Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Erythropoietin

Gene

EPO

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone
Biological processErythrocyte maturation

Names & Taxonomyi

Protein namesi
Recommended name:
Erythropoietin
Gene namesi
Name:EPO
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 25

Organism-specific databases

VGNCiVGNC:28549 EPO

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000000839726 – 192ErythropoietinAdd BLAST167

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi32 ↔ 187By similarity
Glycosylationi49N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi54 ↔ 58By similarity
Glycosylationi63N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi108N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP48617
PRIDEiP48617

Expressioni

Tissue specificityi

Produced by kidney or liver of adult mammals and by liver of fetal or neonatal mammals.

Gene expression databases

BgeeiENSBTAG00000003430

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004450

Structurei

3D structure databases

ProteinModelPortaliP48617
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the EPO/TPO family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHW5 Eukaryota
ENOG410XTRF LUCA
GeneTreeiENSGT00390000017226
HOGENOMiHOG000052505
HOVERGENiHBG003978
InParanoidiP48617
KOiK05437
OMAiEAENVTM
OrthoDBiEOG091G0PMA
TreeFamiTF333413

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR019767 EPO/TPO_CS
IPR001323 EPO_TPO
IPR003013 Erythroptn
PANTHERiPTHR10370 PTHR10370, 1 hit
PfamiView protein in Pfam
PF00758 EPO_TPO, 1 hit
PIRSFiPIRSF001951 EPO, 1 hit
PRINTSiPR00272 ERYTHROPTN
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00817 EPO_TPO, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48617-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGARDCTPLL MLSFLLFPLG FPVLGAPARL ICDSRVLERY ILEAREAENA
60 70 80 90 100
TMGCAEGCSF NENITVPDTK VNFYAWKRME VQQQALEVWQ GLALLSEAIL
110 120 130 140 150
RGQALLANAS QPCEALRLHV DKAVSGLRSL TSLLRALGAQ KEAISLPDAT
160 170 180 190
PSAAPLRAFT VDALSKLFRI YSNFLRGKLT LYTGEACRRG DR
Length:192
Mass (Da):21,076
Last modified:February 1, 1996 - v1
Checksum:iDBC419022F7B483A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41354 mRNA Translation: AAB41268.1
U44762 mRNA Translation: AAA86653.1
EF374049 Genomic DNA Translation: ABN48309.1
RefSeqiNP_776334.1, NM_173909.2
UniGeneiBt.525

Genome annotation databases

EnsembliENSBTAT00000004450; ENSBTAP00000004450; ENSBTAG00000003430
GeneIDi280784
KEGGibta:280784

Similar proteinsi

Entry informationi

Entry nameiEPO_BOVIN
AccessioniPrimary (citable) accession number: P48617
Secondary accession number(s): A3FFT0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: March 28, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health