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P48651 (PTSS1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphatidylserine synthase 1
Short name=PSS-1
Short name=PtdSer synthase 1
EC=2.7.8.-
Alternative name(s):
Serine-exchange enzyme I
Gene names
Name:PTDSS1
Synonyms:KIAA0024, PSSA
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length473 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes a base-exchange reaction in which the polar head group of phosphatidylcholine is replaced by L-serine By similarity.

Pathway

Phospholipid metabolism; phosphatidylserine biosynthesis.

Subcellular location

Membrane; Multi-pass membrane protein.

Miscellaneous

May provide a precursor for the biosynthesis of phosphatidylethanolamine. Phosphatidylserine can be decarboxylated to phosphatidylethanolamine.

Sequence similarities

Belongs to the phosphatidyl serine synthase family.

Ontologies

Keywords
   Biological processPhospholipid biosynthesis
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   Molecular functionTransferase
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processphosphatidylserine biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functiontransferase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 473473Phosphatidylserine synthase 1
PRO_0000056829

Regions

Transmembrane36 – 5621Helical; Potential
Transmembrane73 – 9321Helical; Potential
Transmembrane103 – 12321Helical; Potential
Transmembrane161 – 18121Helical; Potential
Transmembrane187 – 20721Helical; Potential
Transmembrane217 – 23721Helical; Potential
Transmembrane287 – 30721Helical; Potential
Transmembrane310 – 33021Helical; Potential
Transmembrane356 – 37621Helical; Potential
Transmembrane384 – 40421Helical; Potential

Amino acid modifications

Modified residue4171Phosphoserine Ref.6
Modified residue4241Phosphotyrosine Ref.4
Modified residue4251Phosphoserine Ref.3 Ref.4 Ref.6
Modified residue4421Phosphoserine Ref.5 Ref.7

Natural variations

Natural variant4231T → N.
Corresponds to variant rs7835798 [ dbSNP | Ensembl ].
VAR_048735

Sequences

Sequence LengthMass (Da)Tools
P48651 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: CFC8F50A33CE038D

FASTA47355,528
        10         20         30         40         50         60 
MASCVGSRTL SKDDVNYKMH FRMINEQQVE DITIDFFYRP HTITLLSFTI VSLMYFAFTR 

        70         80         90        100        110        120 
DDSVPEDNIW RGILSVIFFF LIISVLAFPN GPFTRPHPAL WRMVFGLSVL YFLFLVFLLF 

       130        140        150        160        170        180 
LNFEQVKSLM YWLDPNLRYA TREADVMEYA VNCHVITWER IISHFDIFAF GHFWGWAMKA 

       190        200        210        220        230        240 
LLIRSYGLCW TISITWELTE LFFMHLLPNF AECWWDQVIL DILLCNGGGI WLGMVVCRFL 

       250        260        270        280        290        300 
EMRTYHWASF KDIHTTTGKI KRAVLQFTPA SWTYVRWFDP KSSFQRVAGV YLFMIIWQLT 

       310        320        330        340        350        360 
ELNTFFLKHI FVFQASHPLS WGRILFIGGI TAPTVRQYYA YLTDTQCKRV GTQCWVFGVI 

       370        380        390        400        410        420 
GFLEAIVCIK FGQDLFSKTQ ILYVVLWLLC VAFTTFLCLY GMIWYAEHYG HREKTYSECE 

       430        440        450        460        470 
DGTYSPEISW HHRKGTKGSE DSPPKHAGNN ESHSSRRRNR HSKSKVTNGV GKK

« Hide

References

[1]"Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1."
Nomura N., Miyajima N., Sazuka T., Tanaka A., Kawarabayasi Y., Sato S., Nagase T., Seki N., Ishikawa K., Tabata S.
DNA Res. 1:27-35(1994) [PubMed: 7584026] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Bone marrow.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain and Lymph.
[3]"Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis."
Wang B., Malik R., Nigg E.A., Korner R.
Anal. Chem. 80:9526-9533(2008) [PubMed: 19007248] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-425, MASS SPECTROMETRY.
Tissue: Cervix carcinoma.
[4]"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
J. Proteome Res. 7:1346-1351(2008) [PubMed: 18220336] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-424 AND SER-425, MASS SPECTROMETRY.
Tissue: Cervix carcinoma.
[5]"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-442, MASS SPECTROMETRY.
Tissue: Cervix carcinoma.
[6]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-417 AND SER-425, MASS SPECTROMETRY.
Tissue: Cervix carcinoma.
[7]"Large-scale proteomics analysis of the human kinome."
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H.
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed: 19369195] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-442, MASS SPECTROMETRY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		D14694 mRNA. Translation: BAA03520.1.
BC004192 mRNA. Translation: AAH04192.1.
BC004390 mRNA. Translation: AAH04390.1.
IPIIPI00010746.
RefSeqNP_055569.1. NM_014754.1.
UniGeneHs.292579.

3D structure databases

ProteinModelPortalP48651.
ModBaseSearch...

Protein-protein interaction databases

STRINGP48651.

PTM databases

PhosphoSiteP48651.

Polymorphism databases

DMDM1346881.

Proteomic databases

PeptideAtlasP48651.
PRIDEP48651.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000337004; ENSP00000337331; ENSG00000156471.
GeneID9791.
KEGGhsa:9791.
UCSCuc003yht.1. human.

Organism-specific databases

CTD9791.
GeneCardsGC08P097343.
H-InvDBHIX0007665.
HGNCHGNC:9587. PTDSS1.
HPAHPA016852.
MIM612792. gene.
neXtProtNX_P48651.
PharmGKBPA33939.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG07811.
GeneTreeENSGT00530000063576.
HOGENOMHBG557778.
HOVERGENHBG053765.
InParanoidP48651.
OMAEFFYRPH.
OrthoDBEOG4PNXGW.
PhylomeDBP48651.

Enzyme and pathway databases

BioCycMetaCyc:ENSG00000156471-MONOMER.

Gene expression databases

ArrayExpressP48651.
BgeeP48651.
CleanExHS_PTDSS1.
GenevestigatorP48651.

Family and domain databases

InterProIPR004277. PSS.
[Graphical view]
KOK08729.
PANTHERPTHR12615. PSS. 1 hit.
PfamPF03034. PSS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

DrugBankDB00144. Phosphatidylserine.
NextBio36870.
SOURCESearch...

Entry information

Entry namePTSS1_HUMAN
AccessionPrimary (citable) accession number: P48651
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: January 25, 2012
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents