P48739 (PIPNB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphatidylinositol transfer protein beta isoform
Short name=PI-TP-beta
Short name=PtdIns transfer protein beta
Short name=PtdInsTP beta

Gene names

Name:

PITPNB

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	271 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Catalyzes the transfer of PtdIns and phosphatidylcholine between membranes.
Subcellular location	Cytoplasm By similarity. Golgi apparatus By similarity.
Tissue specificity	Widely expressed in various tissues including brain.
Post-translational modification	Constitutive phosphorylation of Ser-262 has no effect on phospholipid transfer activity but is required for Golgi targeting By similarity.
Sequence similarities	Belongs to the PtdIns transfer protein family. PI transfer class I subfamily.

Ontologies

Keywords
Biological process	Transport
Cellular component	Cytoplasm Golgi apparatus
Coding sequence diversity	Alternative splicing
Ligand	Lipid-binding
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	glycerophospholipid biosynthetic process Traceable author statement. Source: Reactome in utero embryonic development Inferred from electronic annotation. Source: Compara phospholipid transport Traceable author statement. Source: Reactome small molecule metabolic process Traceable author statement. Source: Reactome
Cellular_component	Golgi membrane Traceable author statement. Source: Reactome endoplasmic reticulum membrane Traceable author statement. Source: Reactome
Molecular_function	lipid binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P48739-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P48739-2)

The sequence of this isoform differs from the canonical sequence as follows:
     257-271: MRKRGSVRGTSAADV → LRNQGQVRGTSAASDE

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 271	270	Phosphatidylinositol transfer protein beta isoform		PRO_0000191643
Amino acid modifications
	Modified residue	215	1	N6-acetyllysine Ref.5
	Modified residue	262	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	257 – 271	15	MRKRG…SAADV → LRNQGQVRGTSAASDE in isoform 2.		VSP_012762

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: AC5333FBC0F6CA06	FASTA	271	31,540
	10 20 30 40 50 60 MVLIKEFRVV LPCSVQEYQV GQLYSVAEAS KNETGGGEGI EVLKNEPYEK DGEKGQYTHK 70 80 90 100 110 120 IYHLKSKVPA FVRMIAPEGS LVFHEKAWNA YPYCRTIVTN EYMKDDFFIK IETWHKPDLG 130 140 150 160 170 180 TLENVHGLDP NTWKTVEIVH IDIADRSQVE PADYKADEDP ALFQSVKTKR GPLGPNWKKE 190 200 210 220 230 240 LANSPDCPQM CAYKLVTIKF KWWGLQSKVE NFIQKQEKRI FTNFHRQLFC WIDKWIDLTM 250 260 270 EDIRRMEDET QKELETMRKR GSVRGTSAAD V
	Isoform 2 [UniParc]. Checksum: 05142EA9F80BA7CB	FASTA	272	31,638
	10 20 30 40 50 60 MVLIKEFRVV LPCSVQEYQV GQLYSVAEAS KNETGGGEGI EVLKNEPYEK DGEKGQYTHK 70 80 90 100 110 120 IYHLKSKVPA FVRMIAPEGS LVFHEKAWNA YPYCRTIVTN EYMKDDFFIK IETWHKPDLG 130 140 150 160 170 180 TLENVHGLDP NTWKTVEIVH IDIADRSQVE PADYKADEDP ALFQSVKTKR GPLGPNWKKE 190 200 210 220 230 240 LANSPDCPQM CAYKLVTIKF KWWGLQSKVE NFIQKQEKRI FTNFHRQLFC WIDKWIDLTM 250 260 270 EDIRRMEDET QKELETLRNQ GQVRGTSAAS DE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and expression of human cDNA encoding phosphatidylinositol transfer protein beta." Tanaka S., Yamashita S., Hosaka K. Biochim. Biophys. Acta 1259:199-202(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Brain.
[2]	"A genome annotation-driven approach to cloning the human ORFeome." Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I. Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]	"The DNA sequence of human chromosome 22." Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H. Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Lymph and Skin.
[5]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-215, MASS SPECTROMETRY.
[6]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D30037 mRNA. Translation: BAA06277.1. CR456541 mRNA. Translation: CAG30427.1. AL031591 Genomic DNA. Translation: CAB63033.1. AL031591 Genomic DNA. Translation: CAQ68296.1. BC018704 mRNA. Translation: AAH18704.1. BC031427 mRNA. Translation: AAH31427.1.
IPI	IPI00334907. IPI01014285.
RefSeq	NP_036531.1. NM_012399.3.
UniGene	Hs.705323.
3D structure databases
ProteinModelPortal	P48739.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-5002601.
STRING	9606.ENSP00000334738.
PTM databases
PhosphoSite	P48739.
Polymorphism databases
DMDM	1346772.
Proteomic databases
PaxDb	P48739.
PRIDE	P48739.
Protocols and materials databases
DNASU	23760.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000320996; ENSP00000321266; ENSG00000180957. ENST00000335272; ENSP00000334738; ENSG00000180957.
GeneID	23760.
KEGG	hsa:23760.
UCSC	uc003adk.3. human. uc003adl.3. human.
Organism-specific databases
CTD	23760.
GeneCards	GC22M028202.
HGNC	HGNC:9002. PITPNB.
HPA	HPA000528.
MIM	606876. gene.
neXtProt	NX_P48739.
PharmGKB	PA33336.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG250489.
HOVERGEN	HBG058915.
OrthoDB	EOG42JNS2.
Enzyme and pathway databases
Reactome	REACT_111217. Metabolism.
Gene expression databases
ArrayExpress	P48739.
Bgee	P48739.
CleanEx	HS_PITPNB.
Genevestigator	P48739.
GermOnline	ENSG00000180957. Homo sapiens.
Family and domain databases
Gene3D	3.30.530.20. 1 hit.
InterPro	IPR001666. PI_transfer. IPR023393. START-like_dom. [Graphical view]
PANTHER	PTHR10658. PTHR10658. 1 hit.
Pfam	PF02121. IP_trans. 1 hit. [Graphical view]
PRINTS	PR00391. PITRANSFER.
ProtoNet	Search...
Other
ChiTaRS	PITPNB. human.
GenomeRNAi	23760.
NextBio	46707.
SOURCE	Search...

Entry information

Entry name

PIPNB_HUMAN

Accession

Primary (citable) accession number: P48739
Secondary accession number(s): B3KYB8, Q8N5W1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 114 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.