Reviewed,
UniProtKB/Swiss-Prot P48723 (HSP13_HUMAN)
Last modified
November 25, 2008.
Version 77.
History...
Clusters with 100%,
90%,
50% identity |
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Heat shock 70 kDa protein 13 Alternative name(s): Stress 70 protein chaperone microsome-associated 60 kDa protein Microsomal stress 70 protein ATPase core | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 471 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Has peptide-independent ATPase activity. |
| Subunit structure | Binds UBQLN2. |
| Subcellular location | |
| Tissue specificity | Constitutively expressed in all tissues. |
| Sequence similarities | Belongs to the heat shock protein 70 family. |
Ontologies
Keywords | |
|---|---|
| Cellular component | Endoplasmic reticulum Microsome |
| Domain | Signal |
| Ligand | ATP-binding Nucleotide-binding |
Gene Ontology (GO) | |
| Cellular component | endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-KW microsome Ref.1Traceable author statement. Source: ProtInc |
| Molecular function | ATP binding Inferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Stch encodes the 'ATPase core' of a microsomal stress 70 protein." Otterson G.A., Flynn G.C., Kratzke R.A., Coxon A., Johnston P.G., Kaye F.J. EMBO J. 13:1216-1225(1994) [PubMed: 8131751] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | Blechschmidt K., Nordsiek G., Groet J., Nizetic D., Hildmann T., Drescher B., Weber J., Menzel U., Schattevoy R., Yaspo M.-L., Rosenthal A. Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [3] | "The DNA sequence of human chromosome 21." Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A. Yaspo M.-L.Nature 405:311-319(2000) [PubMed: 10830953] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis. |
| [5] | "A family of ubiquitin-like proteins binds the ATPase domain of Hsp70-like Stch." Kaye F.J., Modi S., Ivanovska I., Koonin E.V., Thress K., Kubo A., Kornbluth S., Rose M.D. FEBS Lett. 467:348-355(2000) [PubMed: 10675567] [Abstract] Cited for: INTERACTION WITH UBQLN2. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| U04735 mRNA. Translation: AAA16954.1. AF130249 Genomic DNA. Translation: AAD21091.1. AL163206 Genomic DNA. Translation: CAB90390.1. BC036370 mRNA. Translation: AAH36370.1. | |
| PIR | S42631. |
| RefSeq | NP_008879.3. |
| UniGene | Hs.352341 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1HJO based on UniProtKB P08107. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P48723. |
2-D gel databases | |
| REPRODUCTION-2DPAGE | IPI00299299. |
Genome annotation databases | |
| Ensembl | ENSG00000155304. Homo sapiens. [Contig view] |
| GeneID | 6782. |
| KEGG | hsa:6782. |
Organism-specific databases | |
| H-InvDB | HIX0027792. |
| HGNC | HGNC:11375. HSPA13. |
| HPA | HPA014797. |
| MIM | 601100. gene. |
| PharmGKB | PA36192. |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOGENOM | P48723. |
| HOVERGEN | P48723. |
Gene expression databases | |
| ArrayExpress | P48723. |
| GermOnline | ENSG00000155304. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR001023. Hsp70. IPR013126. Hsp_70. [Graphical view] |
| PANTHER | PTHR19375. Hsp70. 1 hit. |
| Pfam | PF00012. HSP70. 2 hits. [Graphical view] |
| PRINTS | PR00301. HEATSHOCK70. |
| ProDom | PD000089. Hsp70. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| PROSITE | PS00297. HSP70_1. 1 hit. PS00329. HSP70_2. 1 hit. PS01036. HSP70_3. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 26484. |
| SOURCE | Search... |
Entry information
| Entry name | HSP13_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P48723 Secondary accession number(s): Q8NE40 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 21 Human chromosome 21: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

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