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Protein

Homeobox protein ATH1

Gene

ATH1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor which may be involved in the signal transduction pathway downstream of the COP1 gene. Controls floral competency as a specific activator of FLC expression. Is responsive of the nuclear import of SHOOT MERISTEMLESS (STM).1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi372 – 43463HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: TAIR
  • sequence-specific DNA binding Source: TAIR
  • transcription factor activity, sequence-specific DNA binding Source: TAIR

GO - Biological processi

  • floral organ abscission Source: TAIR
  • negative regulation of cell proliferation Source: TAIR
  • photomorphogenesis Source: TAIR
  • regulation of gibberellin biosynthetic process Source: TAIR
  • shoot organ boundary specification Source: TAIR
  • transcription, DNA-templated Source: UniProtKB-KW
  • vegetative to reproductive phase transition of meristem Source: TAIR
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein ATH1
Gene namesi
Name:ATH1
Ordered Locus Names:At4g32980
ORF Names:F26P21.100
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

TAIRiAT4G32980.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 473473Homeobox protein ATH1PRO_0000048821Add
BLAST

Proteomic databases

PaxDbiP48731.
PRIDEiP48731.

PTM databases

iPTMnetiP48731.

Expressioni

Tissue specificityi

Most abundant in flowers.

Developmental stagei

Down-regulated in the shoot apical meristem (SAM) upon floral induction.1 Publication

Inductioni

By light. In etiolated seedlings, maximally expressed after 3 days of illumination.

Gene expression databases

GenevisibleiP48731. AT.

Interactioni

Subunit structurei

May form heterodimeric complex with the TALE/KNOX protein STM.

Binary interactionsi

WithEntry#Exp.IntActNotes
STMQ388745EBI-912904,EBI-530523

Protein-protein interaction databases

BioGridi14720. 12 interactions.
IntActiP48731. 9 interactions.
STRINGi3702.AT4G32980.1.

Structurei

3D structure databases

ProteinModelPortaliP48731.
SMRiP48731. Positions 380-434.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni205 – 22117SR/KY domainAdd
BLAST
Regioni266 – 33671BELL domainAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi3 – 86Poly-Asn
Compositional biasi30 – 4819Ser/Thr-richAdd
BLAST
Compositional biasi88 – 10316His/Pro-richAdd
BLAST

Domaini

The SR/KY and BELL domains are responsive for the interaction between the TALE/BELL proteins and the TALE/KNOX proteins.

Sequence similaritiesi

Belongs to the TALE/BELL homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0773. Eukaryota.
ENOG410XPMQ. LUCA.
HOGENOMiHOG000034160.
InParanoidiP48731.
OMAiDDRYSHC.
PhylomeDBiP48731.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
IPR006563. POX_dom.
[Graphical view]
PfamiPF05920. Homeobox_KN. 1 hit.
PF07526. POX. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
SM00574. POX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48731-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNNNNNNTF SSLDNVMTNQ NPLLMDFIPS REDSTSFSTM LPWNTIRSDP
60 70 80 90 100
LQMGGFDIFN SMLTNKYLSS SPRSIDVQDN RNVEFMAPPP HPPPLHPLDH
110 120 130 140 150
LRHYDDSSNN MWGFEANSEF QAFSGVVGPS EPMMSTFGEE DFPFLISNKR
160 170 180 190 200
NNELSLSLAS DVSDECSEIS LCAATRLASE QASCSSKDIS NNVVTQGFSQ
210 220 230 240 250
LIFGSKYLHS VQEILSHFAA YSLDYSSRGT ESGAASSAFT SRFENITEFL
260 270 280 290 300
DGDSNNSEAG FGSTFQRRAL EAKKTHLLDL LQMVDDRYSH CVDEIHTVIS
310 320 330 340 350
AFHAATELDP QLHTRFALQT VSFLYKNLRE RICKKIISMG SVLERGKDKT
360 370 380 390 400
QETSMFHQHC LLQQLKRKNH QIWRPQRGLP EKSVSVLRNW MFQNFLHPYP
410 420 430 440 450
KDSEKHLLAI RSGLTRSQVS NWFINARVRL WKPMIEEMYA EMNKRKLNNS
460 470
HIQPNGPTLR MPKSVMMSQA MHK
Length:473
Mass (Da):53,900
Last modified:February 1, 1996 - v1
Checksum:iADF8B1DBCA16A10F
GO

Sequence cautioni

The sequence CAC51426.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80126 mRNA. Translation: CAA56426.1.
X80127 Genomic DNA. Translation: CAC51426.1. Sequence problems.
AL031804 Genomic DNA. Translation: CAA21207.1.
AL161582 Genomic DNA. Translation: CAB80015.1.
CP002687 Genomic DNA. Translation: AEE86154.1.
AY072174 mRNA. Translation: AAL59996.1.
AY096513 mRNA. Translation: AAM20163.1.
Z83320 Genomic DNA. Translation: CAB05910.1.
PIRiT05306.
RefSeqiNP_195024.1. NM_119452.3.
UniGeneiAt.76.

Genome annotation databases

EnsemblPlantsiAT4G32980.1; AT4G32980.1; AT4G32980.
GeneIDi829435.
GrameneiAT4G32980.1; AT4G32980.1; AT4G32980.
KEGGiath:AT4G32980.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80126 mRNA. Translation: CAA56426.1.
X80127 Genomic DNA. Translation: CAC51426.1. Sequence problems.
AL031804 Genomic DNA. Translation: CAA21207.1.
AL161582 Genomic DNA. Translation: CAB80015.1.
CP002687 Genomic DNA. Translation: AEE86154.1.
AY072174 mRNA. Translation: AAL59996.1.
AY096513 mRNA. Translation: AAM20163.1.
Z83320 Genomic DNA. Translation: CAB05910.1.
PIRiT05306.
RefSeqiNP_195024.1. NM_119452.3.
UniGeneiAt.76.

3D structure databases

ProteinModelPortaliP48731.
SMRiP48731. Positions 380-434.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi14720. 12 interactions.
IntActiP48731. 9 interactions.
STRINGi3702.AT4G32980.1.

PTM databases

iPTMnetiP48731.

Proteomic databases

PaxDbiP48731.
PRIDEiP48731.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G32980.1; AT4G32980.1; AT4G32980.
GeneIDi829435.
GrameneiAT4G32980.1; AT4G32980.1; AT4G32980.
KEGGiath:AT4G32980.

Organism-specific databases

TAIRiAT4G32980.

Phylogenomic databases

eggNOGiKOG0773. Eukaryota.
ENOG410XPMQ. LUCA.
HOGENOMiHOG000034160.
InParanoidiP48731.
OMAiDDRYSHC.
PhylomeDBiP48731.

Miscellaneous databases

PROiP48731.

Gene expression databases

GenevisibleiP48731. AT.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
IPR006563. POX_dom.
[Graphical view]
PfamiPF05920. Homeobox_KN. 1 hit.
PF07526. POX. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
SM00574. POX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The homeobox gene ATH1 of Arabidopsis is derepressed in the photomorphogenic mutants cop1 and det1."
    Quaedvlieg N., Dockx J., Rook F., Weisbeek P.J., Smeekens S.C.M.
    Plant Cell 7:117-129(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: cv. Columbia.
    Tissue: Rosette leaf and Seedling.
  2. "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana."
    Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M., de Simone V., Obermaier B.
    , Mache R., Mueller M., Kreis M., Delseny M., Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D., Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J., Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B., Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J., Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M., Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C., Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J., Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S., Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A., Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M., Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E., Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R., Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K., Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K., de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M., Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G., Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K., Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K., Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W., Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H., Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B., Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J., Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K., O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A., Martienssen R., McCombie W.R.
    Nature 402:769-777(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Analysis of the chromatin domain organisation around the plastocyanin gene reveals an MAR-specific sequence element in Arabidopsis thaliana."
    van Drunen C.M., Oosterling R.W., Keultjes G.M., Weisbeek P.J., van Driel R., Smeekens S.C.M.
    Nucleic Acids Res. 25:3904-3911(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-228.
    Strain: cv. Columbia.
    Tissue: Rosette leaf.
  6. "Competence to respond to floral inductive signals requires the homeobox genes PENNYWISE and POUND-FOOLISH."
    Smith H.M.S., Campbell B.C.C., Hake S.
    Curr. Biol. 14:812-817(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY ORGANIZATION.
  7. "Nuclear import of the transcription factor SHOOT MERISTEMLESS depends on heterodimerization with BLH proteins expressed in discrete sub-domains of the shoot apical meristem of Arabidopsis thaliana."
    Cole M., Nolte C., Werr W.
    Nucleic Acids Res. 34:1281-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH STM.
  8. "The Arabidopsis TALE homeobox gene ATH1 controls floral competency through positive regulation of FLC."
    Proveniers M., Rutjens B., Brand M., Smeekens S.C.M.
    Plant J. 52:899-913(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiATH1_ARATH
AccessioniPrimary (citable) accession number: P48731
Secondary accession number(s): Q7X9S7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: February 17, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.