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P48668

- K2C6C_HUMAN

UniProt

P48668 - K2C6C_HUMAN

Protein

Keratin, type II cytoskeletal 6C

Gene

KRT6C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 132 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei414 – 4141Stutter

    GO - Molecular functioni

    1. structural molecule activity Source: InterPro

    GO - Biological processi

    1. intermediate filament cytoskeleton organization Source: UniProt

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Keratin, type II cytoskeletal 6C
    Alternative name(s):
    Cytokeratin-6C
    Short name:
    CK-6C
    Cytokeratin-6E
    Short name:
    CK-6E
    Keratin K6h
    Keratin-6C
    Short name:
    K6C
    Type-II keratin Kb12
    Gene namesi
    Name:KRT6C
    Synonyms:KRT6E
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:20406. KRT6C.

    Subcellular locationi

    GO - Cellular componenti

    1. intermediate filament Source: UniProtKB
    2. keratin filament Source: InterPro

    Keywords - Cellular componenti

    Intermediate filament, Keratin

    Pathology & Biotechi

    Organism-specific databases

    Orphaneti2199. Epidermolytic palmoplantar keratoderma.
    PharmGKBiPA134891227.

    Protein family/group databases

    Allergomei415. Hom s 5.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 564563Keratin, type II cytoskeletal 6CPRO_0000063735Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication
    Modified residuei60 – 601Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiP48668.
    PaxDbiP48668.
    PRIDEiP48668.

    PTM databases

    PhosphoSiteiP48668.

    Expressioni

    Tissue specificityi

    Constitutively expressed in distinct types of epithelia such as those in oral mucosa, esophagus, papillae of tongue and hair follicle outer root sheath.

    Gene expression databases

    BgeeiP48668.
    CleanExiHS_KRT6C.
    GenevestigatoriP48668.

    Organism-specific databases

    HPAiHPA045697.

    Interactioni

    Subunit structurei

    Heterodimer of a type I and a type II keratin. KRT6 isomers associate with KRT16 and/or KRT17.

    Protein-protein interaction databases

    BioGridi130423. 10 interactions.
    IntActiP48668. 4 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP48668.
    SMRiP48668. Positions 160-302, 329-471.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni2 – 162161HeadAdd
    BLAST
    Regioni163 – 472310RodAdd
    BLAST
    Regioni163 – 19836Coil 1AAdd
    BLAST
    Regioni199 – 21719Linker 1Add
    BLAST
    Regioni218 – 30992Coil 1BAdd
    BLAST
    Regioni310 – 33324Linker 12Add
    BLAST
    Regioni334 – 472139Coil 2Add
    BLAST
    Regioni473 – 56492TailAdd
    BLAST

    Sequence similaritiesi

    Belongs to the intermediate filament family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG315845.
    HOGENOMiHOG000230976.
    HOVERGENiHBG013015.
    InParanoidiP48668.
    KOiK07605.
    OMAiTEINRMI.
    OrthoDBiEOG7FV3Q8.
    PhylomeDBiP48668.
    TreeFamiTF317854.

    Family and domain databases

    InterProiIPR001664. IF.
    IPR018039. Intermediate_filament_CS.
    IPR003054. Keratin_II.
    [Graphical view]
    PANTHERiPTHR23239. PTHR23239. 1 hit.
    PfamiPF00038. Filament. 1 hit.
    [Graphical view]
    PRINTSiPR01276. TYPE2KERATIN.
    PROSITEiPS00226. IF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P48668-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASTSTTIRS HSSSRRGFSA NSARLPGVSR SGFSSISVSR SRGSGGLGGA    50
    CGGAGFGSRS LYGLGGSKRI SIGGGSCAIS GGYGSRAGGS YGFGGAGSGF 100
    GFGGGAGIGF GLGGGAGLAG GFGGPGFPVC PPGGIQEVTV NQSLLTPLNL 150
    QIDPAIQRVR AEEREQIKTL NNKFASFIDK VRFLEQQNKV LDTKWTLLQE 200
    QGTKTVRQNL EPLFEQYINN LRRQLDSIVG ERGRLDSELR NMQDLVEDLK 250
    NKYEDEINKR TAAENEFVTL KKDVDAAYMN KVELQAKADT LTDEINFLRA 300
    LYDAELSQMQ THISDTSVVL SMDNNRNLDL DSIIAEVKAQ YEEIAQRSRA 350
    EAESWYQTKY EELQVTAGRH GDDLRNTKQE IAEINRMIQR LRSEIDHVKK 400
    QCASLQAAIA DAEQRGEMAL KDAKNKLEGL EDALQKAKQD LARLLKEYQE 450
    LMNVKLALDV EIATYRKLLE GEECRLNGEG VGQVNVSVVQ STISSGYGGA 500
    SGVGSGLGLG GGSSYSYGSG LGIGGGFSSS SGRAIGGGLS SVGGGSSTIK 550
    YTTTSSSSRK SYKH 564
    Length:564
    Mass (Da):60,025
    Last modified:January 23, 2007 - v3
    Checksum:iFABEABD829A75612
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti88 – 881G → R in AAC41770. (PubMed:7543104)Curated
    Sequence conflicti88 – 881G → R in AAC41769. (PubMed:7543104)Curated
    Sequence conflicti89 – 891G → A in AAC41769. (PubMed:7543104)Curated
    Sequence conflicti111 – 1111G → D in AAC41770. (PubMed:7543104)Curated
    Sequence conflicti111 – 1111G → D in AAC41769. (PubMed:7543104)Curated
    Sequence conflicti192 – 1921D → E in AAC41769. (PubMed:7543104)Curated
    Sequence conflicti241 – 2411N → G in AAC41769. (PubMed:7543104)Curated
    Sequence conflicti249 – 2491L → F in AAC41769. (PubMed:7543104)Curated
    Sequence conflicti404 – 4041S → N in AAC41769. (PubMed:7543104)Curated
    Sequence conflicti486 – 4861V → I in AAC41769. (PubMed:7543104)Curated
    Sequence conflicti493 – 4931I → V in AAC41769. (PubMed:7543104)Curated
    Sequence conflicti523 – 5231I → V in AAC41769. (PubMed:7543104)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti182 – 1821R → Q.1 Publication
    Corresponds to variant rs11608915 [ dbSNP | Ensembl ].
    VAR_035031
    Natural varianti227 – 2271S → N.1 Publication
    Corresponds to variant rs17099602 [ dbSNP | Ensembl ].
    VAR_035032
    Natural varianti481 – 4811V → I.1 Publication
    Corresponds to variant rs412533 [ dbSNP | Ensembl ].
    VAR_035033

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42611 mRNA. Translation: AAC41770.1.
    L42601
    , L42593, L42594, L42595, L42596, L42597, L42598, L42599 Genomic DNA. Translation: AAC41769.1.
    AC055736 Genomic DNA. No translation available.
    BC110639 mRNA. Translation: AAI10640.1.
    BC130583 mRNA. Translation: AAI30584.1.
    BC130585 mRNA. Translation: AAI30586.1.
    BK000962 Genomic DNA. Translation: DAA01484.1.
    CCDSiCCDS8829.1.
    PIRiI61768.
    I61770.
    RefSeqiNP_775109.2. NM_173086.4.
    UniGeneiHs.700779.
    Hs.709234.

    Genome annotation databases

    EnsembliENST00000252250; ENSP00000252250; ENSG00000170465.
    GeneIDi286887.
    KEGGihsa:286887.
    UCSCiuc001sal.4. human.

    Polymorphism databases

    DMDMi59803089.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42611 mRNA. Translation: AAC41770.1 .
    L42601
    , L42593 , L42594 , L42595 , L42596 , L42597 , L42598 , L42599 Genomic DNA. Translation: AAC41769.1 .
    AC055736 Genomic DNA. No translation available.
    BC110639 mRNA. Translation: AAI10640.1 .
    BC130583 mRNA. Translation: AAI30584.1 .
    BC130585 mRNA. Translation: AAI30586.1 .
    BK000962 Genomic DNA. Translation: DAA01484.1 .
    CCDSi CCDS8829.1.
    PIRi I61768.
    I61770.
    RefSeqi NP_775109.2. NM_173086.4.
    UniGenei Hs.700779.
    Hs.709234.

    3D structure databases

    ProteinModelPortali P48668.
    SMRi P48668. Positions 160-302, 329-471.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 130423. 10 interactions.
    IntActi P48668. 4 interactions.

    Protein family/group databases

    Allergomei 415. Hom s 5.

    PTM databases

    PhosphoSitei P48668.

    Polymorphism databases

    DMDMi 59803089.

    Proteomic databases

    MaxQBi P48668.
    PaxDbi P48668.
    PRIDEi P48668.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000252250 ; ENSP00000252250 ; ENSG00000170465 .
    GeneIDi 286887.
    KEGGi hsa:286887.
    UCSCi uc001sal.4. human.

    Organism-specific databases

    CTDi 286887.
    GeneCardsi GC12M052865.
    HGNCi HGNC:20406. KRT6C.
    HPAi HPA045697.
    MIMi 612315. gene.
    neXtProti NX_P48668.
    Orphaneti 2199. Epidermolytic palmoplantar keratoderma.
    PharmGKBi PA134891227.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG315845.
    HOGENOMi HOG000230976.
    HOVERGENi HBG013015.
    InParanoidi P48668.
    KOi K07605.
    OMAi TEINRMI.
    OrthoDBi EOG7FV3Q8.
    PhylomeDBi P48668.
    TreeFami TF317854.

    Miscellaneous databases

    GenomeRNAii 286887.
    NextBioi 96315.
    PROi P48668.
    SOURCEi Search...

    Gene expression databases

    Bgeei P48668.
    CleanExi HS_KRT6C.
    Genevestigatori P48668.

    Family and domain databases

    InterProi IPR001664. IF.
    IPR018039. Intermediate_filament_CS.
    IPR003054. Keratin_II.
    [Graphical view ]
    PANTHERi PTHR23239. PTHR23239. 1 hit.
    Pfami PF00038. Filament. 1 hit.
    [Graphical view ]
    PRINTSi PR01276. TYPE2KERATIN.
    PROSITEi PS00226. IF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of multiple human genes and cDNAs encoding highly related type II keratin 6 isoforms."
      Takahashi K., Paladini R.D., Coulombe P.A.
      J. Biol. Chem. 270:18581-18592(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANTS ASN-227 AND ILE-481.
      Tissue: Skin.
    2. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-182.
      Tissue: Skin.
    4. Bienvenut W.V., Vousden K.H., Lukashchuk N.
      Submitted (MAR-2008) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 2-9; 16-24; 31-40; 43-86; 169-189; 195-204; 208-222; 224-369; 376-386; 425-436; 456-475 AND 534-550, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Lung carcinoma.
    5. "Genes for intermediate filament proteins and the draft sequence of the human genome: novel keratin genes and a surprisingly high number of pseudogenes related to keratin genes 8 and 18."
      Hesse M., Magin T.M., Weber K.
      J. Cell Sci. 114:2569-2575(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    6. "Phosphorylation of human keratin 8 in vivo at conserved head domain serine 23 and at epidermal growth factor-stimulated tail domain serine 431."
      Ku N.-O., Omary M.B.
      J. Biol. Chem. 272:7556-7564(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-60.

    Entry informationi

    Entry nameiK2C6C_HUMAN
    AccessioniPrimary (citable) accession number: P48668
    Secondary accession number(s): A1L4L5
    , P48666, Q2TAZ9, Q7RTN9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 132 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    There are at least six isoforms of human type II keratin-6 (K6).
    There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3