P48617 (EPO_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Erythropoietin

Gene names

Name:

EPO

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	192 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass.
Subcellular location	Secreted.
Tissue specificity	Produced by kidney or liver of adult mammals and by liver of fetal or neonatal mammals.
Sequence similarities	Belongs to the EPO/TPO family.

Ontologies

Keywords
Biological process	Erythrocyte maturation
Cellular component	Secreted
Domain	Signal
Molecular function	Hormone
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	apoptotic process Inferred from electronic annotation. Source: Compara cellular hyperosmotic response Inferred from electronic annotation. Source: Compara embryo implantation Inferred from electronic annotation. Source: Compara erythrocyte maturation Inferred from electronic annotation. Source: UniProtKB-KW hemoglobin biosynthetic process Inferred from electronic annotation. Source: Compara negative regulation of ion transmembrane transporter activity Inferred from electronic annotation. Source: Compara negative regulation of myeloid cell apoptotic process Inferred from electronic annotation. Source: Compara negative regulation of sodium ion transport Inferred from electronic annotation. Source: Compara peptidyl-serine phosphorylation Inferred from electronic annotation. Source: Compara positive regulation of DNA replication Inferred from electronic annotation. Source: Compara positive regulation of Ras protein signal transduction Inferred from electronic annotation. Source: Compara positive regulation of cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: Compara positive regulation of tyrosine phosphorylation of Stat5 protein Inferred from electronic annotation. Source: Compara regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara response to hypoxia Inferred from electronic annotation. Source: Compara
Cellular_component	extracellular space Inferred from electronic annotation. Source: Compara
Molecular_function	eukaryotic cell surface binding Inferred from electronic annotation. Source: Compara protein kinase activator activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 25	25	Potential
	Chain	26 – 192	167	Erythropoietin		PRO_0000008397
Amino acid modifications
	Glycosylation	49	1	N-linked (GlcNAc...) Potential
	Glycosylation	63	1	N-linked (GlcNAc...) Potential
	Glycosylation	108	1	N-linked (GlcNAc...) Potential
	Disulfide bond	32 ↔ 187		By similarity
	Disulfide bond	54 ↔ 58		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P48617 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: DBC419022F7B483A	FASTA	192	21,076
	10 20 30 40 50 60 MGARDCTPLL MLSFLLFPLG FPVLGAPARL ICDSRVLERY ILEAREAENA TMGCAEGCSF 70 80 90 100 110 120 NENITVPDTK VNFYAWKRME VQQQALEVWQ GLALLSEAIL RGQALLANAS QPCEALRLHV 130 140 150 160 170 180 DKAVSGLRSL TSLLRALGAQ KEAISLPDAT PSAAPLRAFT VDALSKLFRI YSNFLRGKLT 190 LYTGEACRRG DR

References

[1]	"Cloning of a cDNA encoding bovine erythropoietin and analysis of its transcription in selected tissues." Suliman H.B., Majiwa P.A.O., Feldman B.F., Mertens B., Logan-Henfrey L.L. Gene 171:275-280(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Boran. Tissue: Kidney.
[2]	"Cloning and sequence analysis on erythropoietin (EPO) gene of Bos taurus (San Jiang yellow cattle)." Jin S., Zhong J.C., Chen Z.H., Ma Z.J. Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	L41354 mRNA. Translation: AAB41268.1. U44762 mRNA. Translation: AAA86653.1. EF374049 Genomic DNA. Translation: ABN48309.1.
IPI	IPI00701863.
RefSeq	NP_776334.1. NM_173909.2.
UniGene	Bt.525.
3D structure databases
ProteinModelPortal	P48617.
SMR	P48617. Positions 26-192.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000004450; ENSBTAP00000004450; ENSBTAG00000003430.
GeneID	280784.
KEGG	bta:280784.
Organism-specific databases
CTD	2056.
Phylogenomic databases
eggNOG	NOG43828.
GeneTree	ENSGT00390000017226.
HOGENOM	HOG000052505.
HOVERGEN	HBG003978.
InParanoid	P48617.
KO	K05437.
OMA	NVTMGCA.
OrthoDB	EOG41VK4C.
Family and domain databases
Gene3D	1.20.1250.10. 1 hit.
InterPro	IPR009079. 4_helix_cytokine-like_core. IPR012351. 4_helix_cytokine_core. IPR019767. EPO/TPO_CS. IPR001323. EPO_TPO. IPR003013. Erythroptn. [Graphical view]
PANTHER	PTHR10370. PTHR10370. 1 hit.
Pfam	PF00758. EPO_TPO. 1 hit. [Graphical view]
PIRSF	PIRSF001951. EPO. 1 hit.
PRINTS	PR00272. ERYTHROPTN.
SUPFAM	SSF47266. 4_helix_cytokine. 1 hit.
PROSITE	PS00817. EPO_TPO. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20804945.

Entry information

Entry name

EPO_BOVIN

Accession

Primary (citable) accession number: P48617
Secondary accession number(s): A3FFT0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	April 3, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program