ID   HSP77_HUMAN             Reviewed;         367 AA.
AC   P48741; P19790;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 2.
DT   14-DEC-2011, entry version 80.
DE   RecName: Full=Putative heat shock 70 kDa protein 7;
DE   AltName: Full=Heat shock 70 kDa protein B;
GN   Name=HSPA7; Synonyms=HSP70B;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA   Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
RA   Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA   McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA   Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA   Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA   Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA   Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA   Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA   Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA   Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
RA   Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
RA   Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
RA   Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
RA   Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
RA   Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
RA   Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
RA   Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
RA   Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
RA   Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
RA   Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
RA   Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
RA   Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
RA   Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-247.
RX   MEDLINE=85270444; PubMed=3927293; DOI=10.1073/pnas.82.15.4949;
RA   Voellmy R., Ahmed A., Schiller P., Bromley P., Rungger D.;
RT   "Isolation and functional analysis of a human 70,000-dalton heat shock
RT   protein gene segment.";
RL   Proc. Natl. Acad. Sci. U.S.A. 82:4949-4953(1985).
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family.
CC   -!- CAUTION: Could be the product of a pseudogene.
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DR   EMBL; AL451067; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; M11236; AAA52696.1; -; Genomic_DNA.
DR   IPI; IPI00011134; -.
DR   PIR; A25773; A25773.
DR   UniGene; Hs.662180; -.
DR   UniGene; Hs.690634; -.
DR   ProteinModelPortal; P48741; -.
DR   SMR; P48741; 6-347.
DR   IntAct; P48741; 8.
DR   STRING; P48741; -.
DR   PhosphoSite; P48741; -.
DR   DMDM; 158518381; -.
DR   PRIDE; P48741; -.
DR   GeneCards; GC01P161575; -.
DR   HGNC; HGNC:5240; HSPA7.
DR   MIM; 140556; gene.
DR   neXtProt; NX_P48741; -.
DR   HOVERGEN; HBG051845; -.
DR   Genevestigator; P48741; -.
DR   GermOnline; ENSG00000203745; Homo sapiens.
DR   GO; GO:0005524; F:ATP binding; NAS:UniProtKB.
DR   GO; GO:0006986; P:response to unfolded protein; NAS:UniProtKB.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR001023; Hsp70.
DR   InterPro; IPR013126; Hsp_70.
DR   PANTHER; PTHR19375; Hsp70; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   PRINTS; PR00301; HEATSHOCK70.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; PARTIAL.
PE   5: Uncertain;
KW   ATP-binding; Complete proteome; Nucleotide-binding;
KW   Reference proteome; Stress response.
FT   CHAIN         1    367       Putative heat shock 70 kDa protein 7.
FT                                /FTId=PRO_0000078267.
FT   CONFLICT     59     59       S -> N (in Ref. 2; AAA52696).
FT   CONFLICT     95     95       Q -> K (in Ref. 2; AAA52696).
FT   CONFLICT     99     99       E -> G (in Ref. 2; AAA52696).
FT   CONFLICT    127    127       S -> T (in Ref. 2; AAA52696).
FT   CONFLICT    191    191       G -> R (in Ref. 2; AAA52696).
FT   CONFLICT    213    213       S -> T (in Ref. 2; AAA52696).
SQ   SEQUENCE   367 AA;  40244 MW;  060DFA210A29A5D4 CRC64;
     MQAPRELAVG IDLGTTYSCV GVFQQGRVEI LANDQGNRTT PSYVAFTDTE RLVGDAAKSQ
     AALNPHNTVF DAKRLIGRKF ADTTVQSDMK HWPFQVVSEG GKPKVRVCYR GEDKTFYPEE
     ISSMVLSKMK ETAEAYLGQP VKHAVITVPT YFSNSQRQAT KDAGAIAGLK VLPIINEATA
     AAIAYGLDRR GAGKRNVLIF DLGGGTFDVS VLSIDAGVFE VKATAGDTHL GGEDFDNRLV
     NHFMEEFRRK HGKDLSGNKR ALRRLRTACE RAKRTPSSST QATLEIDSLF EGVDFYKSIT
     RARFEELCSD LFRSTLEPVE KALRDAKLDK AQIHDFVLGG GLHSHPQGAE VAAGLLQRQG
     AEQEHQP
//