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P48668 (K2C6C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 131. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Keratin, type II cytoskeletal 6C
Alternative name(s):
Cytokeratin-6C
Short name=CK-6C
Cytokeratin-6E
Short name=CK-6E
Keratin K6h
Keratin-6C
Short name=K6C
Type-II keratin Kb12
Gene names
Name:KRT6C
Synonyms:KRT6E
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length564 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Heterodimer of a type I and a type II keratin. KRT6 isomers associate with KRT16 and/or KRT17.

Tissue specificity

Constitutively expressed in distinct types of epithelia such as those in oral mucosa, esophagus, papillae of tongue and hair follicle outer root sheath.

Miscellaneous

There are at least six isoforms of human type II keratin-6 (K6).

There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).

Sequence similarities

Belongs to the intermediate filament family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.4
Chain2 – 564563Keratin, type II cytoskeletal 6C
PRO_0000063735

Regions

Region2 – 162161Head
Region163 – 472310Rod
Region163 – 19836Coil 1A
Region199 – 21719Linker 1
Region218 – 30992Coil 1B
Region310 – 33324Linker 12
Region334 – 472139Coil 2
Region473 – 56492Tail

Sites

Site4141Stutter

Amino acid modifications

Modified residue21N-acetylalanine Ref.4
Modified residue601Phosphoserine Ref.6

Natural variations

Natural variant1821R → Q. Ref.3
Corresponds to variant rs11608915 [ dbSNP | Ensembl ].
VAR_035031
Natural variant2271S → N. Ref.1
Corresponds to variant rs17099602 [ dbSNP | Ensembl ].
VAR_035032
Natural variant4811V → I. Ref.1
Corresponds to variant rs412533 [ dbSNP | Ensembl ].
VAR_035033

Experimental info

Sequence conflict881G → R in AAC41770. Ref.1
Sequence conflict881G → R in AAC41769. Ref.1
Sequence conflict891G → A in AAC41769. Ref.1
Sequence conflict1111G → D in AAC41770. Ref.1
Sequence conflict1111G → D in AAC41769. Ref.1
Sequence conflict1921D → E in AAC41769. Ref.1
Sequence conflict2411N → G in AAC41769. Ref.1
Sequence conflict2491L → F in AAC41769. Ref.1
Sequence conflict4041S → N in AAC41769. Ref.1
Sequence conflict4861V → I in AAC41769. Ref.1
Sequence conflict4931I → V in AAC41769. Ref.1
Sequence conflict5231I → V in AAC41769. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P48668 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: FABEABD829A75612

FASTA56460,025
        10         20         30         40         50         60 
MASTSTTIRS HSSSRRGFSA NSARLPGVSR SGFSSISVSR SRGSGGLGGA CGGAGFGSRS 

        70         80         90        100        110        120 
LYGLGGSKRI SIGGGSCAIS GGYGSRAGGS YGFGGAGSGF GFGGGAGIGF GLGGGAGLAG 

       130        140        150        160        170        180 
GFGGPGFPVC PPGGIQEVTV NQSLLTPLNL QIDPAIQRVR AEEREQIKTL NNKFASFIDK 

       190        200        210        220        230        240 
VRFLEQQNKV LDTKWTLLQE QGTKTVRQNL EPLFEQYINN LRRQLDSIVG ERGRLDSELR 

       250        260        270        280        290        300 
NMQDLVEDLK NKYEDEINKR TAAENEFVTL KKDVDAAYMN KVELQAKADT LTDEINFLRA 

       310        320        330        340        350        360 
LYDAELSQMQ THISDTSVVL SMDNNRNLDL DSIIAEVKAQ YEEIAQRSRA EAESWYQTKY 

       370        380        390        400        410        420 
EELQVTAGRH GDDLRNTKQE IAEINRMIQR LRSEIDHVKK QCASLQAAIA DAEQRGEMAL 

       430        440        450        460        470        480 
KDAKNKLEGL EDALQKAKQD LARLLKEYQE LMNVKLALDV EIATYRKLLE GEECRLNGEG 

       490        500        510        520        530        540 
VGQVNVSVVQ STISSGYGGA SGVGSGLGLG GGSSYSYGSG LGIGGGFSSS SGRAIGGGLS 

       550        560 
SVGGGSSTIK YTTTSSSSRK SYKH 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterization of multiple human genes and cDNAs encoding highly related type II keratin 6 isoforms."
Takahashi K., Paladini R.D., Coulombe P.A.
J. Biol. Chem. 270:18581-18592(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANTS ASN-227 AND ILE-481.
Tissue: Skin.
[2]"The finished DNA sequence of human chromosome 12."
Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. expand/collapse author list , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-182.
Tissue: Skin.
[4]Bienvenut W.V., Vousden K.H., Lukashchuk N.
Submitted (MAR-2008) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 2-9; 16-24; 31-40; 43-86; 169-189; 195-204; 208-222; 224-369; 376-386; 425-436; 456-475 AND 534-550, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
Tissue: Lung carcinoma.
[5]"Genes for intermediate filament proteins and the draft sequence of the human genome: novel keratin genes and a surprisingly high number of pseudogenes related to keratin genes 8 and 18."
Hesse M., Magin T.M., Weber K.
J. Cell Sci. 114:2569-2575(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[6]"Phosphorylation of human keratin 8 in vivo at conserved head domain serine 23 and at epidermal growth factor-stimulated tail domain serine 431."
Ku N.-O., Omary M.B.
J. Biol. Chem. 272:7556-7564(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION AT SER-60.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42611 mRNA. Translation: AAC41770.1.
L42601 expand/collapse EMBL AC list , L42593, L42594, L42595, L42596, L42597, L42598, L42599 Genomic DNA. Translation: AAC41769.1.
AC055736 Genomic DNA. No translation available.
BC110639 mRNA. Translation: AAI10640.1.
BC130583 mRNA. Translation: AAI30584.1.
BC130585 mRNA. Translation: AAI30586.1.
BK000962 Genomic DNA. Translation: DAA01484.1.
CCDSCCDS8829.1.
PIRI61768.
I61770.
RefSeqNP_775109.2. NM_173086.4.
UniGeneHs.700779.
Hs.709234.

3D structure databases

ProteinModelPortalP48668.
SMRP48668. Positions 160-302, 329-471.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid130423. 10 interactions.
IntActP48668. 4 interactions.

Protein family/group databases

Allergome415. Hom s 5.

PTM databases

PhosphoSiteP48668.

Polymorphism databases

DMDM59803089.

Proteomic databases

MaxQBP48668.
PaxDbP48668.
PRIDEP48668.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000252250; ENSP00000252250; ENSG00000170465.
GeneID286887.
KEGGhsa:286887.
UCSCuc001sal.4. human.

Organism-specific databases

CTD286887.
GeneCardsGC12M052865.
HGNCHGNC:20406. KRT6C.
HPAHPA045697.
MIM612315. gene.
neXtProtNX_P48668.
Orphanet2199. Epidermolytic palmoplantar keratoderma.
PharmGKBPA134891227.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG315845.
HOGENOMHOG000230976.
HOVERGENHBG013015.
InParanoidP48668.
KOK07605.
OMATEINRMI.
OrthoDBEOG7FV3Q8.
PhylomeDBP48668.
TreeFamTF317854.

Gene expression databases

BgeeP48668.
CleanExHS_KRT6C.
GenevestigatorP48668.

Family and domain databases

InterProIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR003054. Keratin_II.
[Graphical view]
PANTHERPTHR23239. PTHR23239. 1 hit.
PfamPF00038. Filament. 1 hit.
[Graphical view]
PRINTSPR01276. TYPE2KERATIN.
PROSITEPS00226. IF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi286887.
NextBio96315.
PROP48668.
SOURCESearch...

Entry information

Entry nameK2C6C_HUMAN
AccessionPrimary (citable) accession number: P48668
Secondary accession number(s): A1L4L5 expand/collapse secondary AC list , P48666, Q2TAZ9, Q7RTN9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 131 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM