P48668 (K2C6C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Keratin, type II cytoskeletal 6C

Alternative name(s):
Cytokeratin-6C
Short name=CK-6C
Cytokeratin-6E
Short name=CK-6E
Keratin K6h
Keratin-6C
Short name=K6C
Type-II keratin Kb12

Gene names

Name:	KRT6C
Synonyms:	KRT6E

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	564 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Heterodimer of a type I and a type II keratin. KRT6 isomers associate with KRT16 and/or KRT17.
Tissue specificity	Constitutively expressed in distinct types of epithelia such as those in oral mucosa, esophagus, papillae of tongue and hair follicle outer root sheath.
Miscellaneous	There are at least six isoforms of human type II keratin-6 (K6). There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).
Sequence similarities	Belongs to the intermediate filament family.

Ontologies

Keywords
Cellular component	Intermediate filament Keratin
Coding sequence diversity	Polymorphism
Domain	Coiled coil
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	cytoskeleton organization Non-traceable author statement. Source: UniProtKB
Cellular_component	intermediate filament Non-traceable author statement Ref.6. Source: UniProtKB keratin filament Inferred from electronic annotation. Source: InterPro
Molecular_function	structural molecule activity Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.4
	Chain	2 – 564	563	Keratin, type II cytoskeletal 6C		PRO_0000063735
Regions
	Region	2 – 162	161	Head
	Region	163 – 472	310	Rod
	Region	163 – 198	36	Coil 1A
	Region	199 – 217	19	Linker 1
	Region	218 – 309	92	Coil 1B
	Region	310 – 333	24	Linker 12
	Region	334 – 472	139	Coil 2
	Region	473 – 564	92	Tail
Sites
	Site	414	1	Stutter
Amino acid modifications
	Modified residue	2	1	N-acetylalanine Ref.4
	Modified residue	60	1	Phosphoserine Ref.6
Natural variations
	Natural variant	182	1	R → Q. Ref.3 Corresponds to variant rs11608915 [ dbSNP | Ensembl ].		VAR_035031
	Natural variant	227	1	S → N. Ref.1 Corresponds to variant rs17099602 [ dbSNP | Ensembl ].		VAR_035032
	Natural variant	481	1	V → I. Ref.1 Corresponds to variant rs412533 [ dbSNP | Ensembl ].		VAR_035033
Experimental info
	Sequence conflict	88	1	G → R in AAC41770. Ref.1
	Sequence conflict	88	1	G → R in AAC41769. Ref.1
	Sequence conflict	89	1	G → A in AAC41769. Ref.1
	Sequence conflict	111	1	G → D in AAC41770. Ref.1
	Sequence conflict	111	1	G → D in AAC41769. Ref.1
	Sequence conflict	192	1	D → E in AAC41769. Ref.1
	Sequence conflict	241	1	N → G in AAC41769. Ref.1
	Sequence conflict	249	1	L → F in AAC41769. Ref.1
	Sequence conflict	404	1	S → N in AAC41769. Ref.1
	Sequence conflict	486	1	V → I in AAC41769. Ref.1
	Sequence conflict	493	1	I → V in AAC41769. Ref.1
	Sequence conflict	523	1	I → V in AAC41769. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P48668 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: FABEABD829A75612	FASTA	564	60,025
	10 20 30 40 50 60 MASTSTTIRS HSSSRRGFSA NSARLPGVSR SGFSSISVSR SRGSGGLGGA CGGAGFGSRS 70 80 90 100 110 120 LYGLGGSKRI SIGGGSCAIS GGYGSRAGGS YGFGGAGSGF GFGGGAGIGF GLGGGAGLAG 130 140 150 160 170 180 GFGGPGFPVC PPGGIQEVTV NQSLLTPLNL QIDPAIQRVR AEEREQIKTL NNKFASFIDK 190 200 210 220 230 240 VRFLEQQNKV LDTKWTLLQE QGTKTVRQNL EPLFEQYINN LRRQLDSIVG ERGRLDSELR 250 260 270 280 290 300 NMQDLVEDLK NKYEDEINKR TAAENEFVTL KKDVDAAYMN KVELQAKADT LTDEINFLRA 310 320 330 340 350 360 LYDAELSQMQ THISDTSVVL SMDNNRNLDL DSIIAEVKAQ YEEIAQRSRA EAESWYQTKY 370 380 390 400 410 420 EELQVTAGRH GDDLRNTKQE IAEINRMIQR LRSEIDHVKK QCASLQAAIA DAEQRGEMAL 430 440 450 460 470 480 KDAKNKLEGL EDALQKAKQD LARLLKEYQE LMNVKLALDV EIATYRKLLE GEECRLNGEG 490 500 510 520 530 540 VGQVNVSVVQ STISSGYGGA SGVGSGLGLG GGSSYSYGSG LGIGGGFSSS SGRAIGGGLS 550 560 SVGGGSSTIK YTTTSSSSRK SYKH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of multiple human genes and cDNAs encoding highly related type II keratin 6 isoforms." Takahashi K., Paladini R.D., Coulombe P.A. J. Biol. Chem. 270:18581-18592(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANTS ASN-227 AND ILE-481. Tissue: Skin.
[2]	"The finished DNA sequence of human chromosome 12." Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A. Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-182. Tissue: Skin.
[4]	Bienvenut W.V., Vousden K.H., Lukashchuk N. Submitted (MAR-2008) to UniProtKB Cited for: PROTEIN SEQUENCE OF 2-9; 16-24; 31-40; 43-86; 169-189; 195-204; 208-222; 224-369; 376-386; 425-436; 456-475 AND 534-550, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, MASS SPECTROMETRY. Tissue: Lung carcinoma.
[5]	"Genes for intermediate filament proteins and the draft sequence of the human genome: novel keratin genes and a surprisingly high number of pseudogenes related to keratin genes 8 and 18." Hesse M., Magin T.M., Weber K. J. Cell Sci. 114:2569-2575(2001) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[6]	"Phosphorylation of human keratin 8 in vivo at conserved head domain serine 23 and at epidermal growth factor-stimulated tail domain serine 431." Ku N.-O., Omary M.B. J. Biol. Chem. 272:7556-7564(1997) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION AT SER-60.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L42611 mRNA. Translation: AAC41770.1. L42601 , L42593, L42594, L42595, L42596, L42597, L42598, L42599 Genomic DNA. Translation: AAC41769.1. AC055736 Genomic DNA. No translation available. BC110639 mRNA. Translation: AAI10640.1. BC130583 mRNA. Translation: AAI30584.1. BC130585 mRNA. Translation: AAI30586.1. BK000962 Genomic DNA. Translation: DAA01484.1.
IPI	IPI00299145.
PIR	I61768. I61770.
RefSeq	NP_775109.2. NM_173086.4.
UniGene	Hs.700779. Hs.709234.
3D structure databases
ProteinModelPortal	P48668.
ModBase	Search...
Protein-protein interaction databases
IntAct	P48668. 4 interactions.
PTM databases
PhosphoSite	P48668.
Polymorphism databases
DMDM	59803089.
Proteomic databases
PaxDb	P48668.
PRIDE	P48668.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000252250; ENSP00000252250; ENSG00000170465.
GeneID	286887.
KEGG	hsa:286887.
UCSC	uc001sal.4. human.
Organism-specific databases
CTD	286887.
GeneCards	GC12M052865.
HGNC	HGNC:20406. KRT6C.
HPA	HPA045697.
MIM	612315. gene.
neXtProt	NX_P48668.
Orphanet	496. Thost-Unna palmoplantar keratoderma.
PharmGKB	PA134891227.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG315845.
HOGENOM	HOG000230976.
HOVERGEN	HBG013015.
InParanoid	P48668.
KO	K07605.
OMA	QTITHRG.
PhylomeDB	P48668.
Gene expression databases
Bgee	P48668.
CleanEx	HS_KRT6C.
Genevestigator	P48668.
GermOnline	ENSG00000170465. Homo sapiens.
Family and domain databases
InterPro	IPR016044. F. IPR001664. IF. IPR018039. Intermediate_filament_CS. IPR003054. Keratin_II. [Graphical view]
PANTHER	PTHR23239. PTHR23239. 1 hit. PTHR23239:SF18. PTHR23239:SF18. 1 hit.
Pfam	PF00038. Filament. 1 hit. [Graphical view]
PRINTS	PR01276. TYPE2KERATIN.
PROSITE	PS00226. IF. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	286887.
NextBio	96315.
SOURCE	Search...

Entry information

Entry name

K2C6C_HUMAN

Accession

Primary (citable) accession number: P48668
Secondary accession number(s): A1L4L5 , P48666, Q2TAZ9, Q7RTN9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 120 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.