P48728 (GCST_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aminomethyltransferase, mitochondrial
EC=2.1.2.10

Alternative name(s):
Glycine cleavage system T protein
Short name=GCVT

Gene names

Name:	AMT
Synonyms:	GCST

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	403 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine.
Catalytic activity	[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3.
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H.
Subcellular location	Mitochondrion.
Involvement in disease	Non-ketotic hyperglycinemia (NKH) [MIM:605899]: Autosomal recessive disease characterized by accumulation of a large amount of glycine in body fluid and by severe neurological symptoms. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.8 Ref.9 Ref.10 Ref.11 Ref.12
Sequence similarities	Belongs to the GcvT family.

Ontologies

Keywords
Cellular component	Mitochondrion
Coding sequence diversity	Alternative splicing
Disease	Disease mutation
Domain	Transit peptide
Molecular function	Aminotransferase Transferase
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	glycine catabolic process Traceable author statement Ref.9. Source: ProtInc
Cellular_component	mitochondrion Traceable author statement Ref.2. Source: ProtInc
Molecular_function	aminomethyltransferase activity Inferred from electronic annotation. Source: EC transaminase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P48728-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P48728-2)

The sequence of this isoform differs from the canonical sequence as follows:
     30-85: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: P48728-3)

The sequence of this isoform differs from the canonical sequence as follows:
     113-156: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: P48728-4)

The sequence of this isoform differs from the canonical sequence as follows:
     380-403: VRRKQQMAVVSKMPFVPTNYYTLK → LPSGPCF

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Transit peptide

1 – 28

28

Mitochondrion By similarity

Chain

29 – 403

375

Aminomethyltransferase, mitochondrial

PRO_0000010755

Sites

Binding site

232

1

Substrate

Binding site

261

1

Substrate

Binding site

399

1

Substrate

Natural variations

Alternative sequence

30 – 85

56

Missing in isoform 2.

VSP_042557

Alternative sequence

113 – 156

44

Missing in isoform 3.

VSP_043288

Alternative sequence

380 – 403

24

VRRKQ…YYTLK → LPSGPCF in isoform 4.

VSP_045418

Natural variant

42

1

H → R in NKH. Ref.9

VAR_007951

Natural variant

47

1

G → R in NKH. Ref.8

VAR_007952

Natural variant

145

1

N → I in NKH. Ref.12

VAR_016847

Natural variant

211

1

E → K in NKH. Ref.11

VAR_016848

Natural variant

269

1

G → D in NKH. Ref.8

VAR_007953

Natural variant

276

1

D → H in NKH. Ref.10

VAR_007954

Natural variant

320

1

R → H in NKH. Ref.8 Ref.11 Ref.12

VAR_007955

Experimental info

Sequence conflict

95

1

V → C in BAA03512. Ref.2

Secondary structure

1

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403

Helix Strand Turn

Details...

Helix

39 – 44

6

Beta strand

48 – 52

5

Beta strand

55 – 60

6

Helix

65 – 74

10

Beta strand

75 – 80

6

Beta strand

84 – 91

8

Helix

94 – 101

8

Beta strand

102 – 104

3

Beta strand

113 – 120

8

Beta strand

126 – 134

9

Beta strand

138 – 144

7

Helix

146 – 148

3

Helix

149 – 165

17

Beta strand

171 – 174

4

Beta strand

178 – 184

7

Helix

187 – 192

6

Helix

199 – 201

3

Beta strand

206 – 212

7

Beta strand

215 – 222

8

Beta strand

225 – 235

11

Helix

237 – 248

12

Beta strand

253 – 255

3

Helix

258 – 267

10

Turn

273 – 275

3

Turn

283 – 287

5

Helix

289 – 291

3

Helix

294 – 299

6

Helix

305 – 312

8

Beta strand

319 – 328

10

Beta strand

335 – 337

3

Beta strand

343 – 353

11

Turn

354 – 357

4

Beta strand

358 – 365

8

Helix

367 – 369

3

Beta strand

375 – 380

6

Beta strand

383 – 390

8

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 218DC9EEADFA9102	FASTA	403	43,946
	10 20 30 40 50 60 MQRAVSVVAR LGFRLQAFPP ALCRPLSCAQ EVLRRTPLYD FHLAHGGKMV AFAGWSLPVQ 70 80 90 100 110 120 YRDSHTDSHL HTRQHCSLFD VSHMLQTKIL GSDRVKLMES LVVGDIAELR PNQGTLSLFT 130 140 150 160 170 180 NEAGGILDDL IVTNTSEGHL YVVSNAGCWE KDLALMQDKV RELQNQGRDV GLEVLDNALL 190 200 210 220 230 240 ALQGPTAAQV LQAGVADDLR KLPFMTSAVM EVFGVSGCRV TRCGYTGEDG VEISVPVAGA 250 260 270 280 290 300 VHLATAILKN PEVKLAGLAA RDSLRLEAGL CLYGNDIDEH TTPVEGSLSW TLGKRRRAAM 310 320 330 340 350 360 DFPGAKVIVP QLKGRVQRRR VGLMCEGAPM RAHSPILNME GTKIGTVTSG CPSPSLKKNV 370 380 390 400 AMGYVPCEYS RPGTMLLVEV RRKQQMAVVS KMPFVPTNYY TLK
	Isoform 2 [UniParc]. Checksum: 4C99E4B0F9C76299	FASTA	347	37,434
	10 20 30 40 50 60 MQRAVSVVAR LGFRLQAFPP ALCRPLSCAQ TKILGSDRVK LMESLVVGDI AELRPNQGTL 70 80 90 100 110 120 SLFTNEAGGI LDDLIVTNTS EGHLYVVSNA GCWEKDLALM QDKVRELQNQ GRDVGLEVLD 130 140 150 160 170 180 NALLALQGPT AAQVLQAGVA DDLRKLPFMT SAVMEVFGVS GCRVTRCGYT GEDGVEISVP 190 200 210 220 230 240 VAGAVHLATA ILKNPEVKLA GLAARDSLRL EAGLCLYGND IDEHTTPVEG SLSWTLGKRR 250 260 270 280 290 300 RAAMDFPGAK VIVPQLKGRV QRRRVGLMCE GAPMRAHSPI LNMEGTKIGT VTSGCPSPSL 310 320 330 340 KKNVAMGYVP CEYSRPGTML LVEVRRKQQM AVVSKMPFVP TNYYTLK
	Isoform 3 [UniParc]. Checksum: B1DA25DDC565ECB8	FASTA	359	39,267
	10 20 30 40 50 60 MQRAVSVVAR LGFRLQAFPP ALCRPLSCAQ EVLRRTPLYD FHLAHGGKMV AFAGWSLPVQ 70 80 90 100 110 120 YRDSHTDSHL HTRQHCSLFD VSHMLQTKIL GSDRVKLMES LVVGDIAELR PNQDKVRELQ 130 140 150 160 170 180 NQGRDVGLEV LDNALLALQG PTAAQVLQAG VADDLRKLPF MTSAVMEVFG VSGCRVTRCG 190 200 210 220 230 240 YTGEDGVEIS VPVAGAVHLA TAILKNPEVK LAGLAARDSL RLEAGLCLYG NDIDEHTTPV 250 260 270 280 290 300 EGSLSWTLGK RRRAAMDFPG AKVIVPQLKG RVQRRRVGLM CEGAPMRAHS PILNMEGTKI 310 320 330 340 350 GTVTSGCPSP SLKKNVAMGY VPCEYSRPGT MLLVEVRRKQ QMAVVSKMPF VPTNYYTLK
	Isoform 4 [UniParc]. Checksum: 3938EB3D01A8846B	FASTA	386	41,780
	10 20 30 40 50 60 MQRAVSVVAR LGFRLQAFPP ALCRPLSCAQ EVLRRTPLYD FHLAHGGKMV AFAGWSLPVQ 70 80 90 100 110 120 YRDSHTDSHL HTRQHCSLFD VSHMLQTKIL GSDRVKLMES LVVGDIAELR PNQGTLSLFT 130 140 150 160 170 180 NEAGGILDDL IVTNTSEGHL YVVSNAGCWE KDLALMQDKV RELQNQGRDV GLEVLDNALL 190 200 210 220 230 240 ALQGPTAAQV LQAGVADDLR KLPFMTSAVM EVFGVSGCRV TRCGYTGEDG VEISVPVAGA 250 260 270 280 290 300 VHLATAILKN PEVKLAGLAA RDSLRLEAGL CLYGNDIDEH TTPVEGSLSW TLGKRRRAAM 310 320 330 340 350 360 DFPGAKVIVP QLKGRVQRRR VGLMCEGAPM RAHSPILNME GTKIGTVTSG CPSPSLKKNV 370 380 AMGYVPCEYS RPGTMLLVEL PSGPCF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and sequence determination of cDNA encoding human T-protein of the glycine cleavage system." Hayasaka K., Nanao K., Takada G., Okamura-Ikeda K., Motokawa Y. Biochem. Biophys. Res. Commun. 192:766-771(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Structure and chromosomal localization of the aminomethyltransferase gene (AMT)." Nanao K., Takada G., Takahashi E., Seki N., Komatsu Y., Okamura-Ikeda K., Motokawa Y., Hayasaka K. Genomics 19:27-30(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3). Tissue: Cerebellum, Heart and Thalamus.
[4]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-386 (ISOFORM 4). Tissue: Colon.
[7]	"Crystal structure of human T-protein of glycine cleavage system at 2.0 A resolution and its implication for understanding non-ketotic hyperglycinemia." Okamura-Ikeda K., Hosaka H., Yoshimura M., Yamashita E., Toma S., Nakagawa A., Fujiwara K., Motokawa Y., Taniguchi H. J. Mol. Biol. 351:1146-1159(2005) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 29-403 ALONE AND IN COMPLEX WITH 5-METHYLTETRAHYDROFOLATE, SUBSTRATE-BINDING SITES.
[8]	"Identification of the mutations in the T-protein gene causing typical and atypical nonketotic hyperglycinemia." Nanao K., Okamura-Ikeda K., Motokawa Y., Danks D.M., Baumgartner E.R., Takada G., Hayasaka K. Hum. Genet. 93:655-658(1994) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS NKH ARG-47; ASP-269 AND HIS-320.
[9]	"A missense mutation (His42Arg) in the T-protein gene from a large Israeli-Arab kindred with nonketotic hyperglycinemia." Kure S., Mandel H., Rolland M.-O., Sakata Y., Shinka T., Drugan A., Boneh A., Tada K., Matsubara Y., Narisawa K. Hum. Genet. 102:430-434(1998) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT NKH ARG-42.
[10]	"A one-base deletion (183delC) and a missense mutation (D276H) in the T-protein gene from a Japanese family with nonketotic hyperglycinemia." Kure S., Shinka T., Sakata Y., Osamu N., Takayanagi M., Tada K., Matsubara Y., Narisawa K. J. Hum. Genet. 43:135-137(1998) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT NKH HIS-276.
[11]	"Biochemical and molecular investigations of patients with nonketotic hyperglycinemia." Toone J.R., Applegarth D.A., Coulter-Mackie M.B., James E.R. Mol. Genet. Metab. 70:116-121(2000) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS NKH LYS-211 AND HIS-320.
[12]	"Recurrent mutations in P- and T-proteins of the glycine cleavage complex and a novel T-protein mutation (N145I): a strategy for the molecular investigation of patients with nonketotic hyperglycinemia (NKH)." Toone J.R., Applegarth D.A., Coulter-Mackie M.B., James E.R. Mol. Genet. Metab. 72:322-325(2001) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS NKH ILE-145 AND HIS-320.
+	Additional computationally mapped references.

Web resources

GeneReviews

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

D13811 mRNA. Translation: BAA02967.1.
D14686 Genomic DNA. Translation: BAA03512.1.
AK290600 mRNA. Translation: BAF83289.1.
AK293481 mRNA. Translation: BAG56972.1.
AK296177 mRNA. Translation: BAG58912.1.
AC104452 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW64984.1.
BC007546 mRNA. Translation: AAH07546.2.

IPI

IPI00299300.
IPI00793058.
IPI00910686.
IPI00925396.

PIR

I54192.

RefSeq

NP_000472.2. NM_000481.3.
NP_001158182.1. NM_001164710.1.
NP_001158183.1. NM_001164711.1.
NP_001158184.1. NM_001164712.1.

UniGene

Hs.102.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1WSR	X-ray	2.00	A/B	29-403	[»]
1WSV	X-ray	2.60	A/B	29-403	[»]

ProteinModelPortal

P48728.

ModBase

Search...

Protein-protein interaction databases

STRING

9606.ENSP00000273588.

PTM databases

PhosphoSite

P48728.

Polymorphism databases

DMDM

1346122.

Proteomic databases

PaxDb

P48728.

PRIDE

P48728.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000273588; ENSP00000273588; ENSG00000145020.
ENST00000395338; ENSP00000378747; ENSG00000145020.
ENST00000458307; ENSP00000415619; ENSG00000145020.
ENST00000538581; ENSP00000443200; ENSG00000145020.

GeneID

275.

KEGG

hsa:275.

UCSC

uc003cww.3. human.
uc003cwx.3. human.
uc011bco.2. human.
uc011bcq.2. human.

Organism-specific databases

CTD

275.

GeneCards

GC03M049429.

HGNC

HGNC:473. AMT.

HPA

HPA005566.

MIM

238310. gene.
605899. phenotype.

neXtProt

NX_P48728.

Orphanet

289863. Atypical glycine encephalopathy.
289860. Infantile glycine encephalopathy.
289857. Neonatal glycine encephalopathy.

PharmGKB

PA24780.

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG0404.

HOGENOM

HOG000239380.

HOVERGEN

HBG005822.

InParanoid

P48728.

KO

K00605.

OMA

KALYGGM.

PhylomeDB

P48728.

Enzyme and pathway databases

SABIO-RK

P48728.

Gene expression databases

ArrayExpress

P48728.

Bgee

P48728.

CleanEx

HS_AMT.

Genevestigator

P48728.

GermOnline

ENSG00000145020. Homo sapiens.

Family and domain databases

Gene3D

3.30.1360.120. 2 hits.

InterPro

IPR013977. GCV_T_C.
IPR006222. GCV_T_N.
IPR006223. GcvT.
IPR027266. TrmE/GcvT_dom1.
[Graphical view]

PANTHER

PTHR13847:SF5. PTHR13847:SF5. 1 hit.

Pfam

PF01571. GCV_T. 1 hit.
PF08669. GCV_T_C. 1 hit.
[Graphical view]

PIRSF

PIRSF006487. GcvT. 1 hit.

TIGRFAMs

TIGR00528. gcvT. 1 hit.

ProtoNet

Search...

Other

ChiTaRS

AMT. human.

DrugBank

DB00157. NADH.
DB00116. Tetrahydrofolic acid.

EvolutionaryTrace

P48728.

GenomeRNAi

275.

NextBio

1109.

SOURCE

Search...

Entry information

Entry name

GCST_HUMAN

Accession

Primary (citable) accession number: P48728
Secondary accession number(s): A8K3I5 , B4DE61, B4DJQ0, E9PBG1, Q96IG6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	May 29, 2013
This is version 125 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.