Reviewed, UniProtKB/Swiss-Prot P48741 (HSP77_HUMAN)

Names and origin

Protein names

Recommended name:
    Putative heat shock 70 kDa protein 7
Alternative name(s):
    Heat shock 70 kDa protein B

Gene names

Name:	HSPA7
Synonyms:	HSP70B

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	367 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Uncertain.

General annotation (Comments)

Sequence similarities	Belongs to the heat shock protein 70 family.
Caution	Could be the product of a pseudogene.

Ontologies

Keywords
Biological process	Stress response
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	response to unfolded protein Non-traceable author statement. Source: UniProtKB
Molecular function	ATP binding Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 367	367	Putative heat shock 70 kDa protein 7		PRO_0000078267
Experimental info
	Sequence conflict	59	1	S → N in AAA52696. Ref.2
	Sequence conflict	95	1	Q → K in AAA52696. Ref.2
	Sequence conflict	99	1	E → G in AAA52696. Ref.2
	Sequence conflict	127	1	S → T in AAA52696. Ref.2
	Sequence conflict	191	1	G → R in AAA52696. Ref.2
	Sequence conflict	213	1	S → T in AAA52696. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P48741-1 [UniParc]. Last modified September 11, 2007. Version 2. Checksum: 060DFA210A29A5D4	FASTA	367	40,244
	10 20 30 40 50 60 MQAPRELAVG IDLGTTYSCV GVFQQGRVEI LANDQGNRTT PSYVAFTDTE RLVGDAAKSQ 70 80 90 100 110 120 AALNPHNTVF DAKRLIGRKF ADTTVQSDMK HWPFQVVSEG GKPKVRVCYR GEDKTFYPEE 130 140 150 160 170 180 ISSMVLSKMK ETAEAYLGQP VKHAVITVPT YFSNSQRQAT KDAGAIAGLK VLPIINEATA 190 200 210 220 230 240 AAIAYGLDRR GAGKRNVLIF DLGGGTFDVS VLSIDAGVFE VKATAGDTHL GGEDFDNRLV 250 260 270 280 290 300 NHFMEEFRRK HGKDLSGNKR ALRRLRTACE RAKRTPSSST QATLEIDSLF EGVDFYKSIT 310 320 330 340 350 360 RARFEELCSD LFRSTLEPVE KALRDAKLDK AQIHDFVLGG GLHSHPQGAE VAAGLLQRQG AEQEHQP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Isolation and functional analysis of a human 70,000-dalton heat shock protein gene segment." Voellmy R., Ahmed A., Schiller P., Bromley P., Rungger D. Proc. Natl. Acad. Sci. U.S.A. 82:4949-4953(1985) [PubMed: 3927293] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-247.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL451067 Genomic DNA. No translation available. M11236 Genomic DNA. Translation: AAA52696.1.
IPI	IPI00011134.
PIR	A25773.
UniGene	Hs.690634
3D structure databases
HSSP	HSSP built from PDB template 1HJO based on UniProtKB P08107.
SMR	P48741. Positions 8-247.
ModBase	Search...
Protein-protein interaction databases
STRING	P48741.
PTM databases
PhosphoSite	P48741.
Proteomic databases
PRIDE	P48741.
Organism-specific databases
GeneCards	GC01U990091.
H-InvDB	HIX0056994.
HGNC	HGNC:5240. HSPA7.
MIM	140556. gene.
PharmGKB	PA29506.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	P48741.
Gene expression databases
Genevestigator	P48741.
GermOnline	ENSG00000203745. Homo sapiens.
Family and domain databases
InterPro	IPR018181. Heat_shock_70_CS. IPR001023. Hsp70. IPR013126. Hsp_70. [Graphical view]
Pfam	PF00012. HSP70. 1 hit. [Graphical view]
PRINTS	PR00301. HEATSHOCK70.
PROSITE	PS00297. HSP70_1. 1 hit. PS00329. HSP70_2. 1 hit. PS01036. HSP70_3. Partial match. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

HSP77_HUMAN

Accession

Primary (citable) accession number: P48741
Secondary accession number(s): P19790

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	September 11, 2007
Last modified:	November 3, 2009
This is version 69 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.