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Protein

Serine/threonine-protein phosphatase PP1-beta

Gene

gsp-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Serine/threonine-protein phosphatase essential for chromosomal dynamics during meiosis and mitosis. Antagonizes the function of air-2 in the regulation of chromosome cohesion. Dephosphorylates histone H3 at 'Ser-10'. Also involved in the activation of chloride channel clh-3 during cell swelling and meiotic maturation. Essential for embryogenesis.5 Publications

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Enzyme regulationi

Inhibited by okadaic acid.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi63Manganese 1By similarity1
Metal bindingi65Manganese 1By similarity1
Metal bindingi91Manganese 1By similarity1
Metal bindingi91Manganese 2By similarity1
Metal bindingi123Manganese 2By similarity1
Active sitei124Proton donorBy similarity1
Metal bindingi172Manganese 2By similarity1
Metal bindingi247Manganese 2By similarity1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • protein serine/threonine phosphatase activity Source: WormBase

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, Developmental protein, Hydrolase, Protein phosphatase
Biological processCell cycle, Cell division, Meiosis, Mitosis
LigandManganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP1-beta (EC:3.1.3.16)
Alternative name(s):
CeGLC-7-beta
Glc seven-like phosphatase 2
Gene namesi
Name:gsp-2
ORF Names:F56C9.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiF56C9.1 ; CE01319 ; WBGene00001748 ; gsp-2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000589131 – 333Serine/threonine-protein phosphatase PP1-betaAdd BLAST333

Proteomic databases

EPDiP48727
PaxDbiP48727
PeptideAtlasiP48727
PRIDEiP48727

Expressioni

Tissue specificityi

Expressed in gonads, nervous system, intestine and muscles.1 Publication

Developmental stagei

Expressed at early embryonic stages.1 Publication

Gene expression databases

BgeeiWBGene00001748

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
lab-1Q176042EBI-2418500,EBI-16011794

Protein-protein interaction databases

BioGridi532125, 1 interactor
DIPiDIP-25119N
IntActiP48727, 4 interactors
STRINGi6239.F56C9.1.1

Structurei

3D structure databases

ProteinModelPortaliP48727
SMRiP48727
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-1 subfamily.Curated

Phylogenomic databases

eggNOGiENOG410IN85 Eukaryota
ENOG410XPVF LUCA
GeneTreeiENSGT00530000062911
HOGENOMiHOG000172697
InParanoidiP48727
KOiK06269
OMAiQRGYEFF
OrthoDBiEOG091G0EKF
PhylomeDBiP48727

Family and domain databases

Gene3Di3.60.21.10, 1 hit
InterProiView protein in InterPro
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like
IPR037979 PPP1CA/PPP1CB
IPR006186 Ser/Thr-sp_prot-phosphatase
IPR031675 STPPase_N
PANTHERiPTHR11668:SF377 PTHR11668:SF377, 1 hit
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit
PF16891 STPPase_N, 1 hit
PRINTSiPR00114 STPHPHTASE
SMARTiView protein in SMART
SM00156 PP2Ac, 1 hit
PROSITEiView protein in PROSITE
PS00125 SER_THR_PHOSPHATASE, 1 hit

Sequencei

Sequence statusi: Complete.

P48727-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVEKLNLDN IISRLLEVRG SKPGKNVQLT ESEIKGLCQK SREIFLSQPI
60 70 80 90 100
LLELEAPLKI CGDVHGQYYD LLRLFEYGGF PPESNYLFLG DYVDRGKQSL
110 120 130 140 150
ETICLLLAYK IKYPENFFLL RGNHECASIN RIYGFYDECK RRYNIKLWKT
160 170 180 190 200
FTDCFNCLPV AAIIDEKIFC CHGGLSPDLQ SMEQIRRIMR PTDVPDQGLL
210 220 230 240 250
CDLLWSDPDK DVTGWGENDR GVSFTFGPEV VAKFLHKHDL DLICRAHQVV
260 270 280 290 300
EDGYEFFAKR QLVTLFSAPN YCGEFDNAGS MMTVDETLMC SFQILKPADK
310 320 330
KKYPYGAGGV GSNRPVTPPR NAPAAQPKKG AKK
Length:333
Mass (Da):37,792
Last modified:February 1, 1996 - v1
Checksum:iA73CE460AC78054E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080186 Genomic DNA Translation: CCD61828.1
PIRiT16476
RefSeqiNP_001022616.1, NM_001027445.4
UniGeneiCel.24408

Genome annotation databases

EnsemblMetazoaiF56C9.1; F56C9.1; WBGene00001748
GeneIDi3564807
KEGGicel:CELE_F56C9.1
UCSCiF56C9.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiGLC7B_CAEEL
AccessioniPrimary (citable) accession number: P48727
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: April 25, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health