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P48681 (NEST_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nestin
Gene names
Name:NES
ORF Names:Nbla00170
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1621 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells By similarity.

Subunit structure

Forms homodimers and homotetramers in vitro. In mixtures with other intermediate filament proteins such as vimentin and alpha-internexin, tis protein preferentially forms heterodimers which can assemble to form intermediate filaments if nestin does not exceed 25%. Interacts with FHOD3 By similarity.

Tissue specificity

CNS stem cells.

Developmental stage

Upon terminal neural differentiation, nestin is down-regulated and replaced by neurofilaments.

Post-translational modification

Constitutively phosphorylated. This increases during mitosis when the cytoplasmic intermediate filament network is reorganized By similarity.

Sequence similarities

Belongs to the intermediate filament family.

Ontologies

Keywords
   Biological processNeurogenesis
   Cellular componentIntermediate filament
   Coding sequence diversityPolymorphism
   DomainCoiled coil
   Molecular functionDevelopmental protein
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG2/M transition of mitotic cell cycle

Inferred from direct assay PubMed 19384922. Source: DFLAT

brain development

Inferred from sequence or structural similarity. Source: UniProtKB

cell projection morphogenesis

Inferred from electronic annotation. Source: Ensembl

central nervous system development

Non-traceable author statement Ref.3. Source: UniProtKB

embryonic camera-type eye development

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of catalytic activity

Inferred from direct assay PubMed 21185309. Source: UniProtKB

negative regulation of neuron apoptotic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of protein binding

Inferred from direct assay PubMed 21185309. Source: UniProtKB

positive regulation of intermediate filament depolymerization

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of neural precursor cell proliferation

Inferred from sequence or structural similarity. Source: UniProtKB

stem cell proliferation

Inferred from mutant phenotype PubMed 19384922. Source: DFLAT

   Cellular_componentcytoplasm

Inferred from direct assay PubMed 19384922. Source: DFLAT

intermediate filament

Non-traceable author statement Ref.3. Source: UniProtKB

intermediate filament cytoskeleton

Inferred from direct assay. Source: HPA

   Molecular_functionintermediate filament binding

Inferred from sequence or structural similarity. Source: UniProtKB

structural molecule activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 16211621Nestin
PRO_0000063853

Regions

Region1 – 77Head
Region8 – 313306Rod
Region8 – 4336Coil 1A
Region44 – 5512Linker 1
Region56 – 15196Coil 1B
Region152 – 17322Linker 12
Region174 – 19219Coil 2A
Region193 – 1953Linker 2
Region196 – 313118Coil 2B
Region314 – 16211308Tail

Amino acid modifications

Modified residue11N-acetylmethionine Ref.12
Modified residue3111Phosphoserine Ref.6
Modified residue3151Phosphothreonine Ref.6
Modified residue3251Phosphoserine Ref.6 Ref.11
Modified residue3551Phosphoserine Ref.11
Modified residue3581Phosphoserine Ref.9 Ref.11
Modified residue3881Phosphothreonine Ref.6
Modified residue3981Phosphoserine Ref.6 Ref.9
Modified residue4711Phosphoserine Ref.6 Ref.9 Ref.11
Modified residue5481Phosphoserine Ref.6 Ref.9 Ref.11
Modified residue5641Phosphoserine Ref.6
Modified residue5781Phosphoserine Ref.6 Ref.11
Modified residue5881Phosphoserine Ref.6
Modified residue6801Phosphoserine Ref.5 Ref.9 Ref.11
Modified residue7461Phosphoserine Ref.6 Ref.11
Modified residue7681Phosphoserine Ref.6 Ref.11
Modified residue7901Phosphoserine Ref.11
Modified residue8201Phosphoserine Ref.11
Modified residue8311Phosphoserine Ref.11
Modified residue8511Phosphothreonine Ref.6
Modified residue8941Phosphoserine Ref.11
Modified residue9051Phosphoserine Ref.6 Ref.11
Modified residue9131Phosphoserine Ref.11
Modified residue9341Phosphoserine Ref.11
Modified residue12611Phosphoserine Ref.11
Modified residue12821Phosphoserine Ref.11
Modified residue12861Phosphoserine Ref.11
Modified residue13471Phosphoserine Ref.11
Modified residue14091Phosphoserine Ref.5
Modified residue14181Phosphoserine Ref.5 Ref.6 Ref.7 Ref.11
Modified residue14521Phosphoserine Ref.11
Modified residue14961Phosphoserine Ref.11
Modified residue14981Phosphoserine Ref.11
Modified residue15771Phosphoserine Ref.11
Modified residue16171Phosphoserine Ref.11
Modified residue16181Phosphoserine Ref.11

Natural variations

Natural variant1301V → A.
Corresponds to variant rs4278369 [ dbSNP | Ensembl ].
VAR_061301
Natural variant8151V → I. Ref.4
Corresponds to variant rs951781 [ dbSNP | Ensembl ].
VAR_049814
Natural variant10161S → N. Ref.1
Corresponds to variant rs2365718 [ dbSNP | Ensembl ].
VAR_049815
Natural variant11011P → L. Ref.1
Corresponds to variant rs2886443 [ dbSNP | Ensembl ].
VAR_049816
Natural variant11331R → S.
Corresponds to variant rs17393797 [ dbSNP | Ensembl ].
VAR_049817
Natural variant12751P → L. Ref.1 Ref.6 Ref.11
Corresponds to variant rs3748570 [ dbSNP | Ensembl ].
VAR_049818

Experimental info

Sequence conflict241A → G in CAA46780. Ref.1
Sequence conflict391E → G in CAA46780. Ref.1
Sequence conflict451A → R in CAA46780. Ref.1
Sequence conflict961Q → E in CAA46780. Ref.1
Sequence conflict1301V → G in CAA46780. Ref.1
Sequence conflict1611C → L in CAA46780. Ref.1
Sequence conflict1671Missing in CAA46780. Ref.1
Sequence conflict205 – 2073GQA → DQT in CAA46780. Ref.1
Sequence conflict2121G → A in CAA46780. Ref.1
Sequence conflict2211G → V in CAA46780. Ref.1
Sequence conflict595 – 61218ELLKD…KEAVG → RAIKGCGGSETSRKRGCR in CAA46780. Ref.1
Sequence conflict857 – 90852QGAMN…RSPEE → KSGGNESSRKGNSRTTGVCG SEPRDIQTPGRGESGIIEIS GSMEPGEFEISRG in CAA46780. Ref.1
Sequence conflict9751E → K in CAA46780. Ref.1
Sequence conflict10081I → F in CAA46780. Ref.1
Sequence conflict10501A → T in CAA46780. Ref.1
Sequence conflict12351P → L in CAA46780. Ref.1
Sequence conflict12561Missing in CAA46780. Ref.1
Sequence conflict1314 – 132512DPTGE…PPPQG → TPLESRGHPLK in CAA46780. Ref.1
Sequence conflict1344 – 13452AP → E in CAA46780. Ref.1
Sequence conflict14721S → N in BAE45713. Ref.4
Sequence conflict15421L → M in BAE45713. Ref.4
Sequence conflict1563 – 15686VGQGMP → SGARNA in CAA46780. Ref.1
Sequence conflict1589 – 15913TSW → RSS in CAA46780. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P48681 [UniParc].

Last modified May 1, 2007. Version 2.
Checksum: 0E4F967C11F44C13

FASTA1,621177,439
        10         20         30         40         50         60 
MEGCMGEESF QMWELNRRLE AYLARVKALE EQNELLSAEL GGLRAQSADT SWRAHADDEL 

        70         80         90        100        110        120 
AALRALVDQR WREKHAAEVA RDNLAEELEG VAGRCQQLRL ARERTTEEVA RNRRAVEAEK 

       130        140        150        160        170        180 
CARAWLSSQV AELERELEAL RVAHEEERVG LNAQAACAPR CPAPPRGPPA PAPEVEELAR 

       190        200        210        220        230        240 
RLGEAWRGAV RGYQERVAHM ETSLGQARER LGRAVQGARE GRLELQQLQA ERGGLLERRA 

       250        260        270        280        290        300 
ALEQRLEGRW QERLRATEKF QLAVEALEQE KQGLQSQIAQ VLEGRQQLAH LKMSLSLEVA 

       310        320        330        340        350        360 
TYRTLLEAEN SRLQTPGGGS KTSLSFQDPK LELQFPRTPE GRRLGSLLPV LSPTSLPSPL 

       370        380        390        400        410        420 
PATLETPVPA FLKNQEFLQA RTPTLASTPI PPTPQAPSPA VDAEIRAQDA PLSLLQTQGG 

       430        440        450        460        470        480 
RKQAPEPLRA EARVAIPASV LPGPEEPGGQ RQEASTGQSP EDHASLAPPL SPDHSSLEAK 

       490        500        510        520        530        540 
DGESGGSRVF SICRGEGEGQ IWGLVEKETA IEGKVVSSLQ QEIWEEEDLN RKEIQDSQVP 

       550        560        570        580        590        600 
LEKETLKSLG EEIQESLKTL ENQSHETLER ENQECPRSLE EDLETLKSLE KENKELLKDV 

       610        620        630        640        650        660 
EVVRPLEKEA VGQLKPTGKE DTQTLQSLQK ENQELMKSLE GNLETFLFPG TENQELVSSL 

       670        680        690        700        710        720 
QENLESLTAL EKENQEPLRS PEVGDEEALR PLTKENQEPL RSLEDENKEA FRSLEKENQE 

       730        740        750        760        770        780 
PLKTLEEEDQ SIVRPLETEN HKSLRSLEEQ DQETLRTLEK ETQQRRRSLG EQDQMTLRPP 

       790        800        810        820        830        840 
EKVDLEPLKS LDQEIARPLE NENQEFLKSL KEESVEAVKS LETEILESLK SAGQENLETL 

       850        860        870        880        890        900 
KSPETQAPLW TPEEINQGAM NPLEKEIQEP LESVEVNQET FRLLEEENQE SLRSLGAWNL 

       910        920        930        940        950        960 
ENLRSPEEVD KESQRNLEEE ENLGKGEYQE SLRSLEEEGQ ELPQSADVQR WEDTVEKDQE 

       970        980        990       1000       1010       1020 
LAQESPPGMA GVENEDEAEL NLREQDGFTG KEEVVEQGEL NATEEVWIPG EGHPESPEPK 

      1030       1040       1050       1060       1070       1080 
EQRGLVEGAS VKGGAEGLQD PEGQSQQVGA PGLQAPQGLP EAIEPLVEDD VAPGGDQASP 

      1090       1100       1110       1120       1130       1140 
EVMLGSEPAM GESAAGAEPG PGQGVGGLGD PGHLTREEVM EPPLEEESLE AKRVQGLEGP 

      1150       1160       1170       1180       1190       1200 
RKDLEEAGGL GTEFSELPGK SRDPWEPPRE GREESEAEAP RGAEEAFPAE TLGHTGSDAP 

      1210       1220       1230       1240       1250       1260 
SPWPLGSEEA EEDVPPVLVS PSPTYTPILE DAPGPQPQAE GSQEASWGVQ GRAEALGKVE 

      1270       1280       1290       1300       1310       1320 
SEQEELGSGE IPEGPQEEGE ESREESEEDE LGETLPDSTP LGFYLRSPTS PRWDPTGEQR 

      1330       1340       1350       1360       1370       1380 
PPPQGETGKE GWDPAVLASE GLEAPPSEKE EGEEGEEECG RDSDLSEEFE DLGTEAPFLP 

      1390       1400       1410       1420       1430       1440 
GVPGEVAEPL GQVPQLLLDP AAWDRDGESD GFADEEESGE EGEEDQEEGR EPGAGRWGPG 

      1450       1460       1470       1480       1490       1500 
SSVGSLQALS SSQRGEFLES DSVSVSVPWD DSLRGAVAGA PKTALETESQ DSAEPSGSEE 

      1510       1520       1530       1540       1550       1560 
ESDPVSLERE DKVPGPLEIP SGMEDAGPGA DIIGVNGQGP NLEGKSQHVN GGVMNGLEQS 

      1570       1580       1590       1600       1610       1620 
EEVGQGMPLV SEGDRGSPFQ EEEGSALKTS WAGAPVHLGQ GQFLKFTQRE GDRESWSSGE 


D 

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References

« Hide 'large scale' references
[1]"Characterization of the human nestin gene reveals a close evolutionary relationship to neurofilaments."
Dahlstrand J., McKay R.D.G., Zimmerman L.B., Lendahl U.
J. Cell Sci. 103:589-597(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ASN-1016; LEU-1101 AND LEU-1275.
Tissue: Placenta.
[2]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Heterogeneity of neural progenitor cells revealed by enhancers in the nestin gene."
Yaworsky P.J., Kappen C.
Dev. Biol. 205:309-321(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 297-310.
[4]"Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma."
Ohira M., Morohashi A., Nakamura Y., Isogai E., Furuya K., Hamano S., Machida T., Aoyama M., Fukumura M., Miyazaki K., Suzuki Y., Sugano S., Hirato J., Nakagawara A.
Cancer Lett. 197:63-68(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 604-1621, VARIANT ILE-815.
Tissue: Neuroblastoma.
[5]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-680; SER-1409 AND SER-1418, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[6]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-311; THR-315; SER-325; THR-388; SER-398; SER-471; SER-548; SER-564; SER-578; SER-588; SER-746; SER-768; THR-851; SER-905 AND SER-1418, VARIANT [LARGE SCALE ANALYSIS] LEU-1275, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[7]"Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."
Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J.
Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1418, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
[8]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-358; SER-398; SER-471; SER-548 AND SER-680, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[10]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[11]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-325; SER-355; SER-358; SER-471; SER-548; SER-578; SER-680; SER-746; SER-768; SER-790; SER-820; SER-831; SER-894; SER-905; SER-913; SER-934; SER-1261; SER-1282; SER-1286; SER-1347; SER-1418; SER-1452; SER-1496; SER-1498; SER-1577; SER-1617 AND SER-1618, VARIANT [LARGE SCALE ANALYSIS] LEU-1275, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[12]"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL590666 Genomic DNA. Translation: CAI16338.1.
X65964 Genomic DNA. Translation: CAA46780.1.
AF004335 Genomic DNA. Translation: AAB64426.1.
AB073350 mRNA. Translation: BAE45713.1.
CCDSCCDS1151.1.
PIRS21424.
RefSeqNP_006608.1. NM_006617.1.
UniGeneHs.527971.

3D structure databases

ProteinModelPortalP48681.
SMRP48681. Positions 7-155, 220-311.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115983. 5 interactions.
STRING9606.ENSP00000357206.

PTM databases

PhosphoSiteP48681.

Polymorphism databases

DMDM146345464.

Proteomic databases

MaxQBP48681.
PaxDbP48681.
PRIDEP48681.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000368223; ENSP00000357206; ENSG00000132688.
GeneID10763.
KEGGhsa:10763.
UCSCuc001fpq.3. human.

Organism-specific databases

CTD10763.
GeneCardsGC01M156639.
H-InvDBHIX0001169.
HGNCHGNC:7756. NES.
HPACAB005889.
CAB058692.
HPA007007.
HPA026111.
MIM600915. gene.
neXtProtNX_P48681.
PharmGKBPA31556.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG12793.
HOGENOMHOG000113766.
HOVERGENHBG006463.
InParanoidP48681.
KOK07609.
OMADHASLAP.
OrthoDBEOG773XKP.
PhylomeDBP48681.
TreeFamTF336633.

Gene expression databases

ArrayExpressP48681.
BgeeP48681.
CleanExHS_NES.
GenevestigatorP48681.

Family and domain databases

InterProIPR001664. IF.
IPR018039. Intermediate_filament_CS.
[Graphical view]
PANTHERPTHR23239. PTHR23239. 1 hit.
PfamPF00038. Filament. 2 hits.
[Graphical view]
PROSITEPS00226. IF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiNestin_(protein).
GenomeRNAi10763.
NextBio40873.
PROP48681.
SOURCESearch...

Entry information

Entry nameNEST_HUMAN
AccessionPrimary (citable) accession number: P48681
Secondary accession number(s): O00552, Q3LIF5, Q5SYZ6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: May 1, 2007
Last modified: July 9, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM