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Protein

Glutathione reductase

Gene

gor

Organism
Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Maintains high levels of reduced glutathione in the cytosol.

Miscellaneous

The active site is a redox-active disulfide bond.

Catalytic activityi

2 glutathione + NADP+ = glutathione disulfide + NADPH.

Cofactori

FADBy similarityNote: Binds 1 FAD per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei448Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi34 – 42FADBy similarity9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione reductase (EC:1.8.1.7)
Short name:
GR
Short name:
GRase
Gene namesi
Name:gor
Ordered Locus Names:all4968
OrganismiNostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)
Taxonomic identifieri103690 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
Proteomesi
  • UP000002483 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000679731 – 459Glutathione reductaseAdd BLAST459

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi42 ↔ 47Redox-activeBy similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP48638

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi103690.all4968

Structurei

3D structure databases

ProteinModelPortaliP48638
SMRiP48638
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiENOG4105DC8 Bacteria
COG1249 LUCA
HOGENOMiHOG000276712
KOiK00383
OMAiKCAIIEA
OrthoDBiPOG091H0239

Family and domain databases

Gene3Di3.30.390.30, 1 hit
3.50.50.60, 3 hits
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR016156 FAD/NAD-linked_Rdtase_dimer_sf
IPR006324 Glut-diS_reduct
IPR001100 Pyr_nuc-diS_OxRdtase
IPR004099 Pyr_nucl-diS_OxRdtase_dimer
IPR012999 Pyr_OxRdtase_I_AS
PfamiView protein in Pfam
PF07992 Pyr_redox_2, 1 hit
PF02852 Pyr_redox_dim, 1 hit
PIRSFiPIRSF000350 Mercury_reductase_MerA, 1 hit
SUPFAMiSSF51905 SSF51905, 1 hit
SSF55424 SSF55424, 1 hit
TIGRFAMsiTIGR01424 gluta_reduc_2, 1 hit
PROSITEiView protein in PROSITE
PS00076 PYRIDINE_REDOX_1, 1 hit

Sequencei

Sequence statusi: Complete.

P48638-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTFDYDLFVI GAGSGGLAAS KRAASYGAKV AIAENDLVGG TCVIRGCVPK
60 70 80 90 100
KLMVYGSHFP ALFEDAAGYG WQVGKAELNW EHFITSIDKE VRRLSQLHIS
110 120 130 140 150
FLEKAGVELI SGRATLVDNH TVEVGERKFT ADKILIAVGG RPIKPELPGM
160 170 180 190 200
EYGITSNEIF HLKTQPKHIA IIGSGYIGTE FAGIMRGLGS QVTQITRGDK
210 220 230 240 250
ILKGFDEDIR TEIQEGMTNH GIRIIPKNVV TAIEQVPEGL KISLSGEDQE
260 270 280 290 300
PIIADVFLVA TGRVPNVDGL GLENAGVDVV DSSIEGPGYS TMNAIAVNEY
310 320 330 340 350
SQTSQPNIYA VGDVTDRLNL TPVAIGEGRA FADSEFGNNR REFSHETIAT
360 370 380 390 400
AVFSNPQAST VGLTEAEARA KLGDDAVTIY RTRFRPMYHS FTGKQERIMM
410 420 430 440 450
KLVVDTKTDK VLGAHMVGEN AAEIIQGVAI AVKMGATKKD FDATVGIHPS

SAEEFVTMR
Length:459
Mass (Da):49,478
Last modified:January 23, 2002 - v2
Checksum:i29C1F06CE2195888
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti234E → Q in CAA61856 (PubMed:7559423).Curated1
Sequence conflicti340R → L in CAA61856 (PubMed:7559423).Curated1
Sequence conflicti361V → L in CAA61856 (PubMed:7559423).Curated1
Sequence conflicti372L → H in CAA61856 (PubMed:7559423).Curated1
Sequence conflicti381 – 383RTR → AP in CAA61856 (PubMed:7559423).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89712 Genomic DNA Translation: CAA61856.1
BA000019 Genomic DNA Translation: BAB76667.1
PIRiAH2426
I39477
RefSeqiWP_010999094.1, NC_003272.1

Genome annotation databases

EnsemblBacteriaiBAB76667; BAB76667; BAB76667
KEGGiana:all4968

Similar proteinsi

Entry informationi

Entry nameiGSHR_NOSS1
AccessioniPrimary (citable) accession number: P48638
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 23, 2002
Last modified: May 23, 2018
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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