ID   HSP77_HUMAN             Reviewed;         367 AA.
AC   P48741; P19790;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 2.
DT   08-NOV-2023, entry version 136.
DE   RecName: Full=Putative heat shock 70 kDa protein 7;
DE   AltName: Full=Heat shock 70 kDa protein B;
GN   Name=HSPA7; Synonyms=HSP70B;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-247.
RX   PubMed=3927293; DOI=10.1073/pnas.82.15.4949;
RA   Voellmy R., Ahmed A., Schiller P., Bromley P., Rungger D.;
RT   "Isolation and functional analysis of a human 70,000-dalton heat shock
RT   protein gene segment.";
RL   Proc. Natl. Acad. Sci. U.S.A. 82:4949-4953(1985).
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family. {ECO:0000305}.
CC   -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR   EMBL; AL451067; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; M11236; AAA52696.1; -; Genomic_DNA.
DR   PIR; A25773; A25773.
DR   AlphaFoldDB; P48741; -.
DR   SMR; P48741; -.
DR   IntAct; P48741; 46.
DR   GlyConnect; 1695; 1 N-Linked glycan (1 site).
DR   iPTMnet; P48741; -.
DR   PhosphoSitePlus; P48741; -.
DR   SwissPalm; P48741; -.
DR   BioMuta; HGNC:5240; -.
DR   EPD; P48741; -.
DR   jPOST; P48741; -.
DR   MassIVE; P48741; -.
DR   MaxQB; P48741; -.
DR   PeptideAtlas; P48741; -.
DR   ProteomicsDB; 55940; -.
DR   Pumba; P48741; -.
DR   AGR; HGNC:5240; -.
DR   GeneCards; HSPA7; -.
DR   HGNC; HGNC:5240; HSPA7.
DR   MIM; 140556; gene.
DR   neXtProt; NX_P48741; -.
DR   InParanoid; P48741; -.
DR   PhylomeDB; P48741; -.
DR   PathwayCommons; P48741; -.
DR   Reactome; R-HSA-3371453; Regulation of HSF1-mediated heat shock response.
DR   SignaLink; P48741; -.
DR   Pharos; P48741; Tdark.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; P48741; Protein.
DR   GO; GO:0072562; C:blood microparticle; HDA:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0031072; F:heat shock protein binding; IBA:GO_Central.
DR   GO; GO:0044183; F:protein folding chaperone; IBA:GO_Central.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IBA:GO_Central.
DR   GO; GO:0051085; P:chaperone cofactor-dependent protein refolding; IBA:GO_Central.
DR   GO; GO:0042026; P:protein refolding; IBA:GO_Central.
DR   Gene3D; 3.30.30.30; -; 1.
DR   Gene3D; 3.30.420.40; -; 2.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375:SF168; HEAT SHOCK 70 KDA PROTEIN 6-RELATED; 1.
DR   PANTHER; PTHR19375; HEAT SHOCK PROTEIN 70KDA; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   PRINTS; PR00301; HEATSHOCK70.
DR   SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
PE   5: Uncertain;
KW   ATP-binding; Nucleotide-binding; Reference proteome; Stress response.
FT   CHAIN           1..367
FT                   /note="Putative heat shock 70 kDa protein 7"
FT                   /id="PRO_0000078267"
FT   CONFLICT        59
FT                   /note="S -> N (in Ref. 2; AAA52696)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        95
FT                   /note="Q -> K (in Ref. 2; AAA52696)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        99
FT                   /note="E -> G (in Ref. 2; AAA52696)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        127
FT                   /note="S -> T (in Ref. 2; AAA52696)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        191
FT                   /note="G -> R (in Ref. 2; AAA52696)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        213
FT                   /note="S -> T (in Ref. 2; AAA52696)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   367 AA;  40244 MW;  060DFA210A29A5D4 CRC64;
     MQAPRELAVG IDLGTTYSCV GVFQQGRVEI LANDQGNRTT PSYVAFTDTE RLVGDAAKSQ
     AALNPHNTVF DAKRLIGRKF ADTTVQSDMK HWPFQVVSEG GKPKVRVCYR GEDKTFYPEE
     ISSMVLSKMK ETAEAYLGQP VKHAVITVPT YFSNSQRQAT KDAGAIAGLK VLPIINEATA
     AAIAYGLDRR GAGKRNVLIF DLGGGTFDVS VLSIDAGVFE VKATAGDTHL GGEDFDNRLV
     NHFMEEFRRK HGKDLSGNKR ALRRLRTACE RAKRTPSSST QATLEIDSLF EGVDFYKSIT
     RARFEELCSD LFRSTLEPVE KALRDAKLDK AQIHDFVLGG GLHSHPQGAE VAAGLLQRQG
     AEQEHQP
//