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P48741

- HSP77_HUMAN

UniProt

P48741 - HSP77_HUMAN

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Protein

Putative heat shock 70 kDa protein 7

Gene

HSPA7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein uncertaini

Functioni

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. response to stress Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative heat shock 70 kDa protein 7
Alternative name(s):
Heat shock 70 kDa protein B
Gene namesi
Name:HSPA7
Synonyms:HSP70B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:5240. HSPA7.

Subcellular locationi

GO - Cellular componenti

  1. blood microparticle Source: UniProt
  2. extracellular vesicular exosome Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 367367Putative heat shock 70 kDa protein 7PRO_0000078267Add
BLAST

Proteomic databases

PRIDEiP48741.

PTM databases

PhosphoSiteiP48741.

Expressioni

Gene expression databases

GenevestigatoriP48741.

Interactioni

Protein-protein interaction databases

IntActiP48741. 10 interactions.

Structurei

3D structure databases

ProteinModelPortaliP48741.
SMRiP48741. Positions 6-347.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

HOVERGENiHBG051845.
InParanoidiP48741.
PhylomeDBiP48741.

Family and domain databases

InterProiIPR018181. Heat_shock_70_CS.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48741-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQAPRELAVG IDLGTTYSCV GVFQQGRVEI LANDQGNRTT PSYVAFTDTE
60 70 80 90 100
RLVGDAAKSQ AALNPHNTVF DAKRLIGRKF ADTTVQSDMK HWPFQVVSEG
110 120 130 140 150
GKPKVRVCYR GEDKTFYPEE ISSMVLSKMK ETAEAYLGQP VKHAVITVPT
160 170 180 190 200
YFSNSQRQAT KDAGAIAGLK VLPIINEATA AAIAYGLDRR GAGKRNVLIF
210 220 230 240 250
DLGGGTFDVS VLSIDAGVFE VKATAGDTHL GGEDFDNRLV NHFMEEFRRK
260 270 280 290 300
HGKDLSGNKR ALRRLRTACE RAKRTPSSST QATLEIDSLF EGVDFYKSIT
310 320 330 340 350
RARFEELCSD LFRSTLEPVE KALRDAKLDK AQIHDFVLGG GLHSHPQGAE
360
VAAGLLQRQG AEQEHQP
Length:367
Mass (Da):40,244
Last modified:September 11, 2007 - v2
Checksum:i060DFA210A29A5D4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti59 – 591S → N in AAA52696. (PubMed:3927293)Curated
Sequence conflicti95 – 951Q → K in AAA52696. (PubMed:3927293)Curated
Sequence conflicti99 – 991E → G in AAA52696. (PubMed:3927293)Curated
Sequence conflicti127 – 1271S → T in AAA52696. (PubMed:3927293)Curated
Sequence conflicti191 – 1911G → R in AAA52696. (PubMed:3927293)Curated
Sequence conflicti213 – 2131S → T in AAA52696. (PubMed:3927293)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL451067 Genomic DNA. No translation available.
M11236 Genomic DNA. Translation: AAA52696.1.
PIRiA25773.
UniGeneiHs.662180.
Hs.690634.

Genome annotation databases

UCSCiuc010pkp.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL451067 Genomic DNA. No translation available.
M11236 Genomic DNA. Translation: AAA52696.1 .
PIRi A25773.
UniGenei Hs.662180.
Hs.690634.

3D structure databases

ProteinModelPortali P48741.
SMRi P48741. Positions 6-347.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P48741. 10 interactions.

PTM databases

PhosphoSitei P48741.

Proteomic databases

PRIDEi P48741.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi uc010pkp.1. human.

Organism-specific databases

GeneCardsi GC01P161575.
HGNCi HGNC:5240. HSPA7.
MIMi 140556. gene.
neXtProti NX_P48741.
GenAtlasi Search...

Phylogenomic databases

HOVERGENi HBG051845.
InParanoidi P48741.
PhylomeDBi P48741.

Miscellaneous databases

NextBioi 13103.
SOURCEi Search...

Gene expression databases

Genevestigatori P48741.

Family and domain databases

InterProi IPR018181. Heat_shock_70_CS.
IPR013126. Hsp_70_fam.
[Graphical view ]
Pfami PF00012. HSP70. 1 hit.
[Graphical view ]
PRINTSi PR00301. HEATSHOCK70.
PROSITEi PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Isolation and functional analysis of a human 70,000-dalton heat shock protein gene segment."
    Voellmy R., Ahmed A., Schiller P., Bromley P., Rungger D.
    Proc. Natl. Acad. Sci. U.S.A. 82:4949-4953(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-247.

Entry informationi

Entry nameiHSP77_HUMAN
AccessioniPrimary (citable) accession number: P48741
Secondary accession number(s): P19790
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: September 11, 2007
Last modified: October 29, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3