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P48745

- NOV_HUMAN

UniProt

P48745 - NOV_HUMAN

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Protein

Protein NOV homolog

Gene

NOV

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Immediate-early protein likely to play a role in cell growth regulation.By similarity

GO - Biological processi

  1. regulation of cell growth Source: InterPro
  2. regulation of gene expression Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Enzyme and pathway databases

SignaLinkiP48745.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein NOV homolog
Short name:
NovH
Alternative name(s):
CCN family member 3
Insulin-like growth factor-binding protein 9
Short name:
IBP-9
Short name:
IGF-binding protein 9
Short name:
IGFBP-9
Nephroblastoma-overexpressed gene protein homolog
Gene namesi
Name:NOV
Synonyms:CCN3, IGFBP9, NOVH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:7885. NOV.

Subcellular locationi

GO - Cellular componenti

  1. axon Source: Ensembl
  2. dendrite Source: Ensembl
  3. extracellular matrix Source: Ensembl
  4. extracellular region Source: UniProtKB-KW
  5. intracellular membrane-bounded organelle Source: HPA
  6. neuronal cell body Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31687.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 31311 PublicationAdd
BLAST
Chaini32 – 357326Protein NOV homologPRO_0000014415Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi97 – 971N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi264 ↔ 301By similarity
Glycosylationi280 – 2801N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi281 ↔ 315By similarity
Disulfide bondi292 ↔ 331By similarity
Disulfide bondi295 ↔ 333By similarity
Disulfide bondi300 ↔ 337By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP48745.
PaxDbiP48745.
PeptideAtlasiP48745.
PRIDEiP48745.

Expressioni

Tissue specificityi

Expressed in bone marrow, thymic cells and nephroblastoma. Increased expression in Wilms tumor of the stromal type.1 Publication

Inductioni

Expression is down-regulated by WT1.1 Publication

Gene expression databases

BgeeiP48745.
CleanExiHS_NOV.
ExpressionAtlasiP48745. baseline and differential.
GenevestigatoriP48745.

Organism-specific databases

HPAiHPA019684.

Interactioni

Subunit structurei

Interacts with FBLN1.1 Publication

Protein-protein interaction databases

BioGridi110918. 14 interactions.
IntActiP48745. 1 interaction.
STRINGi9606.ENSP00000259526.

Structurei

3D structure databases

ProteinModelPortaliP48745.
SMRiP48745. Positions 47-143.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 10574IGFBP N-terminalPROSITE-ProRule annotationAdd
BLAST
Domaini108 – 17467VWFCPROSITE-ProRule annotationAdd
BLAST
Domaini205 – 25046TSP type-1PROSITE-ProRule annotationAdd
BLAST
Domaini264 – 33875CTCKPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the CCN family.Curated
Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation
Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
Contains 1 TSP type-1 domain.PROSITE-ProRule annotation
Contains 1 VWFC domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG72934.
GeneTreeiENSGT00760000119225.
HOGENOMiHOG000231462.
HOVERGENiHBG000635.
InParanoidiP48745.
OMAiCCTPHNT.
OrthoDBiEOG7N8ZXB.
PhylomeDBiP48745.
TreeFamiTF326070.

Family and domain databases

InterProiIPR006207. Cys_knot_C.
IPR006208. Glyco_hormone_CN.
IPR009030. Growth_fac_rcpt_N_dom.
IPR000867. IGFBP-like.
IPR012395. IGFBP_CNN.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. Thrombospondin_1_rpt.
IPR001007. VWF_C.
[Graphical view]
PfamiPF00007. Cys_knot. 1 hit.
PF00219. IGFBP. 1 hit.
PF00090. TSP_1. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view]
PIRSFiPIRSF036495. IGFBP_rP_CNN. 1 hit.
SMARTiSM00041. CT. 1 hit.
SM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEiPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48745-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQSVQSTSFC LRKQCLCLTF LLLHLLGQVA ATQRCPPQCP GRCPATPPTC
60 70 80 90 100
APGVRAVLDG CSCCLVCARQ RGESCSDLEP CDESSGLYCD RSADPSNQTG
110 120 130 140 150
ICTAVEGDNC VFDGVIYRSG EKFQPSCKFQ CTCRDGQIGC VPRCQLDVLL
160 170 180 190 200
PEPNCPAPRK VEVPGECCEK WICGPDEEDS LGGLTLAAYR PEATLGVEVS
210 220 230 240 250
DSSVNCIEQT TEWTACSKSC GMGFSTRVTN RNRQCEMLKQ TRLCMVRPCE
260 270 280 290 300
QEPEQPTDKK GKKCLRTKKS LKAIHLQFKN CTSLHTYKPR FCGVCSDGRC
310 320 330 340 350
CTPHNTKTIQ AEFQCSPGQI VKKPVMVIGT CTCHTNCPKN NEAFLQELEL

KTTRGKM
Length:357
Mass (Da):39,162
Last modified:February 1, 1996 - v1
Checksum:i035D5BF4576BD85B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti26 – 272LG → CL(PubMed:1756408)Curated
Sequence conflicti97 – 971N → K in CAG33713. 1 PublicationCurated
Sequence conflicti97 – 971N → K in AAH15028. (PubMed:15489334)Curated
Sequence conflicti231 – 2311R → G in BAG35274. (PubMed:14702039)Curated
Sequence conflicti357 – 3571M → I in CAG33713. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti42 – 421R → Q.
Corresponds to variant rs2279112 [ dbSNP | Ensembl ].
VAR_049568
Natural varianti233 – 2331R → H.
Corresponds to variant rs11538929 [ dbSNP | Ensembl ].
VAR_049569

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X78351
, X78352, X78353, X78354 Genomic DNA. Translation: CAA55146.1.
X96584 mRNA. Translation: CAA65403.1.
AY082381 mRNA. Translation: AAL92490.1.
AK312355 mRNA. Translation: BAG35274.1.
CR457432 mRNA. Translation: CAG33713.1.
BC015028 mRNA. Translation: AAH15028.1.
CCDSiCCDS6328.1.
PIRiI38069.
RefSeqiNP_002505.1. NM_002514.3.
UniGeneiHs.235935.

Genome annotation databases

EnsembliENST00000259526; ENSP00000259526; ENSG00000136999.
GeneIDi4856.
KEGGihsa:4856.
UCSCiuc003yoq.2. human.

Polymorphism databases

DMDMi1352515.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X78351
, X78352 , X78353 , X78354 Genomic DNA. Translation: CAA55146.1 .
X96584 mRNA. Translation: CAA65403.1 .
AY082381 mRNA. Translation: AAL92490.1 .
AK312355 mRNA. Translation: BAG35274.1 .
CR457432 mRNA. Translation: CAG33713.1 .
BC015028 mRNA. Translation: AAH15028.1 .
CCDSi CCDS6328.1.
PIRi I38069.
RefSeqi NP_002505.1. NM_002514.3.
UniGenei Hs.235935.

3D structure databases

ProteinModelPortali P48745.
SMRi P48745. Positions 47-143.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110918. 14 interactions.
IntActi P48745. 1 interaction.
STRINGi 9606.ENSP00000259526.

Chemistry

DrugBanki DB00071. "Insulin.
DB00030. Insulin Regular.

Polymorphism databases

DMDMi 1352515.

Proteomic databases

MaxQBi P48745.
PaxDbi P48745.
PeptideAtlasi P48745.
PRIDEi P48745.

Protocols and materials databases

DNASUi 4856.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000259526 ; ENSP00000259526 ; ENSG00000136999 .
GeneIDi 4856.
KEGGi hsa:4856.
UCSCi uc003yoq.2. human.

Organism-specific databases

CTDi 4856.
GeneCardsi GC08P120428.
HGNCi HGNC:7885. NOV.
HPAi HPA019684.
MIMi 164958. gene.
neXtProti NX_P48745.
PharmGKBi PA31687.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG72934.
GeneTreei ENSGT00760000119225.
HOGENOMi HOG000231462.
HOVERGENi HBG000635.
InParanoidi P48745.
OMAi CCTPHNT.
OrthoDBi EOG7N8ZXB.
PhylomeDBi P48745.
TreeFami TF326070.

Enzyme and pathway databases

SignaLinki P48745.

Miscellaneous databases

GeneWikii NOV_(gene).
GenomeRNAii 4856.
NextBioi 18706.
PROi P48745.
SOURCEi Search...

Gene expression databases

Bgeei P48745.
CleanExi HS_NOV.
ExpressionAtlasi P48745. baseline and differential.
Genevestigatori P48745.

Family and domain databases

InterProi IPR006207. Cys_knot_C.
IPR006208. Glyco_hormone_CN.
IPR009030. Growth_fac_rcpt_N_dom.
IPR000867. IGFBP-like.
IPR012395. IGFBP_CNN.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. Thrombospondin_1_rpt.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF00007. Cys_knot. 1 hit.
PF00219. IGFBP. 1 hit.
PF00090. TSP_1. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view ]
PIRSFi PIRSF036495. IGFBP_rP_CNN. 1 hit.
SMARTi SM00041. CT. 1 hit.
SM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEi PS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structural analysis of the human nov proto-oncogene and expression in Wilms tumor."
    Martinerie C., Huff V., Joubert I., Badzioch M., Saunders G.F., Strong L.C., Perbal B.
    Oncogene 9:2729-2732(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Placenta.
  2. "Regulation of nov by WT1: a potential role for nov in nephrogenesis."
    Martinerie C., Chevalier G., Rauscher F.J. III, Perbal B.
    Oncogene 12:1479-1492(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION.
  3. "Cloning, sequencing and expression of human nov gene."
    Jiang D., Gou D., Li W.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Amygdala.
  5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.
  7. "Expression of a gene encoding a novel potential IGF binding protein in human tissues."
    Martinerie C., Perbal B.
    C. R. Acad. Sci. III, Sci. Vie 313:345-351(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 26-102, TISSUE SPECIFICITY.
  8. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 32-46.
  9. "The C-terminal domain of the regulatory protein NOVH is sufficient to promote interaction with fibulin 1C: a clue for a role of NOVH in cell-adhesion signaling."
    Perbal B., Martinerie C., Sainson R., Werner M., He B., Roizman B.
    Proc. Natl. Acad. Sci. U.S.A. 96:869-874(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FBLN1.

Entry informationi

Entry nameiNOV_HUMAN
AccessioniPrimary (citable) accession number: P48745
Secondary accession number(s): B2R5X7
, Q6I9S3, Q96BY5, Q9UDE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 29, 2014
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3