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P48645 (NMU_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neuromedin-U

Cleaved into the following chain:

  1. Neuromedin-U-25
    Short name=NmU-25
Gene names
Name:NMU
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length174 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates contractions of the ileum and urinary bladder.

Subcellular location

Secreted.

Tissue specificity

Expressed throughout the enteric nervous system with highest levels being found in the jejunum.

Sequence similarities

Belongs to the NmU family.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainSignal
   Molecular functionNeuropeptide
   PTMAmidation
Cleavage on pair of basic residues
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled receptor signaling pathway

Traceable author statement PubMed 10811630. Source: ProtInc

digestion

Traceable author statement Ref.1. Source: ProtInc

eating behavior

Inferred from electronic annotation. Source: Ensembl

gastric acid secretion

Inferred from electronic annotation. Source: Ensembl

neuropeptide signaling pathway

Inferred from electronic annotation. Source: UniProtKB-KW

photoperiodism

Inferred from electronic annotation. Source: Ensembl

positive regulation of hormone secretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of smooth muscle contraction

Inferred from electronic annotation. Source: Ensembl

positive regulation of synaptic transmission

Inferred from electronic annotation. Source: Ensembl

regulation of smooth muscle contraction

Traceable author statement Ref.1. Source: ProtInc

sensory perception of pain

Inferred from electronic annotation. Source: Ensembl

signal transduction

Traceable author statement Ref.1. Source: ProtInc

   Cellular_componentextracellular region

Traceable author statement. Source: Reactome

terminal bouton

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionreceptor binding

Traceable author statement PubMed 10811630. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3434 Potential
Propeptide35 – 10369
PRO_0000019772
Propeptide104 – 13835 By similarity
PRO_0000262495
Propeptide139 – 1413 By similarity
PRO_0000262496
Peptide142 – 16625Neuromedin-U-25
PRO_0000019773
Propeptide170 – 1745
PRO_0000019774

Amino acid modifications

Modified residue1661Asparagine amide By similarity

Natural variations

Natural variant791E → G.
Corresponds to variant rs35892915 [ dbSNP | Ensembl ].
VAR_053538
Natural variant1481F → L.
Corresponds to variant rs12108463 [ dbSNP | Ensembl ].
VAR_053539

Sequences

Sequence LengthMass (Da)Tools
P48645 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 8ABD8138769FA815

FASTA17419,741
        10         20         30         40         50         60 
MLRTESCRPR SPAGQVAAAS PLLLLLLLLA WCAGACRGAP ILPQGLQPEQ QLQLWNEIDD 

        70         80         90        100        110        120 
TCSSFLSIDS QPQASNALEE LCFMIMGMLP KPQEQDEKDN TKRFLFHYSK TQKLGKSNVV 

       130        140        150        160        170 
SSVVHPLLQL VPHLHERRMK RFRVDEEFQS PFASQSRGYF LFRPRNGRRS AGFI 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterization of the cDNA encoding the human neuromedin U (NmU) precursor: NmU expression in the human gastrointestinal tract."
Austin C., Lo G., Nandha K.A., Meleagros L., Bloom S.R.
J. Mol. Endocrinol. 14:157-169(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Pituitary.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Ovary.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X76029 mRNA. Translation: CAA53619.1.
BC012908 mRNA. Translation: AAH12908.1.
CCDSCCDS3501.1.
PIRI38063.
RefSeqNP_006672.1. NM_006681.3.
UniGeneHs.418367.

3D structure databases

ProteinModelPortalP48645.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116082. 3 interactions.
STRING9606.ENSP00000264218.

Polymorphism databases

DMDM1346685.

Proteomic databases

MaxQBP48645.
PRIDEP48645.

Protocols and materials databases

DNASU10874.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000264218; ENSP00000264218; ENSG00000109255.
GeneID10874.
KEGGhsa:10874.
UCSCuc003hbc.3. human.

Organism-specific databases

CTD10874.
GeneCardsGC04M056461.
HGNCHGNC:7859. NMU.
HPAHPA025926.
MIM605103. gene.
neXtProtNX_P48645.
PharmGKBPA31663.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG47198.
HOGENOMHOG000113806.
HOVERGENHBG000378.
InParanoidP48645.
KOK05249.
OMAFQSPFAS.
OrthoDBEOG7SJD6G.
PhylomeDBP48645.
TreeFamTF338319.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressP48645.
BgeeP48645.
CleanExHS_NMU.
GenevestigatorP48645.

Family and domain databases

InterProIPR018070. Neuromedin-U_amidation-site.
IPR008200. NMU_C.
[Graphical view]
PfamPF02070. NMU. 1 hit.
[Graphical view]
SMARTSM00084. NMU. 1 hit.
[Graphical view]
PROSITEPS00967. NMU. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi10874.
NextBio41291.
PROP48645.
SOURCESearch...

Entry information

Entry nameNMU_HUMAN
AccessionPrimary (citable) accession number: P48645
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: July 9, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM