Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Putative heat shock 70 kDa protein 7

Gene

HSPA7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein uncertaini

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-3371453. Regulation of HSF1-mediated heat shock response.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative heat shock 70 kDa protein 7
Alternative name(s):
Heat shock 70 kDa protein B
Gene namesi
Name:HSPA7
Synonyms:HSP70B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:5240. HSPA7.

Subcellular locationi

GO - Cellular componenti

  • blood microparticle Source: UniProtKB
  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi3311.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000782671 – 367Putative heat shock 70 kDa protein 7Add BLAST367

Proteomic databases

EPDiP48741.
MaxQBiP48741.
PaxDbiP48741.
PeptideAtlasiP48741.
PRIDEiP48741.

PTM databases

iPTMnetiP48741.
PhosphoSitePlusiP48741.
SwissPalmiP48741.

Expressioni

Organism-specific databases

HPAiHPA052504.

Interactioni

Protein-protein interaction databases

IntActiP48741. 11 interactors.
STRINGi9606.ENSP00000310219.

Structurei

3D structure databases

ProteinModelPortaliP48741.
SMRiP48741.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

eggNOGiKOG0101. Eukaryota.
COG0443. LUCA.
HOVERGENiHBG051845.
InParanoidiP48741.
PhylomeDBiP48741.

Family and domain databases

InterProiIPR018181. Heat_shock_70_CS.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48741-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQAPRELAVG IDLGTTYSCV GVFQQGRVEI LANDQGNRTT PSYVAFTDTE
60 70 80 90 100
RLVGDAAKSQ AALNPHNTVF DAKRLIGRKF ADTTVQSDMK HWPFQVVSEG
110 120 130 140 150
GKPKVRVCYR GEDKTFYPEE ISSMVLSKMK ETAEAYLGQP VKHAVITVPT
160 170 180 190 200
YFSNSQRQAT KDAGAIAGLK VLPIINEATA AAIAYGLDRR GAGKRNVLIF
210 220 230 240 250
DLGGGTFDVS VLSIDAGVFE VKATAGDTHL GGEDFDNRLV NHFMEEFRRK
260 270 280 290 300
HGKDLSGNKR ALRRLRTACE RAKRTPSSST QATLEIDSLF EGVDFYKSIT
310 320 330 340 350
RARFEELCSD LFRSTLEPVE KALRDAKLDK AQIHDFVLGG GLHSHPQGAE
360
VAAGLLQRQG AEQEHQP
Length:367
Mass (Da):40,244
Last modified:September 11, 2007 - v2
Checksum:i060DFA210A29A5D4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti59S → N in AAA52696 (PubMed:3927293).Curated1
Sequence conflicti95Q → K in AAA52696 (PubMed:3927293).Curated1
Sequence conflicti99E → G in AAA52696 (PubMed:3927293).Curated1
Sequence conflicti127S → T in AAA52696 (PubMed:3927293).Curated1
Sequence conflicti191G → R in AAA52696 (PubMed:3927293).Curated1
Sequence conflicti213S → T in AAA52696 (PubMed:3927293).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL451067 Genomic DNA. No translation available.
M11236 Genomic DNA. Translation: AAA52696.1.
PIRiA25773.
UniGeneiHs.662180.
Hs.690634.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL451067 Genomic DNA. No translation available.
M11236 Genomic DNA. Translation: AAA52696.1.
PIRiA25773.
UniGeneiHs.662180.
Hs.690634.

3D structure databases

ProteinModelPortaliP48741.
SMRiP48741.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP48741. 11 interactors.
STRINGi9606.ENSP00000310219.

PTM databases

iPTMnetiP48741.
PhosphoSitePlusiP48741.
SwissPalmiP48741.

Proteomic databases

EPDiP48741.
MaxQBiP48741.
PaxDbiP48741.
PeptideAtlasiP48741.
PRIDEiP48741.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

DisGeNETi3311.
GeneCardsiHSPA7.
HGNCiHGNC:5240. HSPA7.
HPAiHPA052504.
MIMi140556. gene.
neXtProtiNX_P48741.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0101. Eukaryota.
COG0443. LUCA.
HOVERGENiHBG051845.
InParanoidiP48741.
PhylomeDBiP48741.

Enzyme and pathway databases

ReactomeiR-HSA-3371453. Regulation of HSF1-mediated heat shock response.

Miscellaneous databases

SOURCEiSearch...

Family and domain databases

InterProiIPR018181. Heat_shock_70_CS.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHSP77_HUMAN
AccessioniPrimary (citable) accession number: P48741
Secondary accession number(s): P19790
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: September 11, 2007
Last modified: November 2, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.