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Reviewed, UniProtKB/Swiss-Prot P48634 (BAT2_HUMAN)

Last modified July 7, 2009. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Large proline-rich protein BAT2
Alternative name(s):
    HLA-B-associated transcript 2
Gene names
Name: BAT2
Synonyms: G2
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length2157 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

May play a role in the regulation of pre-mRNA splicing. Ref.9

Subcellular location

Cytoplasm. Nucleus. Ref.12

Tissue specificity

Limited to cell-lines of leukemic origin.

Developmental stage

Broadly expressed during the 11th week of gestation, with highest levels in the central nervous system, spinal ganglia, osteoblasts and osteocytes (at protein level). Ref.12

Sequence caution

The sequence AAA35585.1 differs from that shown. Reason: Frameshift at positions 38 and 58.

The sequence AAA35586.1 differs from that shown. Reason: Frameshift at positions 38 and 58.

The sequence CAA78744.1 differs from that shown. Reason: Frameshift at positions 38 and 58.

Ontologies

Keywords
   Cellular componentCytoplasm
Nucleus
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainRepeat
   PTMPhosphoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionprotein binding Ref.9

Inferred from physical interaction. Source: IntAct

Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P48634-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P48634-2)

The sequence of this isoform differs from the canonical sequence as follows:
     413-424: Missing.
     1050-1148: RSREFRSYRE...PPPPGAPPSP → QANSAVTESF...PTTRSPTLHR
     1155-1177: ARGGRVFTPRGVPSRRGRGGGRP → CPGVGESSLPEGAISPGPRRREA
     1852-1864: AMDSQLHPNSGGF → SHGLSITSKQWRL
Isoform 3 (identifier: P48634-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1050-1148: RSREFRSYRE...PPPPGAPPSP → QANSAVTESF...PTTRSPTLHR
     1155-1177: ARGGRVFTPRGVPSRRGRGGGRP → CPGVGESSLPEGAISPGPRRREA
     1852-1864: AMDSQLHPNSGGF → SHGLSITSKQWRL

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier
Sequence conflict10821M → L in CAA78744. Ref.7
Isoform 4 (identifier: P48634-4)

The sequence of this isoform differs from the canonical sequence as follows:
     834-1457: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 21572157Large proline-rich protein BAT2
PRO_0000064829

Regions

Repeat41 – 95551-1
Repeat98 – 154571-2
Repeat281 – 337571-3
Repeat337 – 430942-1
Repeat488 – 561742-2
Repeat1757 – 1812561-4
Repeat1916 – 1965503-1
Repeat1982 – 2031503-2
Repeat2057 – 2106503-3
Region41 – 181217724 X 57 AA type A repeats
Region337 – 5612252 X type B repeats
Region1916 – 21061913 X 50 AA type C repeats
Compositional bias466 – 4716Poly-Arg
Compositional bias472 – 4754Poly-Glu
Compositional bias658 – 66912Poly-Gln
Compositional bias696 – 7005Poly-Pro
Compositional bias826 – 8338Poly-Pro
Compositional bias913 – 9164Poly-Pro
Compositional bias955 – 9584Poly-Pro
Compositional bias1139 – 11424Poly-Pro
Compositional bias1239 – 12446Poly-Arg
Compositional bias1355 – 13606Poly-Gly
Compositional bias1413 – 14219Poly-Gly
Compositional bias1451 – 14577Poly-Pro

Amino acid modifications

Modified residue1141Phosphoserine Ref.15
Modified residue1661Phosphoserine By similarity
Modified residue2041Phosphoserine Ref.15
Modified residue3421Phosphoserine Ref.15 Ref.13 Ref.18
Modified residue3501Phosphoserine Ref.15 Ref.13 Ref.18
Modified residue3801Phosphoserine Ref.18 Ref.10
Modified residue3831Phosphoserine Ref.18
Modified residue4561Phosphoserine Ref.15 Ref.18
Modified residue5171Phosphothreonine Ref.15
Modified residue6091Phosphothreonine Ref.17
Modified residue6101Phosphothreonine Ref.18 Ref.10
Modified residue7591Phosphoserine Ref.18
Modified residue7611Phosphoserine Ref.15 Ref.18 Ref.10
Modified residue7641Phosphoserine Ref.15 Ref.18
Modified residue7661Phosphoserine Ref.18
Modified residue7821Phosphothreonine By similarity
Modified residue8081Phosphoserine By similarity
Modified residue9971Phosphothreonine Ref.18
Modified residue10041Phosphoserine Ref.18
Modified residue10141Phosphoserine Ref.18 Ref.11
Modified residue10851Phosphoserine Ref.18
Modified residue10871Phosphothreonine Ref.18
Modified residue10891Phosphoserine Ref.13 Ref.18
Modified residue10921Phosphoserine Ref.13 Ref.18
Modified residue10941Phosphotyrosine Ref.18
Modified residue11471Phosphoserine Ref.18
Modified residue12191Phosphoserine Ref.13 Ref.18 Ref.10 Ref.17 Ref.16
Modified residue13061Phosphoserine Ref.18
Modified residue13471Phosphothreonine Ref.18 Ref.14
Modified residue13531Phosphothreonine By similarity

Natural variations

Alternative sequence413 – 42412Missing in isoform 2.
VSP_015099
Alternative sequence834 – 1457624Missing in isoform 4.
VSP_030865
Alternative sequence1050 – 114899RSREF…APPSP → QANSAVTESFEEMMGVEVGQ GDQTTLLLPEAAMPARHGAR VQSMRKSPSGAGSGAQKQAA RPMRVIWLLQTRRLPHPRRE HSPRSSRSPTTRSPTLHR in isoform 2 and isoform 3.
VSP_015100
Alternative sequence1155 – 117723ARGGR…GGGRP → CPGVGESSLPEGAISPGPRR REA in isoform 2 and isoform 3.
VSP_015101
Alternative sequence1852 – 186413AMDSQ…NSGGF → SHGLSITSKQWRL in isoform 2 and isoform 3.
VSP_015102
Natural variant571P → R: dbSNP rs1062968. Ref.1
VAR_023215
Natural variant821D → V: dbSNP rs6921213.
VAR_045992
Natural variant1061P → L: dbSNP rs2280801. Ref.2 Ref.5
VAR_023216
Natural variant4771R → C: dbSNP rs17857493. Ref.6
VAR_045993
Natural variant5441K → T: dbSNP rs1046080. Ref.1 Ref.5
VAR_023217
Natural variant6941Q → K: dbSNP rs2844469. Ref.7
VAR_023218
Natural variant7421D → E: dbSNP rs1046081. Ref.1
VAR_023219
Natural variant8041R → C: dbSNP rs11538262.
VAR_045994
Natural variant10871T → I in a breast cancer sample; somatic mutation. Ref.20
VAR_035796
Natural variant11521R → H in a breast cancer sample; somatic mutation. Ref.20
VAR_035797
Natural variant12851G → A: dbSNP rs2736158. Ref.3
VAR_023220
Natural variant14071S → N: dbSNP rs35464047.
VAR_045995
Natural variant14151G → A: dbSNP rs2857703. Ref.7
VAR_023221
Natural variant15031P → L: dbSNP rs2272593. Ref.5 Ref.6
VAR_023222
Natural variant15441G → D: dbSNP rs34175432.
VAR_045996
Natural variant15631R → Q: dbSNP rs11538263.
VAR_045997
Natural variant17401R → H: dbSNP rs1046089. Ref.5 Ref.3
VAR_023223
Natural variant17441G → A: dbSNP rs2844491. Ref.7
VAR_023224
Natural variant17741V → M: dbSNP rs11538264.
VAR_045998
Natural variant17751V → M: dbSNP rs11538264.
VAR_023225
Natural variant18951V → L: dbSNP rs3132453. Ref.5
VAR_023226
Natural variant20061P → S: dbSNP rs10885. Ref.5
VAR_023227
Natural variant20751R → W: dbSNP rs34137317.
VAR_056742
Natural variant21301P → L: dbSNP rs1046756. Ref.3
VAR_023228

Experimental info

Sequence conflict571P → A in CAA78744. Ref.7
Sequence conflict107 – 12317ESQPL…SNQPK → NRTTAGFTDACLQPAE in CAA78744. Ref.7
Sequence conflict7621G → L in AAA35585. Ref.1
Sequence conflict7621G → L in AAA35586. Ref.1
Sequence conflict7621G → R in CAA78744. Ref.7
Sequence conflict7641S → L in AAA35585. Ref.1
Sequence conflict7641S → L in AAA35586. Ref.1
Sequence conflict7641S → L in CAA78744. Ref.7
Sequence conflict8461A → T in CAA78744. Ref.7
Sequence conflict902 – 91110PARGVGSGGQ → LPASRSGA in AAA35585. Ref.1
Sequence conflict902 – 91110PARGVGSGGQ → LPASRSGA in AAA35586. Ref.1
Sequence conflict902 – 91110PARGVGSGGQ → LPASRSGA in CAA78744. Ref.7
Sequence conflict9341R → G in AAH42295. Ref.6
Sequence conflict10491A → G in AAA35585. Ref.1
Sequence conflict10491A → G in AAA35586. Ref.1
Sequence conflict13001R → P in AAA35585. Ref.1
Sequence conflict13001R → P in AAA35586. Ref.1
Sequence conflict14611Missing in CAA78744. Ref.7
Sequence conflict16261S → T in AAA35585. Ref.1
Sequence conflict16261S → T in AAA35586. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified August 30, 2005. Version 2.
Checksum: C500E03BE15382C9

FASTA2,157228,860
        10         20         30         40         50         60 
MSDRSGPTAK GKDGKKYSSL NLFDTYKGKS LEIQKPAVAP RHGLQSLGKV AIARRMPPPA 

        70         80         90        100        110        120 
NLPSLKAENK GNDPNVSLVP KDGTGWASKQ EQSDPKSSDA STAQPPESQP LPASQTPASN 

       130        140        150        160        170        180 
QPKRPPAAPE NTPLVPSGVK SWAQASVTHG AHGDGGRASS LLSRFSREEF PTLQAAGDQD 

       190        200        210        220        230        240 
KAAKERESAE QSSGPGPSLR PQNSTTWRDG GGRGPDELEG PDSKLHHGHD PRGGLQPSGP 

       250        260        270        280        290        300 
PQFPPYRGMM PPFMYPPYLP FPPPYGPQGP YRYPTPDGPS RFPRVAGPRG SGPPMRLVEP 

       310        320        330        340        350        360 
VGRPSILKED NLKEFDQLDQ ENDDGWAGAH EEVDYTEKLK FSDEEDGRDS DEEGAEGHRD 

       370        380        390        400        410        420 
SQSASGEERP PEADGKKGNS PNSEPPTPKT AWAETSRPPE TEPGPPAPKP PLPPPHRGPA 

       430        440        450        460        470        480 
GNWGPPGDYP DRGGPPCKPP APEDEDEAWR QRRKQSSSEI SLAVERARRR REEEERRMQE 

       490        500        510        520        530        540 
ERRAACAEKL KRLDEKFGAP DKRLKAEPAA PPAAPSTPAP PPAVPKELPA PPAPPPASAP 

       550        560        570        580        590        600 
TPEKEPEEPA QAPPAQSTPT PGVAAAPTLV SGGGSTSSTS SGSFEASPVE PQLPSKEGPE 

       610        620        630        640        650        660 
PPEEVPPPTT PPVPKVEPKG DGIGPTRQPP SQGLGYPKYQ KSLPPRFQRQ QQEQLLKQQQ 

       670        680        690        700        710        720 
QHQWQQHQQG SAPPTPVPPS PPQPVTLGAV PAPQAPPPPP KALYPGALGR PPPMPPMNFD 

       730        740        750        760        770        780 
PRWMMIPPYV DPRLLQGRPP LDFYPPGVHP SGLVPRERSD SGGSSSEPFD RHAPAMLRER 

       790        800        810        820        830        840 
GTPPVDPKLA WVGDVFTATP AEPRPLTSPL RQAADEDDKG MRSETPPVPP PPPYLASYPG 

       850        860        870        880        890        900 
FPENGAPGPP ISRFPLEEPG PRPLPWPPGS DEVAKIQTPP PKKEPPKEET AQLTGPEAGR 

       910        920        930        940        950        960 
KPARGVGSGG QGPPPPRRES RTETRWGPRP GSSRRGIPPE EPGAPPRRAG PIKKPPPPTK 

       970        980        990       1000       1010       1020 
VEELPPKPLE QGDETPKPPK PDPLKITKGK LGGPKETPPN GNLSPAPRLR RDYSYERVGP 

      1030       1040       1050       1060       1070       1080 
TSCRGRGRGE YFARGRGFRG TYGGRGRGAR SREFRSYREF RGDDGRGGGT GGPNHPPAPR 

      1090       1100       1110       1120       1130       1140 
GRTASETRSE GSEYEEIPKR RRQRGSETGS ETHESDLAPS DKEAPTPKEG TLTQVPLAPP 

      1150       1160       1170       1180       1190       1200 
PPGAPPSPAP ARFTARGGRV FTPRGVPSRR GRGGGRPPPQ VCPGWSPPAK SLAPKKPPTG 

      1210       1220       1230       1240       1250       1260 
PLPPSKEPLK EKLIPGPLSP VARGGSNGGS NVGMEDGERP RRRRHGRAQQ QDKPPRFRRL 

      1270       1280       1290       1300       1310       1320 
KQERENAARG SEGKPSLTLP ASAPGPEEAL TTVTVAPAPR RAAAKSPDLS NQNSDQANEE 

      1330       1340       1350       1360       1370       1380 
WETASESSDF TSERRGDKEA PPPVLLTPKA VGTPGGGGGG AVPGISAMSR GDLSQRAKDL 

      1390       1400       1410       1420       1430       1440 
SKRSFSSQRP GMERQNRRPG PGGKAGSSGS SSGGGGGGPG GRTGPGRGDK RSWPSPKNRS 

      1450       1460       1470       1480       1490       1500 
RPPEERPPGL PLPPPPPSSS AVFRLDQVIH SNPAGIQQAL AQLSSRQGSV TAPGGHPRHK 

      1510       1520       1530       1540       1550       1560 
PGPPQAPQGP SPRPPTRYEP QRVNSGLSSD PHFEEPGPMV RGVGGTPRDS AGVSPFPPKR 

      1570       1580       1590       1600       1610       1620 
RERPPRKPEL LQEESLPPPH SSGFLGSKPE GPGPQAESRD TGTEALTPHI WNRLHTATSR 

      1630       1640       1650       1660       1670       1680 
KSYRPSSMEP WMEPLSPFED VAGTEMSQSD SGVDLSGDSQ VSSGPCSQRS SPDGGLKGAA 

      1690       1700       1710       1720       1730       1740 
EGPPKRPGGS SPLNAVPCEG PPGSEPPRRP PPAPHDGDRK ELPREQPLPP GPIGTERSQR 

      1750       1760       1770       1780       1790       1800 
TDRGTEPGPI RPSHRPGPPV QFGTSDKDSD LRLVVGDSLK AEKELTASVT EAIPVSRDWE 

      1810       1820       1830       1840       1850       1860 
LLPSAAASAE PQSKNLDSGH CVPEPSSSGQ RLYPEVFYGS AGPSSSQISG GAMDSQLHPN 

      1870       1880       1890       1900       1910       1920 
SGGFRPGTPS LHPYRSQPLY LPPGPAPPSA LLSGVALKGQ FLDFSTMQAT ELGKLPAGGV 

      1930       1940       1950       1960       1970       1980 
LYPPPSFLYS PAFCPSPLPD TSLLQVRQDL PSPSDFYSTP LQPGGQSGFL PSGAPAQQML 

      1990       2000       2010       2020       2030       2040 
LPMVDSQLPV VNFGSLPPAP PPAPPPLSLL PVGPALQPPS LAVRPPPAPA TRVLPSPARP 

      2050       2060       2070       2080       2090       2100 
FPASLGRAEL HPVELKPFQD YQKLSSNLGG PGSSRTPPTG RSFSGLNSRL KATPSTYSGV 

      2110       2120       2130       2140       2150 
FRTQRVDLYQ QASPPDALRW IPKPWERTGP PPREGPSRRA EEPGSRGDKE PGLPPPR 

« Hide

Isoform 2.

Checksum: 7C69D322CC1DEA94
Show »

FASTA2,144227,837
Isoform 3.

Checksum: F25CC23B9CDDBAD8
Show »

FASTA2,156229,061
Isoform 4.

Checksum: 9D3D9BD5D7FB086F
Show »

FASTA1,533163,044

References

« Hide 'large scale' references
[1]"A gene pair from the human major histocompatibility complex encodes large proline-rich proteins with multiple repeated motifs and a single ubiquitin-like domain."
Banerji J., Sands J., Strominger J.L., Spies T.
Proc. Natl. Acad. Sci. U.S.A. 87:2374-2378(1990) [PubMed: 2156268] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 2), VARIANTS ARG-57; THR-544 AND GLU-742.
Tissue: T-cell.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), VARIANT LEU-106.
Tissue: Brain.
[3]"Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.
Genome Res. 13:2621-2636(2003) [PubMed: 14656967] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS ALA-1285; HIS-1740 AND LEU-2130.
[4]"Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region."
Shiina S., Tamiya G., Oka A., Inoko H.
Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed: 14574404] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS LEU-106; THR-544; LEU-1503; HIS-1740; LEU-1895 AND SER-2006.
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS CYS-477 AND LEU-1503.
Tissue: Lymph, Placenta and Uterus.
[7]"Dense Alu clustering and a potential new member of the NF kappa B family within a 90 kilobase HLA class III segment."
Iris F.J.M., Bougueleret L., Prieur S., Caterina D., Primas G., Perrot V., Jurka J., Rodriguez-Tome P., Claverie J.-M., Dausset J., Cohen D.
Nat. Genet. 3:137-145(1993) [PubMed: 8499947] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-1874 (ISOFORM 3), VARIANTS LYS-694; ALA-1415 AND ALA-1744.
[8]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Blocker H., Heubner D., Hoerlein A., Michel G., Wedler H., Kohrer K., Ottenwalder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 871-2157 (ISOFORM 1).
Tissue: Uterine endothelium.
[9]"Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region."
Lehner B., Semple J.I., Brown S.E., Counsell D., Campbell R.D., Sanderson C.M.
Genomics 83:153-167(2004) [PubMed: 14667819] [Abstract]
Cited for: FUNCTION.
[10]"Large-scale characterization of HeLa cell nuclear phosphoproteins."
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-380; SER-761; THR-610 AND SER-1219, MASS SPECTROMETRY.
Tissue: Epithelium.
[11]"Global phosphoproteome of HT-29 human colon adenocarcinoma cells."
Kim J.-E., Tannenbaum S.R., White F.M.
J. Proteome Res. 4:1339-1346(2005) [PubMed: 16083285] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1014, MASS SPECTROMETRY.
[12]"Antibodies generated by a novel DNA vaccination identify the MHC class III encoded BAT2 polypeptide."
Schneiders A., Thiel S., Winkler J., Moeller P., Koch N.
Vaccine 23:2540-2550(2005) [PubMed: 15752841] [Abstract]
Cited for: SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
[13]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed: 17081983] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-342; SER-350; SER-1089; SER-1092 AND SER-1219, MASS SPECTROMETRY.
Tissue: Epithelium.
[14]"A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
Nat. Biotechnol. 24:1285-1292(2006) [PubMed: 16964243] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1347, MASS SPECTROMETRY.
Tissue: Epithelium.
[15]"Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry."
Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.
Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007) [PubMed: 17287340] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-114; SER-204; SER-342; SER-350; SER-456; THR-517; SER-761 AND SER-764, MASS SPECTROMETRY.
[16]"Phosphoproteome of resting human platelets."
Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., Schuetz C., Walter U., Gambaryan S., Sickmann A.
J. Proteome Res. 7:526-534(2008) [PubMed: 18088087] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1219, MASS SPECTROMETRY.
Tissue: Platelet.
[17]"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
J. Proteome Res. 7:1346-1351(2008) [PubMed: 18220336] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-609 AND SER-1219, MASS SPECTROMETRY.
[18]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-342; SER-350; SER-380; SER-383; SER-456; THR-610; SER-759; SER-761; SER-764; SER-766; THR-997; SER-1004; SER-1014; SER-1085; THR-1087; SER-1089; SER-1092; TYR-1094; SER-1147; SER-1219; SER-1306 AND THR-1347, MASS SPECTROMETRY.
[19]Colinge J., Superti-Furga G., Bennett K.L.
Submitted (OCT-2008) to UniProtKB
Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[20]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed: 16959974] [Abstract]
Cited for: VARIANTS [LARGE SCALE ANALYSIS] ILE-1087 AND HIS-1152.
+Additional computationally mapped references.

Cross-references

Sequence databases

M33509 mRNA. Translation: AAA35585.1. Frameshift.
M33518, M33512 Genomic DNA. Translation: AAA35586.1. Frameshift.
AB210034 mRNA. Translation: BAE06116.1. Different initiation.
AF129756 Genomic DNA. Translation: AAD18086.1.
BA000025 Genomic DNA. Translation: BAB63391.1.
AL662847 Genomic DNA. Translation: CAI17698.2.
AL662801 Genomic DNA. Translation: CAI18313.1.
AL805934 Genomic DNA. Translation: CAI18500.1.
BX511262 Genomic DNA. Translation: CAI95572.1.
CR753892 Genomic DNA. Translation: CAQ06959.1.
BC030127 mRNA. Translation: AAH30127.1.
BC032134 mRNA. Translation: AAH32134.1.
BC042295 mRNA. Translation: AAH42295.1.
BC060668 mRNA. Translation: AAH60668.1.
Z15025 Genomic DNA. Translation: CAA78744.1. Frameshift.
CR749245 mRNA. Translation: CAH18101.1.
IPIIPI00010700.
IPI00084746.
IPI00642817.
IPI00885161.
PIRB35098.
S37671.
RefSeqNP_542417.2.
UniGeneHs.123239
Hs.436093

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

IntActP48634. 24 interactions.

Proteomic databases

PRIDEP48634.

Genome annotation databases

EnsemblENSG00000206318. Homo sapiens. [Contig view]
ENSG00000206427. Homo sapiens. [Contig view]
GeneID7916.
KEGGhsa:7916.

Organism-specific databases

GeneCardsGC06P031696.
GC06Pc31723.
GC06Pf31721.
H-InvDBHIX0032766.
HIX0057983.
HIX0058163.
HGNCHGNC:13918. BAT2.
MIM142580. gene.
PharmGKBPA25263.
GenAtlasSearch...

Phylogenomic databases

HOVERGENP48634.

Family and domain databases

InterProIPR009738. BAT2_N.
[Graphical view]
PfamPF07001. BAT2_N. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio30387.
SOURCESearch...

Entry information

Entry nameBAT2_HUMAN
AccessionPrimary (citable) accession number: P48634
Secondary accession number(s): B0UZE9 expand/collapse secondary AC list , O95875, Q05BK4, Q4LE37, Q5SQ29, Q5SQ30, Q5ST84, Q5STX6, Q5STX7, Q68DW9, Q6P9P7, Q6PIN1, Q8MGQ9, Q96QC6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: August 30, 2005
Last modified: July 7, 2009
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents