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P48726

- PP2A1_PARTE

UniProt

P48726 - PP2A1_PARTE

Protein

Serine/threonine-protein phosphatase PP2A catalytic subunit 1

Gene

Ppn1

Organism
Paramecium tetraurelia
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 2 (23 Oct 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi62 – 621Manganese 1By similarity
    Metal bindingi64 – 641Manganese 1By similarity
    Metal bindingi90 – 901Manganese 1By similarity
    Metal bindingi90 – 901Manganese 2By similarity
    Metal bindingi122 – 1221Manganese 2By similarity
    Active sitei123 – 1231Proton donorBy similarity
    Metal bindingi172 – 1721Manganese 2By similarity
    Metal bindingi247 – 2471Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. phosphoprotein phosphatase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein phosphatase PP2A catalytic subunit 1 (EC:3.1.3.16)
    Short name:
    PPN 1
    Gene namesi
    Name:Ppn1
    ORF Names:GSPATT00001010001
    OrganismiParamecium tetraurelia
    Taxonomic identifieri5888 [NCBI]
    Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaPeniculidaParameciidaeParamecium
    ProteomesiUP000000600: Partially assembled WGS sequence

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 315315Serine/threonine-protein phosphatase PP2A catalytic subunit 1PRO_0000058867Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei315 – 3151Leucine methyl esterBy similarity

    Post-translational modificationi

    Reversibly methyl esterified on Leu-315 by leucine carboxyl methyltransferase 1 (PPM1) and protein phosphatase methylesterase 1 (PPE1). Carboxyl methylation influences the affinity of the catalytic subunit for the different regulatory subunits, thereby modulating the PP2A holoenzyme's substrate specificity, enzyme activity and cellular localization.

    Keywords - PTMi

    Methylation

    Structurei

    3D structure databases

    ProteinModelPortaliP48726.
    SMRiP48726. Positions 15-315.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PPP phosphatase family. PP-2A subfamily.Curated

    Phylogenomic databases

    KOiK04382.

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    PRINTSiPR00114. STPHPHTASE.
    SMARTiSM00156. PP2Ac. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 1 hit.
    PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P48726-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASLNKLSSN EIGNIDRQIA KLKQGQILSE QEVKSLCIKA KEILQDEPNI    50
    IQVRAPLTIC GDIHGQFHDL IELFQIGGNL PDTNYLFLGD YVDRGSQSVE 100
    TFSLMLSLKV RYKDRIVLLR GNHENREINK IYGFYDECFR KYGNEIVWKQ 150
    FTEVFGYLPL SAIVEQQIFC AHGGLSPAME SVDQIKQLNR VQDIPHEGLM 200
    CDLLWSDPEE TKNGWGISPR GAGWTWGCDI TEKFLHSNKL KQIARAHQLV 250
    MEGIQKVHNQ KTITIFSAPN YCYRCGNQAC IVEVDEQLKM NQTQFEPAPR 300
    ENEPHTTRRV PDYFL 315
    Length:315
    Mass (Da):36,134
    Last modified:October 23, 2007 - v2
    Checksum:i2C67AB335B8C4650
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti34 – 341K → R in AAA68611. 1 PublicationCurated
    Sequence conflicti47 – 493EPN → GPH in AAA68611. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U27497 Genomic DNA. Translation: AAA68611.1.
    CT868096 Genomic DNA. Translation: CAK71296.1.
    RefSeqiXP_001438693.1. XM_001438656.1.

    Genome annotation databases

    EnsemblProtistsiCAK71296; CAK71296; GSPATT00001010001.
    GeneIDi5024478.
    KEGGiptm:GSPATT00001010001.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U27497 Genomic DNA. Translation: AAA68611.1 .
    CT868096 Genomic DNA. Translation: CAK71296.1 .
    RefSeqi XP_001438693.1. XM_001438656.1.

    3D structure databases

    ProteinModelPortali P48726.
    SMRi P48726. Positions 15-315.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi CAK71296 ; CAK71296 ; GSPATT00001010001 .
    GeneIDi 5024478.
    KEGGi ptm:GSPATT00001010001.

    Phylogenomic databases

    KOi K04382.

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    PRINTSi PR00114. STPHPHTASE.
    SMARTi SM00156. PP2Ac. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Russell C.B., Fick J.E., Hinrichsen R.D., Klumpp S.
      Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Stock 51.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Stock d4-2.

    Entry informationi

    Entry nameiPP2A1_PARTE
    AccessioniPrimary (citable) accession number: P48726
    Secondary accession number(s): A0CKH9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: October 23, 2007
    Last modified: October 1, 2014
    This is version 68 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3