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Protein

Heat shock 70 kDa protein 13

Gene

HSPA13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Has peptide-independent ATPase activity.

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000155304-MONOMER.
ReactomeiR-HSA-3371453. Regulation of HSF1-mediated heat shock response.

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock 70 kDa protein 13
Alternative name(s):
Microsomal stress-70 protein ATPase core
Stress-70 protein chaperone microsome-associated 60 kDa protein
Gene namesi
Name:HSPA13
Synonyms:STCH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:11375. HSPA13.

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
  • intracellular membrane-bounded organelle Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Microsome

Pathology & Biotechi

Organism-specific databases

DisGeNETi6782.
OpenTargetsiENSG00000155304.
PharmGKBiPA162391697.

Polymorphism and mutation databases

BioMutaiHSPA13.
DMDMi1351125.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001355823 – 471Heat shock 70 kDa protein 13Add BLAST449

Proteomic databases

EPDiP48723.
MaxQBiP48723.
PaxDbiP48723.
PeptideAtlasiP48723.
PRIDEiP48723.
TopDownProteomicsiP48723.

2D gel databases

REPRODUCTION-2DPAGEIPI00299299.

PTM databases

iPTMnetiP48723.
PhosphoSitePlusiP48723.

Expressioni

Tissue specificityi

Constitutively expressed in all tissues.

Gene expression databases

BgeeiENSG00000155304.
CleanExiHS_HSPA13.
ExpressionAtlasiP48723. baseline and differential.
GenevisibleiP48723. HS.

Organism-specific databases

HPAiHPA014797.

Interactioni

Subunit structurei

Binds UBQLN2.

Binary interactionsi

WithEntry#Exp.IntActNotes
SGTAO437655EBI-750892,EBI-347996
UBQLN1Q9UMX07EBI-750892,EBI-741480
UBQLN1Q9UMX0-23EBI-750892,EBI-10173939

Protein-protein interaction databases

BioGridi112659. 14 interactors.
IntActiP48723. 11 interactors.
MINTiMINT-1461282.
STRINGi9606.ENSP00000285667.

Structurei

3D structure databases

ProteinModelPortaliP48723.
SMRiP48723.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0101. Eukaryota.
COG0443. LUCA.
GeneTreeiENSGT00820000127001.
HOGENOMiHOG000228135.
HOVERGENiHBG098979.
InParanoidiP48723.
KOiK09491.
OMAiQIYQTYG.
OrthoDBiEOG091G06OD.
PhylomeDBiP48723.
TreeFamiTF105047.

Family and domain databases

InterProiIPR018181. Heat_shock_70_CS.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 2 hits.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48723-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAREMTILGS AVLTLLLAGY LAQQYLPLPT PKVIGIDLGT TYCSVGVFFP
60 70 80 90 100
GTGKVKVIPD ENGHISIPSM VSFTDNDVYV GYESVELADS NPQNTIYDAK
110 120 130 140 150
RFIGKIFTAE ELEAEIGRYP FKVLNKNGMV EFSVTSNETI TVSPEYVGSR
160 170 180 190 200
LLLKLKEMAE AYLGMPVANA VISVPAEFDL KQRNSTIEAA NLAGLKILRV
210 220 230 240 250
INEPTAAAMA YGLHKADVFH VLVIDLGGGT LDVSLLNKQG GMFLTRAMSG
260 270 280 290 300
NNKLGGQDFN QRLLQYLYKQ IYQTYGFVPS RKEEIHRLRQ AVEMVKLNLT
310 320 330 340 350
LHQSAQLSVL LTVEEQDRKE PHSSDTELPK DKLSSADDHR VNSGFGRGLS
360 370 380 390 400
DKKSGESQVL FETEISRKLF DTLNEDLFQK ILVPIQQVLK EGHLEKTEID
410 420 430 440 450
EVVLVGGSTR IPRIRQVIQE FFGKDPNTSV DPDLAVVTGV AIQAGIDGGS
460 470
WPLQVSALEI PNKHLQKTNF N
Length:471
Mass (Da):51,927
Last modified:February 1, 1996 - v1
Checksum:iC78028E7CB0D03F3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti450S → F in AAH36370 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04735 mRNA. Translation: AAA16954.1.
AF130249 Genomic DNA. Translation: AAD21091.1.
AK312396 mRNA. Translation: BAG35313.1.
AL163206 Genomic DNA. Translation: CAB90390.1.
CH471079 Genomic DNA. Translation: EAX10056.1.
BC036370 mRNA. Translation: AAH36370.1.
CCDSiCCDS13567.1.
PIRiS42631.
RefSeqiNP_008879.3. NM_006948.4.
UniGeneiHs.352341.

Genome annotation databases

EnsembliENST00000285667; ENSP00000285667; ENSG00000155304.
GeneIDi6782.
KEGGihsa:6782.
UCSCiuc002yjt.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04735 mRNA. Translation: AAA16954.1.
AF130249 Genomic DNA. Translation: AAD21091.1.
AK312396 mRNA. Translation: BAG35313.1.
AL163206 Genomic DNA. Translation: CAB90390.1.
CH471079 Genomic DNA. Translation: EAX10056.1.
BC036370 mRNA. Translation: AAH36370.1.
CCDSiCCDS13567.1.
PIRiS42631.
RefSeqiNP_008879.3. NM_006948.4.
UniGeneiHs.352341.

3D structure databases

ProteinModelPortaliP48723.
SMRiP48723.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112659. 14 interactors.
IntActiP48723. 11 interactors.
MINTiMINT-1461282.
STRINGi9606.ENSP00000285667.

PTM databases

iPTMnetiP48723.
PhosphoSitePlusiP48723.

Polymorphism and mutation databases

BioMutaiHSPA13.
DMDMi1351125.

2D gel databases

REPRODUCTION-2DPAGEIPI00299299.

Proteomic databases

EPDiP48723.
MaxQBiP48723.
PaxDbiP48723.
PeptideAtlasiP48723.
PRIDEiP48723.
TopDownProteomicsiP48723.

Protocols and materials databases

DNASUi6782.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000285667; ENSP00000285667; ENSG00000155304.
GeneIDi6782.
KEGGihsa:6782.
UCSCiuc002yjt.4. human.

Organism-specific databases

CTDi6782.
DisGeNETi6782.
GeneCardsiHSPA13.
HGNCiHGNC:11375. HSPA13.
HPAiHPA014797.
MIMi601100. gene.
neXtProtiNX_P48723.
OpenTargetsiENSG00000155304.
PharmGKBiPA162391697.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0101. Eukaryota.
COG0443. LUCA.
GeneTreeiENSGT00820000127001.
HOGENOMiHOG000228135.
HOVERGENiHBG098979.
InParanoidiP48723.
KOiK09491.
OMAiQIYQTYG.
OrthoDBiEOG091G06OD.
PhylomeDBiP48723.
TreeFamiTF105047.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000155304-MONOMER.
ReactomeiR-HSA-3371453. Regulation of HSF1-mediated heat shock response.

Miscellaneous databases

ChiTaRSiHSPA13. human.
GeneWikiiSTCH.
GenomeRNAii6782.
PROiP48723.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000155304.
CleanExiHS_HSPA13.
ExpressionAtlasiP48723. baseline and differential.
GenevisibleiP48723. HS.

Family and domain databases

InterProiIPR018181. Heat_shock_70_CS.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 2 hits.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHSP13_HUMAN
AccessioniPrimary (citable) accession number: P48723
Secondary accession number(s): B2R616, Q8NE40
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 30, 2016
This is version 150 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.