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P48645

- NMU_HUMAN

UniProt

P48645 - NMU_HUMAN

Protein

Neuromedin-U

Gene

NMU

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates contractions of the ileum and urinary bladder.

    GO - Molecular functioni

    1. receptor binding Source: ProtInc

    GO - Biological processi

    1. digestion Source: ProtInc
    2. eating behavior Source: Ensembl
    3. gastric acid secretion Source: Ensembl
    4. G-protein coupled receptor signaling pathway Source: ProtInc
    5. neuropeptide signaling pathway Source: UniProtKB-KW
    6. photoperiodism Source: Ensembl
    7. positive regulation of hormone secretion Source: Ensembl
    8. positive regulation of smooth muscle contraction Source: Ensembl
    9. positive regulation of synaptic transmission Source: Ensembl
    10. regulation of smooth muscle contraction Source: ProtInc
    11. sensory perception of pain Source: Ensembl
    12. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    Neuropeptide

    Enzyme and pathway databases

    ReactomeiREACT_14819. Peptide ligand-binding receptors.
    REACT_18283. G alpha (q) signalling events.
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neuromedin-U
    Cleaved into the following chain:
    Neuromedin-U-25
    Short name:
    NmU-25
    Gene namesi
    Name:NMU
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:7859. NMU.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. terminal bouton Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31663.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3434Sequence AnalysisAdd
    BLAST
    Propeptidei35 – 10369PRO_0000019772Add
    BLAST
    Propeptidei104 – 13835By similarityPRO_0000262495Add
    BLAST
    Propeptidei139 – 1413By similarityPRO_0000262496
    Peptidei142 – 16625Neuromedin-U-25PRO_0000019773Add
    BLAST
    Propeptidei170 – 1745PRO_0000019774

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei166 – 1661Asparagine amideBy similarity

    Keywords - PTMi

    Amidation, Cleavage on pair of basic residues

    Proteomic databases

    MaxQBiP48645.
    PRIDEiP48645.

    Expressioni

    Tissue specificityi

    Expressed throughout the enteric nervous system with highest levels being found in the jejunum.

    Gene expression databases

    ArrayExpressiP48645.
    BgeeiP48645.
    CleanExiHS_NMU.
    GenevestigatoriP48645.

    Organism-specific databases

    HPAiHPA025926.

    Interactioni

    Protein-protein interaction databases

    BioGridi116082. 3 interactions.
    STRINGi9606.ENSP00000264218.

    Structurei

    3D structure databases

    ProteinModelPortaliP48645.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NmU family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG47198.
    HOGENOMiHOG000113806.
    HOVERGENiHBG000378.
    InParanoidiP48645.
    KOiK05249.
    OMAiFQSPFAS.
    OrthoDBiEOG7SJD6G.
    PhylomeDBiP48645.
    TreeFamiTF338319.

    Family and domain databases

    InterProiIPR018070. Neuromedin-U_amidation-site.
    IPR008200. NMU_C.
    [Graphical view]
    PfamiPF02070. NMU. 1 hit.
    [Graphical view]
    SMARTiSM00084. NMU. 1 hit.
    [Graphical view]
    PROSITEiPS00967. NMU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P48645-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLRTESCRPR SPAGQVAAAS PLLLLLLLLA WCAGACRGAP ILPQGLQPEQ    50
    QLQLWNEIDD TCSSFLSIDS QPQASNALEE LCFMIMGMLP KPQEQDEKDN 100
    TKRFLFHYSK TQKLGKSNVV SSVVHPLLQL VPHLHERRMK RFRVDEEFQS 150
    PFASQSRGYF LFRPRNGRRS AGFI 174
    Length:174
    Mass (Da):19,741
    Last modified:February 1, 1996 - v1
    Checksum:i8ABD8138769FA815
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti79 – 791E → G.
    Corresponds to variant rs35892915 [ dbSNP | Ensembl ].
    VAR_053538
    Natural varianti148 – 1481F → L.
    Corresponds to variant rs12108463 [ dbSNP | Ensembl ].
    VAR_053539

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X76029 mRNA. Translation: CAA53619.1.
    BC012908 mRNA. Translation: AAH12908.1.
    CCDSiCCDS3501.1.
    PIRiI38063.
    RefSeqiNP_006672.1. NM_006681.3.
    UniGeneiHs.418367.

    Genome annotation databases

    EnsembliENST00000264218; ENSP00000264218; ENSG00000109255.
    GeneIDi10874.
    KEGGihsa:10874.
    UCSCiuc003hbc.3. human.

    Polymorphism databases

    DMDMi1346685.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X76029 mRNA. Translation: CAA53619.1 .
    BC012908 mRNA. Translation: AAH12908.1 .
    CCDSi CCDS3501.1.
    PIRi I38063.
    RefSeqi NP_006672.1. NM_006681.3.
    UniGenei Hs.418367.

    3D structure databases

    ProteinModelPortali P48645.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116082. 3 interactions.
    STRINGi 9606.ENSP00000264218.

    Polymorphism databases

    DMDMi 1346685.

    Proteomic databases

    MaxQBi P48645.
    PRIDEi P48645.

    Protocols and materials databases

    DNASUi 10874.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000264218 ; ENSP00000264218 ; ENSG00000109255 .
    GeneIDi 10874.
    KEGGi hsa:10874.
    UCSCi uc003hbc.3. human.

    Organism-specific databases

    CTDi 10874.
    GeneCardsi GC04M056461.
    HGNCi HGNC:7859. NMU.
    HPAi HPA025926.
    MIMi 605103. gene.
    neXtProti NX_P48645.
    PharmGKBi PA31663.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG47198.
    HOGENOMi HOG000113806.
    HOVERGENi HBG000378.
    InParanoidi P48645.
    KOi K05249.
    OMAi FQSPFAS.
    OrthoDBi EOG7SJD6G.
    PhylomeDBi P48645.
    TreeFami TF338319.

    Enzyme and pathway databases

    Reactomei REACT_14819. Peptide ligand-binding receptors.
    REACT_18283. G alpha (q) signalling events.
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GenomeRNAii 10874.
    NextBioi 41291.
    PROi P48645.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P48645.
    Bgeei P48645.
    CleanExi HS_NMU.
    Genevestigatori P48645.

    Family and domain databases

    InterProi IPR018070. Neuromedin-U_amidation-site.
    IPR008200. NMU_C.
    [Graphical view ]
    Pfami PF02070. NMU. 1 hit.
    [Graphical view ]
    SMARTi SM00084. NMU. 1 hit.
    [Graphical view ]
    PROSITEi PS00967. NMU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of the cDNA encoding the human neuromedin U (NmU) precursor: NmU expression in the human gastrointestinal tract."
      Austin C., Lo G., Nandha K.A., Meleagros L., Bloom S.R.
      J. Mol. Endocrinol. 14:157-169(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Pituitary.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Ovary.

    Entry informationi

    Entry nameiNMU_HUMAN
    AccessioniPrimary (citable) accession number: P48645
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3