SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P48634

- PRC2A_HUMAN

UniProt

P48634 - PRC2A_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Protein PRRC2A

Gene
PRRC2A, BAT2, G2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May play a role in the regulation of pre-mRNA splicing.1 Publication

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
  2. protein binding Source: IntAct
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein PRRC2A
Alternative name(s):
HLA-B-associated transcript 2
Large proline-rich protein BAT2
Proline-rich and coiled-coil-containing protein 2A
Protein G2
Gene namesi
Name:PRRC2A
Synonyms:BAT2, G2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:13918. PRRC2A.

Subcellular locationi

Cytoplasm. Nucleus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. extracellular vesicular exosome Source: UniProt
  3. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25263.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 21572157Protein PRRC2APRO_0000064829Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei27 – 271N6-acetyllysine1 Publication
Modified residuei35 – 351N6-acetyllysine By similarity
Modified residuei166 – 1661Phosphoserine By similarity
Modified residuei342 – 3421Phosphoserine2 Publications
Modified residuei350 – 3501Phosphoserine2 Publications
Modified residuei380 – 3801Phosphoserine4 Publications
Modified residuei383 – 3831Phosphoserine1 Publication
Modified residuei456 – 4561Phosphoserine2 Publications
Modified residuei610 – 6101Phosphothreonine2 Publications
Modified residuei759 – 7591Phosphoserine1 Publication
Modified residuei761 – 7611Phosphoserine2 Publications
Modified residuei764 – 7641Phosphoserine1 Publication
Modified residuei808 – 8081Phosphoserine1 Publication
Modified residuei997 – 9971Phosphothreonine By similarity
Modified residuei1004 – 10041Phosphoserine By similarity
Modified residuei1085 – 10851Phosphoserine1 Publication
Modified residuei1089 – 10891Phosphoserine2 Publications
Modified residuei1092 – 10921Phosphoserine1 Publication
Modified residuei1094 – 10941Phosphotyrosine1 Publication
Modified residuei1110 – 11101Phosphoserine1 Publication
Modified residuei1147 – 11471Phosphoserine1 Publication
Modified residuei1196 – 11961N6-acetyllysine1 Publication
Modified residuei1219 – 12191Phosphoserine3 Publications
Modified residuei1306 – 13061Phosphoserine1 Publication
Modified residuei1353 – 13531Phosphothreonine1 Publication
Modified residuei2113 – 21131Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP48634.
PaxDbiP48634.
PRIDEiP48634.

Expressioni

Tissue specificityi

Limited to cell-lines of leukemic origin.

Developmental stagei

Broadly expressed during the 11th week of gestation, with highest levels in the central nervous system, spinal ganglia, osteoblasts and osteocytes (at protein level).1 Publication

Gene expression databases

BgeeiP48634.
GenevestigatoriP48634.

Organism-specific databases

HPAiCAB026383.
HPA046791.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ATXN1P542534EBI-347545,EBI-930964
JUNP054122EBI-347545,EBI-852823

Protein-protein interaction databases

BioGridi113646. 42 interactions.
IntActiP48634. 32 interactions.
MINTiMINT-1032109.
STRINGi9606.ENSP00000404619.

Structurei

3D structure databases

ProteinModelPortaliP48634.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati41 – 95551-1Add
BLAST
Repeati98 – 154571-2Add
BLAST
Repeati281 – 337571-3Add
BLAST
Repeati337 – 430942-1Add
BLAST
Repeati488 – 561742-2Add
BLAST
Repeati1757 – 1812561-4Add
BLAST
Repeati1916 – 1965503-1Add
BLAST
Repeati1982 – 2031503-2Add
BLAST
Repeati2057 – 2106503-3Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni41 – 181217724 X 57 AA type A repeatsAdd
BLAST
Regioni337 – 5612252 X type B repeatsAdd
BLAST
Regioni1916 – 21061913 X 50 AA type C repeatsAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi466 – 4716Poly-Arg
Compositional biasi472 – 4754Poly-Glu
Compositional biasi658 – 66912Poly-GlnAdd
BLAST
Compositional biasi696 – 7005Poly-Pro
Compositional biasi826 – 8338Poly-Pro
Compositional biasi913 – 9164Poly-Pro
Compositional biasi955 – 9584Poly-Pro
Compositional biasi1139 – 11424Poly-Pro
Compositional biasi1239 – 12446Poly-Arg
Compositional biasi1355 – 13606Poly-Gly
Compositional biasi1413 – 14219Poly-Gly
Compositional biasi1451 – 14577Poly-Pro

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG271062.
HOVERGENiHBG004820.
InParanoidiP48634.
OMAiHITNIYL.
OrthoDBiEOG7DZ8J2.
PhylomeDBiP48634.
TreeFamiTF328738.

Family and domain databases

InterProiIPR009738. BAT2_N.
[Graphical view]
PfamiPF07001. BAT2_N. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P48634-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSDRSGPTAK GKDGKKYSSL NLFDTYKGKS LEIQKPAVAP RHGLQSLGKV     50
AIARRMPPPA NLPSLKAENK GNDPNVSLVP KDGTGWASKQ EQSDPKSSDA 100
STAQPPESQP LPASQTPASN QPKRPPAAPE NTPLVPSGVK SWAQASVTHG 150
AHGDGGRASS LLSRFSREEF PTLQAAGDQD KAAKERESAE QSSGPGPSLR 200
PQNSTTWRDG GGRGPDELEG PDSKLHHGHD PRGGLQPSGP PQFPPYRGMM 250
PPFMYPPYLP FPPPYGPQGP YRYPTPDGPS RFPRVAGPRG SGPPMRLVEP 300
VGRPSILKED NLKEFDQLDQ ENDDGWAGAH EEVDYTEKLK FSDEEDGRDS 350
DEEGAEGHRD SQSASGEERP PEADGKKGNS PNSEPPTPKT AWAETSRPPE 400
TEPGPPAPKP PLPPPHRGPA GNWGPPGDYP DRGGPPCKPP APEDEDEAWR 450
QRRKQSSSEI SLAVERARRR REEEERRMQE ERRAACAEKL KRLDEKFGAP 500
DKRLKAEPAA PPAAPSTPAP PPAVPKELPA PPAPPPASAP TPETEPEEPA 550
QAPPAQSTPT PGVAAAPTLV SGGGSTSSTS SGSFEASPVE PQLPSKEGPE 600
PPEEVPPPTT PPVPKVEPKG DGIGPTRQPP SQGLGYPKYQ KSLPPRFQRQ 650
QQEQLLKQQQ QHQWQQHQQG SAPPTPVPPS PPQPVTLGAV PAPQAPPPPP 700
KALYPGALGR PPPMPPMNFD PRWMMIPPYV DPRLLQGRPP LDFYPPGVHP 750
SGLVPRERSD SGGSSSEPFD RHAPAMLRER GTPPVDPKLA WVGDVFTATP 800
AEPRPLTSPL RQAADEDDKG MRSETPPVPP PPPYLASYPG FPENGAPGPP 850
ISRFPLEEPG PRPLPWPPGS DEVAKIQTPP PKKEPPKEET AQLTGPEAGR 900
KPARGVGSGG QGPPPPRRES RTETRWGPRP GSSRRGIPPE EPGAPPRRAG 950
PIKKPPPPTK VEELPPKPLE QGDETPKPPK PDPLKITKGK LGGPKETPPN 1000
GNLSPAPRLR RDYSYERVGP TSCRGRGRGE YFARGRGFRG TYGGRGRGAR 1050
SREFRSYREF RGDDGRGGGT GGPNHPPAPR GRTASETRSE GSEYEEIPKR 1100
RRQRGSETGS ETHESDLAPS DKEAPTPKEG TLTQVPLAPP PPGAPPSPAP 1150
ARFTARGGRV FTPRGVPSRR GRGGGRPPPQ VCPGWSPPAK SLAPKKPPTG 1200
PLPPSKEPLK EKLIPGPLSP VARGGSNGGS NVGMEDGERP RRRRHGRAQQ 1250
QDKPPRFRRL KQERENAARG SEGKPSLTLP ASAPGPEEAL TTVTVAPAPR 1300
RAAAKSPDLS NQNSDQANEE WETASESSDF TSERRGDKEA PPPVLLTPKA 1350
VGTPGGGGGG AVPGISAMSR GDLSQRAKDL SKRSFSSQRP GMERQNRRPG 1400
PGGKAGSSGS SSGGGGGGPG GRTGPGRGDK RSWPSPKNRS RPPEERPPGL 1450
PLPPPPPSSS AVFRLDQVIH SNPAGIQQAL AQLSSRQGSV TAPGGHPRHK 1500
PGLPQAPQGP SPRPPTRYEP QRVNSGLSSD PHFEEPGPMV RGVGGTPRDS 1550
AGVSPFPPKR RERPPRKPEL LQEESLPPPH SSGFLGSKPE GPGPQAESRD 1600
TGTEALTPHI WNRLHTATSR KSYRPSSMEP WMEPLSPFED VAGTEMSQSD 1650
SGVDLSGDSQ VSSGPCSQRS SPDGGLKGAA EGPPKRPGGS SPLNAVPCEG 1700
PPGSEPPRRP PPAPHDGDRK ELPREQPLPP GPIGTERSQR TDRGTEPGPI 1750
RPSHRPGPPV QFGTSDKDSD LRLVVGDSLK AEKELTASVT EAIPVSRDWE 1800
LLPSAAASAE PQSKNLDSGH CVPEPSSSGQ RLYPEVFYGS AGPSSSQISG 1850
GAMDSQLHPN SGGFRPGTPS LHPYRSQPLY LPPGPAPPSA LLSGLALKGQ 1900
FLDFSTMQAT ELGKLPAGGV LYPPPSFLYS PAFCPSPLPD TSLLQVRQDL 1950
PSPSDFYSTP LQPGGQSGFL PSGAPAQQML LPMVDSQLPV VNFGSLPPAP 2000
PPAPPPLSLL PVGPALQPPS LAVRPPPAPA TRVLPSPARP FPASLGRAEL 2050
HPVELKPFQD YQKLSSNLGG PGSSRTPPTG RSFSGLNSRL KATPSTYSGV 2100
FRTQRVDLYQ QASPPDALRW IPKPWERTGP PPREGPSRRA EEPGSRGDKE 2150
PGLPPPR 2157
Length:2,157
Mass (Da):228,863
Last modified:May 18, 2010 - v3
Checksum:i7353342E72F0D393
GO
Isoform 2 (identifier: P48634-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     413-424: Missing.
     1050-1148: RSREFRSYRE...PPPPGAPPSP → QANSAVTESF...PTTRSPTLHR
     1155-1177: ARGGRVFTPRGVPSRRGRGGGRP → CPGVGESSLPEGAISPGPRRREA
     1852-1864: AMDSQLHPNSGGF → SHGLSITSKQWRL

Show »
Length:2,144
Mass (Da):227,840
Checksum:i9DF7B60612E16D90
GO
Isoform 3 (identifier: P48634-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1050-1148: RSREFRSYRE...PPPPGAPPSP → QANSAVTESF...PTTRSPTLHR
     1155-1177: ARGGRVFTPRGVPSRRGRGGGRP → CPGVGESSLPEGAISPGPRRREA
     1852-1864: AMDSQLHPNSGGF → SHGLSITSKQWRL

Show »
Length:2,156
Mass (Da):229,064
Checksum:i13C2A71F42213DDC
GO
Isoform 4 (identifier: P48634-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     834-1457: Missing.

Note: No experimental confirmation available.

Show »
Length:1,533
Mass (Da):163,047
Checksum:i0F496D1F2EB629E7
GO

Sequence cautioni

The sequence AAA35585.1 differs from that shown. Reason: Frameshift at positions 38 and 58.
The sequence AAA35586.1 differs from that shown. Reason: Frameshift at positions 38 and 58.
The sequence CAA78744.1 differs from that shown. Reason: Frameshift at positions 38 and 58.
The sequence BAE06116.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti57 – 571P → R.1 Publication
Corresponds to variant rs1062968 [ dbSNP | Ensembl ].
VAR_023215
Natural varianti82 – 821D → V.
Corresponds to variant rs6921213 [ dbSNP | Ensembl ].
VAR_045992
Natural varianti106 – 1061P → L.2 Publications
Corresponds to variant rs2280801 [ dbSNP | Ensembl ].
VAR_023216
Natural varianti477 – 4771R → C.1 Publication
Corresponds to variant rs17857493 [ dbSNP | Ensembl ].
VAR_045993
Natural varianti544 – 5441T → K.7 Publications
Corresponds to variant rs1046080 [ dbSNP | Ensembl ].
VAR_023217
Natural varianti694 – 6941Q → K.1 Publication
Corresponds to variant rs2844469 [ dbSNP | Ensembl ].
VAR_023218
Natural varianti742 – 7421D → E.1 Publication
Corresponds to variant rs1046081 [ dbSNP | Ensembl ].
VAR_023219
Natural varianti804 – 8041R → C.
Corresponds to variant rs11538262 [ dbSNP | Ensembl ].
VAR_045994
Natural varianti1087 – 10871T → I in a breast cancer sample; somatic mutation. 1 Publication
VAR_035796
Natural varianti1152 – 11521R → H in a breast cancer sample; somatic mutation. 1 Publication
VAR_035797
Natural varianti1285 – 12851G → A.1 Publication
Corresponds to variant rs2736158 [ dbSNP | Ensembl ].
VAR_023220
Natural varianti1407 – 14071S → N.
Corresponds to variant rs35464047 [ dbSNP | Ensembl ].
VAR_045995
Natural varianti1415 – 14151G → A.1 Publication
Corresponds to variant rs2857703 [ dbSNP | Ensembl ].
VAR_023221
Natural varianti1503 – 15031L → P.9 Publications
Corresponds to variant rs2272593 [ dbSNP | Ensembl ].
VAR_023222
Natural varianti1544 – 15441G → D.
Corresponds to variant rs34175432 [ dbSNP | Ensembl ].
VAR_045996
Natural varianti1563 – 15631R → Q.
Corresponds to variant rs11538263 [ dbSNP | Ensembl ].
VAR_045997
Natural varianti1740 – 17401R → H.3 Publications
Corresponds to variant rs1046089 [ dbSNP | Ensembl ].
VAR_023223
Natural varianti1744 – 17441G → A.1 Publication
Corresponds to variant rs2844491 [ dbSNP | Ensembl ].
VAR_023224
Natural varianti1774 – 17741V → M.
Corresponds to variant rs11538264 [ dbSNP | Ensembl ].
VAR_045998
Natural varianti1775 – 17751V → M.
Corresponds to variant rs11538264 [ dbSNP | Ensembl ].
VAR_023225
Natural varianti1895 – 18951L → V.8 Publications
Corresponds to variant rs3132453 [ dbSNP | Ensembl ].
VAR_023226
Natural varianti2006 – 20061P → S.1 Publication
Corresponds to variant rs10885 [ dbSNP | Ensembl ].
VAR_023227
Natural varianti2075 – 20751R → W.
Corresponds to variant rs34137317 [ dbSNP | Ensembl ].
VAR_056742
Natural varianti2130 – 21301P → L.1 Publication
Corresponds to variant rs1046756 [ dbSNP | Ensembl ].
VAR_023228

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei413 – 42412Missing in isoform 2. VSP_015099Add
BLAST
Alternative sequencei834 – 1457624Missing in isoform 4. VSP_030865Add
BLAST
Alternative sequencei1050 – 114899RSREF…APPSP → QANSAVTESFEEMMGVEVGQ GDQTTLLLPEAAMPARHGAR VQSMRKSPSGAGSGAQKQAA RPMRVIWLLQTRRLPHPRRE HSPRSSRSPTTRSPTLHR in isoform 2 and isoform 3. VSP_015100Add
BLAST
Alternative sequencei1155 – 117723ARGGR…GGGRP → CPGVGESSLPEGAISPGPRR REA in isoform 2 and isoform 3. VSP_015101Add
BLAST
Alternative sequencei1852 – 186413AMDSQ…NSGGF → SHGLSITSKQWRL in isoform 2 and isoform 3. VSP_015102Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti57 – 571P → A in CAA78744. 1 Publication
Sequence conflicti107 – 12317ESQPL…SNQPK → NRTTAGFTDACLQPAE in CAA78744. 1 PublicationAdd
BLAST
Sequence conflicti762 – 7621G → L in AAA35585. 1 Publication
Sequence conflicti762 – 7621G → L in AAA35586. 1 Publication
Sequence conflicti762 – 7621G → R in CAA78744. 1 Publication
Sequence conflicti764 – 7641S → L in AAA35585. 1 Publication
Sequence conflicti764 – 7641S → L in AAA35586. 1 Publication
Sequence conflicti764 – 7641S → L in CAA78744. 1 Publication
Sequence conflicti846 – 8461A → T in CAA78744. 1 Publication
Sequence conflicti902 – 91110PARGVGSGGQ → LPASRSGA in AAA35585. 1 Publication
Sequence conflicti902 – 91110PARGVGSGGQ → LPASRSGA in AAA35586. 1 Publication
Sequence conflicti902 – 91110PARGVGSGGQ → LPASRSGA in CAA78744. 1 Publication
Sequence conflicti934 – 9341R → G in AAH42295. 1 Publication
Sequence conflicti1049 – 10491A → G in AAA35585. 1 Publication
Sequence conflicti1049 – 10491A → G in AAA35586. 1 Publication
Sequence conflicti1300 – 13001R → P in AAA35585. 1 Publication
Sequence conflicti1300 – 13001R → P in AAA35586. 1 Publication
Sequence conflicti1461 – 14611Missing in CAA78744. 1 Publication
Sequence conflicti1626 – 16261S → T in AAA35585. 1 Publication
Sequence conflicti1626 – 16261S → T in AAA35586. 1 Publication
Isoform 3 (identifier: P48634-3)
Sequence conflicti1082 – 10821M → L in CAA78744. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M33509 mRNA. Translation: AAA35585.1. Frameshift.
M33518, M33512 Genomic DNA. Translation: AAA35586.1. Frameshift.
AB210034 mRNA. Translation: BAE06116.1. Different initiation.
AF129756 Genomic DNA. Translation: AAD18086.1.
CR354443 Genomic DNA. Translation: CAQ06970.1.
BA000025 Genomic DNA. Translation: BAB63391.1.
AL662847 Genomic DNA. Translation: CAI17698.2.
AL662801 Genomic DNA. Translation: CAI18313.1.
AL805934 Genomic DNA. Translation: CAI18500.1.
BX511262 Genomic DNA. Translation: CAI95572.1.
CR753892 Genomic DNA. Translation: CAQ06959.1.
CR759761 Genomic DNA. Translation: CAQ10847.1.
CH471081 Genomic DNA. Translation: EAX03452.1.
BC030127 mRNA. Translation: AAH30127.1.
BC032134 mRNA. Translation: AAH32134.1.
BC042295 mRNA. Translation: AAH42295.1.
BC060668 mRNA. Translation: AAH60668.1.
Z15025 Genomic DNA. Translation: CAA78744.1. Frameshift.
CR749245 mRNA. Translation: CAH18101.1.
CCDSiCCDS4708.1. [P48634-1]
PIRiB35098.
S37671.
RefSeqiNP_004629.3. NM_004638.3. [P48634-1]
NP_542417.2. NM_080686.2. [P48634-1]
UniGeneiHs.123239.
Hs.436093.

Genome annotation databases

EnsembliENST00000376007; ENSP00000365175; ENSG00000204469. [P48634-1]
ENST00000376033; ENSP00000365201; ENSG00000204469. [P48634-1]
ENST00000383455; ENSP00000372947; ENSG00000206427.
ENST00000383464; ENSP00000372956; ENSG00000206427.
ENST00000414956; ENSP00000404619; ENSG00000226618.
ENST00000416335; ENSP00000415182; ENSG00000231370.
ENST00000422962; ENSP00000415363; ENSG00000231825.
ENST00000428775; ENSP00000387910; ENSG00000225164.
ENST00000430737; ENSP00000413977; ENSG00000231825.
ENST00000432252; ENSP00000408226; ENSG00000225748.
ENST00000435971; ENSP00000409444; ENSG00000225164.
ENST00000439762; ENSP00000400540; ENSG00000231370.
ENST00000454306; ENSP00000387477; ENSG00000225748.
ENST00000458561; ENSP00000396812; ENSG00000226618.
GeneIDi7916.
KEGGihsa:7916.
UCSCiuc003nvb.4. human. [P48634-1]

Polymorphism databases

DMDMi296439424.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M33509 mRNA. Translation: AAA35585.1 . Frameshift.
M33518 , M33512 Genomic DNA. Translation: AAA35586.1 . Frameshift.
AB210034 mRNA. Translation: BAE06116.1 . Different initiation.
AF129756 Genomic DNA. Translation: AAD18086.1 .
CR354443 Genomic DNA. Translation: CAQ06970.1 .
BA000025 Genomic DNA. Translation: BAB63391.1 .
AL662847 Genomic DNA. Translation: CAI17698.2 .
AL662801 Genomic DNA. Translation: CAI18313.1 .
AL805934 Genomic DNA. Translation: CAI18500.1 .
BX511262 Genomic DNA. Translation: CAI95572.1 .
CR753892 Genomic DNA. Translation: CAQ06959.1 .
CR759761 Genomic DNA. Translation: CAQ10847.1 .
CH471081 Genomic DNA. Translation: EAX03452.1 .
BC030127 mRNA. Translation: AAH30127.1 .
BC032134 mRNA. Translation: AAH32134.1 .
BC042295 mRNA. Translation: AAH42295.1 .
BC060668 mRNA. Translation: AAH60668.1 .
Z15025 Genomic DNA. Translation: CAA78744.1 . Frameshift.
CR749245 mRNA. Translation: CAH18101.1 .
CCDSi CCDS4708.1. [P48634-1 ]
PIRi B35098.
S37671.
RefSeqi NP_004629.3. NM_004638.3. [P48634-1 ]
NP_542417.2. NM_080686.2. [P48634-1 ]
UniGenei Hs.123239.
Hs.436093.

3D structure databases

ProteinModelPortali P48634.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113646. 42 interactions.
IntActi P48634. 32 interactions.
MINTi MINT-1032109.
STRINGi 9606.ENSP00000404619.

Polymorphism databases

DMDMi 296439424.

Proteomic databases

MaxQBi P48634.
PaxDbi P48634.
PRIDEi P48634.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000376007 ; ENSP00000365175 ; ENSG00000204469 . [P48634-1 ]
ENST00000376033 ; ENSP00000365201 ; ENSG00000204469 . [P48634-1 ]
ENST00000383455 ; ENSP00000372947 ; ENSG00000206427 .
ENST00000383464 ; ENSP00000372956 ; ENSG00000206427 .
ENST00000414956 ; ENSP00000404619 ; ENSG00000226618 .
ENST00000416335 ; ENSP00000415182 ; ENSG00000231370 .
ENST00000422962 ; ENSP00000415363 ; ENSG00000231825 .
ENST00000428775 ; ENSP00000387910 ; ENSG00000225164 .
ENST00000430737 ; ENSP00000413977 ; ENSG00000231825 .
ENST00000432252 ; ENSP00000408226 ; ENSG00000225748 .
ENST00000435971 ; ENSP00000409444 ; ENSG00000225164 .
ENST00000439762 ; ENSP00000400540 ; ENSG00000231370 .
ENST00000454306 ; ENSP00000387477 ; ENSG00000225748 .
ENST00000458561 ; ENSP00000396812 ; ENSG00000226618 .
GeneIDi 7916.
KEGGi hsa:7916.
UCSCi uc003nvb.4. human. [P48634-1 ]

Organism-specific databases

CTDi 7916.
GeneCardsi GC06P031719.
GC06Pj31575.
GC06Pk31570.
GC06Pl31627.
GC06Pm31664.
GC06Pn31578.
GC06Po31578.
HGNCi HGNC:13918. PRRC2A.
HPAi CAB026383.
HPA046791.
MIMi 142580. gene.
neXtProti NX_P48634.
PharmGKBi PA25263.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG271062.
HOVERGENi HBG004820.
InParanoidi P48634.
OMAi HITNIYL.
OrthoDBi EOG7DZ8J2.
PhylomeDBi P48634.
TreeFami TF328738.

Miscellaneous databases

ChiTaRSi PRRC2A. human.
GeneWikii BAT2.
GenomeRNAii 7916.
NextBioi 30387.
PROi P48634.
SOURCEi Search...

Gene expression databases

Bgeei P48634.
Genevestigatori P48634.

Family and domain databases

InterProi IPR009738. BAT2_N.
[Graphical view ]
Pfami PF07001. BAT2_N. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A gene pair from the human major histocompatibility complex encodes large proline-rich proteins with multiple repeated motifs and a single ubiquitin-like domain."
    Banerji J., Sands J., Strominger J.L., Spies T.
    Proc. Natl. Acad. Sci. U.S.A. 87:2374-2378(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 2), VARIANTS ARG-57; GLU-742; PRO-1503 AND VAL-1895.
    Tissue: T-cell.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), VARIANTS LEU-106; LYS-544; PRO-1503 AND VAL-1895.
    Tissue: Brain.
  3. "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
    Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.
    Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS LYS-544; ALA-1285; PRO-1503; HIS-1740; VAL-1895 AND LEU-2130.
  4. "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region."
    Shiina S., Tamiya G., Oka A., Inoko H.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS LYS-544; PRO-1503 AND VAL-1895.
  5. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS LEU-106; LYS-544; PRO-1503; HIS-1740; VAL-1895 AND SER-2006.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS LYS-544; PRO-1503; HIS-1740 AND VAL-1895.
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS CYS-477; LYS-544; PRO-1503 AND VAL-1895.
    Tissue: Lymph, Placenta and Uterus.
  8. "Dense Alu clustering and a potential new member of the NF kappa B family within a 90 kilobase HLA class III segment."
    Iris F.J.M., Bougueleret L., Prieur S., Caterina D., Primas G., Perrot V., Jurka J., Rodriguez-Tome P., Claverie J.-M., Dausset J., Cohen D.
    Nat. Genet. 3:137-145(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-1874 (ISOFORM 3), VARIANTS LYS-544; LYS-694; ALA-1415; PRO-1503 AND ALA-1744.
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 871-2157 (ISOFORM 1), VARIANTS PRO-1503 AND VAL-1895.
    Tissue: Uterine endothelium.
  10. "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region."
    Lehner B., Semple J.I., Brown S.E., Counsell D., Campbell R.D., Sanderson C.M.
    Genomics 83:153-167(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  11. "Antibodies generated by a novel DNA vaccination identify the MHC class III encoded BAT2 polypeptide."
    Schneiders A., Thiel S., Winkler J., Moeller P., Koch N.
    Vaccine 23:2540-2550(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
  12. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-342 AND SER-350, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1219, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Platelet.
  15. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-380; SER-383; SER-456; THR-610; SER-759; SER-761; SER-764; SER-1085; SER-1089; SER-1092; TYR-1094; SER-1147 AND SER-1306, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  16. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  17. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-380; SER-456; THR-610; SER-761 AND SER-1089, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  18. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-27 AND LYS-1196, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  19. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-380; SER-808; SER-1219; THR-1353 AND SER-2113, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  20. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  21. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-342; SER-350; SER-380; SER-1110 AND SER-1219, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  22. Cited for: VARIANTS [LARGE SCALE ANALYSIS] ILE-1087 AND HIS-1152.

Entry informationi

Entry nameiPRC2A_HUMAN
AccessioniPrimary (citable) accession number: P48634
Secondary accession number(s): B0UX77
, B0UZE9, B0UZL3, O95875, Q05BK4, Q4LE37, Q5SQ29, Q5SQ30, Q5ST84, Q5STX6, Q5STX7, Q68DW9, Q6P9P7, Q6PIN1, Q8MGQ9, Q96QC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: May 18, 2010
Last modified: September 3, 2014
This is version 126 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi