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Protein

Neuromedin-U

Gene

NMU

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates contractions of the ileum and urinary bladder.

GO - Molecular functioni

  • receptor binding Source: ProtInc

GO - Biological processi

  • digestion Source: ProtInc
  • eating behavior Source: Ensembl
  • gastric acid secretion Source: Ensembl
  • G-protein coupled receptor signaling pathway Source: ProtInc
  • neuropeptide signaling pathway Source: UniProtKB-KW
  • photoperiodism Source: Ensembl
  • positive regulation of hormone secretion Source: Ensembl
  • positive regulation of smooth muscle contraction Source: Ensembl
  • positive regulation of synaptic transmission Source: Ensembl
  • regulation of smooth muscle contraction Source: ProtInc
  • sensory perception of pain Source: Ensembl
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Neuropeptide

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuromedin-U
Cleaved into the following chain:
Neuromedin-U-25
Short name:
NmU-25
Gene namesi
Name:NMU
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:7859. NMU.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31663.

Polymorphism and mutation databases

BioMutaiNMU.
DMDMi1346685.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434Sequence AnalysisAdd
BLAST
Propeptidei35 – 10369PRO_0000019772Add
BLAST
Propeptidei104 – 13835By similarityPRO_0000262495Add
BLAST
Propeptidei139 – 1413By similarityPRO_0000262496
Peptidei142 – 16625Neuromedin-U-25PRO_0000019773Add
BLAST
Propeptidei170 – 1745PRO_0000019774

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei166 – 1661Asparagine amideBy similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

MaxQBiP48645.
PRIDEiP48645.

Expressioni

Tissue specificityi

Expressed throughout the enteric nervous system with highest levels being found in the jejunum.

Gene expression databases

BgeeiP48645.
CleanExiHS_NMU.
ExpressionAtlasiP48645. baseline and differential.
GenevisibleiP48645. HS.

Organism-specific databases

HPAiHPA025926.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRTAP5-9P263713EBI-10210351,EBI-3958099
NOTCH2NLQ7Z3S93EBI-10210351,EBI-945833

Protein-protein interaction databases

BioGridi116082. 12 interactions.
IntActiP48645. 3 interactions.
STRINGi9606.ENSP00000264218.

Structurei

3D structure databases

ProteinModelPortaliP48645.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NmU family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG47198.
GeneTreeiENSGT00510000048726.
HOGENOMiHOG000113806.
HOVERGENiHBG000378.
InParanoidiP48645.
KOiK05249.
OMAiFQSPFAS.
OrthoDBiEOG7SJD6G.
PhylomeDBiP48645.
TreeFamiTF338319.

Family and domain databases

InterProiIPR018070. Neuromedin-U_amidation-site.
IPR008200. NMU_C.
[Graphical view]
PfamiPF02070. NMU. 1 hit.
[Graphical view]
SMARTiSM00084. NMU. 1 hit.
[Graphical view]
PROSITEiPS00967. NMU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48645-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRTESCRPR SPAGQVAAAS PLLLLLLLLA WCAGACRGAP ILPQGLQPEQ
60 70 80 90 100
QLQLWNEIDD TCSSFLSIDS QPQASNALEE LCFMIMGMLP KPQEQDEKDN
110 120 130 140 150
TKRFLFHYSK TQKLGKSNVV SSVVHPLLQL VPHLHERRMK RFRVDEEFQS
160 170
PFASQSRGYF LFRPRNGRRS AGFI
Length:174
Mass (Da):19,741
Last modified:February 1, 1996 - v1
Checksum:i8ABD8138769FA815
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti79 – 791E → G.
Corresponds to variant rs35892915 [ dbSNP | Ensembl ].
VAR_053538
Natural varianti148 – 1481F → L.
Corresponds to variant rs12108463 [ dbSNP | Ensembl ].
VAR_053539

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76029 mRNA. Translation: CAA53619.1.
BC012908 mRNA. Translation: AAH12908.1.
CCDSiCCDS3501.1.
PIRiI38063.
RefSeqiNP_001278974.1. NM_001292045.1.
NP_001278975.1. NM_001292046.1.
NP_006672.1. NM_006681.3.
UniGeneiHs.418367.

Genome annotation databases

EnsembliENST00000264218; ENSP00000264218; ENSG00000109255.
GeneIDi10874.
KEGGihsa:10874.
UCSCiuc003hbc.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76029 mRNA. Translation: CAA53619.1.
BC012908 mRNA. Translation: AAH12908.1.
CCDSiCCDS3501.1.
PIRiI38063.
RefSeqiNP_001278974.1. NM_001292045.1.
NP_001278975.1. NM_001292046.1.
NP_006672.1. NM_006681.3.
UniGeneiHs.418367.

3D structure databases

ProteinModelPortaliP48645.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116082. 12 interactions.
IntActiP48645. 3 interactions.
STRINGi9606.ENSP00000264218.

Polymorphism and mutation databases

BioMutaiNMU.
DMDMi1346685.

Proteomic databases

MaxQBiP48645.
PRIDEiP48645.

Protocols and materials databases

DNASUi10874.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264218; ENSP00000264218; ENSG00000109255.
GeneIDi10874.
KEGGihsa:10874.
UCSCiuc003hbc.3. human.

Organism-specific databases

CTDi10874.
GeneCardsiGC04M056461.
HGNCiHGNC:7859. NMU.
HPAiHPA025926.
MIMi605103. gene.
neXtProtiNX_P48645.
PharmGKBiPA31663.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG47198.
GeneTreeiENSGT00510000048726.
HOGENOMiHOG000113806.
HOVERGENiHBG000378.
InParanoidiP48645.
KOiK05249.
OMAiFQSPFAS.
OrthoDBiEOG7SJD6G.
PhylomeDBiP48645.
TreeFamiTF338319.

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GenomeRNAii10874.
NextBioi41291.
PROiP48645.
SOURCEiSearch...

Gene expression databases

BgeeiP48645.
CleanExiHS_NMU.
ExpressionAtlasiP48645. baseline and differential.
GenevisibleiP48645. HS.

Family and domain databases

InterProiIPR018070. Neuromedin-U_amidation-site.
IPR008200. NMU_C.
[Graphical view]
PfamiPF02070. NMU. 1 hit.
[Graphical view]
SMARTiSM00084. NMU. 1 hit.
[Graphical view]
PROSITEiPS00967. NMU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of the cDNA encoding the human neuromedin U (NmU) precursor: NmU expression in the human gastrointestinal tract."
    Austin C., Lo G., Nandha K.A., Meleagros L., Bloom S.R.
    J. Mol. Endocrinol. 14:157-169(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pituitary.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.

Entry informationi

Entry nameiNMU_HUMAN
AccessioniPrimary (citable) accession number: P48645
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 24, 2015
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.