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P48726 (PP2A1_PARTE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein phosphatase PP2A catalytic subunit 1

Short name=PPN 1
EC=3.1.3.16
Gene names
Name:Ppn1
ORF Names:GSPATT00001010001
OrganismParamecium tetraurelia [Reference proteome]
Taxonomic identifier5888 [NCBI]
Taxonomic lineageEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaPeniculidaParameciidaeParamecium

Protein attributes

Sequence length315 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactor

Binds 2 manganese ions per subunit By similarity.

Post-translational modification

Reversibly methyl esterified on Leu-315 by leucine carboxyl methyltransferase 1 (PPM1) and protein phosphatase methylesterase 1 (PPE1). Carboxyl methylation influences the affinity of the catalytic subunit for the different regulatory subunits, thereby modulating the PP2A holoenzyme's substrate specificity, enzyme activity and cellular localization.

Sequence similarities

Belongs to the PPP phosphatase family. PP-2A subfamily.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 315315Serine/threonine-protein phosphatase PP2A catalytic subunit 1
PRO_0000058867

Sites

Active site1231Proton donor By similarity
Metal binding621Manganese 1 By similarity
Metal binding641Manganese 1 By similarity
Metal binding901Manganese 1 By similarity
Metal binding901Manganese 2 By similarity
Metal binding1221Manganese 2 By similarity
Metal binding1721Manganese 2 By similarity
Metal binding2471Manganese 2 By similarity

Amino acid modifications

Modified residue3151Leucine methyl ester By similarity

Experimental info

Sequence conflict341K → R in AAA68611. Ref.1
Sequence conflict47 – 493EPN → GPH in AAA68611. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P48726 [UniParc].

Last modified October 23, 2007. Version 2.
Checksum: 2C67AB335B8C4650

FASTA31536,134
        10         20         30         40         50         60 
MASLNKLSSN EIGNIDRQIA KLKQGQILSE QEVKSLCIKA KEILQDEPNI IQVRAPLTIC 

        70         80         90        100        110        120 
GDIHGQFHDL IELFQIGGNL PDTNYLFLGD YVDRGSQSVE TFSLMLSLKV RYKDRIVLLR 

       130        140        150        160        170        180 
GNHENREINK IYGFYDECFR KYGNEIVWKQ FTEVFGYLPL SAIVEQQIFC AHGGLSPAME 

       190        200        210        220        230        240 
SVDQIKQLNR VQDIPHEGLM CDLLWSDPEE TKNGWGISPR GAGWTWGCDI TEKFLHSNKL 

       250        260        270        280        290        300 
KQIARAHQLV MEGIQKVHNQ KTITIFSAPN YCYRCGNQAC IVEVDEQLKM NQTQFEPAPR 

       310 
ENEPHTTRRV PDYFL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U27497 Genomic DNA. Translation: AAA68611.1.
CT868096 Genomic DNA. Translation: CAK71296.1.
RefSeqXP_001438693.1. XM_001438656.1.

3D structure databases

ProteinModelPortalP48726.
SMRP48726. Positions 15-315.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsCAK71296; CAK71296; GSPATT00001010001.
GeneID5024478.
KEGGptm:GSPATT00001010001.

Phylogenomic databases

KOK04382.

Family and domain databases

Gene3D3.60.21.10. 1 hit.
InterProIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSPR00114. STPHPHTASE.
SMARTSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMSSF56300. SSF56300. 1 hit.
PROSITEPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePP2A1_PARTE
AccessionPrimary (citable) accession number: P48726
Secondary accession number(s): A0CKH9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: October 23, 2007
Last modified: July 9, 2014
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families