Reviewed,
UniProtKB/Swiss-Prot P48735 (IDHP_HUMAN)
Last modified
June 16, 2009.
Version 88.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Isocitrate dehydrogenase [NADP], mitochondrial Short name=IDH EC=1.1.1.42 Alternative name(s): Oxalosuccinate decarboxylase NADP(+)-specific ICDH IDP ICD-M | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 452 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex. |
| Catalytic activity | Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. Oxalosuccinate + NADP+ = 2-oxoglutarate + CO2 + NADPH. |
| Cofactor | Binds 1 magnesium or manganese ion per subunit By similarity. |
| Subunit structure | Homodimer. |
| Subcellular location | |
| Sequence similarities | Belongs to the isocitrate and isopropylmalate dehydrogenases family. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Transit peptide | 1 – 39 | 39 | Mitochondrion By similarity | ||||||
| Chain | 40 – 452 | 413 | Isocitrate dehydrogenase [NADP], mitochondrial | PRO_0000014420 | |||||
Regions | |||||||||
| Nucleotide binding | 115 – 117 | 3 | NADP By similarity | ||||||
| Nucleotide binding | 349 – 354 | 6 | NADP By similarity | ||||||
| Region | 134 – 140 | 7 | Substrate binding By similarity | ||||||
Sites | |||||||||
| Metal binding | 291 | 1 | Magnesium or manganese By similarity | ||||||
| Metal binding | 314 | 1 | Magnesium or manganese By similarity | ||||||
| Binding site | 117 | 1 | Substrate By similarity | ||||||
| Binding site | 122 | 1 | NADP By similarity | ||||||
| Binding site | 149 | 1 | Substrate By similarity | ||||||
| Binding site | 172 | 1 | Substrate By similarity | ||||||
| Binding site | 299 | 1 | NADP By similarity | ||||||
| Binding site | 367 | 1 | NADP; via amide nitrogen and carbonyl oxygen By similarity | ||||||
| Site | 179 | 1 | Critical for catalysis By similarity | ||||||
| Site | 251 | 1 | Critical for catalysis By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 106 | 1 | N6-acetyllysine By similarity | ||||||
| Modified residue | 272 | 1 | N6-acetyllysine By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 34 | 1 | Q → H in CAA49208. Ref.1 | ||||||
| Sequence conflict | 435 | 1 | T → M in CAA49208. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | Huh T.-L., Oh I.-U., Kim Y.O., Huh J.-W., Song B.J. Submitted (NOV-1992) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Heart. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon and Skin. |
| [3] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| X69433 mRNA. Translation: CAA49208.1. BC009244 mRNA. Translation: AAH09244.1. BC071828 mRNA. Translation: AAH71828.1. | |
| IPI | IPI00011107. |
| PIR | S57499. |
| RefSeq | NP_002159.2. |
| UniGene | Hs.596461 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1LWD based on UniProtKB P33198. |
| SMR | P48735. Positions 40-452. |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | P48735. |
2-D gel databases | |
| OGP | P48735. |
Proteomic databases | |
| PeptideAtlas | P48735. |
| PRIDE | P48735. |
Genome annotation databases | |
| Ensembl | ENSG00000182054. Homo sapiens. [Contig view] |
| GeneID | 3418. |
| KEGG | hsa:3418. |
| NMPDR | fig|9606.3.peg.11234. |
Organism-specific databases | |
| GeneCards | GC15M088428. |
| HGNC | HGNC:5383. IDH2. |
| MIM | 147650. gene. |
| PharmGKB | PA29631. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | P48735. |
| HOVERGEN | P48735. |
| OMA | P48735. GGMLWAC. |
Enzyme and pathway databases | |
| BRENDA | 1.1.1.42. 247. |
Gene expression databases | |
| ArrayExpress | P48735. |
| Bgee | P48735. |
| CleanEx | HS_IDH2. |
| GermOnline | ENSG00000182054. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR019818. IsoCit/isopropylmalate_DH_CS. IPR001804. Isocitrate/isopropylmalate_DH. IPR004790. Isocitrate_DH_NADP-dep_euk. [Graphical view] |
| Gene3D | G3DSA:3.40.718.10. IDH_IMDH. 1 hit. |
| PANTHER | PTHR11822. IDH_NADP_euk. 1 hit. |
| Pfam | PF00180. Iso_dh. 1 hit. [Graphical view] |
| PIRSF | PIRSF000108. IDH_NADP. 1 hit. |
| TIGRFAMs | TIGR00127. nadp_idh_euk. 1 hit. |
| PROSITE | PS00470. IDH_IMDH. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 13474. |
| SOURCE | Search... |
Entry information
| Entry name | IDHP_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P48735 Secondary accession number(s): Q96GT3 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 15 Human chromosome 15: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


