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P48645

- NMU_HUMAN

UniProt

P48645 - NMU_HUMAN

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Protein

Neuromedin-U

Gene

NMU

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates contractions of the ileum and urinary bladder.

GO - Molecular functioni

  1. receptor binding Source: ProtInc

GO - Biological processi

  1. digestion Source: ProtInc
  2. eating behavior Source: Ensembl
  3. gastric acid secretion Source: Ensembl
  4. G-protein coupled receptor signaling pathway Source: ProtInc
  5. neuropeptide signaling pathway Source: UniProtKB-KW
  6. photoperiodism Source: Ensembl
  7. positive regulation of hormone secretion Source: Ensembl
  8. positive regulation of smooth muscle contraction Source: Ensembl
  9. positive regulation of synaptic transmission Source: Ensembl
  10. regulation of smooth muscle contraction Source: ProtInc
  11. sensory perception of pain Source: Ensembl
  12. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Neuropeptide

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuromedin-U
Cleaved into the following chain:
Neuromedin-U-25
Short name:
NmU-25
Gene namesi
Name:NMU
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:7859. NMU.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. terminal bouton Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31663.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434Sequence AnalysisAdd
BLAST
Propeptidei35 – 10369PRO_0000019772Add
BLAST
Propeptidei104 – 13835By similarityPRO_0000262495Add
BLAST
Propeptidei139 – 1413By similarityPRO_0000262496
Peptidei142 – 16625Neuromedin-U-25PRO_0000019773Add
BLAST
Propeptidei170 – 1745PRO_0000019774

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei166 – 1661Asparagine amideBy similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

MaxQBiP48645.
PRIDEiP48645.

Expressioni

Tissue specificityi

Expressed throughout the enteric nervous system with highest levels being found in the jejunum.

Gene expression databases

BgeeiP48645.
CleanExiHS_NMU.
ExpressionAtlasiP48645. baseline and differential.
GenevestigatoriP48645.

Organism-specific databases

HPAiHPA025926.

Interactioni

Protein-protein interaction databases

BioGridi116082. 7 interactions.
STRINGi9606.ENSP00000264218.

Structurei

3D structure databases

ProteinModelPortaliP48645.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NmU family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG47198.
GeneTreeiENSGT00510000048726.
HOGENOMiHOG000113806.
HOVERGENiHBG000378.
InParanoidiP48645.
KOiK05249.
OMAiFQSPFAS.
OrthoDBiEOG7SJD6G.
PhylomeDBiP48645.
TreeFamiTF338319.

Family and domain databases

InterProiIPR018070. Neuromedin-U_amidation-site.
IPR008200. NMU_C.
[Graphical view]
PfamiPF02070. NMU. 1 hit.
[Graphical view]
SMARTiSM00084. NMU. 1 hit.
[Graphical view]
PROSITEiPS00967. NMU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48645-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLRTESCRPR SPAGQVAAAS PLLLLLLLLA WCAGACRGAP ILPQGLQPEQ
60 70 80 90 100
QLQLWNEIDD TCSSFLSIDS QPQASNALEE LCFMIMGMLP KPQEQDEKDN
110 120 130 140 150
TKRFLFHYSK TQKLGKSNVV SSVVHPLLQL VPHLHERRMK RFRVDEEFQS
160 170
PFASQSRGYF LFRPRNGRRS AGFI
Length:174
Mass (Da):19,741
Last modified:February 1, 1996 - v1
Checksum:i8ABD8138769FA815
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti79 – 791E → G.
Corresponds to variant rs35892915 [ dbSNP | Ensembl ].
VAR_053538
Natural varianti148 – 1481F → L.
Corresponds to variant rs12108463 [ dbSNP | Ensembl ].
VAR_053539

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76029 mRNA. Translation: CAA53619.1.
BC012908 mRNA. Translation: AAH12908.1.
CCDSiCCDS3501.1.
PIRiI38063.
RefSeqiNP_001278974.1. NM_001292045.1.
NP_001278975.1. NM_001292046.1.
NP_006672.1. NM_006681.3.
UniGeneiHs.418367.

Genome annotation databases

EnsembliENST00000264218; ENSP00000264218; ENSG00000109255.
GeneIDi10874.
KEGGihsa:10874.
UCSCiuc003hbc.3. human.

Polymorphism databases

DMDMi1346685.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76029 mRNA. Translation: CAA53619.1 .
BC012908 mRNA. Translation: AAH12908.1 .
CCDSi CCDS3501.1.
PIRi I38063.
RefSeqi NP_001278974.1. NM_001292045.1.
NP_001278975.1. NM_001292046.1.
NP_006672.1. NM_006681.3.
UniGenei Hs.418367.

3D structure databases

ProteinModelPortali P48645.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116082. 7 interactions.
STRINGi 9606.ENSP00000264218.

Polymorphism databases

DMDMi 1346685.

Proteomic databases

MaxQBi P48645.
PRIDEi P48645.

Protocols and materials databases

DNASUi 10874.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000264218 ; ENSP00000264218 ; ENSG00000109255 .
GeneIDi 10874.
KEGGi hsa:10874.
UCSCi uc003hbc.3. human.

Organism-specific databases

CTDi 10874.
GeneCardsi GC04M056461.
HGNCi HGNC:7859. NMU.
HPAi HPA025926.
MIMi 605103. gene.
neXtProti NX_P48645.
PharmGKBi PA31663.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG47198.
GeneTreei ENSGT00510000048726.
HOGENOMi HOG000113806.
HOVERGENi HBG000378.
InParanoidi P48645.
KOi K05249.
OMAi FQSPFAS.
OrthoDBi EOG7SJD6G.
PhylomeDBi P48645.
TreeFami TF338319.

Enzyme and pathway databases

Reactomei REACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GenomeRNAii 10874.
NextBioi 41291.
PROi P48645.
SOURCEi Search...

Gene expression databases

Bgeei P48645.
CleanExi HS_NMU.
ExpressionAtlasi P48645. baseline and differential.
Genevestigatori P48645.

Family and domain databases

InterProi IPR018070. Neuromedin-U_amidation-site.
IPR008200. NMU_C.
[Graphical view ]
Pfami PF02070. NMU. 1 hit.
[Graphical view ]
SMARTi SM00084. NMU. 1 hit.
[Graphical view ]
PROSITEi PS00967. NMU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of the cDNA encoding the human neuromedin U (NmU) precursor: NmU expression in the human gastrointestinal tract."
    Austin C., Lo G., Nandha K.A., Meleagros L., Bloom S.R.
    J. Mol. Endocrinol. 14:157-169(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pituitary.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.

Entry informationi

Entry nameiNMU_HUMAN
AccessioniPrimary (citable) accession number: P48645
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 29, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3