P48723 (HSP13_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 105.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Heat shock 70 kDa protein 13 Alternative name(s): Microsomal stress-70 protein ATPase core Stress-70 protein chaperone microsome-associated 60 kDa protein | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 471 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Has peptide-independent ATPase activity. |
| Subunit structure | Binds UBQLN2. |
| Subcellular location | |
| Tissue specificity | Constitutively expressed in all tissues. |
| Sequence similarities | Belongs to the heat shock protein 70 family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Endoplasmic reticulum Microsome |
| Domain | Signal |
| Ligand | ATP-binding Nucleotide-binding |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Cellular component | endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-SubCell microsomeTraceable author statement. Source: ProtInc |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | U04735 mRNA. Translation: AAA16954.1. AF130249 Genomic DNA. Translation: AAD21091.1. AK312396 mRNA. Translation: BAG35313.1. AL163206 Genomic DNA. Translation: CAB90390.1. CH471079 Genomic DNA. Translation: EAX10056.1. BC036370 mRNA. Translation: AAH36370.1. |
| IPI | IPI00299299. |
| PIR | S42631. |
| RefSeq | NP_008879.3. NM_006948.4. |
| UniGene | Hs.352341. |
3D structure databases | |
| ProteinModelPortal | P48723. |
| SMR | P48723. Positions 26-450. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P48723. 4 interactions. |
| MINT | MINT-1461282. |
| STRING | P48723. |
Polymorphism databases | |
| DMDM | 1351125. |
2D gel databases | |
| REPRODUCTION-2DPAGE | IPI00299299. |
Proteomic databases | |
| PRIDE | P48723. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000285667; ENSP00000285667; ENSG00000155304. |
| GeneID | 6782. |
| KEGG | hsa:6782. |
| UCSC | uc002yjt.1. human. |
Organism-specific databases | |
| CTD | 6782. |
| GeneCards | GC21M015743. |
| H-InvDB | HIX0027792. |
| HGNC | HGNC:11375. HSPA13. |
| HPA | HPA014797. |
| MIM | 601100. gene. |
| neXtProt | NX_P48723. |
| PharmGKB | PA162391697. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | HBG334976. |
| HOVERGEN | HBG098979. |
| InParanoid | P48723. |
| OMA | NEDLFQK. |
| OrthoDB | EOG4BK543. |
| PhylomeDB | P48723. |
Gene expression databases | |
| ArrayExpress | P48723. |
| Bgee | P48723. |
| CleanEx | HS_HSPA13. |
| Genevestigator | P48723. |
| GermOnline | ENSG00000155304. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR018181. Heat_shock_70_CS. IPR001023. Hsp70. IPR013126. Hsp_70. [Graphical view] |
| KO | K09491. |
| PANTHER | PTHR19375. Hsp70. 1 hit. |
| Pfam | PF00012. HSP70. 2 hits. [Graphical view] |
| PRINTS | PR00301. HEATSHOCK70. |
| PROSITE | PS00297. HSP70_1. 1 hit. PS00329. HSP70_2. 1 hit. PS01036. HSP70_3. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 26484. |
| SOURCE | Search... |
Entry information
| Entry name | HSP13_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P48723 Secondary accession number(s): B2R616, Q8NE40 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 21 Human chromosome 21: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with