Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Homeobox protein ATH1

Gene

ATH1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor which may be involved in the signal transduction pathway downstream of the COP1 gene. Controls floral competency as a specific activator of FLC expression. Is responsive of the nuclear import of SHOOT MERISTEMLESS (STM).1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi372 – 434HomeoboxPROSITE-ProRule annotationAdd BLAST63

GO - Molecular functioni

  • DNA binding Source: TAIR
  • DNA binding transcription factor activity Source: TAIR
  • sequence-specific DNA binding Source: TAIR

GO - Biological processi

  • floral organ abscission Source: TAIR
  • negative regulation of cell proliferation Source: TAIR
  • photomorphogenesis Source: TAIR
  • regulation of gibberellin biosynthetic process Source: TAIR
  • shoot organ boundary specification Source: TAIR
  • transcription, DNA-templated Source: UniProtKB-KW
  • vegetative to reproductive phase transition of meristem Source: TAIR

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein ATH1
Gene namesi
Name:ATH1
Ordered Locus Names:At4g32980
ORF Names:F26P21.100
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G32980
TAIRilocus:2005494 AT4G32980

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000488211 – 473Homeobox protein ATH1Add BLAST473

Proteomic databases

PaxDbiP48731

PTM databases

iPTMnetiP48731

Expressioni

Tissue specificityi

Most abundant in flowers.

Developmental stagei

Down-regulated in the shoot apical meristem (SAM) upon floral induction.1 Publication

Inductioni

By light. In etiolated seedlings, maximally expressed after 3 days of illumination.

Gene expression databases

ExpressionAtlasiP48731 baseline and differential
GenevisibleiP48731 AT

Interactioni

Subunit structurei

May form heterodimeric complex with the TALE/KNOX protein STM.

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi14720, 12 interactors
IntActiP48731, 20 interactors
STRINGi3702.AT4G32980.1

Structurei

3D structure databases

ProteinModelPortaliP48731
SMRiP48731
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni205 – 221SR/KY domainAdd BLAST17
Regioni266 – 336BELL domainAdd BLAST71

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi3 – 8Poly-Asn6
Compositional biasi30 – 48Ser/Thr-richAdd BLAST19
Compositional biasi88 – 103His/Pro-richAdd BLAST16

Domaini

The SR/KY and BELL domains are responsive for the interaction between the TALE/BELL proteins and the TALE/KNOX proteins.

Sequence similaritiesi

Belongs to the TALE/BELL homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0773 Eukaryota
ENOG410XPMQ LUCA
HOGENOMiHOG000034160
InParanoidiP48731
OMAiRFENITE
OrthoDBiEOG0936075S
PhylomeDBiP48731

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
IPR008422 Homeobox_KN_domain
IPR006563 POX_dom
PfamiView protein in Pfam
PF05920 Homeobox_KN, 1 hit
PF07526 POX, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00574 POX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P48731-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNNNNNNTF SSLDNVMTNQ NPLLMDFIPS REDSTSFSTM LPWNTIRSDP
60 70 80 90 100
LQMGGFDIFN SMLTNKYLSS SPRSIDVQDN RNVEFMAPPP HPPPLHPLDH
110 120 130 140 150
LRHYDDSSNN MWGFEANSEF QAFSGVVGPS EPMMSTFGEE DFPFLISNKR
160 170 180 190 200
NNELSLSLAS DVSDECSEIS LCAATRLASE QASCSSKDIS NNVVTQGFSQ
210 220 230 240 250
LIFGSKYLHS VQEILSHFAA YSLDYSSRGT ESGAASSAFT SRFENITEFL
260 270 280 290 300
DGDSNNSEAG FGSTFQRRAL EAKKTHLLDL LQMVDDRYSH CVDEIHTVIS
310 320 330 340 350
AFHAATELDP QLHTRFALQT VSFLYKNLRE RICKKIISMG SVLERGKDKT
360 370 380 390 400
QETSMFHQHC LLQQLKRKNH QIWRPQRGLP EKSVSVLRNW MFQNFLHPYP
410 420 430 440 450
KDSEKHLLAI RSGLTRSQVS NWFINARVRL WKPMIEEMYA EMNKRKLNNS
460 470
HIQPNGPTLR MPKSVMMSQA MHK
Length:473
Mass (Da):53,900
Last modified:February 1, 1996 - v1
Checksum:iADF8B1DBCA16A10F
GO

Sequence cautioni

The sequence CAC51426 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80126 mRNA Translation: CAA56426.1
X80127 Genomic DNA Translation: CAC51426.1 Sequence problems.
AL031804 Genomic DNA Translation: CAA21207.1
AL161582 Genomic DNA Translation: CAB80015.1
CP002687 Genomic DNA Translation: AEE86154.1
CP002687 Genomic DNA Translation: ANM66154.1
AY072174 mRNA Translation: AAL59996.1
AY096513 mRNA Translation: AAM20163.1
Z83320 Genomic DNA Translation: CAB05910.1
PIRiT05306
RefSeqiNP_001328067.1, NM_001342189.1
NP_195024.1, NM_119452.4
UniGeneiAt.76

Genome annotation databases

EnsemblPlantsiAT4G32980.1; AT4G32980.1; AT4G32980
AT4G32980.2; AT4G32980.2; AT4G32980
GeneIDi829435
GrameneiAT4G32980.1; AT4G32980.1; AT4G32980
AT4G32980.2; AT4G32980.2; AT4G32980
KEGGiath:AT4G32980

Similar proteinsi

Entry informationi

Entry nameiATH1_ARATH
AccessioniPrimary (citable) accession number: P48731
Secondary accession number(s): Q7X9S7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 23, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health