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Protein

Glutathione reductase, chloroplastic

Gene

GR

Organism
Glycine max (Soybean) (Glycine hispida)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Maintains high levels of reduced glutathione in the chloroplast.

Miscellaneous

The active site is a redox-active disulfide bond.

Catalytic activityi

2 glutathione + NADP+ = glutathione disulfide + NADPH.

Cofactori

FADBy similarityNote: Binds 1 FAD per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei269NADPBy similarity1
Binding sitei275NADPBy similarity1
Active sitei507Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi105 – 113FADBy similarity9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione reductase, chloroplastic (EC:1.8.1.7)
Short name:
GR
Short name:
GRase
Gene namesi
Name:GR
OrganismiGlycine max (Soybean) (Glycine hispida)
Taxonomic identifieri3847 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaeGlycineSoja
Proteomesi
  • UP000008827 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 52ChloroplastSequence analysisAdd BLAST52
ChainiPRO_000003028253 – 544Glutathione reductase, chloroplasticAdd BLAST492

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi113 ↔ 118Redox-activeBy similarity

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi3847.GLYMA02G16010.3

Structurei

3D structure databases

ProteinModelPortaliP48640
SMRiP48640
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Redox-active center, Transit peptide

Phylogenomic databases

eggNOGiKOG0405 Eukaryota
COG1249 LUCA
InParanoidiP48640
KOiK00383

Family and domain databases

Gene3Di3.30.390.30, 1 hit
3.50.50.60, 3 hits
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR016156 FAD/NAD-linked_Rdtase_dimer_sf
IPR006324 Glut-diS_reduct
IPR001100 Pyr_nuc-diS_OxRdtase
IPR004099 Pyr_nucl-diS_OxRdtase_dimer
IPR012999 Pyr_OxRdtase_I_AS
PfamiView protein in Pfam
PF07992 Pyr_redox_2, 1 hit
PF02852 Pyr_redox_dim, 1 hit
PIRSFiPIRSF000350 Mercury_reductase_MerA, 1 hit
SUPFAMiSSF51905 SSF51905, 1 hit
SSF55424 SSF55424, 1 hit
TIGRFAMsiTIGR01424 gluta_reduc_2, 1 hit
PROSITEiView protein in PROSITE
PS00076 PYRIDINE_REDOX_1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48640-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATSLSVSPS LSLNTLFIAK ALPLSRPSFL SLPLPKSLLS LSTRRRTFIV
60 70 80 90 100
RAESQNGRDP VPAHYDFDLF TIGAGSGGVR ARRFAANYGA SVAICELPFS
110 120 130 140 150
TISSETTGVG GTCVIRGCVP KKLLVYASKF SHEFEESNGF GWRYDSEPKH
160 170 180 190 200
DWSSFIANKN AELQRLTGIY KNILNNAGVK LIEGHGKMID PHTVDVNGKL
210 220 230 240 250
YSAKHILVAV GGRPFIPDIP GKELAIDSDA ALDLPTKPVK IAIVGGGYIA
260 270 280 290 300
LEFAGIFNGL KSEVHVFIRQ KKVLRGFDEE IRDFVEEQMS VRGIEFHTEE
310 320 330 340 350
SPQAITKSAD GSFSLKTNKG TVDGFSHIMF ATGRRPNTQN LGLESVGVKL
360 370 380 390 400
AKDGAIEVDE YSQTSVYSIW AVGDVTNRIN LTPVALMEGG ALVKTLFQDN
410 420 430 440 450
PTKPDYRAVP SAVFSQPPIG QVGLTEEQAV QQYGDIDIFT ANFRPLKATL
460 470 480 490 500
SGLPDRVFMK LVVCAKTNEV LGLHMCGEDA PEIVQGFAVA LKARLTKADF
510 520 530 540
DATVGIHPSA AEEFVTMRTP TRKIRKSESS EGKSGSQAKA AAGV
Length:544
Mass (Da):58,783
Last modified:February 1, 1996 - v1
Checksum:i7A71449EA21CE639
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11632 mRNA Translation: AAA33962.1
PIRiT07155
RefSeqiNP_001238006.1, NM_001251077.1
UniGeneiGma.32269

Genome annotation databases

GeneIDi547793
KEGGigmx:547793

Similar proteinsi

Entry informationi

Entry nameiGSHRP_SOYBN
AccessioniPrimary (citable) accession number: P48640
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 23, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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