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Protein

Ferripyoverdine receptor

Gene

fpvA

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for the siderophore ferripyoverdine.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron

Protein family/group databases

TCDBi1.B.14.1.6. the outer membrane receptor (omr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Ferripyoverdine receptor
Gene namesi
Name:fpvA
Ordered Locus Names:PA2398
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA2398.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4343Sequence analysisAdd
BLAST
Chaini44 – 815772Ferripyoverdine receptorPRO_0000034751Add
BLAST

Proteomic databases

PaxDbiP48632.

Expressioni

Inductioni

By the siderophore, pyoverdine, and under iron starvation conditions.

Interactioni

Protein-protein interaction databases

STRINGi208964.PA2398.

Structurei

Secondary structure

1
815
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi46 – 505Combined sources
Beta strandi52 – 543Combined sources
Helixi55 – 6511Combined sources
Beta strandi69 – 724Combined sources
Helixi74 – 774Combined sources
Beta strandi85 – 895Combined sources
Helixi91 – 999Combined sources
Turni100 – 1034Combined sources
Beta strandi105 – 1095Combined sources
Beta strandi112 – 1165Combined sources
Beta strandi132 – 1343Combined sources
Turni154 – 1563Combined sources
Helixi162 – 1643Combined sources
Beta strandi166 – 1727Combined sources
Helixi174 – 1807Combined sources
Helixi185 – 1906Combined sources
Beta strandi196 – 2016Combined sources
Beta strandi204 – 2096Combined sources
Beta strandi217 – 2193Combined sources
Turni229 – 2379Combined sources
Helixi240 – 2423Combined sources
Beta strandi243 – 2519Combined sources
Helixi254 – 2574Combined sources
Beta strandi262 – 2709Combined sources
Beta strandi278 – 2869Combined sources
Turni287 – 2893Combined sources
Beta strandi290 – 30213Combined sources
Beta strandi306 – 31813Combined sources
Beta strandi326 – 34116Combined sources
Beta strandi344 – 35916Combined sources
Beta strandi362 – 3698Combined sources
Beta strandi392 – 40615Combined sources
Turni407 – 4093Combined sources
Beta strandi410 – 43021Combined sources
Beta strandi441 – 46626Combined sources
Beta strandi468 – 49023Combined sources
Beta strandi499 – 5013Combined sources
Beta strandi519 – 53820Combined sources
Beta strandi540 – 56021Combined sources
Beta strandi563 – 57816Combined sources
Beta strandi580 – 59415Combined sources
Beta strandi611 – 62414Combined sources
Helixi625 – 6273Combined sources
Beta strandi629 – 64517Combined sources
Helixi648 – 6514Combined sources
Beta strandi664 – 68219Combined sources
Beta strandi685 – 69814Combined sources
Beta strandi699 – 7013Combined sources
Beta strandi710 – 72011Combined sources
Helixi723 – 7253Combined sources
Beta strandi728 – 73710Combined sources
Beta strandi740 – 7467Combined sources
Turni747 – 7504Combined sources
Beta strandi751 – 7577Combined sources
Beta strandi760 – 77213Combined sources
Beta strandi775 – 7839Combined sources
Beta strandi790 – 7934Combined sources
Beta strandi797 – 8015Combined sources
Beta strandi805 – 81410Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1XKHX-ray3.60A/B/C129-815[»]
2IAHX-ray2.73A44-815[»]
2O5PX-ray2.77A/B44-815[»]
2W16X-ray2.71A/B44-815[»]
2W6TX-ray2.90A/B44-815[»]
2W6UX-ray3.00A/B44-815[»]
2W75X-ray2.90A/B44-815[»]
2W76X-ray2.80A/B44-815[»]
2W77X-ray2.90A/B44-815[»]
2W78X-ray3.00A/B44-815[»]
DisProtiDP00183.
ProteinModelPortaliP48632.
SMRiP48632. Positions 44-815.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP48632.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi798 – 81518TonB C-terminal boxAdd
BLAST

Sequence similaritiesi

Belongs to the TonB-dependent receptor family.Curated

Keywords - Domaini

Signal, TonB box, Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiENOG4105CNM. Bacteria.
COG4773. LUCA.
HOGENOMiHOG000217242.
InParanoidiP48632.
KOiK16088.
OMAiGETHTDP.
OrthoDBiEOG67DPGD.
PhylomeDBiP48632.

Family and domain databases

Gene3Di2.170.130.10. 1 hit.
2.40.170.20. 1 hit.
InterProiIPR012910. Plug_dom.
IPR011662. Secretin/TonB_short_N.
IPR000531. TonB-dep_rcpt_b-brl.
IPR010917. TonB_rcpt_CS.
IPR010105. TonB_sidphr_rcpt.
[Graphical view]
PfamiPF07715. Plug. 1 hit.
PF07660. STN. 1 hit.
PF00593. TonB_dep_Rec. 1 hit.
[Graphical view]
SMARTiSM00965. STN. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01783. TonB-siderophor. 1 hit.
PROSITEiPS01156. TONB_DEPENDENT_REC_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48632-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAPHGLSPL SKAFLMRRAF QRRILPHSLA MALSLPLAGY VQAQEVEFDI
60 70 80 90 100
PPQALGSALQ EFGRQADIQV LYRPEEVRNK RSSAIKGKLE PNQAITELLR
110 120 130 140 150
GTGASVDFQG NAITISVAEA ADSSVDLGAT MITSNQLGTI TEDSGSYTPG
160 170 180 190 200
TIATATRLVL TPRETPQSIT VVTRQNMDDF GLNNIDDVMR HTPGITVSAY
210 220 230 240 250
DTDRNNYYAR GFSINNFQYD GIPSTARNVG YSAGNTLSDM AIYDRVEVLK
260 270 280 290 300
GATGLLTGAG SLGATINLIR KKPTHEFKGH VELGAGSWDN YRSELDVSGP
310 320 330 340 350
LTESGNVRGR AVAAYQDKHS FMDHYERKTS VYYGILEFDL NPDTMLTVGA
360 370 380 390 400
DYQDNDPKGS GWSGSFPLFD SQGNRNDVSR SFNNGAKWSS WEQYTRTVFA
410 420 430 440 450
NLEHNFANGW VGKVQLDHKI NGYHAPLGAI MGDWPAPDNS AKIVAQKYTG
460 470 480 490 500
ETKSNSLDIY LTGPFQFLGR EHELVVGTSA SFSHWEGKSY WNLRNYDNTT
510 520 530 540 550
DDFINWDGDI GKPDWGTPSQ YIDDKTRQLG SYMTARFNVT DDLNLFLGGR
560 570 580 590 600
VVDYRVTGLN PTIRESGRFI PYVGAVYDLN DTYSVYASYT DIFMPQDSWY
610 620 630 640 650
RDSSNKLLEP DEGQNYEIGI KGEYLDGRLN TSLAYFEIHE ENRAEEDALY
660 670 680 690 700
NSKPTNPAIT YAYKGIKAKT KGYEAEISGE LAPGWQVQAG YTHKIIRDDS
710 720 730 740 750
GKKVSTWEPQ DQLSLYTSYK FKGALDKLTV GGGARWQGKS WQMVYNNPRS
760 770 780 790 800
RWEKFSQEDY WLVDLMARYQ ITDKLSASVN VNNVFDKTYY TNIGFYTSAS
810
YGDPRNLMFS TRWDF
Length:815
Mass (Da):91,167
Last modified:December 8, 2000 - v2
Checksum:iA11AE4AA5A290F35
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti716 – 7161Y → F in AAA25819 (PubMed:8335619).Curated
Sequence conflicti745 – 7462Missing in AAA25819 (PubMed:8335619).Curated
Sequence conflicti750 – 7501S → R in AAA25819 (PubMed:8335619).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10210 Genomic DNA. Translation: AAA25819.1.
U07359 Genomic DNA. Translation: AAB60199.1.
AE004091 Genomic DNA. Translation: AAG05786.1.
PIRiA40601.
H83345.
RefSeqiNP_251088.1. NC_002516.2.
WP_004349900.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG05786; AAG05786; PA2398.
GeneIDi878605.
KEGGipae:PA2398.
PATRICi19839259. VBIPseAer58763_2509.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10210 Genomic DNA. Translation: AAA25819.1.
U07359 Genomic DNA. Translation: AAB60199.1.
AE004091 Genomic DNA. Translation: AAG05786.1.
PIRiA40601.
H83345.
RefSeqiNP_251088.1. NC_002516.2.
WP_004349900.1. NC_002516.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1XKHX-ray3.60A/B/C129-815[»]
2IAHX-ray2.73A44-815[»]
2O5PX-ray2.77A/B44-815[»]
2W16X-ray2.71A/B44-815[»]
2W6TX-ray2.90A/B44-815[»]
2W6UX-ray3.00A/B44-815[»]
2W75X-ray2.90A/B44-815[»]
2W76X-ray2.80A/B44-815[»]
2W77X-ray2.90A/B44-815[»]
2W78X-ray3.00A/B44-815[»]
DisProtiDP00183.
ProteinModelPortaliP48632.
SMRiP48632. Positions 44-815.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi208964.PA2398.

Protein family/group databases

TCDBi1.B.14.1.6. the outer membrane receptor (omr) family.

Proteomic databases

PaxDbiP48632.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG05786; AAG05786; PA2398.
GeneIDi878605.
KEGGipae:PA2398.
PATRICi19839259. VBIPseAer58763_2509.

Organism-specific databases

PseudoCAPiPA2398.

Phylogenomic databases

eggNOGiENOG4105CNM. Bacteria.
COG4773. LUCA.
HOGENOMiHOG000217242.
InParanoidiP48632.
KOiK16088.
OMAiGETHTDP.
OrthoDBiEOG67DPGD.
PhylomeDBiP48632.

Miscellaneous databases

EvolutionaryTraceiP48632.

Family and domain databases

Gene3Di2.170.130.10. 1 hit.
2.40.170.20. 1 hit.
InterProiIPR012910. Plug_dom.
IPR011662. Secretin/TonB_short_N.
IPR000531. TonB-dep_rcpt_b-brl.
IPR010917. TonB_rcpt_CS.
IPR010105. TonB_sidphr_rcpt.
[Graphical view]
PfamiPF07715. Plug. 1 hit.
PF07660. STN. 1 hit.
PF00593. TonB_dep_Rec. 1 hit.
[Graphical view]
SMARTiSM00965. STN. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01783. TonB-siderophor. 1 hit.
PROSITEiPS01156. TONB_DEPENDENT_REC_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and nucleotide sequence analysis of the ferripyoverdine receptor gene fpvA of Pseudomonas aeruginosa."
    Poole K., Neshat S., Krebes K., Heinrichs D.E.
    J. Bacteriol. 175:4597-4604(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 44-64.
    Strain: CD10.
  2. "Characterisation of the pvdE gene which is required for pyoverdine synthesis in Pseudomonas aeruginosa."
    McMorran B.J., Merriman M.E., Rombel I.T., Lamont I.L.
    Gene 176:55-59(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-49.
    Strain: PAO.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

Entry informationi

Entry nameiFPVA_PSEAE
AccessioniPrimary (citable) accession number: P48632
Secondary accession number(s): Q51339
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: December 8, 2000
Last modified: July 6, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-16 is the initiator.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.