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P48739

- PIPNB_HUMAN

UniProt

P48739 - PIPNB_HUMAN

Protein

Phosphatidylinositol transfer protein beta isoform

Gene

PITPNB

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the transfer of PtdIns and phosphatidylcholine between membranes.

    GO - Molecular functioni

    1. lipid binding Source: UniProtKB-KW

    GO - Biological processi

    1. glycerophospholipid biosynthetic process Source: Reactome
    2. in utero embryonic development Source: Ensembl
    3. lipid metabolic process Source: ProtInc
    4. phospholipid metabolic process Source: Reactome
    5. phospholipid transport Source: Reactome
    6. small molecule metabolic process Source: Reactome

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    Lipid-binding

    Enzyme and pathway databases

    ReactomeiREACT_121079. PI and PC transport between ER and Golgi membranes.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphatidylinositol transfer protein beta isoform
    Short name:
    PI-TP-beta
    Short name:
    PtdIns transfer protein beta
    Short name:
    PtdInsTP beta
    Gene namesi
    Name:PITPNB
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 22

    Organism-specific databases

    HGNCiHGNC:9002. PITPNB.

    Subcellular locationi

    Cytoplasm By similarity. Golgi apparatus By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: Reactome
    2. extracellular vesicular exosome Source: UniProt
    3. Golgi membrane Source: Reactome

    Keywords - Cellular componenti

    Cytoplasm, Golgi apparatus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33336.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 271270Phosphatidylinositol transfer protein beta isoformPRO_0000191643Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei215 – 2151N6-acetyllysine1 Publication
    Modified residuei262 – 2621PhosphoserineBy similarity

    Post-translational modificationi

    Constitutive phosphorylation of Ser-262 has no effect on phospholipid transfer activity but is required for Golgi targeting.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiP48739.
    PaxDbiP48739.
    PRIDEiP48739.

    PTM databases

    PhosphoSiteiP48739.

    Expressioni

    Tissue specificityi

    Widely expressed in various tissues including brain.

    Gene expression databases

    ArrayExpressiP48739.
    BgeeiP48739.
    CleanExiHS_PITPNB.
    GenevestigatoriP48739.

    Organism-specific databases

    HPAiHPA000528.

    Interactioni

    Protein-protein interaction databases

    BioGridi117261. 4 interactions.
    IntActiP48739. 1 interaction.
    MINTiMINT-5002601.
    STRINGi9606.ENSP00000334738.

    Structurei

    3D structure databases

    ProteinModelPortaliP48739.
    SMRiP48739. Positions 2-270.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG250489.
    HOGENOMiHOG000006717.
    HOVERGENiHBG058915.
    OMAiFIQKSER.
    OrthoDBiEOG7PGDRB.
    PhylomeDBiP48739.
    TreeFamiTF313279.

    Family and domain databases

    Gene3Di3.30.530.20. 1 hit.
    InterProiIPR001666. PI_transfer.
    IPR023393. START-like_dom.
    [Graphical view]
    PANTHERiPTHR10658. PTHR10658. 1 hit.
    PfamiPF02121. IP_trans. 1 hit.
    [Graphical view]
    PRINTSiPR00391. PITRANSFER.

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P48739-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVLIKEFRVV LPCSVQEYQV GQLYSVAEAS KNETGGGEGI EVLKNEPYEK    50
    DGEKGQYTHK IYHLKSKVPA FVRMIAPEGS LVFHEKAWNA YPYCRTIVTN 100
    EYMKDDFFIK IETWHKPDLG TLENVHGLDP NTWKTVEIVH IDIADRSQVE 150
    PADYKADEDP ALFQSVKTKR GPLGPNWKKE LANSPDCPQM CAYKLVTIKF 200
    KWWGLQSKVE NFIQKQEKRI FTNFHRQLFC WIDKWIDLTM EDIRRMEDET 250
    QKELETMRKR GSVRGTSAAD V 271
    Length:271
    Mass (Da):31,540
    Last modified:January 23, 2007 - v2
    Checksum:iAC5333FBC0F6CA06
    GO
    Isoform 2 (identifier: P48739-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         257-271: MRKRGSVRGTSAADV → LRNQGQVRGTSAASDE

    Show »
    Length:272
    Mass (Da):31,638
    Checksum:i05142EA9F80BA7CB
    GO
    Isoform 3 (identifier: P48739-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-7: MVLIKEF → MGDLLMEKC

    Show »
    Length:273
    Mass (Da):31,700
    Checksum:i547F67C88E573741
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 77MVLIKEF → MGDLLMEKC in isoform 3. 1 PublicationVSP_055132
    Alternative sequencei257 – 27115MRKRG…SAADV → LRNQGQVRGTSAASDE in isoform 2. 1 PublicationVSP_012762Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D30037 mRNA. Translation: BAA06277.1.
    CR456541 mRNA. Translation: CAG30427.1.
    AK302367 mRNA. Translation: BAH13686.1.
    AL031591 Genomic DNA. Translation: CAB63033.1.
    AL031591 Genomic DNA. Translation: CAQ68296.1.
    CH471095 Genomic DNA. Translation: EAW59743.1.
    BC018704 mRNA. Translation: AAH18704.1.
    BC031427 mRNA. Translation: AAH31427.1.
    CCDSiCCDS13842.1. [P48739-1]
    CCDS63432.1. [P48739-3]
    CCDS63433.1. [P48739-2]
    RefSeqiNP_001271206.1. NM_001284277.1. [P48739-2]
    NP_001271207.1. NM_001284278.1.
    NP_036531.1. NM_012399.4. [P48739-1]
    UniGeneiHs.705323.

    Genome annotation databases

    EnsembliENST00000320996; ENSP00000321266; ENSG00000180957. [P48739-2]
    ENST00000335272; ENSP00000334738; ENSG00000180957. [P48739-1]
    ENST00000455418; ENSP00000405179; ENSG00000180957. [P48739-3]
    GeneIDi23760.
    KEGGihsa:23760.
    UCSCiuc003adk.3. human. [P48739-1]
    uc003adl.3. human. [P48739-2]

    Polymorphism databases

    DMDMi1346772.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D30037 mRNA. Translation: BAA06277.1 .
    CR456541 mRNA. Translation: CAG30427.1 .
    AK302367 mRNA. Translation: BAH13686.1 .
    AL031591 Genomic DNA. Translation: CAB63033.1 .
    AL031591 Genomic DNA. Translation: CAQ68296.1 .
    CH471095 Genomic DNA. Translation: EAW59743.1 .
    BC018704 mRNA. Translation: AAH18704.1 .
    BC031427 mRNA. Translation: AAH31427.1 .
    CCDSi CCDS13842.1. [P48739-1 ]
    CCDS63432.1. [P48739-3 ]
    CCDS63433.1. [P48739-2 ]
    RefSeqi NP_001271206.1. NM_001284277.1. [P48739-2 ]
    NP_001271207.1. NM_001284278.1.
    NP_036531.1. NM_012399.4. [P48739-1 ]
    UniGenei Hs.705323.

    3D structure databases

    ProteinModelPortali P48739.
    SMRi P48739. Positions 2-270.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117261. 4 interactions.
    IntActi P48739. 1 interaction.
    MINTi MINT-5002601.
    STRINGi 9606.ENSP00000334738.

    PTM databases

    PhosphoSitei P48739.

    Polymorphism databases

    DMDMi 1346772.

    Proteomic databases

    MaxQBi P48739.
    PaxDbi P48739.
    PRIDEi P48739.

    Protocols and materials databases

    DNASUi 23760.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000320996 ; ENSP00000321266 ; ENSG00000180957 . [P48739-2 ]
    ENST00000335272 ; ENSP00000334738 ; ENSG00000180957 . [P48739-1 ]
    ENST00000455418 ; ENSP00000405179 ; ENSG00000180957 . [P48739-3 ]
    GeneIDi 23760.
    KEGGi hsa:23760.
    UCSCi uc003adk.3. human. [P48739-1 ]
    uc003adl.3. human. [P48739-2 ]

    Organism-specific databases

    CTDi 23760.
    GeneCardsi GC22M028202.
    HGNCi HGNC:9002. PITPNB.
    HPAi HPA000528.
    MIMi 606876. gene.
    neXtProti NX_P48739.
    PharmGKBi PA33336.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG250489.
    HOGENOMi HOG000006717.
    HOVERGENi HBG058915.
    OMAi FIQKSER.
    OrthoDBi EOG7PGDRB.
    PhylomeDBi P48739.
    TreeFami TF313279.

    Enzyme and pathway databases

    Reactomei REACT_121079. PI and PC transport between ER and Golgi membranes.

    Miscellaneous databases

    ChiTaRSi PITPNB. human.
    GeneWikii PITPNB.
    GenomeRNAii 23760.
    NextBioi 35480287.
    PROi P48739.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P48739.
    Bgeei P48739.
    CleanExi HS_PITPNB.
    Genevestigatori P48739.

    Family and domain databases

    Gene3Di 3.30.530.20. 1 hit.
    InterProi IPR001666. PI_transfer.
    IPR023393. START-like_dom.
    [Graphical view ]
    PANTHERi PTHR10658. PTHR10658. 1 hit.
    Pfami PF02121. IP_trans. 1 hit.
    [Graphical view ]
    PRINTSi PR00391. PITRANSFER.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of human cDNA encoding phosphatidylinositol transfer protein beta."
      Tanaka S., Yamashita S., Hosaka K.
      Biochim. Biophys. Acta 1259:199-202(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Testis.
    4. "The DNA sequence of human chromosome 22."
      Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
      , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
      Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Lymph and Skin.
    7. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-215, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPIPNB_HUMAN
    AccessioniPrimary (citable) accession number: P48739
    Secondary accession number(s): B3KYB8, B7Z7Q0, Q8N5W1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 127 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3