P48645 (NMU_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Neuromedin-U

Cleaved into the following chain:

1. Neuromedin-U-25
   Short name=NmU-25

Gene names

Name:

NMU

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	174 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates contractions of the ileum and urinary bladder.
Subcellular location	Secreted.
Tissue specificity	Expressed throughout the enteric nervous system with highest levels being found in the jejunum.
Sequence similarities	Belongs to the NmU family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Molecular function	Neuropeptide
PTM	Amidation Cleavage on pair of basic residues
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G-protein coupled receptor signaling pathway Traceable author statement PubMed 10811630. Source: ProtInc digestion Traceable author statement Ref.1. Source: ProtInc eating behavior Inferred from electronic annotation. Source: Compara gastric acid secretion Inferred from electronic annotation. Source: Compara neuropeptide signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW photoperiodism Inferred from electronic annotation. Source: Compara positive regulation of hormone secretion Inferred from electronic annotation. Source: Compara positive regulation of smooth muscle contraction Inferred from electronic annotation. Source: Compara positive regulation of synaptic transmission Inferred from electronic annotation. Source: Compara regulation of smooth muscle contraction Traceable author statement Ref.1. Source: ProtInc response to stress Inferred from electronic annotation. Source: Compara sensory perception of pain Inferred from electronic annotation. Source: Compara
Cellular_component	extracellular region Traceable author statement. Source: Reactome terminal bouton Inferred from electronic annotation. Source: Compara
Molecular_function	receptor binding Traceable author statement PubMed 10811630. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 34	34	Potential
	Propeptide	35 – 103	69			PRO_0000019772
	Propeptide	104 – 138	35	By similarity		PRO_0000262495
	Propeptide	139 – 141	3	By similarity		PRO_0000262496
	Peptide	142 – 166	25	Neuromedin-U-25		PRO_0000019773
	Propeptide	170 – 174	5			PRO_0000019774
Amino acid modifications
	Modified residue	166	1	Asparagine amide By similarity
Natural variations
	Natural variant	79	1	E → G. Corresponds to variant rs35892915 [ dbSNP | Ensembl ].		VAR_053538
	Natural variant	148	1	F → L. Corresponds to variant rs12108463 [ dbSNP | Ensembl ].		VAR_053539

Sequences

	Sequence		Length	Mass (Da)
	P48645 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 8ABD8138769FA815	FASTA	174	19,741
	10 20 30 40 50 60 MLRTESCRPR SPAGQVAAAS PLLLLLLLLA WCAGACRGAP ILPQGLQPEQ QLQLWNEIDD 70 80 90 100 110 120 TCSSFLSIDS QPQASNALEE LCFMIMGMLP KPQEQDEKDN TKRFLFHYSK TQKLGKSNVV 130 140 150 160 170 SSVVHPLLQL VPHLHERRMK RFRVDEEFQS PFASQSRGYF LFRPRNGRRS AGFI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of the cDNA encoding the human neuromedin U (NmU) precursor: NmU expression in the human gastrointestinal tract." Austin C., Lo G., Nandha K.A., Meleagros L., Bloom S.R. J. Mol. Endocrinol. 14:157-169(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Pituitary.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ovary.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X76029 mRNA. Translation: CAA53619.1. BC012908 mRNA. Translation: AAH12908.1.
IPI	IPI00010721.
PIR	I38063.
RefSeq	NP_006672.1. NM_006681.2.
UniGene	Hs.418367.
3D structure databases
ProteinModelPortal	P48645.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000264218.
Polymorphism databases
DMDM	1346685.
Proteomic databases
PRIDE	P48645.
Protocols and materials databases
DNASU	10874.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000264218; ENSP00000264218; ENSG00000109255.
GeneID	10874.
KEGG	hsa:10874.
UCSC	uc003hbc.3. human.
Organism-specific databases
CTD	10874.
GeneCards	GC04M056461.
HGNC	HGNC:7859. NMU.
HPA	HPA025926.
MIM	605103. gene.
neXtProt	NX_P48645.
PharmGKB	PA31663.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG47198.
HOGENOM	HOG000113806.
HOVERGEN	HBG000378.
InParanoid	P48645.
KO	K05249.
OMA	FQSPFAS.
PhylomeDB	P48645.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	P48645.
Bgee	P48645.
CleanEx	HS_NMU.
Genevestigator	P48645.
GermOnline	ENSG00000109255. Homo sapiens.
Family and domain databases
InterPro	IPR018070. Neuromedin-U_amidation-site. IPR008200. NMU_C. [Graphical view]
Pfam	PF02070. NMU. 1 hit. [Graphical view]
SMART	SM00084. NMU. 1 hit. [Graphical view]
PROSITE	PS00967. NMU. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	10874.
NextBio	41291.
SOURCE	Search...

Entry information

Entry name

NMU_HUMAN

Accession

Primary (citable) accession number: P48645

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	April 3, 2013
This is version 100 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.