P48634 (PRC2A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein PRRC2A

Alternative name(s):
HLA-B-associated transcript 2
Large proline-rich protein BAT2
Proline-rich and coiled-coil-containing protein 2A
Protein G2

Gene names

Name:	PRRC2A
Synonyms:	BAT2, G2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	2157 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role in the regulation of pre-mRNA splicing. Ref.10
Subcellular location	Cytoplasm. Nucleus Ref.11.
Tissue specificity	Limited to cell-lines of leukemic origin.
Developmental stage	Broadly expressed during the 11th week of gestation, with highest levels in the central nervous system, spinal ganglia, osteoblasts and osteocytes (at protein level). Ref.11
Sequence caution	The sequence AAA35585.1 differs from that shown. Reason: Frameshift at positions 38 and 58. The sequence AAA35586.1 differs from that shown. Reason: Frameshift at positions 38 and 58. The sequence BAE06116.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence CAA78744.1 differs from that shown. Reason: Frameshift at positions 38 and 58.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ATXN1	P54253	4	EBI-347545,EBI-930964
JUN	P05412	2	EBI-347545,EBI-852823

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P48634-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P48634-2)

The sequence of this isoform differs from the canonical sequence as follows:
     413-424: Missing.
     1050-1148: RSREFRSYRE...PPPPGAPPSP → QANSAVTESF...PTTRSPTLHR
     1155-1177: ARGGRVFTPRGVPSRRGRGGGRP → CPGVGESSLPEGAISPGPRRREA
     1852-1864: AMDSQLHPNSGGF → SHGLSITSKQWRL

Isoform 3 (identifier: P48634-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1050-1148: RSREFRSYRE...PPPPGAPPSP → QANSAVTESF...PTTRSPTLHR
     1155-1177: ARGGRVFTPRGVPSRRGRGGGRP → CPGVGESSLPEGAISPGPRRREA
     1852-1864: AMDSQLHPNSGGF → SHGLSITSKQWRL

Isoform 4 (identifier: P48634-4)

The sequence of this isoform differs from the canonical sequence as follows:
     834-1457: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2157	2157	Protein PRRC2A		PRO_0000064829
Regions
	Repeat	41 – 95	55	1-1
	Repeat	98 – 154	57	1-2
	Repeat	281 – 337	57	1-3
	Repeat	337 – 430	94	2-1
	Repeat	488 – 561	74	2-2
	Repeat	1757 – 1812	56	1-4
	Repeat	1916 – 1965	50	3-1
	Repeat	1982 – 2031	50	3-2
	Repeat	2057 – 2106	50	3-3
	Region	41 – 1812	1772	4 X 57 AA type A repeats
	Region	337 – 561	225	2 X type B repeats
	Region	1916 – 2106	191	3 X 50 AA type C repeats
	Compositional bias	466 – 471	6	Poly-Arg
	Compositional bias	472 – 475	4	Poly-Glu
	Compositional bias	658 – 669	12	Poly-Gln
	Compositional bias	696 – 700	5	Poly-Pro
	Compositional bias	826 – 833	8	Poly-Pro
	Compositional bias	913 – 916	4	Poly-Pro
	Compositional bias	955 – 958	4	Poly-Pro
	Compositional bias	1139 – 1142	4	Poly-Pro
	Compositional bias	1239 – 1244	6	Poly-Arg
	Compositional bias	1355 – 1360	6	Poly-Gly
	Compositional bias	1413 – 1421	9	Poly-Gly
	Compositional bias	1451 – 1457	7	Poly-Pro
Amino acid modifications
	Modified residue	27	1	N6-acetyllysine Ref.17
	Modified residue	166	1	Phosphoserine By similarity
	Modified residue	342	1	Phosphoserine Ref.12 Ref.20
	Modified residue	350	1	Phosphoserine Ref.12 Ref.20
	Modified residue	380	1	Phosphoserine Ref.15 Ref.16 Ref.18 Ref.20
	Modified residue	383	1	Phosphoserine Ref.15
	Modified residue	456	1	Phosphoserine Ref.15 Ref.16
	Modified residue	610	1	Phosphothreonine Ref.15 Ref.16
	Modified residue	759	1	Phosphoserine Ref.15
	Modified residue	761	1	Phosphoserine Ref.15 Ref.16
	Modified residue	764	1	Phosphoserine Ref.15
	Modified residue	782	1	Phosphothreonine By similarity
	Modified residue	808	1	Phosphoserine Ref.18
	Modified residue	1004	1	Phosphoserine By similarity
	Modified residue	1014	1	Phosphoserine Ref.15
	Modified residue	1085	1	Phosphoserine Ref.15
	Modified residue	1089	1	Phosphoserine Ref.12 Ref.15 Ref.16 Ref.20
	Modified residue	1092	1	Phosphoserine Ref.15
	Modified residue	1094	1	Phosphotyrosine Ref.15
	Modified residue	1110	1	Phosphoserine Ref.20
	Modified residue	1147	1	Phosphoserine Ref.15
	Modified residue	1196	1	N6-acetyllysine Ref.17
	Modified residue	1219	1	Phosphoserine Ref.14 Ref.18 Ref.20
	Modified residue	1306	1	Phosphoserine Ref.15
	Modified residue	1353	1	Phosphothreonine Ref.18
	Modified residue	2113	1	Phosphoserine Ref.18
Natural variations
	Alternative sequence	413 – 424	12	Missing in isoform 2.		VSP_015099
	Alternative sequence	834 – 1457	624	Missing in isoform 4.		VSP_030865
	Alternative sequence	1050 – 1148	99	RSREF…APPSP → QANSAVTESFEEMMGVEVGQ GDQTTLLLPEAAMPARHGAR VQSMRKSPSGAGSGAQKQAA RPMRVIWLLQTRRLPHPRRE HSPRSSRSPTTRSPTLHR in isoform 2 and isoform 3.		VSP_015100
	Alternative sequence	1155 – 1177	23	ARGGR…GGGRP → CPGVGESSLPEGAISPGPRR REA in isoform 2 and isoform 3.		VSP_015101
	Alternative sequence	1852 – 1864	13	AMDSQ…NSGGF → SHGLSITSKQWRL in isoform 2 and isoform 3.		VSP_015102
	Natural variant	57	1	P → R. Ref.1 Corresponds to variant rs1062968 [ dbSNP | Ensembl ].		VAR_023215
	Natural variant	82	1	D → V. Corresponds to variant rs6921213 [ dbSNP | Ensembl ].		VAR_045992
	Natural variant	106	1	P → L. Ref.2 Ref.5 Corresponds to variant rs2280801 [ dbSNP | Ensembl ].		VAR_023216
	Natural variant	477	1	R → C. Ref.7 Corresponds to variant rs17857493 [ dbSNP | Ensembl ].		VAR_045993
	Natural variant	544	1	T → K. Ref.2 Ref.3 Ref.4 Ref.5 Ref.6 Ref.7 Ref.8 Corresponds to variant rs1046080 [ dbSNP | Ensembl ].		VAR_023217
	Natural variant	694	1	Q → K. Ref.8 Corresponds to variant rs2844469 [ dbSNP | Ensembl ].		VAR_023218
	Natural variant	742	1	D → E. Ref.1 Corresponds to variant rs1046081 [ dbSNP | Ensembl ].		VAR_023219
	Natural variant	804	1	R → C. Corresponds to variant rs11538262 [ dbSNP | Ensembl ].		VAR_045994
	Natural variant	1087	1	T → I in a breast cancer sample; somatic mutation. Ref.21		VAR_035796
	Natural variant	1152	1	R → H in a breast cancer sample; somatic mutation. Ref.21		VAR_035797
	Natural variant	1285	1	G → A. Ref.3 Corresponds to variant rs2736158 [ dbSNP | Ensembl ].		VAR_023220
	Natural variant	1407	1	S → N. Corresponds to variant rs35464047 [ dbSNP | Ensembl ].		VAR_045995
	Natural variant	1415	1	G → A. Ref.8 Corresponds to variant rs2857703 [ dbSNP | Ensembl ].		VAR_023221
	Natural variant	1503	1	L → P. Ref.1 Ref.2 Ref.3 Ref.4 Ref.5 Ref.6 Ref.7 Ref.8 Ref.9 Corresponds to variant rs2272593 [ dbSNP | Ensembl ].		VAR_023222
	Natural variant	1544	1	G → D. Corresponds to variant rs34175432 [ dbSNP | Ensembl ].		VAR_045996
	Natural variant	1563	1	R → Q. Corresponds to variant rs11538263 [ dbSNP | Ensembl ].		VAR_045997
	Natural variant	1740	1	R → H. Ref.3 Ref.5 Ref.6 Corresponds to variant rs1046089 [ dbSNP | Ensembl ].		VAR_023223
	Natural variant	1744	1	G → A. Ref.8 Corresponds to variant rs2844491 [ dbSNP | Ensembl ].		VAR_023224
	Natural variant	1774	1	V → M. Corresponds to variant rs11538264 [ dbSNP | Ensembl ].		VAR_045998
	Natural variant	1775	1	V → M. Corresponds to variant rs11538264 [ dbSNP | Ensembl ].		VAR_023225
	Natural variant	1895	1	L → V. Ref.1 Ref.2 Ref.3 Ref.4 Ref.5 Ref.6 Ref.7 Ref.9 Corresponds to variant rs3132453 [ dbSNP | Ensembl ].		VAR_023226
	Natural variant	2006	1	P → S. Ref.5 Corresponds to variant rs10885 [ dbSNP | Ensembl ].		VAR_023227
	Natural variant	2075	1	R → W. Corresponds to variant rs34137317 [ dbSNP | Ensembl ].		VAR_056742
	Natural variant	2130	1	P → L. Ref.3 Corresponds to variant rs1046756 [ dbSNP | Ensembl ].		VAR_023228
Experimental info
	Sequence conflict	57	1	P → A in CAA78744. Ref.8
	Sequence conflict	107 – 123	17	ESQPL…SNQPK → NRTTAGFTDACLQPAE in CAA78744. Ref.8
	Sequence conflict	762	1	G → L in AAA35585. Ref.1
	Sequence conflict	762	1	G → L in AAA35586. Ref.1
	Sequence conflict	762	1	G → R in CAA78744. Ref.8
	Sequence conflict	764	1	S → L in AAA35585. Ref.1
	Sequence conflict	764	1	S → L in AAA35586. Ref.1
	Sequence conflict	764	1	S → L in CAA78744. Ref.8
	Sequence conflict	846	1	A → T in CAA78744. Ref.8
	Sequence conflict	902 – 911	10	PARGVGSGGQ → LPASRSGA in AAA35585. Ref.1
	Sequence conflict	902 – 911	10	PARGVGSGGQ → LPASRSGA in AAA35586. Ref.1
	Sequence conflict	902 – 911	10	PARGVGSGGQ → LPASRSGA in CAA78744. Ref.8
	Sequence conflict	934	1	R → G in AAH42295. Ref.7
	Sequence conflict	1049	1	A → G in AAA35585. Ref.1
	Sequence conflict	1049	1	A → G in AAA35586. Ref.1
	Sequence conflict	1300	1	R → P in AAA35585. Ref.1
	Sequence conflict	1300	1	R → P in AAA35586. Ref.1
	Sequence conflict	1461	1	Missing in CAA78744. Ref.8
	Sequence conflict	1626	1	S → T in AAA35585. Ref.1
	Sequence conflict	1626	1	S → T in AAA35586. Ref.1
Isoform 3:
	Sequence conflict	1082	1	M → L in CAA78744. Ref.8

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 18, 2010. Version 3. Checksum: 7353342E72F0D393	FASTA	2,157	228,863
	10 20 30 40 50 60 MSDRSGPTAK GKDGKKYSSL NLFDTYKGKS LEIQKPAVAP RHGLQSLGKV AIARRMPPPA 70 80 90 100 110 120 NLPSLKAENK GNDPNVSLVP KDGTGWASKQ EQSDPKSSDA STAQPPESQP LPASQTPASN 130 140 150 160 170 180 QPKRPPAAPE NTPLVPSGVK SWAQASVTHG AHGDGGRASS LLSRFSREEF PTLQAAGDQD 190 200 210 220 230 240 KAAKERESAE QSSGPGPSLR PQNSTTWRDG GGRGPDELEG PDSKLHHGHD PRGGLQPSGP 250 260 270 280 290 300 PQFPPYRGMM PPFMYPPYLP FPPPYGPQGP YRYPTPDGPS RFPRVAGPRG SGPPMRLVEP 310 320 330 340 350 360 VGRPSILKED NLKEFDQLDQ ENDDGWAGAH EEVDYTEKLK FSDEEDGRDS DEEGAEGHRD 370 380 390 400 410 420 SQSASGEERP PEADGKKGNS PNSEPPTPKT AWAETSRPPE TEPGPPAPKP PLPPPHRGPA 430 440 450 460 470 480 GNWGPPGDYP DRGGPPCKPP APEDEDEAWR QRRKQSSSEI SLAVERARRR REEEERRMQE 490 500 510 520 530 540 ERRAACAEKL KRLDEKFGAP DKRLKAEPAA PPAAPSTPAP PPAVPKELPA PPAPPPASAP 550 560 570 580 590 600 TPETEPEEPA QAPPAQSTPT PGVAAAPTLV SGGGSTSSTS SGSFEASPVE PQLPSKEGPE 610 620 630 640 650 660 PPEEVPPPTT PPVPKVEPKG DGIGPTRQPP SQGLGYPKYQ KSLPPRFQRQ QQEQLLKQQQ 670 680 690 700 710 720 QHQWQQHQQG SAPPTPVPPS PPQPVTLGAV PAPQAPPPPP KALYPGALGR PPPMPPMNFD 730 740 750 760 770 780 PRWMMIPPYV DPRLLQGRPP LDFYPPGVHP SGLVPRERSD SGGSSSEPFD RHAPAMLRER 790 800 810 820 830 840 GTPPVDPKLA WVGDVFTATP AEPRPLTSPL RQAADEDDKG MRSETPPVPP PPPYLASYPG 850 860 870 880 890 900 FPENGAPGPP ISRFPLEEPG PRPLPWPPGS DEVAKIQTPP PKKEPPKEET AQLTGPEAGR 910 920 930 940 950 960 KPARGVGSGG QGPPPPRRES RTETRWGPRP GSSRRGIPPE EPGAPPRRAG PIKKPPPPTK 970 980 990 1000 1010 1020 VEELPPKPLE QGDETPKPPK PDPLKITKGK LGGPKETPPN GNLSPAPRLR RDYSYERVGP 1030 1040 1050 1060 1070 1080 TSCRGRGRGE YFARGRGFRG TYGGRGRGAR SREFRSYREF RGDDGRGGGT GGPNHPPAPR 1090 1100 1110 1120 1130 1140 GRTASETRSE GSEYEEIPKR RRQRGSETGS ETHESDLAPS DKEAPTPKEG TLTQVPLAPP 1150 1160 1170 1180 1190 1200 PPGAPPSPAP ARFTARGGRV FTPRGVPSRR GRGGGRPPPQ VCPGWSPPAK SLAPKKPPTG 1210 1220 1230 1240 1250 1260 PLPPSKEPLK EKLIPGPLSP VARGGSNGGS NVGMEDGERP RRRRHGRAQQ QDKPPRFRRL 1270 1280 1290 1300 1310 1320 KQERENAARG SEGKPSLTLP ASAPGPEEAL TTVTVAPAPR RAAAKSPDLS NQNSDQANEE 1330 1340 1350 1360 1370 1380 WETASESSDF TSERRGDKEA PPPVLLTPKA VGTPGGGGGG AVPGISAMSR GDLSQRAKDL 1390 1400 1410 1420 1430 1440 SKRSFSSQRP GMERQNRRPG PGGKAGSSGS SSGGGGGGPG GRTGPGRGDK RSWPSPKNRS 1450 1460 1470 1480 1490 1500 RPPEERPPGL PLPPPPPSSS AVFRLDQVIH SNPAGIQQAL AQLSSRQGSV TAPGGHPRHK 1510 1520 1530 1540 1550 1560 PGLPQAPQGP SPRPPTRYEP QRVNSGLSSD PHFEEPGPMV RGVGGTPRDS AGVSPFPPKR 1570 1580 1590 1600 1610 1620 RERPPRKPEL LQEESLPPPH SSGFLGSKPE GPGPQAESRD TGTEALTPHI WNRLHTATSR 1630 1640 1650 1660 1670 1680 KSYRPSSMEP WMEPLSPFED VAGTEMSQSD SGVDLSGDSQ VSSGPCSQRS SPDGGLKGAA 1690 1700 1710 1720 1730 1740 EGPPKRPGGS SPLNAVPCEG PPGSEPPRRP PPAPHDGDRK ELPREQPLPP GPIGTERSQR 1750 1760 1770 1780 1790 1800 TDRGTEPGPI RPSHRPGPPV QFGTSDKDSD LRLVVGDSLK AEKELTASVT EAIPVSRDWE 1810 1820 1830 1840 1850 1860 LLPSAAASAE PQSKNLDSGH CVPEPSSSGQ RLYPEVFYGS AGPSSSQISG GAMDSQLHPN 1870 1880 1890 1900 1910 1920 SGGFRPGTPS LHPYRSQPLY LPPGPAPPSA LLSGLALKGQ FLDFSTMQAT ELGKLPAGGV 1930 1940 1950 1960 1970 1980 LYPPPSFLYS PAFCPSPLPD TSLLQVRQDL PSPSDFYSTP LQPGGQSGFL PSGAPAQQML 1990 2000 2010 2020 2030 2040 LPMVDSQLPV VNFGSLPPAP PPAPPPLSLL PVGPALQPPS LAVRPPPAPA TRVLPSPARP 2050 2060 2070 2080 2090 2100 FPASLGRAEL HPVELKPFQD YQKLSSNLGG PGSSRTPPTG RSFSGLNSRL KATPSTYSGV 2110 2120 2130 2140 2150 FRTQRVDLYQ QASPPDALRW IPKPWERTGP PPREGPSRRA EEPGSRGDKE PGLPPPR
	Isoform 2 [UniParc]. Checksum: 9DF7B60612E16D90	FASTA	2,144	227,840
	10 20 30 40 50 60 MSDRSGPTAK GKDGKKYSSL NLFDTYKGKS LEIQKPAVAP RHGLQSLGKV AIARRMPPPA 70 80 90 100 110 120 NLPSLKAENK GNDPNVSLVP KDGTGWASKQ EQSDPKSSDA STAQPPESQP LPASQTPASN 130 140 150 160 170 180 QPKRPPAAPE NTPLVPSGVK SWAQASVTHG AHGDGGRASS LLSRFSREEF PTLQAAGDQD 190 200 210 220 230 240 KAAKERESAE QSSGPGPSLR PQNSTTWRDG GGRGPDELEG PDSKLHHGHD PRGGLQPSGP 250 260 270 280 290 300 PQFPPYRGMM PPFMYPPYLP FPPPYGPQGP YRYPTPDGPS RFPRVAGPRG SGPPMRLVEP 310 320 330 340 350 360 VGRPSILKED NLKEFDQLDQ ENDDGWAGAH EEVDYTEKLK FSDEEDGRDS DEEGAEGHRD 370 380 390 400 410 420 SQSASGEERP PEADGKKGNS PNSEPPTPKT AWAETSRPPE TEPGPPAPKP PLPPGDYPDR 430 440 450 460 470 480 GGPPCKPPAP EDEDEAWRQR RKQSSSEISL AVERARRRRE EEERRMQEER RAACAEKLKR 490 500 510 520 530 540 LDEKFGAPDK RLKAEPAAPP AAPSTPAPPP AVPKELPAPP APPPASAPTP ETEPEEPAQA 550 560 570 580 590 600 PPAQSTPTPG VAAAPTLVSG GGSTSSTSSG SFEASPVEPQ LPSKEGPEPP EEVPPPTTPP 610 620 630 640 650 660 VPKVEPKGDG IGPTRQPPSQ GLGYPKYQKS LPPRFQRQQQ EQLLKQQQQH QWQQHQQGSA 670 680 690 700 710 720 PPTPVPPSPP QPVTLGAVPA PQAPPPPPKA LYPGALGRPP PMPPMNFDPR WMMIPPYVDP 730 740 750 760 770 780 RLLQGRPPLD FYPPGVHPSG LVPRERSDSG GSSSEPFDRH APAMLRERGT PPVDPKLAWV 790 800 810 820 830 840 GDVFTATPAE PRPLTSPLRQ AADEDDKGMR SETPPVPPPP PYLASYPGFP ENGAPGPPIS 850 860 870 880 890 900 RFPLEEPGPR PLPWPPGSDE VAKIQTPPPK KEPPKEETAQ LTGPEAGRKP ARGVGSGGQG 910 920 930 940 950 960 PPPPRRESRT ETRWGPRPGS SRRGIPPEEP GAPPRRAGPI KKPPPPTKVE ELPPKPLEQG 970 980 990 1000 1010 1020 DETPKPPKPD PLKITKGKLG GPKETPPNGN LSPAPRLRRD YSYERVGPTS CRGRGRGEYF 1030 1040 1050 1060 1070 1080 ARGRGFRGTY GGRGRGAQAN SAVTESFEEM MGVEVGQGDQ TTLLLPEAAM PARHGARVQS 1090 1100 1110 1120 1130 1140 MRKSPSGAGS GAQKQAARPM RVIWLLQTRR LPHPRREHSP RSSRSPTTRS PTLHRAPARF 1150 1160 1170 1180 1190 1200 TCPGVGESSL PEGAISPGPR RREAPPQVCP GWSPPAKSLA PKKPPTGPLP PSKEPLKEKL 1210 1220 1230 1240 1250 1260 IPGPLSPVAR GGSNGGSNVG MEDGERPRRR RHGRAQQQDK PPRFRRLKQE RENAARGSEG 1270 1280 1290 1300 1310 1320 KPSLTLPASA PGPEEALTTV TVAPAPRRAA AKSPDLSNQN SDQANEEWET ASESSDFTSE 1330 1340 1350 1360 1370 1380 RRGDKEAPPP VLLTPKAVGT PGGGGGGAVP GISAMSRGDL SQRAKDLSKR SFSSQRPGME 1390 1400 1410 1420 1430 1440 RQNRRPGPGG KAGSSGSSSG GGGGGPGGRT GPGRGDKRSW PSPKNRSRPP EERPPGLPLP 1450 1460 1470 1480 1490 1500 PPPPSSSAVF RLDQVIHSNP AGIQQALAQL SSRQGSVTAP GGHPRHKPGL PQAPQGPSPR 1510 1520 1530 1540 1550 1560 PPTRYEPQRV NSGLSSDPHF EEPGPMVRGV GGTPRDSAGV SPFPPKRRER PPRKPELLQE 1570 1580 1590 1600 1610 1620 ESLPPPHSSG FLGSKPEGPG PQAESRDTGT EALTPHIWNR LHTATSRKSY RPSSMEPWME 1630 1640 1650 1660 1670 1680 PLSPFEDVAG TEMSQSDSGV DLSGDSQVSS GPCSQRSSPD GGLKGAAEGP PKRPGGSSPL 1690 1700 1710 1720 1730 1740 NAVPCEGPPG SEPPRRPPPA PHDGDRKELP REQPLPPGPI GTERSQRTDR GTEPGPIRPS 1750 1760 1770 1780 1790 1800 HRPGPPVQFG TSDKDSDLRL VVGDSLKAEK ELTASVTEAI PVSRDWELLP SAAASAEPQS 1810 1820 1830 1840 1850 1860 KNLDSGHCVP EPSSSGQRLY PEVFYGSAGP SSSQISGGSH GLSITSKQWR LRPGTPSLHP 1870 1880 1890 1900 1910 1920 YRSQPLYLPP GPAPPSALLS GLALKGQFLD FSTMQATELG KLPAGGVLYP PPSFLYSPAF 1930 1940 1950 1960 1970 1980 CPSPLPDTSL LQVRQDLPSP SDFYSTPLQP GGQSGFLPSG APAQQMLLPM VDSQLPVVNF 1990 2000 2010 2020 2030 2040 GSLPPAPPPA PPPLSLLPVG PALQPPSLAV RPPPAPATRV LPSPARPFPA SLGRAELHPV 2050 2060 2070 2080 2090 2100 ELKPFQDYQK LSSNLGGPGS SRTPPTGRSF SGLNSRLKAT PSTYSGVFRT QRVDLYQQAS 2110 2120 2130 2140 PPDALRWIPK PWERTGPPPR EGPSRRAEEP GSRGDKEPGL PPPR
	Isoform 3 [UniParc]. Checksum: 13C2A71F42213DDC	FASTA	2,156	229,064
	10 20 30 40 50 60 MSDRSGPTAK GKDGKKYSSL NLFDTYKGKS LEIQKPAVAP RHGLQSLGKV AIARRMPPPA 70 80 90 100 110 120 NLPSLKAENK GNDPNVSLVP KDGTGWASKQ EQSDPKSSDA STAQPPESQP LPASQTPASN 130 140 150 160 170 180 QPKRPPAAPE NTPLVPSGVK SWAQASVTHG AHGDGGRASS LLSRFSREEF PTLQAAGDQD 190 200 210 220 230 240 KAAKERESAE QSSGPGPSLR PQNSTTWRDG GGRGPDELEG PDSKLHHGHD PRGGLQPSGP 250 260 270 280 290 300 PQFPPYRGMM PPFMYPPYLP FPPPYGPQGP YRYPTPDGPS RFPRVAGPRG SGPPMRLVEP 310 320 330 340 350 360 VGRPSILKED NLKEFDQLDQ ENDDGWAGAH EEVDYTEKLK FSDEEDGRDS DEEGAEGHRD 370 380 390 400 410 420 SQSASGEERP PEADGKKGNS PNSEPPTPKT AWAETSRPPE TEPGPPAPKP PLPPPHRGPA 430 440 450 460 470 480 GNWGPPGDYP DRGGPPCKPP APEDEDEAWR QRRKQSSSEI SLAVERARRR REEEERRMQE 490 500 510 520 530 540 ERRAACAEKL KRLDEKFGAP DKRLKAEPAA PPAAPSTPAP PPAVPKELPA PPAPPPASAP 550 560 570 580 590 600 TPETEPEEPA QAPPAQSTPT PGVAAAPTLV SGGGSTSSTS SGSFEASPVE PQLPSKEGPE 610 620 630 640 650 660 PPEEVPPPTT PPVPKVEPKG DGIGPTRQPP SQGLGYPKYQ KSLPPRFQRQ QQEQLLKQQQ 670 680 690 700 710 720 QHQWQQHQQG SAPPTPVPPS PPQPVTLGAV PAPQAPPPPP KALYPGALGR PPPMPPMNFD 730 740 750 760 770 780 PRWMMIPPYV DPRLLQGRPP LDFYPPGVHP SGLVPRERSD SGGSSSEPFD RHAPAMLRER 790 800 810 820 830 840 GTPPVDPKLA WVGDVFTATP AEPRPLTSPL RQAADEDDKG MRSETPPVPP PPPYLASYPG 850 860 870 880 890 900 FPENGAPGPP ISRFPLEEPG PRPLPWPPGS DEVAKIQTPP PKKEPPKEET AQLTGPEAGR 910 920 930 940 950 960 KPARGVGSGG QGPPPPRRES RTETRWGPRP GSSRRGIPPE EPGAPPRRAG PIKKPPPPTK 970 980 990 1000 1010 1020 VEELPPKPLE QGDETPKPPK PDPLKITKGK LGGPKETPPN GNLSPAPRLR RDYSYERVGP 1030 1040 1050 1060 1070 1080 TSCRGRGRGE YFARGRGFRG TYGGRGRGAQ ANSAVTESFE EMMGVEVGQG DQTTLLLPEA 1090 1100 1110 1120 1130 1140 AMPARHGARV QSMRKSPSGA GSGAQKQAAR PMRVIWLLQT RRLPHPRREH SPRSSRSPTT 1150 1160 1170 1180 1190 1200 RSPTLHRAPA RFTCPGVGES SLPEGAISPG PRRREAPPQV CPGWSPPAKS LAPKKPPTGP 1210 1220 1230 1240 1250 1260 LPPSKEPLKE KLIPGPLSPV ARGGSNGGSN VGMEDGERPR RRRHGRAQQQ DKPPRFRRLK 1270 1280 1290 1300 1310 1320 QERENAARGS EGKPSLTLPA SAPGPEEALT TVTVAPAPRR AAAKSPDLSN QNSDQANEEW 1330 1340 1350 1360 1370 1380 ETASESSDFT SERRGDKEAP PPVLLTPKAV GTPGGGGGGA VPGISAMSRG DLSQRAKDLS 1390 1400 1410 1420 1430 1440 KRSFSSQRPG MERQNRRPGP GGKAGSSGSS SGGGGGGPGG RTGPGRGDKR SWPSPKNRSR 1450 1460 1470 1480 1490 1500 PPEERPPGLP LPPPPPSSSA VFRLDQVIHS NPAGIQQALA QLSSRQGSVT APGGHPRHKP 1510 1520 1530 1540 1550 1560 GLPQAPQGPS PRPPTRYEPQ RVNSGLSSDP HFEEPGPMVR GVGGTPRDSA GVSPFPPKRR 1570 1580 1590 1600 1610 1620 ERPPRKPELL QEESLPPPHS SGFLGSKPEG PGPQAESRDT GTEALTPHIW NRLHTATSRK 1630 1640 1650 1660 1670 1680 SYRPSSMEPW MEPLSPFEDV AGTEMSQSDS GVDLSGDSQV SSGPCSQRSS PDGGLKGAAE 1690 1700 1710 1720 1730 1740 GPPKRPGGSS PLNAVPCEGP PGSEPPRRPP PAPHDGDRKE LPREQPLPPG PIGTERSQRT 1750 1760 1770 1780 1790 1800 DRGTEPGPIR PSHRPGPPVQ FGTSDKDSDL RLVVGDSLKA EKELTASVTE AIPVSRDWEL 1810 1820 1830 1840 1850 1860 LPSAAASAEP QSKNLDSGHC VPEPSSSGQR LYPEVFYGSA GPSSSQISGG SHGLSITSKQ 1870 1880 1890 1900 1910 1920 WRLRPGTPSL HPYRSQPLYL PPGPAPPSAL LSGLALKGQF LDFSTMQATE LGKLPAGGVL 1930 1940 1950 1960 1970 1980 YPPPSFLYSP AFCPSPLPDT SLLQVRQDLP SPSDFYSTPL QPGGQSGFLP SGAPAQQMLL 1990 2000 2010 2020 2030 2040 PMVDSQLPVV NFGSLPPAPP PAPPPLSLLP VGPALQPPSL AVRPPPAPAT RVLPSPARPF 2050 2060 2070 2080 2090 2100 PASLGRAELH PVELKPFQDY QKLSSNLGGP GSSRTPPTGR SFSGLNSRLK ATPSTYSGVF 2110 2120 2130 2140 2150 RTQRVDLYQQ ASPPDALRWI PKPWERTGPP PREGPSRRAE EPGSRGDKEP GLPPPR
	Isoform 4 [UniParc]. Checksum: 0F496D1F2EB629E7	FASTA	1,533	163,047
	10 20 30 40 50 60 MSDRSGPTAK GKDGKKYSSL NLFDTYKGKS LEIQKPAVAP RHGLQSLGKV AIARRMPPPA 70 80 90 100 110 120 NLPSLKAENK GNDPNVSLVP KDGTGWASKQ EQSDPKSSDA STAQPPESQP LPASQTPASN 130 140 150 160 170 180 QPKRPPAAPE NTPLVPSGVK SWAQASVTHG AHGDGGRASS LLSRFSREEF PTLQAAGDQD 190 200 210 220 230 240 KAAKERESAE QSSGPGPSLR PQNSTTWRDG GGRGPDELEG PDSKLHHGHD PRGGLQPSGP 250 260 270 280 290 300 PQFPPYRGMM PPFMYPPYLP FPPPYGPQGP YRYPTPDGPS RFPRVAGPRG SGPPMRLVEP 310 320 330 340 350 360 VGRPSILKED NLKEFDQLDQ ENDDGWAGAH EEVDYTEKLK FSDEEDGRDS DEEGAEGHRD 370 380 390 400 410 420 SQSASGEERP PEADGKKGNS PNSEPPTPKT AWAETSRPPE TEPGPPAPKP PLPPPHRGPA 430 440 450 460 470 480 GNWGPPGDYP DRGGPPCKPP APEDEDEAWR QRRKQSSSEI SLAVERARRR REEEERRMQE 490 500 510 520 530 540 ERRAACAEKL KRLDEKFGAP DKRLKAEPAA PPAAPSTPAP PPAVPKELPA PPAPPPASAP 550 560 570 580 590 600 TPETEPEEPA QAPPAQSTPT PGVAAAPTLV SGGGSTSSTS SGSFEASPVE PQLPSKEGPE 610 620 630 640 650 660 PPEEVPPPTT PPVPKVEPKG DGIGPTRQPP SQGLGYPKYQ KSLPPRFQRQ QQEQLLKQQQ 670 680 690 700 710 720 QHQWQQHQQG SAPPTPVPPS PPQPVTLGAV PAPQAPPPPP KALYPGALGR PPPMPPMNFD 730 740 750 760 770 780 PRWMMIPPYV DPRLLQGRPP LDFYPPGVHP SGLVPRERSD SGGSSSEPFD RHAPAMLRER 790 800 810 820 830 840 GTPPVDPKLA WVGDVFTATP AEPRPLTSPL RQAADEDDKG MRSETPPVPP PPPSSSAVFR 850 860 870 880 890 900 LDQVIHSNPA GIQQALAQLS SRQGSVTAPG GHPRHKPGLP QAPQGPSPRP PTRYEPQRVN 910 920 930 940 950 960 SGLSSDPHFE EPGPMVRGVG GTPRDSAGVS PFPPKRRERP PRKPELLQEE SLPPPHSSGF 970 980 990 1000 1010 1020 LGSKPEGPGP QAESRDTGTE ALTPHIWNRL HTATSRKSYR PSSMEPWMEP LSPFEDVAGT 1030 1040 1050 1060 1070 1080 EMSQSDSGVD LSGDSQVSSG PCSQRSSPDG GLKGAAEGPP KRPGGSSPLN AVPCEGPPGS 1090 1100 1110 1120 1130 1140 EPPRRPPPAP HDGDRKELPR EQPLPPGPIG TERSQRTDRG TEPGPIRPSH RPGPPVQFGT 1150 1160 1170 1180 1190 1200 SDKDSDLRLV VGDSLKAEKE LTASVTEAIP VSRDWELLPS AAASAEPQSK NLDSGHCVPE 1210 1220 1230 1240 1250 1260 PSSSGQRLYP EVFYGSAGPS SSQISGGAMD SQLHPNSGGF RPGTPSLHPY RSQPLYLPPG 1270 1280 1290 1300 1310 1320 PAPPSALLSG LALKGQFLDF STMQATELGK LPAGGVLYPP PSFLYSPAFC PSPLPDTSLL 1330 1340 1350 1360 1370 1380 QVRQDLPSPS DFYSTPLQPG GQSGFLPSGA PAQQMLLPMV DSQLPVVNFG SLPPAPPPAP 1390 1400 1410 1420 1430 1440 PPLSLLPVGP ALQPPSLAVR PPPAPATRVL PSPARPFPAS LGRAELHPVE LKPFQDYQKL 1450 1460 1470 1480 1490 1500 SSNLGGPGSS RTPPTGRSFS GLNSRLKATP STYSGVFRTQ RVDLYQQASP PDALRWIPKP 1510 1520 1530 WERTGPPPRE GPSRRAEEPG SRGDKEPGLP PPR

References

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[1]	"A gene pair from the human major histocompatibility complex encodes large proline-rich proteins with multiple repeated motifs and a single ubiquitin-like domain." Banerji J., Sands J., Strominger J.L., Spies T. Proc. Natl. Acad. Sci. U.S.A. 87:2374-2378(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 2), VARIANTS ARG-57; GLU-742; PRO-1503 AND VAL-1895. Tissue: T-cell.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), VARIANTS LEU-106; LYS-544; PRO-1503 AND VAL-1895. Tissue: Brain.
[3]	"Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse." Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L. Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS LYS-544; ALA-1285; PRO-1503; HIS-1740; VAL-1895 AND LEU-2130.
[4]	"Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region." Shiina S., Tamiya G., Oka A., Inoko H. Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS LYS-544; PRO-1503 AND VAL-1895.
[5]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS LEU-106; LYS-544; PRO-1503; HIS-1740; VAL-1895 AND SER-2006.
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS LYS-544; PRO-1503; HIS-1740 AND VAL-1895.
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS CYS-477; LYS-544; PRO-1503 AND VAL-1895. Tissue: Lymph, Placenta and Uterus.
[8]	"Dense Alu clustering and a potential new member of the NF kappa B family within a 90 kilobase HLA class III segment." Iris F.J.M., Bougueleret L., Prieur S., Caterina D., Primas G., Perrot V., Jurka J., Rodriguez-Tome P., Claverie J.-M., Dausset J., Cohen D. Nat. Genet. 3:137-145(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-1874 (ISOFORM 3), VARIANTS LYS-544; LYS-694; ALA-1415; PRO-1503 AND ALA-1744.
[9]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 871-2157 (ISOFORM 1), VARIANTS PRO-1503 AND VAL-1895. Tissue: Uterine endothelium.
[10]	"Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region." Lehner B., Semple J.I., Brown S.E., Counsell D., Campbell R.D., Sanderson C.M. Genomics 83:153-167(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[11]	"Antibodies generated by a novel DNA vaccination identify the MHC class III encoded BAT2 polypeptide." Schneiders A., Thiel S., Winkler J., Moeller P., Koch N. Vaccine 23:2540-2550(2005) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
[12]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-342; SER-350 AND SER-1089, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[13]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[14]	"Phosphoproteome of resting human platelets." Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., Schuetz C., Walter U., Gambaryan S., Sickmann A. J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1219, MASS SPECTROMETRY. Tissue: Platelet.
[15]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-380; SER-383; SER-456; THR-610; SER-759; SER-761; SER-764; SER-1014; SER-1085; SER-1089; SER-1092; TYR-1094; SER-1147 AND SER-1306, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[16]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-380; SER-456; THR-610; SER-761 AND SER-1089, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[17]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-27 AND LYS-1196, MASS SPECTROMETRY.
[18]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-380; SER-808; SER-1219; THR-1353 AND SER-2113, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[19]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[20]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-342; SER-350; SER-380; SER-1089; SER-1110 AND SER-1219, MASS SPECTROMETRY.
[21]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] ILE-1087 AND HIS-1152.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M33509 mRNA. Translation: AAA35585.1. Frameshift. M33518, M33512 Genomic DNA. Translation: AAA35586.1. Frameshift. AB210034 mRNA. Translation: BAE06116.1. Different initiation. AF129756 Genomic DNA. Translation: AAD18086.1. CR354443 Genomic DNA. Translation: CAQ06970.1. BA000025 Genomic DNA. Translation: BAB63391.1. AL662847 Genomic DNA. Translation: CAI17698.2. AL662801 Genomic DNA. Translation: CAI18313.1. AL805934 Genomic DNA. Translation: CAI18500.1. BX511262 Genomic DNA. Translation: CAI95572.1. CR753892 Genomic DNA. Translation: CAQ06959.1. CR759761 Genomic DNA. Translation: CAQ10847.1. CH471081 Genomic DNA. Translation: EAX03452.1. BC030127 mRNA. Translation: AAH30127.1. BC032134 mRNA. Translation: AAH32134.1. BC042295 mRNA. Translation: AAH42295.1. BC060668 mRNA. Translation: AAH60668.1. Z15025 Genomic DNA. Translation: CAA78744.1. Frameshift. CR749245 mRNA. Translation: CAH18101.1.
IPI	IPI00010700. IPI00084746. IPI00642817. IPI00885161.
PIR	B35098. S37671.
RefSeq	NP_004629.3. NM_004638.3. NP_542417.2. NM_080686.2.
UniGene	Hs.123239. Hs.436093.
3D structure databases
ProteinModelPortal	P48634.
ModBase	Search...
Protein-protein interaction databases
IntAct	P48634. 32 interactions.
MINT	MINT-1032109.
STRING	9606.ENSP00000404619.
Polymorphism databases
DMDM	296439424.
Proteomic databases
PaxDb	P48634.
PRIDE	P48634.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000376007; ENSP00000365175; ENSG00000204469. ENST00000376033; ENSP00000365201; ENSG00000204469. ENST00000383455; ENSP00000372947; ENSG00000206427. ENST00000383464; ENSP00000372956; ENSG00000206427. ENST00000414956; ENSP00000404619; ENSG00000226618. ENST00000416335; ENSP00000415182; ENSG00000231370. ENST00000422962; ENSP00000415363; ENSG00000231825. ENST00000428775; ENSP00000387910; ENSG00000225164. ENST00000430737; ENSP00000413977; ENSG00000231825. ENST00000432252; ENSP00000408226; ENSG00000225748. ENST00000435971; ENSP00000409444; ENSG00000225164. ENST00000439762; ENSP00000400540; ENSG00000231370. ENST00000454306; ENSP00000387477; ENSG00000225748. ENST00000458561; ENSP00000396812; ENSG00000226618.
GeneID	7916.
KEGG	hsa:7916.
UCSC	uc003nvb.4. human.
Organism-specific databases
CTD	7916.
GeneCards	GC06P031594.
HGNC	HGNC:13918. PRRC2A.
HPA	CAB026383.
MIM	142580. gene.
neXtProt	NX_P48634.
PharmGKB	PA25263.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG271062.
HOVERGEN	HBG004820.
InParanoid	P48634.
OMA	YSYERVG.
OrthoDB	EOG4G7BXH.
PhylomeDB	P48634.
Gene expression databases
ArrayExpress	P48634.
Bgee	P48634.
Genevestigator	P48634.
Family and domain databases
InterPro	IPR009738. BAT2_N. [Graphical view]
Pfam	PF07001. BAT2_N. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	PRRC2A. human.
GenomeRNAi	7916.
NextBio	30387.
SOURCE	Search...

Entry information

Entry name

PRC2A_HUMAN

Accession

Primary (citable) accession number: P48634
Secondary accession number(s): B0UX77 , B0UZE9, B0UZL3, O95875, Q05BK4, Q4LE37, Q5SQ29, Q5SQ30, Q5ST84, Q5STX6, Q5STX7, Q68DW9, Q6P9P7, Q6PIN1, Q8MGQ9, Q96QC6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	May 18, 2010
Last modified:	April 3, 2013
This is version 114 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.