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Protein

Protein PRRC2A

Gene

PRRC2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the regulation of pre-mRNA splicing.1 Publication

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000111960-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein PRRC2A
Alternative name(s):
HLA-B-associated transcript 2
Large proline-rich protein BAT2
Proline-rich and coiled-coil-containing protein 2A
Protein G2
Gene namesi
Name:PRRC2A
Synonyms:BAT2, G2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:13918. PRRC2A.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • extracellular exosome Source: UniProtKB
  • intracellular membrane-bounded organelle Source: HPA
  • membrane Source: UniProtKB
  • nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7916.
OpenTargetsiENSG00000204469.
PharmGKBiPA25263.

Polymorphism and mutation databases

BioMutaiPRRC2A.
DMDMi296439424.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000648291 – 2157Protein PRRC2AAdd BLAST2157

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18PhosphoserineCombined sources1
Modified residuei19PhosphoserineCombined sources1
Modified residuei27N6-acetyllysineCombined sources1
Modified residuei30PhosphoserineCombined sources1
Modified residuei35N6-acetyllysineBy similarity1
Modified residuei146PhosphoserineCombined sources1
Modified residuei166PhosphoserineCombined sources1
Modified residuei204PhosphoserineCombined sources1
Modified residuei272Asymmetric dimethylarginineCombined sources1
Modified residuei296Omega-N-methylarginineCombined sources1
Modified residuei342PhosphoserineCombined sources1
Modified residuei350PhosphoserineCombined sources1
Modified residuei363PhosphoserineCombined sources1
Modified residuei380PhosphoserineCombined sources1
Modified residuei383PhosphoserineCombined sources1
Modified residuei456PhosphoserineCombined sources1
Modified residuei610PhosphothreonineCombined sources1
Modified residuei759PhosphoserineCombined sources1
Modified residuei761PhosphoserineCombined sources1
Modified residuei764PhosphoserineCombined sources1
Modified residuei807PhosphothreonineBy similarity1
Modified residuei808PhosphoserineCombined sources1
Modified residuei904Omega-N-methylarginineBy similarity1
Modified residuei908PhosphoserineCombined sources1
Modified residuei932PhosphoserineCombined sources1
Modified residuei997PhosphothreonineBy similarity1
Modified residuei1004PhosphoserineCombined sources1
Modified residuei1066Omega-N-methylarginineBy similarity1
Modified residuei1083PhosphothreonineCombined sources1
Modified residuei1085PhosphoserineCombined sources1
Modified residuei1089PhosphoserineCombined sources1
Modified residuei1092PhosphoserineCombined sources1
Modified residuei1094PhosphotyrosineCombined sources1
Modified residuei1106PhosphoserineCombined sources1
Modified residuei1110PhosphoserineCombined sources1
Modified residuei1120PhosphoserineCombined sources1
Modified residuei1147PhosphoserineCombined sources1
Modified residuei1196N6-acetyllysineCombined sources1
Modified residuei1219PhosphoserineCombined sources1
Modified residuei1306PhosphoserineCombined sources1
Modified residuei1310PhosphoserineBy similarity1
Modified residuei1323PhosphothreonineBy similarity1
Modified residuei1325PhosphoserineBy similarity1
Modified residuei1328PhosphoserineCombined sources1
Modified residuei1347PhosphothreonineCombined sources1
Modified residuei1353PhosphothreonineCombined sources1
Modified residuei1384PhosphoserineCombined sources1
Modified residuei1386PhosphoserineCombined sources1
Modified residuei1525PhosphoserineCombined sources1
Modified residuei1778PhosphoserineCombined sources1
Modified residuei2036PhosphoserineCombined sources1
Modified residuei2076PhosphothreonineCombined sources1
Modified residuei2082PhosphoserineCombined sources1
Modified residuei2113PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiP48634.
MaxQBiP48634.
PaxDbiP48634.
PeptideAtlasiP48634.
PRIDEiP48634.

PTM databases

iPTMnetiP48634.
PhosphoSitePlusiP48634.

Expressioni

Tissue specificityi

Limited to cell-lines of leukemic origin.

Developmental stagei

Broadly expressed during the 11th week of gestation, with highest levels in the central nervous system, spinal ganglia, osteoblasts and osteocytes (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000204469.
GenevisibleiP48634. HS.

Organism-specific databases

HPAiCAB026383.
HPA046791.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ATXN1P542534EBI-347545,EBI-930964
JUNP054122EBI-347545,EBI-852823

Protein-protein interaction databases

BioGridi113646. 69 interactors.
IntActiP48634. 37 interactors.
MINTiMINT-1032109.
STRINGi9606.ENSP00000365175.

Structurei

3D structure databases

ProteinModelPortaliP48634.
SMRiP48634.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati41 – 951-1Add BLAST55
Repeati98 – 1541-2Add BLAST57
Repeati281 – 3371-3Add BLAST57
Repeati337 – 4302-1Add BLAST94
Repeati488 – 5612-2Add BLAST74
Repeati1757 – 18121-4Add BLAST56
Repeati1916 – 19653-1Add BLAST50
Repeati1982 – 20313-2Add BLAST50
Repeati2057 – 21063-3Add BLAST50

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni41 – 18124 X 57 AA type A repeatsAdd BLAST1772
Regioni337 – 5612 X type B repeatsAdd BLAST225
Regioni1916 – 21063 X 50 AA type C repeatsAdd BLAST191

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi466 – 471Poly-Arg6
Compositional biasi472 – 475Poly-Glu4
Compositional biasi658 – 669Poly-GlnAdd BLAST12
Compositional biasi696 – 700Poly-Pro5
Compositional biasi826 – 833Poly-Pro8
Compositional biasi913 – 916Poly-Pro4
Compositional biasi955 – 958Poly-Pro4
Compositional biasi1139 – 1142Poly-Pro4
Compositional biasi1239 – 1244Poly-Arg6
Compositional biasi1355 – 1360Poly-Gly6
Compositional biasi1413 – 1421Poly-Gly9
Compositional biasi1451 – 1457Poly-Pro7

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4817. Eukaryota.
ENOG410XQRI. LUCA.
GeneTreeiENSGT00530000063496.
HOVERGENiHBG004820.
InParanoidiP48634.
OMAiHITNIYL.
OrthoDBiEOG091G02WC.
PhylomeDBiP48634.
TreeFamiTF328738.

Family and domain databases

InterProiIPR009738. BAT2_N.
IPR033184. PRRC2.
[Graphical view]
PANTHERiPTHR14038. PTHR14038. 1 hit.
PfamiPF07001. BAT2_N. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P48634-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDRSGPTAK GKDGKKYSSL NLFDTYKGKS LEIQKPAVAP RHGLQSLGKV
60 70 80 90 100
AIARRMPPPA NLPSLKAENK GNDPNVSLVP KDGTGWASKQ EQSDPKSSDA
110 120 130 140 150
STAQPPESQP LPASQTPASN QPKRPPAAPE NTPLVPSGVK SWAQASVTHG
160 170 180 190 200
AHGDGGRASS LLSRFSREEF PTLQAAGDQD KAAKERESAE QSSGPGPSLR
210 220 230 240 250
PQNSTTWRDG GGRGPDELEG PDSKLHHGHD PRGGLQPSGP PQFPPYRGMM
260 270 280 290 300
PPFMYPPYLP FPPPYGPQGP YRYPTPDGPS RFPRVAGPRG SGPPMRLVEP
310 320 330 340 350
VGRPSILKED NLKEFDQLDQ ENDDGWAGAH EEVDYTEKLK FSDEEDGRDS
360 370 380 390 400
DEEGAEGHRD SQSASGEERP PEADGKKGNS PNSEPPTPKT AWAETSRPPE
410 420 430 440 450
TEPGPPAPKP PLPPPHRGPA GNWGPPGDYP DRGGPPCKPP APEDEDEAWR
460 470 480 490 500
QRRKQSSSEI SLAVERARRR REEEERRMQE ERRAACAEKL KRLDEKFGAP
510 520 530 540 550
DKRLKAEPAA PPAAPSTPAP PPAVPKELPA PPAPPPASAP TPETEPEEPA
560 570 580 590 600
QAPPAQSTPT PGVAAAPTLV SGGGSTSSTS SGSFEASPVE PQLPSKEGPE
610 620 630 640 650
PPEEVPPPTT PPVPKVEPKG DGIGPTRQPP SQGLGYPKYQ KSLPPRFQRQ
660 670 680 690 700
QQEQLLKQQQ QHQWQQHQQG SAPPTPVPPS PPQPVTLGAV PAPQAPPPPP
710 720 730 740 750
KALYPGALGR PPPMPPMNFD PRWMMIPPYV DPRLLQGRPP LDFYPPGVHP
760 770 780 790 800
SGLVPRERSD SGGSSSEPFD RHAPAMLRER GTPPVDPKLA WVGDVFTATP
810 820 830 840 850
AEPRPLTSPL RQAADEDDKG MRSETPPVPP PPPYLASYPG FPENGAPGPP
860 870 880 890 900
ISRFPLEEPG PRPLPWPPGS DEVAKIQTPP PKKEPPKEET AQLTGPEAGR
910 920 930 940 950
KPARGVGSGG QGPPPPRRES RTETRWGPRP GSSRRGIPPE EPGAPPRRAG
960 970 980 990 1000
PIKKPPPPTK VEELPPKPLE QGDETPKPPK PDPLKITKGK LGGPKETPPN
1010 1020 1030 1040 1050
GNLSPAPRLR RDYSYERVGP TSCRGRGRGE YFARGRGFRG TYGGRGRGAR
1060 1070 1080 1090 1100
SREFRSYREF RGDDGRGGGT GGPNHPPAPR GRTASETRSE GSEYEEIPKR
1110 1120 1130 1140 1150
RRQRGSETGS ETHESDLAPS DKEAPTPKEG TLTQVPLAPP PPGAPPSPAP
1160 1170 1180 1190 1200
ARFTARGGRV FTPRGVPSRR GRGGGRPPPQ VCPGWSPPAK SLAPKKPPTG
1210 1220 1230 1240 1250
PLPPSKEPLK EKLIPGPLSP VARGGSNGGS NVGMEDGERP RRRRHGRAQQ
1260 1270 1280 1290 1300
QDKPPRFRRL KQERENAARG SEGKPSLTLP ASAPGPEEAL TTVTVAPAPR
1310 1320 1330 1340 1350
RAAAKSPDLS NQNSDQANEE WETASESSDF TSERRGDKEA PPPVLLTPKA
1360 1370 1380 1390 1400
VGTPGGGGGG AVPGISAMSR GDLSQRAKDL SKRSFSSQRP GMERQNRRPG
1410 1420 1430 1440 1450
PGGKAGSSGS SSGGGGGGPG GRTGPGRGDK RSWPSPKNRS RPPEERPPGL
1460 1470 1480 1490 1500
PLPPPPPSSS AVFRLDQVIH SNPAGIQQAL AQLSSRQGSV TAPGGHPRHK
1510 1520 1530 1540 1550
PGLPQAPQGP SPRPPTRYEP QRVNSGLSSD PHFEEPGPMV RGVGGTPRDS
1560 1570 1580 1590 1600
AGVSPFPPKR RERPPRKPEL LQEESLPPPH SSGFLGSKPE GPGPQAESRD
1610 1620 1630 1640 1650
TGTEALTPHI WNRLHTATSR KSYRPSSMEP WMEPLSPFED VAGTEMSQSD
1660 1670 1680 1690 1700
SGVDLSGDSQ VSSGPCSQRS SPDGGLKGAA EGPPKRPGGS SPLNAVPCEG
1710 1720 1730 1740 1750
PPGSEPPRRP PPAPHDGDRK ELPREQPLPP GPIGTERSQR TDRGTEPGPI
1760 1770 1780 1790 1800
RPSHRPGPPV QFGTSDKDSD LRLVVGDSLK AEKELTASVT EAIPVSRDWE
1810 1820 1830 1840 1850
LLPSAAASAE PQSKNLDSGH CVPEPSSSGQ RLYPEVFYGS AGPSSSQISG
1860 1870 1880 1890 1900
GAMDSQLHPN SGGFRPGTPS LHPYRSQPLY LPPGPAPPSA LLSGLALKGQ
1910 1920 1930 1940 1950
FLDFSTMQAT ELGKLPAGGV LYPPPSFLYS PAFCPSPLPD TSLLQVRQDL
1960 1970 1980 1990 2000
PSPSDFYSTP LQPGGQSGFL PSGAPAQQML LPMVDSQLPV VNFGSLPPAP
2010 2020 2030 2040 2050
PPAPPPLSLL PVGPALQPPS LAVRPPPAPA TRVLPSPARP FPASLGRAEL
2060 2070 2080 2090 2100
HPVELKPFQD YQKLSSNLGG PGSSRTPPTG RSFSGLNSRL KATPSTYSGV
2110 2120 2130 2140 2150
FRTQRVDLYQ QASPPDALRW IPKPWERTGP PPREGPSRRA EEPGSRGDKE

PGLPPPR
Length:2,157
Mass (Da):228,863
Last modified:May 18, 2010 - v3
Checksum:i7353342E72F0D393
GO
Isoform 2 (identifier: P48634-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     413-424: Missing.
     1050-1148: RSREFRSYRE...PPPPGAPPSP → QANSAVTESF...PTTRSPTLHR
     1155-1177: ARGGRVFTPRGVPSRRGRGGGRP → CPGVGESSLPEGAISPGPRRREA
     1852-1864: AMDSQLHPNSGGF → SHGLSITSKQWRL

Show »
Length:2,144
Mass (Da):227,840
Checksum:i9DF7B60612E16D90
GO
Isoform 3 (identifier: P48634-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1050-1148: RSREFRSYRE...PPPPGAPPSP → QANSAVTESF...PTTRSPTLHR
     1155-1177: ARGGRVFTPRGVPSRRGRGGGRP → CPGVGESSLPEGAISPGPRRREA
     1852-1864: AMDSQLHPNSGGF → SHGLSITSKQWRL

Show »
Length:2,156
Mass (Da):229,064
Checksum:i13C2A71F42213DDC
GO
Isoform 4 (identifier: P48634-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     834-1457: Missing.

Note: No experimental confirmation available.
Show »
Length:1,533
Mass (Da):163,047
Checksum:i0F496D1F2EB629E7
GO

Sequence cautioni

The sequence AAA35585 differs from that shown. Reason: Frameshift at positions 38 and 58.Curated
The sequence AAA35586 differs from that shown. Reason: Frameshift at positions 38 and 58.Curated
The sequence BAE06116 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAA78744 differs from that shown. Reason: Frameshift at positions 38 and 58.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti57P → A in CAA78744 (PubMed:8499947).Curated1
Sequence conflicti107 – 123ESQPL…SNQPK → NRTTAGFTDACLQPAE in CAA78744 (PubMed:8499947).CuratedAdd BLAST17
Sequence conflicti762G → L in AAA35585 (PubMed:2156268).Curated1
Sequence conflicti762G → L in AAA35586 (PubMed:2156268).Curated1
Sequence conflicti762G → R in CAA78744 (PubMed:8499947).Curated1
Sequence conflicti764S → L in AAA35585 (PubMed:2156268).Curated1
Sequence conflicti764S → L in AAA35586 (PubMed:2156268).Curated1
Sequence conflicti764S → L in CAA78744 (PubMed:8499947).Curated1
Sequence conflicti846A → T in CAA78744 (PubMed:8499947).Curated1
Sequence conflicti902 – 911PARGVGSGGQ → LPASRSGA in AAA35585 (PubMed:2156268).Curated10
Sequence conflicti902 – 911PARGVGSGGQ → LPASRSGA in AAA35586 (PubMed:2156268).Curated10
Sequence conflicti902 – 911PARGVGSGGQ → LPASRSGA in CAA78744 (PubMed:8499947).Curated10
Sequence conflicti934R → G in AAH42295 (PubMed:15489334).Curated1
Sequence conflicti1049A → G in AAA35585 (PubMed:2156268).Curated1
Sequence conflicti1049A → G in AAA35586 (PubMed:2156268).Curated1
Sequence conflicti1300R → P in AAA35585 (PubMed:2156268).Curated1
Sequence conflicti1300R → P in AAA35586 (PubMed:2156268).Curated1
Sequence conflicti1461Missing in CAA78744 (PubMed:8499947).Curated1
Sequence conflicti1626S → T in AAA35585 (PubMed:2156268).Curated1
Sequence conflicti1626S → T in AAA35586 (PubMed:2156268).Curated1
Isoform 3 (identifier: P48634-3)
Sequence conflicti1082M → L in CAA78744 (PubMed:8499947).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02321557P → R.1 PublicationCorresponds to variant rs1062968dbSNPEnsembl.1
Natural variantiVAR_04599282D → V.Corresponds to variant rs6921213dbSNPEnsembl.1
Natural variantiVAR_023216106P → L.2 PublicationsCorresponds to variant rs2280801dbSNPEnsembl.1
Natural variantiVAR_045993477R → C.1 PublicationCorresponds to variant rs17857493dbSNPEnsembl.1
Natural variantiVAR_023217544T → K.7 PublicationsCorresponds to variant rs1046080dbSNPEnsembl.1
Natural variantiVAR_023218694Q → K.1 PublicationCorresponds to variant rs2844469dbSNPEnsembl.1
Natural variantiVAR_023219742D → E.1 PublicationCorresponds to variant rs1046081dbSNPEnsembl.1
Natural variantiVAR_045994804R → C.Corresponds to variant rs11538262dbSNPEnsembl.1
Natural variantiVAR_0357961087T → I in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant rs771808977dbSNPEnsembl.1
Natural variantiVAR_0357971152R → H in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant rs151148973dbSNPEnsembl.1
Natural variantiVAR_0232201285G → A.1 PublicationCorresponds to variant rs2736158dbSNPEnsembl.1
Natural variantiVAR_0459951407S → N.Corresponds to variant rs35464047dbSNPEnsembl.1
Natural variantiVAR_0232211415G → A.1 PublicationCorresponds to variant rs2857703dbSNPEnsembl.1
Natural variantiVAR_0232221503L → P.9 PublicationsCorresponds to variant rs2272593dbSNPEnsembl.1
Natural variantiVAR_0459961544G → D.Corresponds to variant rs34175432dbSNPEnsembl.1
Natural variantiVAR_0459971563R → Q.Corresponds to variant rs11538263dbSNPEnsembl.1
Natural variantiVAR_0232231740R → H.3 PublicationsCorresponds to variant rs1046089dbSNPEnsembl.1
Natural variantiVAR_0232241744G → A.1 PublicationCorresponds to variant rs2844491dbSNPEnsembl.1
Natural variantiVAR_0459981774V → M.Corresponds to variant rs11538264dbSNPEnsembl.1
Natural variantiVAR_0232251775V → M.Corresponds to variant rs11538264dbSNPEnsembl.1
Natural variantiVAR_0232261895L → V.8 PublicationsCorresponds to variant rs3132453dbSNPEnsembl.1
Natural variantiVAR_0232272006P → S.1 PublicationCorresponds to variant rs10885dbSNPEnsembl.1
Natural variantiVAR_0567422075R → W.Corresponds to variant rs34137317dbSNPEnsembl.1
Natural variantiVAR_0232282130P → L.1 PublicationCorresponds to variant rs1046756dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_015099413 – 424Missing in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_030865834 – 1457Missing in isoform 4. 1 PublicationAdd BLAST624
Alternative sequenceiVSP_0151001050 – 1148RSREF…APPSP → QANSAVTESFEEMMGVEVGQ GDQTTLLLPEAAMPARHGAR VQSMRKSPSGAGSGAQKQAA RPMRVIWLLQTRRLPHPRRE HSPRSSRSPTTRSPTLHR in isoform 2 and isoform 3. 1 PublicationAdd BLAST99
Alternative sequenceiVSP_0151011155 – 1177ARGGR…GGGRP → CPGVGESSLPEGAISPGPRR REA in isoform 2 and isoform 3. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_0151021852 – 1864AMDSQ…NSGGF → SHGLSITSKQWRL in isoform 2 and isoform 3. 1 PublicationAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33509 mRNA. Translation: AAA35585.1. Frameshift.
M33518, M33512 Genomic DNA. Translation: AAA35586.1. Frameshift.
AB210034 mRNA. Translation: BAE06116.1. Different initiation.
AF129756 Genomic DNA. Translation: AAD18086.1.
CR354443 Genomic DNA. Translation: CAQ06970.1.
BA000025 Genomic DNA. Translation: BAB63391.1.
AL662847 Genomic DNA. Translation: CAI17698.2.
AL662801 Genomic DNA. Translation: CAI18313.1.
AL805934 Genomic DNA. Translation: CAI18500.1.
BX511262 Genomic DNA. Translation: CAI95572.1.
CR753892 Genomic DNA. Translation: CAQ06959.1.
CR759761 Genomic DNA. Translation: CAQ10847.1.
CH471081 Genomic DNA. Translation: EAX03452.1.
BC030127 mRNA. Translation: AAH30127.1.
BC032134 mRNA. Translation: AAH32134.1.
BC042295 mRNA. Translation: AAH42295.1.
BC060668 mRNA. Translation: AAH60668.1.
Z15025 Genomic DNA. Translation: CAA78744.1. Frameshift.
CR749245 mRNA. Translation: CAH18101.1.
CCDSiCCDS4708.1. [P48634-1]
PIRiB35098.
S37671.
RefSeqiNP_004629.3. NM_004638.3. [P48634-1]
NP_542417.2. NM_080686.2. [P48634-1]
UniGeneiHs.123239.
Hs.436093.

Genome annotation databases

EnsembliENST00000376007; ENSP00000365175; ENSG00000204469. [P48634-1]
ENST00000376033; ENSP00000365201; ENSG00000204469. [P48634-1]
ENST00000383455; ENSP00000372947; ENSG00000206427.
ENST00000383464; ENSP00000372956; ENSG00000206427.
ENST00000414956; ENSP00000404619; ENSG00000226618.
ENST00000416335; ENSP00000415182; ENSG00000231370.
ENST00000422962; ENSP00000415363; ENSG00000231825.
ENST00000428775; ENSP00000387910; ENSG00000225164.
ENST00000430737; ENSP00000413977; ENSG00000231825.
ENST00000432252; ENSP00000408226; ENSG00000225748.
ENST00000435971; ENSP00000409444; ENSG00000225164.
ENST00000439762; ENSP00000400540; ENSG00000231370.
ENST00000454306; ENSP00000387477; ENSG00000225748.
ENST00000458561; ENSP00000396812; ENSG00000226618.
GeneIDi7916.
KEGGihsa:7916.
UCSCiuc003nvb.5. human. [P48634-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33509 mRNA. Translation: AAA35585.1. Frameshift.
M33518, M33512 Genomic DNA. Translation: AAA35586.1. Frameshift.
AB210034 mRNA. Translation: BAE06116.1. Different initiation.
AF129756 Genomic DNA. Translation: AAD18086.1.
CR354443 Genomic DNA. Translation: CAQ06970.1.
BA000025 Genomic DNA. Translation: BAB63391.1.
AL662847 Genomic DNA. Translation: CAI17698.2.
AL662801 Genomic DNA. Translation: CAI18313.1.
AL805934 Genomic DNA. Translation: CAI18500.1.
BX511262 Genomic DNA. Translation: CAI95572.1.
CR753892 Genomic DNA. Translation: CAQ06959.1.
CR759761 Genomic DNA. Translation: CAQ10847.1.
CH471081 Genomic DNA. Translation: EAX03452.1.
BC030127 mRNA. Translation: AAH30127.1.
BC032134 mRNA. Translation: AAH32134.1.
BC042295 mRNA. Translation: AAH42295.1.
BC060668 mRNA. Translation: AAH60668.1.
Z15025 Genomic DNA. Translation: CAA78744.1. Frameshift.
CR749245 mRNA. Translation: CAH18101.1.
CCDSiCCDS4708.1. [P48634-1]
PIRiB35098.
S37671.
RefSeqiNP_004629.3. NM_004638.3. [P48634-1]
NP_542417.2. NM_080686.2. [P48634-1]
UniGeneiHs.123239.
Hs.436093.

3D structure databases

ProteinModelPortaliP48634.
SMRiP48634.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113646. 69 interactors.
IntActiP48634. 37 interactors.
MINTiMINT-1032109.
STRINGi9606.ENSP00000365175.

PTM databases

iPTMnetiP48634.
PhosphoSitePlusiP48634.

Polymorphism and mutation databases

BioMutaiPRRC2A.
DMDMi296439424.

Proteomic databases

EPDiP48634.
MaxQBiP48634.
PaxDbiP48634.
PeptideAtlasiP48634.
PRIDEiP48634.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376007; ENSP00000365175; ENSG00000204469. [P48634-1]
ENST00000376033; ENSP00000365201; ENSG00000204469. [P48634-1]
ENST00000383455; ENSP00000372947; ENSG00000206427.
ENST00000383464; ENSP00000372956; ENSG00000206427.
ENST00000414956; ENSP00000404619; ENSG00000226618.
ENST00000416335; ENSP00000415182; ENSG00000231370.
ENST00000422962; ENSP00000415363; ENSG00000231825.
ENST00000428775; ENSP00000387910; ENSG00000225164.
ENST00000430737; ENSP00000413977; ENSG00000231825.
ENST00000432252; ENSP00000408226; ENSG00000225748.
ENST00000435971; ENSP00000409444; ENSG00000225164.
ENST00000439762; ENSP00000400540; ENSG00000231370.
ENST00000454306; ENSP00000387477; ENSG00000225748.
ENST00000458561; ENSP00000396812; ENSG00000226618.
GeneIDi7916.
KEGGihsa:7916.
UCSCiuc003nvb.5. human. [P48634-1]

Organism-specific databases

CTDi7916.
DisGeNETi7916.
GeneCardsiPRRC2A.
HGNCiHGNC:13918. PRRC2A.
HPAiCAB026383.
HPA046791.
MIMi142580. gene.
neXtProtiNX_P48634.
OpenTargetsiENSG00000204469.
PharmGKBiPA25263.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4817. Eukaryota.
ENOG410XQRI. LUCA.
GeneTreeiENSGT00530000063496.
HOVERGENiHBG004820.
InParanoidiP48634.
OMAiHITNIYL.
OrthoDBiEOG091G02WC.
PhylomeDBiP48634.
TreeFamiTF328738.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000111960-MONOMER.

Miscellaneous databases

ChiTaRSiPRRC2A. human.
GeneWikiiBAT2.
GenomeRNAii7916.
PROiP48634.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000204469.
GenevisibleiP48634. HS.

Family and domain databases

InterProiIPR009738. BAT2_N.
IPR033184. PRRC2.
[Graphical view]
PANTHERiPTHR14038. PTHR14038. 1 hit.
PfamiPF07001. BAT2_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPRC2A_HUMAN
AccessioniPrimary (citable) accession number: P48634
Secondary accession number(s): B0UX77
, B0UZE9, B0UZL3, O95875, Q05BK4, Q4LE37, Q5SQ29, Q5SQ30, Q5ST84, Q5STX6, Q5STX7, Q68DW9, Q6P9P7, Q6PIN1, Q8MGQ9, Q96QC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 148 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.