Modified residuei170 – 1701PhosphoserineBy similarity
Modified residuei172 – 1721PhosphoserineBy similarity
Modified residuei253 – 2531PhosphothreonineBy similarity
Modified residuei439 – 4391PhosphoserineBy similarity
Glycosylationi855 – 8551N-linked (GlcNAc...)Sequence Analysis
Glycosylationi864 – 8641N-linked (GlcNAc...)Sequence Analysis
Glycosylationi878 – 8781N-linked (GlcNAc...)Sequence Analysis
Lipidationi1169 – 11691S-palmitoyl cysteineBy similarity

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliP48746.
SMRiP48746. Positions 688-729, 1129-1161.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni704 – 1237534Membrane (anion exchange)Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi5 – 316312Pro-richAdd
BLAST
Compositional biasi74 – 8815His-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG004326.
InParanoidiP48746.
KOiK13855.

Family and domain databases

Gene3Di3.40.1100.10. 1 hit.
InterProiIPR001717. Anion_exchange.
IPR002978. Anion_exchange_2.
IPR018241. Anion_exchange_CS.
IPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 1 hit.
PTHR11453:SF14. PTHR11453:SF14. 1 hit.
PfamiPF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view]
PRINTSiPR00165. ANIONEXCHNGR.
PR01188. ANIONEXHNGR2.
PR01231. HCO3TRNSPORT.
SUPFAMiSSF55804. SSF55804. 2 hits.
TIGRFAMsiTIGR00834. ae. 1 hit.
PROSITEiPS00219. ANION_EXCHANGER_1. 1 hit.
PS00220. ANION_EXCHANGER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48746-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSAPRRPAS GADSFRTPEP ESLGPGTPGF PEQEEDELHR TLGVERFEEI
60 70 80 90 100
LQEAGSRGGE EPGRSYGEED FEYHRQSSHH IHHPLSTHLP PDARRRKTPQ
110 120 130 140 150
GPGRKPRRRP GASPTGATPT IEEGEEDEEE ANEAEGARAP TEPSPASTPS
160 170 180 190 200
SVQFFLQEDE GAERKAERTS PSPPTLLPHQ EAAPWATEGA QTGVPVEEVA
210 220 230 240 250
VVASGTAGGD NGGASGRPLT KAQPGHRSYN LQERRRIGSM TGAEQALLPR
260 270 280 290 300
VPTDESEAQT LATADLDLMK SHRFEDVPGV RRHLVRKNAK GSAQSSREGR
310 320 330 340 350
EPGPTPRSRP RAPHKPHEVF VELNELLLDK NQEPQWRETA RWIKFEEDVE
360 370 380 390 400
EETERWGKPH VASLSFRSLL ELRRTLAHGA VLLDLDQQTL PGVAHQVVEQ
410 420 430 440 450
MVISDQIKAE DRANVLRALL LKHSHPSDEK DFSFPRNISA GSLGSLLGHH
460 470 480 490 500
HGQGAESDPH VTEPLIGGIP ETRLDVERER DVPPSAPPAG ITRSKSKHEL
510 520 530 540 550
KLLEKIPENA EATVVLVGCV EFLSRPTMAF VRLREAVELD AVLEVPVPVR
560 570 580 590 600
FLFLLLGPSS ANMDYHEIGR SISTLMSDKQ FHEAAYLADE REDLLTAINA
610 620 630 640 650
FLDCSVVLPP SEVQGEELLR SVAHFQRQML KKREEQGRLL PPGLGLEPKS
660 670 680 690 700
AQDKALLQMV EAAGAAEDDP LRRTGRPFGG LIRDVRRRYP HYLSDFRDAL
710 720 730 740 750
DPQCVAAVIF IYFAALSPAI TFGGLLGEKT QDLIGVSELI MSTALQGVIF
760 770 780 790 800
CLLGAQPLLV IGFSGPLLVF EEAFFTFCSS NQLEYLVGRV WIGFWLVLLA
810 820 830 840 850
LLMVALEGSF LVRFVSRFTQ EIFAFLISLI FIYETFYKLI KIFQEHPLHG
860 870 880 890 900
CSVSNSSETD SSENATWAGA GSTLGPANRS SAGQAGQGRP RGQPNTALLS
910 920 930 940 950
LVLMAGTFFI AFFLRKFKNS RFFPGRIRRV IGDFGVPIAI LIMVLVDYSI
960 970 980 990 1000
EDTYTQKLSV PSGFSVTAPD KRGWVINPLG EKSPFPVWMM VASLLPAILV
1010 1020 1030 1040 1050
FILIFMETQI TTLIISKKER MLQKGSGFHL DLLLIVAMGG ICALFGLPWL
1060 1070 1080 1090 1100
AAATVRSVTH ANALTVMSKA VAPGDKPKIQ EVKEQRVTGL LVALLVGLSI
1110 1120 1130 1140 1150
VIGDLLRQIP LAVLFGIFLY MGVTSLNGIQ FYERLHLLLM PPKHHPDVTY
1160 1170 1180 1190 1200
VKKVRTLRMH LFTALQLLCL ALLWAVMSTA ASLAFPFILI LTVPLRMVVL
1210 1220 1230
TRIFTEREMK CLDANEAEPV FDEREGVDEY NEMPMPV
Length:1,237
Mass (Da):136,536
Last modified:February 1, 1996 - v1
Checksum:i2811D11051552BB2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S45791 mRNA. Translation: AAB23488.1.
PIRiA56764.
RefSeqiNP_001075788.1. NM_001082319.1.
UniGeneiOcu.3310.

Genome annotation databases

GeneIDi100009159.
KEGGiocu:100009159.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S45791 mRNA. Translation: AAB23488.1.
PIRiA56764.
RefSeqiNP_001075788.1. NM_001082319.1.
UniGeneiOcu.3310.

3D structure databases

ProteinModelPortaliP48746.
SMRiP48746. Positions 688-729, 1129-1161.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100009159.
KEGGiocu:100009159.

Organism-specific databases

CTDi6522.

Phylogenomic databases

HOVERGENiHBG004326.
InParanoidiP48746.
KOiK13855.

Family and domain databases

Gene3Di3.40.1100.10. 1 hit.
InterProiIPR001717. Anion_exchange.
IPR002978. Anion_exchange_2.
IPR018241. Anion_exchange_CS.
IPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 1 hit.
PTHR11453:SF14. PTHR11453:SF14. 1 hit.
PfamiPF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view]
PRINTSiPR00165. ANIONEXCHNGR.
PR01188. ANIONEXHNGR2.
PR01231. HCO3TRNSPORT.
SUPFAMiSSF55804. SSF55804. 2 hits.
TIGRFAMsiTIGR00834. ae. 1 hit.
PROSITEiPS00219. ANION_EXCHANGER_1. 1 hit.
PS00220. ANION_EXCHANGER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "cDNA cloning and localization of a band 3-related protein from ileum."
    Chow A., Dobbins J.W., Aronson P.S., Igarashi P.
    Am. J. Physiol. 263:G345-G352(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: New Zealand white.

Entry informationi

Entry nameiB3A2_RABIT
AccessioniPrimary (citable) accession number: P48746
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: March 4, 2015
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.