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P48741

- HSP77_HUMAN

UniProt

P48741 - HSP77_HUMAN

Protein

Putative heat shock 70 kDa protein 7

Gene

HSPA7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein uncertaini
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 2 (11 Sep 2007)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. response to stress Source: UniProtKB-KW

    Keywords - Biological processi

    Stress response

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative heat shock 70 kDa protein 7
    Alternative name(s):
    Heat shock 70 kDa protein B
    Gene namesi
    Name:HSPA7
    Synonyms:HSP70B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:5240. HSPA7.

    Subcellular locationi

    GO - Cellular componenti

    1. blood microparticle Source: UniProt

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 367367Putative heat shock 70 kDa protein 7PRO_0000078267Add
    BLAST

    Proteomic databases

    PRIDEiP48741.

    PTM databases

    PhosphoSiteiP48741.

    Expressioni

    Gene expression databases

    GenevestigatoriP48741.

    Interactioni

    Protein-protein interaction databases

    IntActiP48741. 10 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP48741.
    SMRiP48741. Positions 6-347.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the heat shock protein 70 family.Curated

    Phylogenomic databases

    HOVERGENiHBG051845.
    PhylomeDBiP48741.

    Family and domain databases

    InterProiIPR018181. Heat_shock_70_CS.
    IPR013126. Hsp_70_fam.
    [Graphical view]
    PfamiPF00012. HSP70. 1 hit.
    [Graphical view]
    PRINTSiPR00301. HEATSHOCK70.
    PROSITEiPS00297. HSP70_1. 1 hit.
    PS00329. HSP70_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P48741-1 [UniParc]FASTAAdd to Basket

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    MQAPRELAVG IDLGTTYSCV GVFQQGRVEI LANDQGNRTT PSYVAFTDTE    50
    RLVGDAAKSQ AALNPHNTVF DAKRLIGRKF ADTTVQSDMK HWPFQVVSEG 100
    GKPKVRVCYR GEDKTFYPEE ISSMVLSKMK ETAEAYLGQP VKHAVITVPT 150
    YFSNSQRQAT KDAGAIAGLK VLPIINEATA AAIAYGLDRR GAGKRNVLIF 200
    DLGGGTFDVS VLSIDAGVFE VKATAGDTHL GGEDFDNRLV NHFMEEFRRK 250
    HGKDLSGNKR ALRRLRTACE RAKRTPSSST QATLEIDSLF EGVDFYKSIT 300
    RARFEELCSD LFRSTLEPVE KALRDAKLDK AQIHDFVLGG GLHSHPQGAE 350
    VAAGLLQRQG AEQEHQP 367
    Length:367
    Mass (Da):40,244
    Last modified:September 11, 2007 - v2
    Checksum:i060DFA210A29A5D4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti59 – 591S → N in AAA52696. (PubMed:3927293)Curated
    Sequence conflicti95 – 951Q → K in AAA52696. (PubMed:3927293)Curated
    Sequence conflicti99 – 991E → G in AAA52696. (PubMed:3927293)Curated
    Sequence conflicti127 – 1271S → T in AAA52696. (PubMed:3927293)Curated
    Sequence conflicti191 – 1911G → R in AAA52696. (PubMed:3927293)Curated
    Sequence conflicti213 – 2131S → T in AAA52696. (PubMed:3927293)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL451067 Genomic DNA. No translation available.
    M11236 Genomic DNA. Translation: AAA52696.1.
    PIRiA25773.
    UniGeneiHs.662180.
    Hs.690634.

    Genome annotation databases

    UCSCiuc010pkp.1. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL451067 Genomic DNA. No translation available.
    M11236 Genomic DNA. Translation: AAA52696.1 .
    PIRi A25773.
    UniGenei Hs.662180.
    Hs.690634.

    3D structure databases

    ProteinModelPortali P48741.
    SMRi P48741. Positions 6-347.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P48741. 10 interactions.

    PTM databases

    PhosphoSitei P48741.

    Proteomic databases

    PRIDEi P48741.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi uc010pkp.1. human.

    Organism-specific databases

    GeneCardsi GC01P161575.
    HGNCi HGNC:5240. HSPA7.
    MIMi 140556. gene.
    neXtProti NX_P48741.
    GenAtlasi Search...

    Phylogenomic databases

    HOVERGENi HBG051845.
    PhylomeDBi P48741.

    Miscellaneous databases

    NextBioi 13103.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori P48741.

    Family and domain databases

    InterProi IPR018181. Heat_shock_70_CS.
    IPR013126. Hsp_70_fam.
    [Graphical view ]
    Pfami PF00012. HSP70. 1 hit.
    [Graphical view ]
    PRINTSi PR00301. HEATSHOCK70.
    PROSITEi PS00297. HSP70_1. 1 hit.
    PS00329. HSP70_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Isolation and functional analysis of a human 70,000-dalton heat shock protein gene segment."
      Voellmy R., Ahmed A., Schiller P., Bromley P., Rungger D.
      Proc. Natl. Acad. Sci. U.S.A. 82:4949-4953(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-247.

    Entry informationi

    Entry nameiHSP77_HUMAN
    AccessioniPrimary (citable) accession number: P48741
    Secondary accession number(s): P19790
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 90 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Could be the product of a pseudogene.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3