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P48745 (NOV_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 124. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein NOV homolog

Short name=NovH
Alternative name(s):
CCN family member 3
Insulin-like growth factor-binding protein 9
Short name=IBP-9
Short name=IGF-binding protein 9
Short name=IGFBP-9
Nephroblastoma-overexpressed gene protein homolog
Gene names
Name:NOV
Synonyms:CCN3, IGFBP9, NOVH
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length357 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Immediate-early protein likely to play a role in cell growth regulation By similarity.

Subunit structure

Interacts with FBLN1. Ref.9

Subcellular location

Secreted.

Tissue specificity

Expressed in bone marrow, thymic cells and nephroblastoma. Increased expression in Wilms tumor of the stromal type. Ref.7

Induction

Expression is down-regulated by WT1. Ref.2

Sequence similarities

Belongs to the CCN family.

Contains 1 CTCK (C-terminal cystine knot-like) domain.

Contains 1 IGFBP N-terminal domain.

Contains 1 TSP type-1 domain.

Contains 1 VWFC domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3131 Ref.8
Chain32 – 357326Protein NOV homolog
PRO_0000014415

Regions

Domain32 – 10574IGFBP N-terminal
Domain108 – 17467VWFC
Domain205 – 25046TSP type-1
Domain264 – 33875CTCK

Amino acid modifications

Glycosylation971N-linked (GlcNAc...) Potential
Glycosylation2801N-linked (GlcNAc...) Potential
Disulfide bond264 ↔ 301 By similarity
Disulfide bond281 ↔ 315 By similarity
Disulfide bond292 ↔ 331 By similarity
Disulfide bond295 ↔ 333 By similarity
Disulfide bond300 ↔ 337 By similarity

Natural variations

Natural variant421R → Q.
Corresponds to variant rs2279112 [ dbSNP | Ensembl ].
VAR_049568
Natural variant2331R → H.
Corresponds to variant rs11538929 [ dbSNP | Ensembl ].
VAR_049569

Experimental info

Sequence conflict26 – 272LG → CL Ref.7
Sequence conflict971N → K in CAG33713. Ref.5
Sequence conflict971N → K in AAH15028. Ref.6
Sequence conflict2311R → G in BAG35274. Ref.4
Sequence conflict3571M → I in CAG33713. Ref.5

Sequences

Sequence LengthMass (Da)Tools
P48745 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 035D5BF4576BD85B

FASTA35739,162
        10         20         30         40         50         60 
MQSVQSTSFC LRKQCLCLTF LLLHLLGQVA ATQRCPPQCP GRCPATPPTC APGVRAVLDG 

        70         80         90        100        110        120 
CSCCLVCARQ RGESCSDLEP CDESSGLYCD RSADPSNQTG ICTAVEGDNC VFDGVIYRSG 

       130        140        150        160        170        180 
EKFQPSCKFQ CTCRDGQIGC VPRCQLDVLL PEPNCPAPRK VEVPGECCEK WICGPDEEDS 

       190        200        210        220        230        240 
LGGLTLAAYR PEATLGVEVS DSSVNCIEQT TEWTACSKSC GMGFSTRVTN RNRQCEMLKQ 

       250        260        270        280        290        300 
TRLCMVRPCE QEPEQPTDKK GKKCLRTKKS LKAIHLQFKN CTSLHTYKPR FCGVCSDGRC 

       310        320        330        340        350 
CTPHNTKTIQ AEFQCSPGQI VKKPVMVIGT CTCHTNCPKN NEAFLQELEL KTTRGKM 

« Hide

References

« Hide 'large scale' references
[1]"Structural analysis of the human nov proto-oncogene and expression in Wilms tumor."
Martinerie C., Huff V., Joubert I., Badzioch M., Saunders G.F., Strong L.C., Perbal B.
Oncogene 9:2729-2732(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Placenta.
[2]"Regulation of nov by WT1: a potential role for nov in nephrogenesis."
Martinerie C., Chevalier G., Rauscher F.J. III, Perbal B.
Oncogene 12:1479-1492(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION.
[3]"Cloning, sequencing and expression of human nov gene."
Jiang D., Gou D., Li W.
Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Amygdala.
[5]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Skin.
[7]"Expression of a gene encoding a novel potential IGF binding protein in human tissues."
Martinerie C., Perbal B.
C. R. Acad. Sci. III, Sci. Vie 313:345-351(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 26-102, TISSUE SPECIFICITY.
[8]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 32-46.
[9]"The C-terminal domain of the regulatory protein NOVH is sufficient to promote interaction with fibulin 1C: a clue for a role of NOVH in cell-adhesion signaling."
Perbal B., Martinerie C., Sainson R., Werner M., He B., Roizman B.
Proc. Natl. Acad. Sci. U.S.A. 96:869-874(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH FBLN1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X78351 expand/collapse EMBL AC list , X78352, X78353, X78354 Genomic DNA. Translation: CAA55146.1.
X96584 mRNA. Translation: CAA65403.1.
AY082381 mRNA. Translation: AAL92490.1.
AK312355 mRNA. Translation: BAG35274.1.
CR457432 mRNA. Translation: CAG33713.1.
BC015028 mRNA. Translation: AAH15028.1.
CCDSCCDS6328.1.
PIRI38069.
RefSeqNP_002505.1. NM_002514.3.
UniGeneHs.235935.

3D structure databases

ProteinModelPortalP48745.
SMRP48745. Positions 272-338.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110918. 11 interactions.
IntActP48745. 1 interaction.
STRING9606.ENSP00000259526.

Chemistry

DrugBankDB00047. Insulin Glargine recombinant.
DB00046. Insulin Lyspro recombinant.
DB00030. Insulin recombinant.
DB00071. Insulin, porcine.

Polymorphism databases

DMDM1352515.

Proteomic databases

PaxDbP48745.
PeptideAtlasP48745.
PRIDEP48745.

Protocols and materials databases

DNASU4856.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000259526; ENSP00000259526; ENSG00000136999.
GeneID4856.
KEGGhsa:4856.
UCSCuc003yoq.2. human.

Organism-specific databases

CTD4856.
GeneCardsGC08P120428.
HGNCHGNC:7885. NOV.
HPAHPA019684.
MIM164958. gene.
neXtProtNX_P48745.
PharmGKBPA31687.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG72934.
HOGENOMHOG000231462.
HOVERGENHBG000635.
InParanoidP48745.
OMACCTPHNT.
OrthoDBEOG7N8ZXB.
PhylomeDBP48745.
TreeFamTF326070.

Enzyme and pathway databases

SignaLinkP48745.

Gene expression databases

ArrayExpressP48745.
BgeeP48745.
CleanExHS_NOV.
GenevestigatorP48745.

Family and domain databases

InterProIPR006207. Cys_knot_C.
IPR006208. Glyco_hormone_CN.
IPR009030. Growth_fac_rcpt_N_dom.
IPR000867. IGFBP-like.
IPR012395. IGFBP_CNN.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. Thrombospondin_1_rpt.
IPR001007. VWF_C.
[Graphical view]
PfamPF00007. Cys_knot. 1 hit.
PF00219. IGFBP. 1 hit.
PF00090. TSP_1. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view]
PIRSFPIRSF036495. IGFBP_rP_CNN. 1 hit.
SMARTSM00041. CT. 1 hit.
SM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMSSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiNOV_(gene).
GenomeRNAi4856.
NextBio18706.
PROP48745.
SOURCESearch...

Entry information

Entry nameNOV_HUMAN
AccessionPrimary (citable) accession number: P48745
Secondary accession number(s): B2R5X7 expand/collapse secondary AC list , Q6I9S3, Q96BY5, Q9UDE4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: July 9, 2014
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM