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P48634

- PRC2A_HUMAN

UniProt

P48634 - PRC2A_HUMAN

Protein

Protein PRRC2A

Gene

PRRC2A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 3 (18 May 2010)
      Previous versions | rss
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    Functioni

    May play a role in the regulation of pre-mRNA splicing.1 Publication

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. protein binding Source: IntAct

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein PRRC2A
    Alternative name(s):
    HLA-B-associated transcript 2
    Large proline-rich protein BAT2
    Proline-rich and coiled-coil-containing protein 2A
    Protein G2
    Gene namesi
    Name:PRRC2A
    Synonyms:BAT2, G2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:13918. PRRC2A.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. extracellular vesicular exosome Source: UniProt
    3. membrane Source: UniProtKB
    4. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25263.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 21572157Protein PRRC2APRO_0000064829Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei27 – 271N6-acetyllysine1 Publication
    Modified residuei35 – 351N6-acetyllysineBy similarity
    Modified residuei166 – 1661PhosphoserineBy similarity
    Modified residuei342 – 3421Phosphoserine2 Publications
    Modified residuei350 – 3501Phosphoserine2 Publications
    Modified residuei380 – 3801Phosphoserine4 Publications
    Modified residuei383 – 3831Phosphoserine1 Publication
    Modified residuei456 – 4561Phosphoserine2 Publications
    Modified residuei610 – 6101Phosphothreonine2 Publications
    Modified residuei759 – 7591Phosphoserine1 Publication
    Modified residuei761 – 7611Phosphoserine2 Publications
    Modified residuei764 – 7641Phosphoserine1 Publication
    Modified residuei808 – 8081Phosphoserine1 Publication
    Modified residuei997 – 9971PhosphothreonineBy similarity
    Modified residuei1004 – 10041PhosphoserineBy similarity
    Modified residuei1085 – 10851Phosphoserine1 Publication
    Modified residuei1089 – 10891Phosphoserine2 Publications
    Modified residuei1092 – 10921Phosphoserine1 Publication
    Modified residuei1094 – 10941Phosphotyrosine1 Publication
    Modified residuei1110 – 11101Phosphoserine1 Publication
    Modified residuei1147 – 11471Phosphoserine1 Publication
    Modified residuei1196 – 11961N6-acetyllysine1 Publication
    Modified residuei1219 – 12191Phosphoserine3 Publications
    Modified residuei1306 – 13061Phosphoserine1 Publication
    Modified residuei1353 – 13531Phosphothreonine1 Publication
    Modified residuei2113 – 21131Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiP48634.
    PaxDbiP48634.
    PRIDEiP48634.

    Expressioni

    Tissue specificityi

    Limited to cell-lines of leukemic origin.

    Developmental stagei

    Broadly expressed during the 11th week of gestation, with highest levels in the central nervous system, spinal ganglia, osteoblasts and osteocytes (at protein level).1 Publication

    Gene expression databases

    BgeeiP48634.
    GenevestigatoriP48634.

    Organism-specific databases

    HPAiCAB026383.
    HPA046791.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ATXN1P542534EBI-347545,EBI-930964
    JUNP054122EBI-347545,EBI-852823

    Protein-protein interaction databases

    BioGridi113646. 43 interactions.
    IntActiP48634. 32 interactions.
    MINTiMINT-1032109.
    STRINGi9606.ENSP00000404619.

    Structurei

    3D structure databases

    ProteinModelPortaliP48634.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati41 – 95551-1Add
    BLAST
    Repeati98 – 154571-2Add
    BLAST
    Repeati281 – 337571-3Add
    BLAST
    Repeati337 – 430942-1Add
    BLAST
    Repeati488 – 561742-2Add
    BLAST
    Repeati1757 – 1812561-4Add
    BLAST
    Repeati1916 – 1965503-1Add
    BLAST
    Repeati1982 – 2031503-2Add
    BLAST
    Repeati2057 – 2106503-3Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni41 – 181217724 X 57 AA type A repeatsAdd
    BLAST
    Regioni337 – 5612252 X type B repeatsAdd
    BLAST
    Regioni1916 – 21061913 X 50 AA type C repeatsAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi466 – 4716Poly-Arg
    Compositional biasi472 – 4754Poly-Glu
    Compositional biasi658 – 66912Poly-GlnAdd
    BLAST
    Compositional biasi696 – 7005Poly-Pro
    Compositional biasi826 – 8338Poly-Pro
    Compositional biasi913 – 9164Poly-Pro
    Compositional biasi955 – 9584Poly-Pro
    Compositional biasi1139 – 11424Poly-Pro
    Compositional biasi1239 – 12446Poly-Arg
    Compositional biasi1355 – 13606Poly-Gly
    Compositional biasi1413 – 14219Poly-Gly
    Compositional biasi1451 – 14577Poly-Pro

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG271062.
    HOVERGENiHBG004820.
    InParanoidiP48634.
    OMAiHITNIYL.
    OrthoDBiEOG7DZ8J2.
    PhylomeDBiP48634.
    TreeFamiTF328738.

    Family and domain databases

    InterProiIPR009738. BAT2_N.
    [Graphical view]
    PfamiPF07001. BAT2_N. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P48634-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSDRSGPTAK GKDGKKYSSL NLFDTYKGKS LEIQKPAVAP RHGLQSLGKV     50
    AIARRMPPPA NLPSLKAENK GNDPNVSLVP KDGTGWASKQ EQSDPKSSDA 100
    STAQPPESQP LPASQTPASN QPKRPPAAPE NTPLVPSGVK SWAQASVTHG 150
    AHGDGGRASS LLSRFSREEF PTLQAAGDQD KAAKERESAE QSSGPGPSLR 200
    PQNSTTWRDG GGRGPDELEG PDSKLHHGHD PRGGLQPSGP PQFPPYRGMM 250
    PPFMYPPYLP FPPPYGPQGP YRYPTPDGPS RFPRVAGPRG SGPPMRLVEP 300
    VGRPSILKED NLKEFDQLDQ ENDDGWAGAH EEVDYTEKLK FSDEEDGRDS 350
    DEEGAEGHRD SQSASGEERP PEADGKKGNS PNSEPPTPKT AWAETSRPPE 400
    TEPGPPAPKP PLPPPHRGPA GNWGPPGDYP DRGGPPCKPP APEDEDEAWR 450
    QRRKQSSSEI SLAVERARRR REEEERRMQE ERRAACAEKL KRLDEKFGAP 500
    DKRLKAEPAA PPAAPSTPAP PPAVPKELPA PPAPPPASAP TPETEPEEPA 550
    QAPPAQSTPT PGVAAAPTLV SGGGSTSSTS SGSFEASPVE PQLPSKEGPE 600
    PPEEVPPPTT PPVPKVEPKG DGIGPTRQPP SQGLGYPKYQ KSLPPRFQRQ 650
    QQEQLLKQQQ QHQWQQHQQG SAPPTPVPPS PPQPVTLGAV PAPQAPPPPP 700
    KALYPGALGR PPPMPPMNFD PRWMMIPPYV DPRLLQGRPP LDFYPPGVHP 750
    SGLVPRERSD SGGSSSEPFD RHAPAMLRER GTPPVDPKLA WVGDVFTATP 800
    AEPRPLTSPL RQAADEDDKG MRSETPPVPP PPPYLASYPG FPENGAPGPP 850
    ISRFPLEEPG PRPLPWPPGS DEVAKIQTPP PKKEPPKEET AQLTGPEAGR 900
    KPARGVGSGG QGPPPPRRES RTETRWGPRP GSSRRGIPPE EPGAPPRRAG 950
    PIKKPPPPTK VEELPPKPLE QGDETPKPPK PDPLKITKGK LGGPKETPPN 1000
    GNLSPAPRLR RDYSYERVGP TSCRGRGRGE YFARGRGFRG TYGGRGRGAR 1050
    SREFRSYREF RGDDGRGGGT GGPNHPPAPR GRTASETRSE GSEYEEIPKR 1100
    RRQRGSETGS ETHESDLAPS DKEAPTPKEG TLTQVPLAPP PPGAPPSPAP 1150
    ARFTARGGRV FTPRGVPSRR GRGGGRPPPQ VCPGWSPPAK SLAPKKPPTG 1200
    PLPPSKEPLK EKLIPGPLSP VARGGSNGGS NVGMEDGERP RRRRHGRAQQ 1250
    QDKPPRFRRL KQERENAARG SEGKPSLTLP ASAPGPEEAL TTVTVAPAPR 1300
    RAAAKSPDLS NQNSDQANEE WETASESSDF TSERRGDKEA PPPVLLTPKA 1350
    VGTPGGGGGG AVPGISAMSR GDLSQRAKDL SKRSFSSQRP GMERQNRRPG 1400
    PGGKAGSSGS SSGGGGGGPG GRTGPGRGDK RSWPSPKNRS RPPEERPPGL 1450
    PLPPPPPSSS AVFRLDQVIH SNPAGIQQAL AQLSSRQGSV TAPGGHPRHK 1500
    PGLPQAPQGP SPRPPTRYEP QRVNSGLSSD PHFEEPGPMV RGVGGTPRDS 1550
    AGVSPFPPKR RERPPRKPEL LQEESLPPPH SSGFLGSKPE GPGPQAESRD 1600
    TGTEALTPHI WNRLHTATSR KSYRPSSMEP WMEPLSPFED VAGTEMSQSD 1650
    SGVDLSGDSQ VSSGPCSQRS SPDGGLKGAA EGPPKRPGGS SPLNAVPCEG 1700
    PPGSEPPRRP PPAPHDGDRK ELPREQPLPP GPIGTERSQR TDRGTEPGPI 1750
    RPSHRPGPPV QFGTSDKDSD LRLVVGDSLK AEKELTASVT EAIPVSRDWE 1800
    LLPSAAASAE PQSKNLDSGH CVPEPSSSGQ RLYPEVFYGS AGPSSSQISG 1850
    GAMDSQLHPN SGGFRPGTPS LHPYRSQPLY LPPGPAPPSA LLSGLALKGQ 1900
    FLDFSTMQAT ELGKLPAGGV LYPPPSFLYS PAFCPSPLPD TSLLQVRQDL 1950
    PSPSDFYSTP LQPGGQSGFL PSGAPAQQML LPMVDSQLPV VNFGSLPPAP 2000
    PPAPPPLSLL PVGPALQPPS LAVRPPPAPA TRVLPSPARP FPASLGRAEL 2050
    HPVELKPFQD YQKLSSNLGG PGSSRTPPTG RSFSGLNSRL KATPSTYSGV 2100
    FRTQRVDLYQ QASPPDALRW IPKPWERTGP PPREGPSRRA EEPGSRGDKE 2150
    PGLPPPR 2157
    Length:2,157
    Mass (Da):228,863
    Last modified:May 18, 2010 - v3
    Checksum:i7353342E72F0D393
    GO
    Isoform 2 (identifier: P48634-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         413-424: Missing.
         1050-1148: RSREFRSYRE...PPPPGAPPSP → QANSAVTESF...PTTRSPTLHR
         1155-1177: ARGGRVFTPRGVPSRRGRGGGRP → CPGVGESSLPEGAISPGPRRREA
         1852-1864: AMDSQLHPNSGGF → SHGLSITSKQWRL

    Show »
    Length:2,144
    Mass (Da):227,840
    Checksum:i9DF7B60612E16D90
    GO
    Isoform 3 (identifier: P48634-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1050-1148: RSREFRSYRE...PPPPGAPPSP → QANSAVTESF...PTTRSPTLHR
         1155-1177: ARGGRVFTPRGVPSRRGRGGGRP → CPGVGESSLPEGAISPGPRRREA
         1852-1864: AMDSQLHPNSGGF → SHGLSITSKQWRL

    Show »
    Length:2,156
    Mass (Da):229,064
    Checksum:i13C2A71F42213DDC
    GO
    Isoform 4 (identifier: P48634-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         834-1457: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,533
    Mass (Da):163,047
    Checksum:i0F496D1F2EB629E7
    GO

    Sequence cautioni

    The sequence AAA35585.1 differs from that shown. Reason: Frameshift at positions 38 and 58.
    The sequence AAA35586.1 differs from that shown. Reason: Frameshift at positions 38 and 58.
    The sequence CAA78744.1 differs from that shown. Reason: Frameshift at positions 38 and 58.
    The sequence BAE06116.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti57 – 571P → A in CAA78744. (PubMed:8499947)Curated
    Sequence conflicti107 – 12317ESQPL…SNQPK → NRTTAGFTDACLQPAE in CAA78744. (PubMed:8499947)CuratedAdd
    BLAST
    Sequence conflicti762 – 7621G → L in AAA35585. (PubMed:2156268)Curated
    Sequence conflicti762 – 7621G → L in AAA35586. (PubMed:2156268)Curated
    Sequence conflicti762 – 7621G → R in CAA78744. (PubMed:8499947)Curated
    Sequence conflicti764 – 7641S → L in AAA35585. (PubMed:2156268)Curated
    Sequence conflicti764 – 7641S → L in AAA35586. (PubMed:2156268)Curated
    Sequence conflicti764 – 7641S → L in CAA78744. (PubMed:8499947)Curated
    Sequence conflicti846 – 8461A → T in CAA78744. (PubMed:8499947)Curated
    Sequence conflicti902 – 91110PARGVGSGGQ → LPASRSGA in AAA35585. (PubMed:2156268)Curated
    Sequence conflicti902 – 91110PARGVGSGGQ → LPASRSGA in AAA35586. (PubMed:2156268)Curated
    Sequence conflicti902 – 91110PARGVGSGGQ → LPASRSGA in CAA78744. (PubMed:8499947)Curated
    Sequence conflicti934 – 9341R → G in AAH42295. (PubMed:15489334)Curated
    Sequence conflicti1049 – 10491A → G in AAA35585. (PubMed:2156268)Curated
    Sequence conflicti1049 – 10491A → G in AAA35586. (PubMed:2156268)Curated
    Sequence conflicti1300 – 13001R → P in AAA35585. (PubMed:2156268)Curated
    Sequence conflicti1300 – 13001R → P in AAA35586. (PubMed:2156268)Curated
    Sequence conflicti1461 – 14611Missing in CAA78744. (PubMed:8499947)Curated
    Sequence conflicti1626 – 16261S → T in AAA35585. (PubMed:2156268)Curated
    Sequence conflicti1626 – 16261S → T in AAA35586. (PubMed:2156268)Curated
    Isoform 3 (identifier: P48634-3)
    Sequence conflicti1082 – 10821M → L in CAA78744. (PubMed:8499947)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti57 – 571P → R.1 Publication
    Corresponds to variant rs1062968 [ dbSNP | Ensembl ].
    VAR_023215
    Natural varianti82 – 821D → V.
    Corresponds to variant rs6921213 [ dbSNP | Ensembl ].
    VAR_045992
    Natural varianti106 – 1061P → L.2 Publications
    Corresponds to variant rs2280801 [ dbSNP | Ensembl ].
    VAR_023216
    Natural varianti477 – 4771R → C.1 Publication
    Corresponds to variant rs17857493 [ dbSNP | Ensembl ].
    VAR_045993
    Natural varianti544 – 5441T → K.7 Publications
    Corresponds to variant rs1046080 [ dbSNP | Ensembl ].
    VAR_023217
    Natural varianti694 – 6941Q → K.1 Publication
    Corresponds to variant rs2844469 [ dbSNP | Ensembl ].
    VAR_023218
    Natural varianti742 – 7421D → E.1 Publication
    Corresponds to variant rs1046081 [ dbSNP | Ensembl ].
    VAR_023219
    Natural varianti804 – 8041R → C.
    Corresponds to variant rs11538262 [ dbSNP | Ensembl ].
    VAR_045994
    Natural varianti1087 – 10871T → I in a breast cancer sample; somatic mutation. 1 Publication
    VAR_035796
    Natural varianti1152 – 11521R → H in a breast cancer sample; somatic mutation. 1 Publication
    VAR_035797
    Natural varianti1285 – 12851G → A.1 Publication
    Corresponds to variant rs2736158 [ dbSNP | Ensembl ].
    VAR_023220
    Natural varianti1407 – 14071S → N.
    Corresponds to variant rs35464047 [ dbSNP | Ensembl ].
    VAR_045995
    Natural varianti1415 – 14151G → A.1 Publication
    Corresponds to variant rs2857703 [ dbSNP | Ensembl ].
    VAR_023221
    Natural varianti1503 – 15031L → P.9 Publications
    Corresponds to variant rs2272593 [ dbSNP | Ensembl ].
    VAR_023222
    Natural varianti1544 – 15441G → D.
    Corresponds to variant rs34175432 [ dbSNP | Ensembl ].
    VAR_045996
    Natural varianti1563 – 15631R → Q.
    Corresponds to variant rs11538263 [ dbSNP | Ensembl ].
    VAR_045997
    Natural varianti1740 – 17401R → H.3 Publications
    Corresponds to variant rs1046089 [ dbSNP | Ensembl ].
    VAR_023223
    Natural varianti1744 – 17441G → A.1 Publication
    Corresponds to variant rs2844491 [ dbSNP | Ensembl ].
    VAR_023224
    Natural varianti1774 – 17741V → M.
    Corresponds to variant rs11538264 [ dbSNP | Ensembl ].
    VAR_045998
    Natural varianti1775 – 17751V → M.
    Corresponds to variant rs11538264 [ dbSNP | Ensembl ].
    VAR_023225
    Natural varianti1895 – 18951L → V.8 Publications
    Corresponds to variant rs3132453 [ dbSNP | Ensembl ].
    VAR_023226
    Natural varianti2006 – 20061P → S.1 Publication
    Corresponds to variant rs10885 [ dbSNP | Ensembl ].
    VAR_023227
    Natural varianti2075 – 20751R → W.
    Corresponds to variant rs34137317 [ dbSNP | Ensembl ].
    VAR_056742
    Natural varianti2130 – 21301P → L.1 Publication
    Corresponds to variant rs1046756 [ dbSNP | Ensembl ].
    VAR_023228

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei413 – 42412Missing in isoform 2. 1 PublicationVSP_015099Add
    BLAST
    Alternative sequencei834 – 1457624Missing in isoform 4. 1 PublicationVSP_030865Add
    BLAST
    Alternative sequencei1050 – 114899RSREF…APPSP → QANSAVTESFEEMMGVEVGQ GDQTTLLLPEAAMPARHGAR VQSMRKSPSGAGSGAQKQAA RPMRVIWLLQTRRLPHPRRE HSPRSSRSPTTRSPTLHR in isoform 2 and isoform 3. 1 PublicationVSP_015100Add
    BLAST
    Alternative sequencei1155 – 117723ARGGR…GGGRP → CPGVGESSLPEGAISPGPRR REA in isoform 2 and isoform 3. 1 PublicationVSP_015101Add
    BLAST
    Alternative sequencei1852 – 186413AMDSQ…NSGGF → SHGLSITSKQWRL in isoform 2 and isoform 3. 1 PublicationVSP_015102Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M33509 mRNA. Translation: AAA35585.1. Frameshift.
    M33518, M33512 Genomic DNA. Translation: AAA35586.1. Frameshift.
    AB210034 mRNA. Translation: BAE06116.1. Different initiation.
    AF129756 Genomic DNA. Translation: AAD18086.1.
    CR354443 Genomic DNA. Translation: CAQ06970.1.
    BA000025 Genomic DNA. Translation: BAB63391.1.
    AL662847 Genomic DNA. Translation: CAI17698.2.
    AL662801 Genomic DNA. Translation: CAI18313.1.
    AL805934 Genomic DNA. Translation: CAI18500.1.
    BX511262 Genomic DNA. Translation: CAI95572.1.
    CR753892 Genomic DNA. Translation: CAQ06959.1.
    CR759761 Genomic DNA. Translation: CAQ10847.1.
    CH471081 Genomic DNA. Translation: EAX03452.1.
    BC030127 mRNA. Translation: AAH30127.1.
    BC032134 mRNA. Translation: AAH32134.1.
    BC042295 mRNA. Translation: AAH42295.1.
    BC060668 mRNA. Translation: AAH60668.1.
    Z15025 Genomic DNA. Translation: CAA78744.1. Frameshift.
    CR749245 mRNA. Translation: CAH18101.1.
    CCDSiCCDS4708.1. [P48634-1]
    PIRiB35098.
    S37671.
    RefSeqiNP_004629.3. NM_004638.3. [P48634-1]
    NP_542417.2. NM_080686.2. [P48634-1]
    UniGeneiHs.123239.
    Hs.436093.

    Genome annotation databases

    EnsembliENST00000376007; ENSP00000365175; ENSG00000204469. [P48634-1]
    ENST00000376033; ENSP00000365201; ENSG00000204469. [P48634-1]
    ENST00000383455; ENSP00000372947; ENSG00000206427.
    ENST00000383464; ENSP00000372956; ENSG00000206427.
    ENST00000414956; ENSP00000404619; ENSG00000226618.
    ENST00000416335; ENSP00000415182; ENSG00000231370.
    ENST00000422962; ENSP00000415363; ENSG00000231825.
    ENST00000428775; ENSP00000387910; ENSG00000225164.
    ENST00000430737; ENSP00000413977; ENSG00000231825.
    ENST00000432252; ENSP00000408226; ENSG00000225748.
    ENST00000435971; ENSP00000409444; ENSG00000225164.
    ENST00000439762; ENSP00000400540; ENSG00000231370.
    ENST00000454306; ENSP00000387477; ENSG00000225748.
    ENST00000458561; ENSP00000396812; ENSG00000226618.
    GeneIDi7916.
    KEGGihsa:7916.
    UCSCiuc003nvb.4. human. [P48634-1]

    Polymorphism databases

    DMDMi296439424.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M33509 mRNA. Translation: AAA35585.1 . Frameshift.
    M33518 , M33512 Genomic DNA. Translation: AAA35586.1 . Frameshift.
    AB210034 mRNA. Translation: BAE06116.1 . Different initiation.
    AF129756 Genomic DNA. Translation: AAD18086.1 .
    CR354443 Genomic DNA. Translation: CAQ06970.1 .
    BA000025 Genomic DNA. Translation: BAB63391.1 .
    AL662847 Genomic DNA. Translation: CAI17698.2 .
    AL662801 Genomic DNA. Translation: CAI18313.1 .
    AL805934 Genomic DNA. Translation: CAI18500.1 .
    BX511262 Genomic DNA. Translation: CAI95572.1 .
    CR753892 Genomic DNA. Translation: CAQ06959.1 .
    CR759761 Genomic DNA. Translation: CAQ10847.1 .
    CH471081 Genomic DNA. Translation: EAX03452.1 .
    BC030127 mRNA. Translation: AAH30127.1 .
    BC032134 mRNA. Translation: AAH32134.1 .
    BC042295 mRNA. Translation: AAH42295.1 .
    BC060668 mRNA. Translation: AAH60668.1 .
    Z15025 Genomic DNA. Translation: CAA78744.1 . Frameshift.
    CR749245 mRNA. Translation: CAH18101.1 .
    CCDSi CCDS4708.1. [P48634-1 ]
    PIRi B35098.
    S37671.
    RefSeqi NP_004629.3. NM_004638.3. [P48634-1 ]
    NP_542417.2. NM_080686.2. [P48634-1 ]
    UniGenei Hs.123239.
    Hs.436093.

    3D structure databases

    ProteinModelPortali P48634.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113646. 43 interactions.
    IntActi P48634. 32 interactions.
    MINTi MINT-1032109.
    STRINGi 9606.ENSP00000404619.

    Polymorphism databases

    DMDMi 296439424.

    Proteomic databases

    MaxQBi P48634.
    PaxDbi P48634.
    PRIDEi P48634.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000376007 ; ENSP00000365175 ; ENSG00000204469 . [P48634-1 ]
    ENST00000376033 ; ENSP00000365201 ; ENSG00000204469 . [P48634-1 ]
    ENST00000383455 ; ENSP00000372947 ; ENSG00000206427 .
    ENST00000383464 ; ENSP00000372956 ; ENSG00000206427 .
    ENST00000414956 ; ENSP00000404619 ; ENSG00000226618 .
    ENST00000416335 ; ENSP00000415182 ; ENSG00000231370 .
    ENST00000422962 ; ENSP00000415363 ; ENSG00000231825 .
    ENST00000428775 ; ENSP00000387910 ; ENSG00000225164 .
    ENST00000430737 ; ENSP00000413977 ; ENSG00000231825 .
    ENST00000432252 ; ENSP00000408226 ; ENSG00000225748 .
    ENST00000435971 ; ENSP00000409444 ; ENSG00000225164 .
    ENST00000439762 ; ENSP00000400540 ; ENSG00000231370 .
    ENST00000454306 ; ENSP00000387477 ; ENSG00000225748 .
    ENST00000458561 ; ENSP00000396812 ; ENSG00000226618 .
    GeneIDi 7916.
    KEGGi hsa:7916.
    UCSCi uc003nvb.4. human. [P48634-1 ]

    Organism-specific databases

    CTDi 7916.
    GeneCardsi GC06P031719.
    GC06Pj31575.
    GC06Pk31570.
    GC06Pl31627.
    GC06Pm31664.
    GC06Pn31578.
    GC06Po31578.
    HGNCi HGNC:13918. PRRC2A.
    HPAi CAB026383.
    HPA046791.
    MIMi 142580. gene.
    neXtProti NX_P48634.
    PharmGKBi PA25263.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG271062.
    HOVERGENi HBG004820.
    InParanoidi P48634.
    OMAi HITNIYL.
    OrthoDBi EOG7DZ8J2.
    PhylomeDBi P48634.
    TreeFami TF328738.

    Miscellaneous databases

    ChiTaRSi PRRC2A. human.
    GeneWikii BAT2.
    GenomeRNAii 7916.
    NextBioi 30387.
    PROi P48634.
    SOURCEi Search...

    Gene expression databases

    Bgeei P48634.
    Genevestigatori P48634.

    Family and domain databases

    InterProi IPR009738. BAT2_N.
    [Graphical view ]
    Pfami PF07001. BAT2_N. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A gene pair from the human major histocompatibility complex encodes large proline-rich proteins with multiple repeated motifs and a single ubiquitin-like domain."
      Banerji J., Sands J., Strominger J.L., Spies T.
      Proc. Natl. Acad. Sci. U.S.A. 87:2374-2378(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 2), VARIANTS ARG-57; GLU-742; PRO-1503 AND VAL-1895.
      Tissue: T-cell.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), VARIANTS LEU-106; LYS-544; PRO-1503 AND VAL-1895.
      Tissue: Brain.
    3. "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
      Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.
      Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS LYS-544; ALA-1285; PRO-1503; HIS-1740; VAL-1895 AND LEU-2130.
    4. "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region."
      Shiina S., Tamiya G., Oka A., Inoko H.
      Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS LYS-544; PRO-1503 AND VAL-1895.
    5. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS LEU-106; LYS-544; PRO-1503; HIS-1740; VAL-1895 AND SER-2006.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS LYS-544; PRO-1503; HIS-1740 AND VAL-1895.
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS CYS-477; LYS-544; PRO-1503 AND VAL-1895.
      Tissue: Lymph, Placenta and Uterus.
    8. "Dense Alu clustering and a potential new member of the NF kappa B family within a 90 kilobase HLA class III segment."
      Iris F.J.M., Bougueleret L., Prieur S., Caterina D., Primas G., Perrot V., Jurka J., Rodriguez-Tome P., Claverie J.-M., Dausset J., Cohen D.
      Nat. Genet. 3:137-145(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-1874 (ISOFORM 3), VARIANTS LYS-544; LYS-694; ALA-1415; PRO-1503 AND ALA-1744.
    9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 871-2157 (ISOFORM 1), VARIANTS PRO-1503 AND VAL-1895.
      Tissue: Uterine endothelium.
    10. "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region."
      Lehner B., Semple J.I., Brown S.E., Counsell D., Campbell R.D., Sanderson C.M.
      Genomics 83:153-167(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    11. "Antibodies generated by a novel DNA vaccination identify the MHC class III encoded BAT2 polypeptide."
      Schneiders A., Thiel S., Winkler J., Moeller P., Koch N.
      Vaccine 23:2540-2550(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
    12. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-342 AND SER-350, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1219, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Platelet.
    15. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-380; SER-383; SER-456; THR-610; SER-759; SER-761; SER-764; SER-1085; SER-1089; SER-1092; TYR-1094; SER-1147 AND SER-1306, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    16. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    17. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-380; SER-456; THR-610; SER-761 AND SER-1089, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    18. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-27 AND LYS-1196, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    19. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-380; SER-808; SER-1219; THR-1353 AND SER-2113, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    20. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    21. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-342; SER-350; SER-380; SER-1110 AND SER-1219, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    22. Cited for: VARIANTS [LARGE SCALE ANALYSIS] ILE-1087 AND HIS-1152.

    Entry informationi

    Entry nameiPRC2A_HUMAN
    AccessioniPrimary (citable) accession number: P48634
    Secondary accession number(s): B0UX77
    , B0UZE9, B0UZL3, O95875, Q05BK4, Q4LE37, Q5SQ29, Q5SQ30, Q5ST84, Q5STX6, Q5STX7, Q68DW9, Q6P9P7, Q6PIN1, Q8MGQ9, Q96QC6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 127 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3