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Protein

Glutathione reductase

Gene

gor

Organism
Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Maintains high levels of reduced glutathione in the cytosol.

Catalytic activityi

2 glutathione + NADP+ = glutathione disulfide + NADPH.

Cofactori

FADBy similarityNote: Binds 1 FAD per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei448Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi34 – 42FADBy similarity9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione reductase (EC:1.8.1.7)
Short name:
GR
Short name:
GRase
Gene namesi
Name:gor
Ordered Locus Names:all4968
OrganismiNostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)
Taxonomic identifieri103690 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
Proteomesi
  • UP000002483 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000679731 – 459Glutathione reductaseAdd BLAST459

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi42 ↔ 47Redox-activeBy similarity

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi103690.all4968.

Structurei

3D structure databases

ProteinModelPortaliP48638.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiENOG4105DC8. Bacteria.
COG1249. LUCA.
HOGENOMiHOG000276712.
KOiK00383.
OMAiRRHAPMR.
OrthoDBiPOG091H0239.

Family and domain databases

Gene3Di3.30.390.30. 1 hit.
3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR006324. Glut-diS_reduct.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR012999. Pyr_OxRdtase_I_AS.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
SSF55424. SSF55424. 1 hit.
TIGRFAMsiTIGR01424. gluta_reduc_2. 1 hit.
PROSITEiPS00076. PYRIDINE_REDOX_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48638-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTFDYDLFVI GAGSGGLAAS KRAASYGAKV AIAENDLVGG TCVIRGCVPK
60 70 80 90 100
KLMVYGSHFP ALFEDAAGYG WQVGKAELNW EHFITSIDKE VRRLSQLHIS
110 120 130 140 150
FLEKAGVELI SGRATLVDNH TVEVGERKFT ADKILIAVGG RPIKPELPGM
160 170 180 190 200
EYGITSNEIF HLKTQPKHIA IIGSGYIGTE FAGIMRGLGS QVTQITRGDK
210 220 230 240 250
ILKGFDEDIR TEIQEGMTNH GIRIIPKNVV TAIEQVPEGL KISLSGEDQE
260 270 280 290 300
PIIADVFLVA TGRVPNVDGL GLENAGVDVV DSSIEGPGYS TMNAIAVNEY
310 320 330 340 350
SQTSQPNIYA VGDVTDRLNL TPVAIGEGRA FADSEFGNNR REFSHETIAT
360 370 380 390 400
AVFSNPQAST VGLTEAEARA KLGDDAVTIY RTRFRPMYHS FTGKQERIMM
410 420 430 440 450
KLVVDTKTDK VLGAHMVGEN AAEIIQGVAI AVKMGATKKD FDATVGIHPS

SAEEFVTMR
Length:459
Mass (Da):49,478
Last modified:January 23, 2002 - v2
Checksum:i29C1F06CE2195888
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti234E → Q in CAA61856 (PubMed:7559423).Curated1
Sequence conflicti340R → L in CAA61856 (PubMed:7559423).Curated1
Sequence conflicti361V → L in CAA61856 (PubMed:7559423).Curated1
Sequence conflicti372L → H in CAA61856 (PubMed:7559423).Curated1
Sequence conflicti381 – 383RTR → AP in CAA61856 (PubMed:7559423).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89712 Genomic DNA. Translation: CAA61856.1.
BA000019 Genomic DNA. Translation: BAB76667.1.
PIRiAH2426.
I39477.
RefSeqiWP_010999094.1. NC_003272.1.

Genome annotation databases

EnsemblBacteriaiBAB76667; BAB76667; BAB76667.
KEGGiana:all4968.
PATRICi22780609. VBINosSp37423_5746.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89712 Genomic DNA. Translation: CAA61856.1.
BA000019 Genomic DNA. Translation: BAB76667.1.
PIRiAH2426.
I39477.
RefSeqiWP_010999094.1. NC_003272.1.

3D structure databases

ProteinModelPortaliP48638.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi103690.all4968.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB76667; BAB76667; BAB76667.
KEGGiana:all4968.
PATRICi22780609. VBINosSp37423_5746.

Phylogenomic databases

eggNOGiENOG4105DC8. Bacteria.
COG1249. LUCA.
HOGENOMiHOG000276712.
KOiK00383.
OMAiRRHAPMR.
OrthoDBiPOG091H0239.

Family and domain databases

Gene3Di3.30.390.30. 1 hit.
3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR006324. Glut-diS_reduct.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR012999. Pyr_OxRdtase_I_AS.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
SSF55424. SSF55424. 1 hit.
TIGRFAMsiTIGR01424. gluta_reduc_2. 1 hit.
PROSITEiPS00076. PYRIDINE_REDOX_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGSHR_NOSS1
AccessioniPrimary (citable) accession number: P48638
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 23, 2002
Last modified: September 7, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The active site is a redox-active disulfide bond.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.