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P48745

- NOV_HUMAN

UniProt

P48745 - NOV_HUMAN

Protein

Protein NOV homolog

Gene

NOV

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Immediate-early protein likely to play a role in cell growth regulation.By similarity

    GO - Biological processi

    1. regulation of cell growth Source: InterPro
    2. regulation of gene expression Source: Ensembl

    Keywords - Molecular functioni

    Growth factor

    Enzyme and pathway databases

    SignaLinkiP48745.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein NOV homolog
    Short name:
    NovH
    Alternative name(s):
    CCN family member 3
    Insulin-like growth factor-binding protein 9
    Short name:
    IBP-9
    Short name:
    IGF-binding protein 9
    Short name:
    IGFBP-9
    Nephroblastoma-overexpressed gene protein homolog
    Gene namesi
    Name:NOV
    Synonyms:CCN3, IGFBP9, NOVH
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:7885. NOV.

    Subcellular locationi

    GO - Cellular componenti

    1. axon Source: Ensembl
    2. dendrite Source: Ensembl
    3. extracellular matrix Source: Ensembl
    4. extracellular region Source: UniProtKB-SubCell
    5. intracellular membrane-bounded organelle Source: HPA
    6. neuronal cell body Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31687.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 31311 PublicationAdd
    BLAST
    Chaini32 – 357326Protein NOV homologPRO_0000014415Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi97 – 971N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi264 ↔ 301By similarity
    Glycosylationi280 – 2801N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi281 ↔ 315By similarity
    Disulfide bondi292 ↔ 331By similarity
    Disulfide bondi295 ↔ 333By similarity
    Disulfide bondi300 ↔ 337By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP48745.
    PeptideAtlasiP48745.
    PRIDEiP48745.

    Expressioni

    Tissue specificityi

    Expressed in bone marrow, thymic cells and nephroblastoma. Increased expression in Wilms tumor of the stromal type.1 Publication

    Inductioni

    Expression is down-regulated by WT1.1 Publication

    Gene expression databases

    ArrayExpressiP48745.
    BgeeiP48745.
    CleanExiHS_NOV.
    GenevestigatoriP48745.

    Organism-specific databases

    HPAiHPA019684.

    Interactioni

    Subunit structurei

    Interacts with FBLN1.1 Publication

    Protein-protein interaction databases

    BioGridi110918. 11 interactions.
    IntActiP48745. 1 interaction.
    STRINGi9606.ENSP00000259526.

    Structurei

    3D structure databases

    ProteinModelPortaliP48745.
    SMRiP48745. Positions 272-338.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini32 – 10574IGFBP N-terminalPROSITE-ProRule annotationAdd
    BLAST
    Domaini108 – 17467VWFCPROSITE-ProRule annotationAdd
    BLAST
    Domaini205 – 25046TSP type-1PROSITE-ProRule annotationAdd
    BLAST
    Domaini264 – 33875CTCKPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CCN family.Curated
    Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation
    Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
    Contains 1 TSP type-1 domain.PROSITE-ProRule annotation
    Contains 1 VWFC domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG72934.
    HOGENOMiHOG000231462.
    HOVERGENiHBG000635.
    InParanoidiP48745.
    OMAiCCTPHNT.
    OrthoDBiEOG7N8ZXB.
    PhylomeDBiP48745.
    TreeFamiTF326070.

    Family and domain databases

    InterProiIPR006207. Cys_knot_C.
    IPR006208. Glyco_hormone_CN.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR000867. IGFBP-like.
    IPR012395. IGFBP_CNN.
    IPR017891. Insulin_GF-bd_Cys-rich_CS.
    IPR000884. Thrombospondin_1_rpt.
    IPR001007. VWF_C.
    [Graphical view]
    PfamiPF00007. Cys_knot. 1 hit.
    PF00219. IGFBP. 1 hit.
    PF00090. TSP_1. 1 hit.
    PF00093. VWC. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036495. IGFBP_rP_CNN. 1 hit.
    SMARTiSM00041. CT. 1 hit.
    SM00121. IB. 1 hit.
    SM00209. TSP1. 1 hit.
    SM00214. VWC. 1 hit.
    [Graphical view]
    SUPFAMiSSF57184. SSF57184. 1 hit.
    SSF82895. SSF82895. 1 hit.
    PROSITEiPS01185. CTCK_1. 1 hit.
    PS01225. CTCK_2. 1 hit.
    PS00222. IGFBP_N_1. 1 hit.
    PS51323. IGFBP_N_2. 1 hit.
    PS50092. TSP1. 1 hit.
    PS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P48745-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQSVQSTSFC LRKQCLCLTF LLLHLLGQVA ATQRCPPQCP GRCPATPPTC    50
    APGVRAVLDG CSCCLVCARQ RGESCSDLEP CDESSGLYCD RSADPSNQTG 100
    ICTAVEGDNC VFDGVIYRSG EKFQPSCKFQ CTCRDGQIGC VPRCQLDVLL 150
    PEPNCPAPRK VEVPGECCEK WICGPDEEDS LGGLTLAAYR PEATLGVEVS 200
    DSSVNCIEQT TEWTACSKSC GMGFSTRVTN RNRQCEMLKQ TRLCMVRPCE 250
    QEPEQPTDKK GKKCLRTKKS LKAIHLQFKN CTSLHTYKPR FCGVCSDGRC 300
    CTPHNTKTIQ AEFQCSPGQI VKKPVMVIGT CTCHTNCPKN NEAFLQELEL 350
    KTTRGKM 357
    Length:357
    Mass (Da):39,162
    Last modified:February 1, 1996 - v1
    Checksum:i035D5BF4576BD85B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti26 – 272LG → CL(PubMed:1756408)Curated
    Sequence conflicti97 – 971N → K in CAG33713. 1 PublicationCurated
    Sequence conflicti97 – 971N → K in AAH15028. (PubMed:15489334)Curated
    Sequence conflicti231 – 2311R → G in BAG35274. (PubMed:14702039)Curated
    Sequence conflicti357 – 3571M → I in CAG33713. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti42 – 421R → Q.
    Corresponds to variant rs2279112 [ dbSNP | Ensembl ].
    VAR_049568
    Natural varianti233 – 2331R → H.
    Corresponds to variant rs11538929 [ dbSNP | Ensembl ].
    VAR_049569

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X78351
    , X78352, X78353, X78354 Genomic DNA. Translation: CAA55146.1.
    X96584 mRNA. Translation: CAA65403.1.
    AY082381 mRNA. Translation: AAL92490.1.
    AK312355 mRNA. Translation: BAG35274.1.
    CR457432 mRNA. Translation: CAG33713.1.
    BC015028 mRNA. Translation: AAH15028.1.
    CCDSiCCDS6328.1.
    PIRiI38069.
    RefSeqiNP_002505.1. NM_002514.3.
    UniGeneiHs.235935.

    Genome annotation databases

    EnsembliENST00000259526; ENSP00000259526; ENSG00000136999.
    GeneIDi4856.
    KEGGihsa:4856.
    UCSCiuc003yoq.2. human.

    Polymorphism databases

    DMDMi1352515.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X78351
    , X78352 , X78353 , X78354 Genomic DNA. Translation: CAA55146.1 .
    X96584 mRNA. Translation: CAA65403.1 .
    AY082381 mRNA. Translation: AAL92490.1 .
    AK312355 mRNA. Translation: BAG35274.1 .
    CR457432 mRNA. Translation: CAG33713.1 .
    BC015028 mRNA. Translation: AAH15028.1 .
    CCDSi CCDS6328.1.
    PIRi I38069.
    RefSeqi NP_002505.1. NM_002514.3.
    UniGenei Hs.235935.

    3D structure databases

    ProteinModelPortali P48745.
    SMRi P48745. Positions 272-338.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110918. 11 interactions.
    IntActi P48745. 1 interaction.
    STRINGi 9606.ENSP00000259526.

    Chemistry

    DrugBanki DB00047. Insulin Glargine recombinant.
    DB00046. Insulin Lyspro recombinant.
    DB00030. Insulin recombinant.
    DB00071. Insulin, porcine.

    Polymorphism databases

    DMDMi 1352515.

    Proteomic databases

    PaxDbi P48745.
    PeptideAtlasi P48745.
    PRIDEi P48745.

    Protocols and materials databases

    DNASUi 4856.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000259526 ; ENSP00000259526 ; ENSG00000136999 .
    GeneIDi 4856.
    KEGGi hsa:4856.
    UCSCi uc003yoq.2. human.

    Organism-specific databases

    CTDi 4856.
    GeneCardsi GC08P120428.
    HGNCi HGNC:7885. NOV.
    HPAi HPA019684.
    MIMi 164958. gene.
    neXtProti NX_P48745.
    PharmGKBi PA31687.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG72934.
    HOGENOMi HOG000231462.
    HOVERGENi HBG000635.
    InParanoidi P48745.
    OMAi CCTPHNT.
    OrthoDBi EOG7N8ZXB.
    PhylomeDBi P48745.
    TreeFami TF326070.

    Enzyme and pathway databases

    SignaLinki P48745.

    Miscellaneous databases

    GeneWikii NOV_(gene).
    GenomeRNAii 4856.
    NextBioi 18706.
    PROi P48745.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P48745.
    Bgeei P48745.
    CleanExi HS_NOV.
    Genevestigatori P48745.

    Family and domain databases

    InterProi IPR006207. Cys_knot_C.
    IPR006208. Glyco_hormone_CN.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR000867. IGFBP-like.
    IPR012395. IGFBP_CNN.
    IPR017891. Insulin_GF-bd_Cys-rich_CS.
    IPR000884. Thrombospondin_1_rpt.
    IPR001007. VWF_C.
    [Graphical view ]
    Pfami PF00007. Cys_knot. 1 hit.
    PF00219. IGFBP. 1 hit.
    PF00090. TSP_1. 1 hit.
    PF00093. VWC. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036495. IGFBP_rP_CNN. 1 hit.
    SMARTi SM00041. CT. 1 hit.
    SM00121. IB. 1 hit.
    SM00209. TSP1. 1 hit.
    SM00214. VWC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57184. SSF57184. 1 hit.
    SSF82895. SSF82895. 1 hit.
    PROSITEi PS01185. CTCK_1. 1 hit.
    PS01225. CTCK_2. 1 hit.
    PS00222. IGFBP_N_1. 1 hit.
    PS51323. IGFBP_N_2. 1 hit.
    PS50092. TSP1. 1 hit.
    PS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structural analysis of the human nov proto-oncogene and expression in Wilms tumor."
      Martinerie C., Huff V., Joubert I., Badzioch M., Saunders G.F., Strong L.C., Perbal B.
      Oncogene 9:2729-2732(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Placenta.
    2. "Regulation of nov by WT1: a potential role for nov in nephrogenesis."
      Martinerie C., Chevalier G., Rauscher F.J. III, Perbal B.
      Oncogene 12:1479-1492(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION.
    3. "Cloning, sequencing and expression of human nov gene."
      Jiang D., Gou D., Li W.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Amygdala.
    5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Skin.
    7. "Expression of a gene encoding a novel potential IGF binding protein in human tissues."
      Martinerie C., Perbal B.
      C. R. Acad. Sci. III, Sci. Vie 313:345-351(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 26-102, TISSUE SPECIFICITY.
    8. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 32-46.
    9. "The C-terminal domain of the regulatory protein NOVH is sufficient to promote interaction with fibulin 1C: a clue for a role of NOVH in cell-adhesion signaling."
      Perbal B., Martinerie C., Sainson R., Werner M., He B., Roizman B.
      Proc. Natl. Acad. Sci. U.S.A. 96:869-874(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH FBLN1.

    Entry informationi

    Entry nameiNOV_HUMAN
    AccessioniPrimary (citable) accession number: P48745
    Secondary accession number(s): B2R5X7
    , Q6I9S3, Q96BY5, Q9UDE4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 125 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3