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Protein

Heat shock 70 kDa protein 13

Gene

HSPA13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Has peptide-independent ATPase activity.

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-3371453. Regulation of HSF1-mediated heat shock response.

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock 70 kDa protein 13
Alternative name(s):
Microsomal stress-70 protein ATPase core
Stress-70 protein chaperone microsome-associated 60 kDa protein
Gene namesi
Name:HSPA13
Synonyms:STCH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:11375. HSPA13.

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
  • intracellular membrane-bounded organelle Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Microsome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162391697.

Polymorphism and mutation databases

BioMutaiHSPA13.
DMDMi1351125.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 471449Heat shock 70 kDa protein 13PRO_0000013558Add
BLAST

Proteomic databases

EPDiP48723.
MaxQBiP48723.
PaxDbiP48723.
PeptideAtlasiP48723.
PRIDEiP48723.
TopDownProteomicsiP48723.

2D gel databases

REPRODUCTION-2DPAGEIPI00299299.

PTM databases

iPTMnetiP48723.
PhosphoSiteiP48723.

Expressioni

Tissue specificityi

Constitutively expressed in all tissues.

Gene expression databases

BgeeiP48723.
CleanExiHS_HSPA13.
GenevisibleiP48723. HS.

Organism-specific databases

HPAiHPA014797.

Interactioni

Subunit structurei

Binds UBQLN2.

Binary interactionsi

WithEntry#Exp.IntActNotes
SGTAO437653EBI-750892,EBI-347996
UBQLN1Q9UMX05EBI-750892,EBI-741480
UBQLN1Q9UMX0-23EBI-750892,EBI-10173939

Protein-protein interaction databases

BioGridi112659. 14 interactions.
IntActiP48723. 9 interactions.
MINTiMINT-1461282.
STRINGi9606.ENSP00000285667.

Structurei

3D structure databases

ProteinModelPortaliP48723.
SMRiP48723. Positions 34-446.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0101. Eukaryota.
COG0443. LUCA.
GeneTreeiENSGT00840000129922.
HOGENOMiHOG000228135.
HOVERGENiHBG098979.
InParanoidiP48723.
KOiK09491.
OMAiQIYQTYG.
OrthoDBiEOG7VMP5B.
PhylomeDBiP48723.
TreeFamiTF105047.

Family and domain databases

InterProiIPR018181. Heat_shock_70_CS.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 2 hits.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48723-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAREMTILGS AVLTLLLAGY LAQQYLPLPT PKVIGIDLGT TYCSVGVFFP
60 70 80 90 100
GTGKVKVIPD ENGHISIPSM VSFTDNDVYV GYESVELADS NPQNTIYDAK
110 120 130 140 150
RFIGKIFTAE ELEAEIGRYP FKVLNKNGMV EFSVTSNETI TVSPEYVGSR
160 170 180 190 200
LLLKLKEMAE AYLGMPVANA VISVPAEFDL KQRNSTIEAA NLAGLKILRV
210 220 230 240 250
INEPTAAAMA YGLHKADVFH VLVIDLGGGT LDVSLLNKQG GMFLTRAMSG
260 270 280 290 300
NNKLGGQDFN QRLLQYLYKQ IYQTYGFVPS RKEEIHRLRQ AVEMVKLNLT
310 320 330 340 350
LHQSAQLSVL LTVEEQDRKE PHSSDTELPK DKLSSADDHR VNSGFGRGLS
360 370 380 390 400
DKKSGESQVL FETEISRKLF DTLNEDLFQK ILVPIQQVLK EGHLEKTEID
410 420 430 440 450
EVVLVGGSTR IPRIRQVIQE FFGKDPNTSV DPDLAVVTGV AIQAGIDGGS
460 470
WPLQVSALEI PNKHLQKTNF N
Length:471
Mass (Da):51,927
Last modified:February 1, 1996 - v1
Checksum:iC78028E7CB0D03F3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti450 – 4501S → F in AAH36370 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04735 mRNA. Translation: AAA16954.1.
AF130249 Genomic DNA. Translation: AAD21091.1.
AK312396 mRNA. Translation: BAG35313.1.
AL163206 Genomic DNA. Translation: CAB90390.1.
CH471079 Genomic DNA. Translation: EAX10056.1.
BC036370 mRNA. Translation: AAH36370.1.
CCDSiCCDS13567.1.
PIRiS42631.
RefSeqiNP_008879.3. NM_006948.4.
UniGeneiHs.352341.

Genome annotation databases

EnsembliENST00000285667; ENSP00000285667; ENSG00000155304.
GeneIDi6782.
KEGGihsa:6782.
UCSCiuc002yjt.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04735 mRNA. Translation: AAA16954.1.
AF130249 Genomic DNA. Translation: AAD21091.1.
AK312396 mRNA. Translation: BAG35313.1.
AL163206 Genomic DNA. Translation: CAB90390.1.
CH471079 Genomic DNA. Translation: EAX10056.1.
BC036370 mRNA. Translation: AAH36370.1.
CCDSiCCDS13567.1.
PIRiS42631.
RefSeqiNP_008879.3. NM_006948.4.
UniGeneiHs.352341.

3D structure databases

ProteinModelPortaliP48723.
SMRiP48723. Positions 34-446.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112659. 14 interactions.
IntActiP48723. 9 interactions.
MINTiMINT-1461282.
STRINGi9606.ENSP00000285667.

PTM databases

iPTMnetiP48723.
PhosphoSiteiP48723.

Polymorphism and mutation databases

BioMutaiHSPA13.
DMDMi1351125.

2D gel databases

REPRODUCTION-2DPAGEIPI00299299.

Proteomic databases

EPDiP48723.
MaxQBiP48723.
PaxDbiP48723.
PeptideAtlasiP48723.
PRIDEiP48723.
TopDownProteomicsiP48723.

Protocols and materials databases

DNASUi6782.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000285667; ENSP00000285667; ENSG00000155304.
GeneIDi6782.
KEGGihsa:6782.
UCSCiuc002yjt.4. human.

Organism-specific databases

CTDi6782.
GeneCardsiHSPA13.
HGNCiHGNC:11375. HSPA13.
HPAiHPA014797.
MIMi601100. gene.
neXtProtiNX_P48723.
PharmGKBiPA162391697.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0101. Eukaryota.
COG0443. LUCA.
GeneTreeiENSGT00840000129922.
HOGENOMiHOG000228135.
HOVERGENiHBG098979.
InParanoidiP48723.
KOiK09491.
OMAiQIYQTYG.
OrthoDBiEOG7VMP5B.
PhylomeDBiP48723.
TreeFamiTF105047.

Enzyme and pathway databases

ReactomeiR-HSA-3371453. Regulation of HSF1-mediated heat shock response.

Miscellaneous databases

ChiTaRSiHSPA13. human.
GeneWikiiSTCH.
GenomeRNAii6782.
PROiP48723.
SOURCEiSearch...

Gene expression databases

BgeeiP48723.
CleanExiHS_HSPA13.
GenevisibleiP48723. HS.

Family and domain databases

InterProiIPR018181. Heat_shock_70_CS.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 2 hits.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Stch encodes the 'ATPase core' of a microsomal stress 70 protein."
    Otterson G.A., Flynn G.C., Kratzke R.A., Coxon A., Johnston P.G., Kaye F.J.
    EMBO J. 13:1216-1225(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Amygdala.
  4. "The DNA sequence of human chromosome 21."
    Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
    , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
    Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  7. "A family of ubiquitin-like proteins binds the ATPase domain of Hsp70-like Stch."
    Kaye F.J., Modi S., Ivanovska I., Koonin E.V., Thress K., Kubo A., Kornbluth S., Rose M.D.
    FEBS Lett. 467:348-355(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH UBQLN2.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiHSP13_HUMAN
AccessioniPrimary (citable) accession number: P48723
Secondary accession number(s): B2R616, Q8NE40
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: July 6, 2016
This is version 146 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.