Reviewed,
UniProtKB/Swiss-Prot P48741 (HSP77_HUMAN)
Last modified
November 3, 2009.
Version 69.
History...
Clusters with 100%,
90%,
50% identity |
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Putative heat shock 70 kDa protein 7 Alternative name(s): Heat shock 70 kDa protein B | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 367 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Uncertain. |
General annotation (Comments)
| Sequence similarities | Belongs to the heat shock protein 70 family. |
| Caution | Could be the product of a pseudogene. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Stress response |
| Ligand | ATP-binding Nucleotide-binding |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | response to unfolded protein Non-traceable author statement. Source: UniProtKB |
| Molecular function | ATP binding Non-traceable author statement. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 367 | 367 | Putative heat shock 70 kDa protein 7 | PRO_0000078267 | |||||
Experimental info | |||||||||
| Sequence conflict | 59 | 1 | S → N in AAA52696. Ref.2 | ||||||
| Sequence conflict | 95 | 1 | Q → K in AAA52696. Ref.2 | ||||||
| Sequence conflict | 99 | 1 | E → G in AAA52696. Ref.2 | ||||||
| Sequence conflict | 127 | 1 | S → T in AAA52696. Ref.2 | ||||||
| Sequence conflict | 191 | 1 | G → R in AAA52696. Ref.2 | ||||||
| Sequence conflict | 213 | 1 | S → T in AAA52696. Ref.2 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. Bentley D.R.Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [2] | "Isolation and functional analysis of a human 70,000-dalton heat shock protein gene segment." Voellmy R., Ahmed A., Schiller P., Bromley P., Rungger D. Proc. Natl. Acad. Sci. U.S.A. 82:4949-4953(1985) [PubMed: 3927293] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-247. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AL451067 Genomic DNA. No translation available. M11236 Genomic DNA. Translation: AAA52696.1. | |
| IPI | IPI00011134. |
| PIR | A25773. |
| UniGene | Hs.690634 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1HJO based on UniProtKB P08107. |
| SMR | P48741. Positions 8-247. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | P48741. |
PTM databases | |
| PhosphoSite | P48741. |
Proteomic databases | |
| PRIDE | P48741. |
Organism-specific databases | |
| GeneCards | GC01U990091. |
| H-InvDB | HIX0056994. |
| HGNC | HGNC:5240. HSPA7. |
| MIM | 140556. gene. |
| PharmGKB | PA29506. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOVERGEN | P48741. |
Gene expression databases | |
| Genevestigator | P48741. |
| GermOnline | ENSG00000203745. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR018181. Heat_shock_70_CS. IPR001023. Hsp70. IPR013126. Hsp_70. [Graphical view] |
| Pfam | PF00012. HSP70. 1 hit. [Graphical view] |
| PRINTS | PR00301. HEATSHOCK70. |
| PROSITE | PS00297. HSP70_1. 1 hit. PS00329. HSP70_2. 1 hit. PS01036. HSP70_3. Partial match. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| SOURCE | Search... |
Entry information
| Entry name | HSP77_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P48741 Secondary accession number(s): P19790 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 1 Human chromosome 1: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

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