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Protein

Retinal dehydrogenase 1

Gene

ALDH1A1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Binds free retinal and cellular retinol-binding protein-bound retinal. Can convert/oxidize retinaldehyde to retinoic acid (By similarity).By similarity

Catalytic activityi

Retinal + NAD+ + H2O = retinoate + NADH.

Pathwayi: retinol metabolism

This protein is involved in the pathway retinol metabolism, which is part of Cofactor metabolism.
View all proteins of this organism that are known to be involved in the pathway retinol metabolism and in Cofactor metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei170 – 1701Transition state stabilizerBy similarity
Active sitei269 – 2691Proton acceptorPROSITE-ProRule annotation
Active sitei303 – 3031NucleophilePROSITE-ProRule annotation
Binding sitei456 – 4561NADBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi246 – 2516NADBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

ReactomeiR-BTA-5365859. RA biosynthesis pathway.
R-BTA-70350. Fructose catabolism.
R-BTA-71384. Ethanol oxidation.
UniPathwayiUPA00912.

Names & Taxonomyi

Protein namesi
Recommended name:
Retinal dehydrogenase 1 (EC:1.2.1.36)
Short name:
RALDH 1
Short name:
RalDH1
Alternative name(s):
ALDH-E1
ALHDII
Aldehyde dehydrogenase family 1 member A1
Aldehyde dehydrogenase, cytosolic
Gene namesi
Name:ALDH1A1
Synonyms:ALDH1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 8

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 501500Retinal dehydrogenase 1PRO_0000056413Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei91 – 911N6-acetyllysineBy similarity
Modified residuei128 – 1281N6-acetyllysineBy similarity
Modified residuei252 – 2521N6-acetyllysineBy similarity
Modified residuei337 – 3371PhosphothreonineBy similarity
Modified residuei353 – 3531N6-acetyllysineBy similarity
Modified residuei367 – 3671N6-acetyllysineBy similarity
Modified residuei410 – 4101N6-acetyllysineBy similarity
Modified residuei413 – 4131PhosphoserineBy similarity
Modified residuei419 – 4191N6-acetyllysineBy similarity
Modified residuei495 – 4951N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP48644.
PeptideAtlasiP48644.
PRIDEiP48644.

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000010661.

Structurei

3D structure databases

ProteinModelPortaliP48644.
SMRiP48644. Positions 8-501.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiKOG2450. Eukaryota.
COG1012. LUCA.
GeneTreeiENSGT00760000118999.
HOGENOMiHOG000271505.
HOVERGENiHBG000097.
InParanoidiP48644.
KOiK07249.
OMAiSSRETSM.
OrthoDBiEOG7PS1F7.
TreeFamiTF300455.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48644-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSAMPDVP APLTNLQFKY TKIFINNEWH SSVSGKKFPV FNPATEEKLC
60 70 80 90 100
EVEEGDKEDV DKAVKAARQA FQIGSPWRTM DASERGRLLN KLADLIERDH
110 120 130 140 150
LLLATMEAMN GGKLFSNAYL MDLGGCIKTL RYCAGWADKI QGRTIPMDGN
160 170 180 190 200
FFTYTRSEPV GVCGQIIPWN FPLLMFLWKI GPALSCGNTV VVKPAEQTPL
210 220 230 240 250
TALHMGSLIK EAGFPPGVVN IVPGYGPTAG AAISSHMDVD KVAFTGSTEV
260 270 280 290 300
GKLIKEAAGK SNLKRVSLEL GGKSPCIVFA DADLDNAVEF AHQGVFYHQG
310 320 330 340 350
QCCIAASRLF VEESIYDEFV RRSVERAKKY VLGNPLTPGV SQGPQIDKEQ
360 370 380 390 400
YEKILDLIES GKKEGAKLEC GGGPWGNKGY FIQPTVFSDV TDDMRIAKEE
410 420 430 440 450
IFGPVQQIMK FKSLDDVIKR ANNTFYGLSA GIFTNDIDKA ITVSSALQSG
460 470 480 490 500
TVWVNCYSVV SAQCPFGGFK MSGNGRELGE YGFHEYTEVK TVTIKISQKN

S
Length:501
Mass (Da):54,806
Last modified:November 13, 2007 - v3
Checksum:iC9025D7034BC7F95
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti67 – 671A → V in AAA74234 (PubMed:7786847).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36128 mRNA. Translation: AAA74234.1.
BT030667 mRNA. Translation: ABS44983.1.
BC105193 mRNA. Translation: AAI05194.1.
RefSeqiNP_776664.1. NM_174239.2.
UniGeneiBt.4732.

Genome annotation databases

EnsembliENSBTAT00000010661; ENSBTAP00000010661; ENSBTAG00000008103.
GeneIDi281615.
KEGGibta:281615.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36128 mRNA. Translation: AAA74234.1.
BT030667 mRNA. Translation: ABS44983.1.
BC105193 mRNA. Translation: AAI05194.1.
RefSeqiNP_776664.1. NM_174239.2.
UniGeneiBt.4732.

3D structure databases

ProteinModelPortaliP48644.
SMRiP48644. Positions 8-501.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000010661.

Proteomic databases

PaxDbiP48644.
PeptideAtlasiP48644.
PRIDEiP48644.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000010661; ENSBTAP00000010661; ENSBTAG00000008103.
GeneIDi281615.
KEGGibta:281615.

Organism-specific databases

CTDi216.

Phylogenomic databases

eggNOGiKOG2450. Eukaryota.
COG1012. LUCA.
GeneTreeiENSGT00760000118999.
HOGENOMiHOG000271505.
HOVERGENiHBG000097.
InParanoidiP48644.
KOiK07249.
OMAiSSRETSM.
OrthoDBiEOG7PS1F7.
TreeFamiTF300455.

Enzyme and pathway databases

UniPathwayiUPA00912.
ReactomeiR-BTA-5365859. RA biosynthesis pathway.
R-BTA-70350. Fructose catabolism.
R-BTA-71384. Ethanol oxidation.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization and localization of an aldehyde dehydrogenase to amacrine cells of bovine retina."
    Saari J.C., Champer R.J., Asson-Batres M.A., Garwin G.G., Huang J., Crabb J.W., Milam A.H.
    Vis. Neurosci. 12:263-272(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Retina.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal liver.

Entry informationi

Entry nameiAL1A1_BOVIN
AccessioniPrimary (citable) accession number: P48644
Secondary accession number(s): A7E3P6, Q3MHL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: November 13, 2007
Last modified: July 6, 2016
This is version 113 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.