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Protein

Ferripyoverdine receptor

Gene

fpvA

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for the siderophore ferripyoverdine.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron

Protein family/group databases

TCDBi1.B.14.1.6. the outer membrane receptor (omr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Ferripyoverdine receptor
Gene namesi
Name:fpvA
Ordered Locus Names:PA2398
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA2398.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 43Sequence analysisAdd BLAST43
ChainiPRO_000003475144 – 815Ferripyoverdine receptorAdd BLAST772

Proteomic databases

PaxDbiP48632.
PRIDEiP48632.

Expressioni

Inductioni

By the siderophore, pyoverdine, and under iron starvation conditions.

Interactioni

Protein-protein interaction databases

STRINGi208964.PA2398.

Structurei

Secondary structure

1815
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi46 – 50Combined sources5
Beta strandi52 – 54Combined sources3
Helixi55 – 65Combined sources11
Beta strandi69 – 72Combined sources4
Helixi74 – 77Combined sources4
Beta strandi85 – 89Combined sources5
Helixi91 – 99Combined sources9
Turni100 – 103Combined sources4
Beta strandi105 – 109Combined sources5
Beta strandi112 – 116Combined sources5
Beta strandi132 – 134Combined sources3
Turni154 – 156Combined sources3
Helixi162 – 164Combined sources3
Beta strandi166 – 172Combined sources7
Helixi174 – 180Combined sources7
Helixi185 – 190Combined sources6
Beta strandi196 – 201Combined sources6
Beta strandi204 – 209Combined sources6
Beta strandi217 – 219Combined sources3
Turni229 – 237Combined sources9
Helixi240 – 242Combined sources3
Beta strandi243 – 251Combined sources9
Helixi254 – 257Combined sources4
Beta strandi262 – 270Combined sources9
Beta strandi278 – 286Combined sources9
Turni287 – 289Combined sources3
Beta strandi290 – 302Combined sources13
Beta strandi306 – 318Combined sources13
Beta strandi326 – 341Combined sources16
Beta strandi344 – 359Combined sources16
Beta strandi362 – 369Combined sources8
Beta strandi392 – 406Combined sources15
Turni407 – 409Combined sources3
Beta strandi410 – 430Combined sources21
Beta strandi441 – 466Combined sources26
Beta strandi468 – 490Combined sources23
Beta strandi499 – 501Combined sources3
Beta strandi519 – 538Combined sources20
Beta strandi540 – 560Combined sources21
Beta strandi563 – 578Combined sources16
Beta strandi580 – 594Combined sources15
Beta strandi611 – 624Combined sources14
Helixi625 – 627Combined sources3
Beta strandi629 – 645Combined sources17
Helixi648 – 651Combined sources4
Beta strandi664 – 682Combined sources19
Beta strandi685 – 698Combined sources14
Beta strandi699 – 701Combined sources3
Beta strandi710 – 720Combined sources11
Helixi723 – 725Combined sources3
Beta strandi728 – 737Combined sources10
Beta strandi740 – 746Combined sources7
Turni747 – 750Combined sources4
Beta strandi751 – 757Combined sources7
Beta strandi760 – 772Combined sources13
Beta strandi775 – 783Combined sources9
Beta strandi790 – 793Combined sources4
Beta strandi797 – 801Combined sources5
Beta strandi805 – 814Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XKHX-ray3.60A/B/C129-815[»]
2IAHX-ray2.73A44-815[»]
2O5PX-ray2.77A/B44-815[»]
2W16X-ray2.71A/B44-815[»]
2W6TX-ray2.90A/B44-815[»]
2W6UX-ray3.00A/B44-815[»]
2W75X-ray2.90A/B44-815[»]
2W76X-ray2.80A/B44-815[»]
2W77X-ray2.90A/B44-815[»]
2W78X-ray3.00A/B44-815[»]
DisProtiDP00183.
ProteinModelPortaliP48632.
SMRiP48632.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP48632.

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi798 – 815TonB C-terminal boxAdd BLAST18

Sequence similaritiesi

Belongs to the TonB-dependent receptor family.Curated

Keywords - Domaini

Signal, TonB box, Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiENOG4105CNM. Bacteria.
COG4773. LUCA.
HOGENOMiHOG000217242.
InParanoidiP48632.
KOiK16088.
OMAiGETHTDP.
PhylomeDBiP48632.

Family and domain databases

Gene3Di2.170.130.10. 1 hit.
2.40.170.20. 1 hit.
InterProiIPR012910. Plug_dom.
IPR011662. Secretin/TonB_short_N.
IPR000531. TonB-dep_rcpt_b-brl.
IPR010917. TonB_rcpt_CS.
IPR010105. TonB_sidphr_rcpt.
[Graphical view]
PfamiPF07715. Plug. 1 hit.
PF07660. STN. 1 hit.
PF00593. TonB_dep_Rec. 1 hit.
[Graphical view]
SMARTiSM00965. STN. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01783. TonB-siderophor. 1 hit.
PROSITEiPS01156. TONB_DEPENDENT_REC_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48632-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAPHGLSPL SKAFLMRRAF QRRILPHSLA MALSLPLAGY VQAQEVEFDI
60 70 80 90 100
PPQALGSALQ EFGRQADIQV LYRPEEVRNK RSSAIKGKLE PNQAITELLR
110 120 130 140 150
GTGASVDFQG NAITISVAEA ADSSVDLGAT MITSNQLGTI TEDSGSYTPG
160 170 180 190 200
TIATATRLVL TPRETPQSIT VVTRQNMDDF GLNNIDDVMR HTPGITVSAY
210 220 230 240 250
DTDRNNYYAR GFSINNFQYD GIPSTARNVG YSAGNTLSDM AIYDRVEVLK
260 270 280 290 300
GATGLLTGAG SLGATINLIR KKPTHEFKGH VELGAGSWDN YRSELDVSGP
310 320 330 340 350
LTESGNVRGR AVAAYQDKHS FMDHYERKTS VYYGILEFDL NPDTMLTVGA
360 370 380 390 400
DYQDNDPKGS GWSGSFPLFD SQGNRNDVSR SFNNGAKWSS WEQYTRTVFA
410 420 430 440 450
NLEHNFANGW VGKVQLDHKI NGYHAPLGAI MGDWPAPDNS AKIVAQKYTG
460 470 480 490 500
ETKSNSLDIY LTGPFQFLGR EHELVVGTSA SFSHWEGKSY WNLRNYDNTT
510 520 530 540 550
DDFINWDGDI GKPDWGTPSQ YIDDKTRQLG SYMTARFNVT DDLNLFLGGR
560 570 580 590 600
VVDYRVTGLN PTIRESGRFI PYVGAVYDLN DTYSVYASYT DIFMPQDSWY
610 620 630 640 650
RDSSNKLLEP DEGQNYEIGI KGEYLDGRLN TSLAYFEIHE ENRAEEDALY
660 670 680 690 700
NSKPTNPAIT YAYKGIKAKT KGYEAEISGE LAPGWQVQAG YTHKIIRDDS
710 720 730 740 750
GKKVSTWEPQ DQLSLYTSYK FKGALDKLTV GGGARWQGKS WQMVYNNPRS
760 770 780 790 800
RWEKFSQEDY WLVDLMARYQ ITDKLSASVN VNNVFDKTYY TNIGFYTSAS
810
YGDPRNLMFS TRWDF
Length:815
Mass (Da):91,167
Last modified:December 8, 2000 - v2
Checksum:iA11AE4AA5A290F35
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti716Y → F in AAA25819 (PubMed:8335619).Curated1
Sequence conflicti745 – 746Missing in AAA25819 (PubMed:8335619).Curated2
Sequence conflicti750S → R in AAA25819 (PubMed:8335619).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10210 Genomic DNA. Translation: AAA25819.1.
U07359 Genomic DNA. Translation: AAB60199.1.
AE004091 Genomic DNA. Translation: AAG05786.1.
PIRiA40601.
H83345.
RefSeqiNP_251088.1. NC_002516.2.
WP_004349900.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG05786; AAG05786; PA2398.
GeneIDi878605.
KEGGipae:PA2398.
PATRICi19839259. VBIPseAer58763_2509.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10210 Genomic DNA. Translation: AAA25819.1.
U07359 Genomic DNA. Translation: AAB60199.1.
AE004091 Genomic DNA. Translation: AAG05786.1.
PIRiA40601.
H83345.
RefSeqiNP_251088.1. NC_002516.2.
WP_004349900.1. NC_002516.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XKHX-ray3.60A/B/C129-815[»]
2IAHX-ray2.73A44-815[»]
2O5PX-ray2.77A/B44-815[»]
2W16X-ray2.71A/B44-815[»]
2W6TX-ray2.90A/B44-815[»]
2W6UX-ray3.00A/B44-815[»]
2W75X-ray2.90A/B44-815[»]
2W76X-ray2.80A/B44-815[»]
2W77X-ray2.90A/B44-815[»]
2W78X-ray3.00A/B44-815[»]
DisProtiDP00183.
ProteinModelPortaliP48632.
SMRiP48632.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi208964.PA2398.

Protein family/group databases

TCDBi1.B.14.1.6. the outer membrane receptor (omr) family.

Proteomic databases

PaxDbiP48632.
PRIDEiP48632.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG05786; AAG05786; PA2398.
GeneIDi878605.
KEGGipae:PA2398.
PATRICi19839259. VBIPseAer58763_2509.

Organism-specific databases

PseudoCAPiPA2398.

Phylogenomic databases

eggNOGiENOG4105CNM. Bacteria.
COG4773. LUCA.
HOGENOMiHOG000217242.
InParanoidiP48632.
KOiK16088.
OMAiGETHTDP.
PhylomeDBiP48632.

Miscellaneous databases

EvolutionaryTraceiP48632.

Family and domain databases

Gene3Di2.170.130.10. 1 hit.
2.40.170.20. 1 hit.
InterProiIPR012910. Plug_dom.
IPR011662. Secretin/TonB_short_N.
IPR000531. TonB-dep_rcpt_b-brl.
IPR010917. TonB_rcpt_CS.
IPR010105. TonB_sidphr_rcpt.
[Graphical view]
PfamiPF07715. Plug. 1 hit.
PF07660. STN. 1 hit.
PF00593. TonB_dep_Rec. 1 hit.
[Graphical view]
SMARTiSM00965. STN. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01783. TonB-siderophor. 1 hit.
PROSITEiPS01156. TONB_DEPENDENT_REC_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFPVA_PSEAE
AccessioniPrimary (citable) accession number: P48632
Secondary accession number(s): Q51339
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: December 8, 2000
Last modified: November 2, 2016
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-16 is the initiator.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.