Reviewed, UniProtKB/Swiss-Prot P48739 (PIPNB_HUMAN)

Names and origin

Protein names

Recommended name:
    Phosphatidylinositol transfer protein beta isoform
      Short name=PtdIns transfer protein beta
      Short name=PtdInsTP
      Short name=PI-TP-beta

Gene names

Name:

PITPNB

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	271 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Catalyzes the transfer of PtdIns and phosphatidylcholine between membranes.
Subcellular location	Cytoplasm By similarity. Golgi apparatus By similarity.
Tissue specificity	Widely expressed in various tissues including brain.
Post-translational modification	Constitutive phosphorylation of Ser-262 has no effect on phospholipid transfer activity but is required for Golgi targeting By similarity.
Sequence similarities	Belongs to the PtdIns transfer protein family. Class I subfamily.

Ontologies

Keywords
Biological process	Transport
Cellular component	Cytoplasm Golgi apparatus
Coding sequence diversity	Alternative splicing
Ligand	Lipid-binding
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	lipid metabolic process Ref.1 Non-traceable author statement. Source: ProtInc transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from direct assay. Source: HPA
Molecular function	lipid binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P48739-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P48739-2)

The sequence of this isoform differs from the canonical sequence as follows:
     257-271: MRKRGSVRGTSAADV → LRNQGQVRGTSAASDE

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 271	270	Phosphatidylinositol transfer protein beta isoform		PRO_0000191643
Amino acid modifications
	Modified residue	57	1	Phosphotyrosine Ref.5
	Modified residue	262	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	257 – 271	15	MRKRG…SAADV → LRNQGQVRGTSAASDE in isoform 2.		VSP_012762

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: AC5333FBC0F6CA06	FASTA	271	31,540
	10 20 30 40 50 60 MVLIKEFRVV LPCSVQEYQV GQLYSVAEAS KNETGGGEGI EVLKNEPYEK DGEKGQYTHK 70 80 90 100 110 120 IYHLKSKVPA FVRMIAPEGS LVFHEKAWNA YPYCRTIVTN EYMKDDFFIK IETWHKPDLG 130 140 150 160 170 180 TLENVHGLDP NTWKTVEIVH IDIADRSQVE PADYKADEDP ALFQSVKTKR GPLGPNWKKE 190 200 210 220 230 240 LANSPDCPQM CAYKLVTIKF KWWGLQSKVE NFIQKQEKRI FTNFHRQLFC WIDKWIDLTM 250 260 270 EDIRRMEDET QKELETMRKR GSVRGTSAAD V
	Isoform 2. Checksum: 05142EA9F80BA7CB	FASTA	272	31,638
	10 20 30 40 50 60 MVLIKEFRVV LPCSVQEYQV GQLYSVAEAS KNETGGGEGI EVLKNEPYEK DGEKGQYTHK 70 80 90 100 110 120 IYHLKSKVPA FVRMIAPEGS LVFHEKAWNA YPYCRTIVTN EYMKDDFFIK IETWHKPDLG 130 140 150 160 170 180 TLENVHGLDP NTWKTVEIVH IDIADRSQVE PADYKADEDP ALFQSVKTKR GPLGPNWKKE 190 200 210 220 230 240 LANSPDCPQM CAYKLVTIKF KWWGLQSKVE NFIQKQEKRI FTNFHRQLFC WIDKWIDLTM 250 260 270 EDIRRMEDET QKELETLRNQ GQVRGTSAAS DE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and expression of human cDNA encoding phosphatidylinositol transfer protein beta." Tanaka S., Yamashita S., Hosaka K. Biochim. Biophys. Acta 1259:199-202(1995) [PubMed: 8541325] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Brain.
[2]	"A genome annotation-driven approach to cloning the human ORFeome." Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I. Genome Biol. 5:RESEARCH84.1-RESEARCH84.11(2004) [PubMed: 15461802] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]	"The DNA sequence of human chromosome 22." Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H. Nature 402:489-495(1999) [PubMed: 10591208] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Lymph and Skin.
[5]	"Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer." Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J., Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L., Mitchell J., Wetzel R., Macneill J., Ren J.M. , Yuan J., Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X., Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J. Cell 131:1190-1203(2007) [PubMed: 18083107] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-57, MASS SPECTROMETRY.
[6]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	D30037 mRNA. Translation: BAA06277.1. CR456541 mRNA. Translation: CAG30427.1. AL031591 Genomic DNA. Translation: CAB63033.1. AL031591 Genomic DNA. Translation: CAQ68296.1. BC018704 mRNA. Translation: AAH18704.1. BC031427 mRNA. Translation: AAH31427.1.
IPI	IPI00334907. IPI00395939.
RefSeq	NP_036531.1.
UniGene	Hs.713581
3D structure databases
HSSP	HSSP built from PDB template 1KCM based on UniProtKB P53810.
SMR	P48739. Positions 2-270.
ModBase	Search...
Protein-protein interaction databases
IntAct	P48739. 2 interactions.
PTM databases
PhosphoSite	P48739.
Proteomic databases
PRIDE	P48739.
Genome annotation databases
Ensembl	ENSG00000180957. Homo sapiens. [Contig view]
GeneID	23760.
KEGG	hsa:23760.
Organism-specific databases
GeneCards	GC22M026572.
HGNC	HGNC:9002. PITPNB.
HPA	HPA000528.
MIM	606876. gene.
PharmGKB	PA33336.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	P48739.
OMA	P48739. LANNPDC.
Gene expression databases
ArrayExpress	P48739.
Bgee	P48739.
CleanEx	HS_PITPNB.
GermOnline	ENSG00000180957. Homo sapiens.
Family and domain databases
InterPro	IPR001666. PI_transfer. [Graphical view]
PANTHER	PTHR10658. PI_transfer. 1 hit.
Pfam	PF02121. IP_trans. 1 hit. [Graphical view]
PRINTS	PR00391. PITRANSFER.
ProtoNet	Search...
Other Resources
NextBio	46707.
SOURCE	Search...

Entry information

Entry name

PIPNB_HUMAN

Accession

Primary (citable) accession number: P48739
Secondary accession number(s): B3KYB8, Q8N5W1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	January 23, 2007
Last modified:	June 16, 2009
This is version 74 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)