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Protein

Erythropoietin

Gene

EPO

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Keywords - Biological processi

Erythrocyte maturation

Names & Taxonomyi

Protein namesi
Recommended name:
Erythropoietin
Gene namesi
Name:EPO
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Chromosome 25

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 192167ErythropoietinPRO_0000008397Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi32 ↔ 187By similarity
Glycosylationi49 – 491N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi54 ↔ 58By similarity
Glycosylationi63 – 631N-linked (GlcNAc...)Sequence Analysis
Glycosylationi108 – 1081N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Produced by kidney or liver of adult mammals and by liver of fetal or neonatal mammals.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004450.

Structurei

3D structure databases

ProteinModelPortaliP48617.
SMRiP48617. Positions 26-192.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the EPO/TPO family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG43828.
GeneTreeiENSGT00390000017226.
HOGENOMiHOG000052505.
HOVERGENiHBG003978.
InParanoidiP48617.
KOiK05437.
OMAiNVTMGCA.
OrthoDBiEOG7DVDCR.
TreeFamiTF333413.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR019767. EPO/TPO_CS.
IPR001323. EPO_TPO.
IPR003013. Erythroptn.
[Graphical view]
PANTHERiPTHR10370. PTHR10370. 1 hit.
PfamiPF00758. EPO_TPO. 1 hit.
[Graphical view]
PIRSFiPIRSF001951. EPO. 1 hit.
PRINTSiPR00272. ERYTHROPTN.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00817. EPO_TPO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48617-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGARDCTPLL MLSFLLFPLG FPVLGAPARL ICDSRVLERY ILEAREAENA
60 70 80 90 100
TMGCAEGCSF NENITVPDTK VNFYAWKRME VQQQALEVWQ GLALLSEAIL
110 120 130 140 150
RGQALLANAS QPCEALRLHV DKAVSGLRSL TSLLRALGAQ KEAISLPDAT
160 170 180 190
PSAAPLRAFT VDALSKLFRI YSNFLRGKLT LYTGEACRRG DR
Length:192
Mass (Da):21,076
Last modified:February 1, 1996 - v1
Checksum:iDBC419022F7B483A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41354 mRNA. Translation: AAB41268.1.
U44762 mRNA. Translation: AAA86653.1.
EF374049 Genomic DNA. Translation: ABN48309.1.
RefSeqiNP_776334.1. NM_173909.2.
UniGeneiBt.525.

Genome annotation databases

EnsembliENSBTAT00000004450; ENSBTAP00000004450; ENSBTAG00000003430.
GeneIDi280784.
KEGGibta:280784.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41354 mRNA. Translation: AAB41268.1.
U44762 mRNA. Translation: AAA86653.1.
EF374049 Genomic DNA. Translation: ABN48309.1.
RefSeqiNP_776334.1. NM_173909.2.
UniGeneiBt.525.

3D structure databases

ProteinModelPortaliP48617.
SMRiP48617. Positions 26-192.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004450.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000004450; ENSBTAP00000004450; ENSBTAG00000003430.
GeneIDi280784.
KEGGibta:280784.

Organism-specific databases

CTDi2056.

Phylogenomic databases

eggNOGiNOG43828.
GeneTreeiENSGT00390000017226.
HOGENOMiHOG000052505.
HOVERGENiHBG003978.
InParanoidiP48617.
KOiK05437.
OMAiNVTMGCA.
OrthoDBiEOG7DVDCR.
TreeFamiTF333413.

Miscellaneous databases

NextBioi20804945.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR019767. EPO/TPO_CS.
IPR001323. EPO_TPO.
IPR003013. Erythroptn.
[Graphical view]
PANTHERiPTHR10370. PTHR10370. 1 hit.
PfamiPF00758. EPO_TPO. 1 hit.
[Graphical view]
PIRSFiPIRSF001951. EPO. 1 hit.
PRINTSiPR00272. ERYTHROPTN.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00817. EPO_TPO. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning of a cDNA encoding bovine erythropoietin and analysis of its transcription in selected tissues."
    Suliman H.B., Majiwa P.A.O., Feldman B.F., Mertens B., Logan-Henfrey L.L.
    Gene 171:275-280(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Boran.
    Tissue: Kidney.
  2. "Cloning and sequence analysis on erythropoietin (EPO) gene of Bos taurus (San Jiang yellow cattle)."
    Jin S., Zhong J.C., Chen Z.H., Ma Z.J.
    Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiEPO_BOVIN
AccessioniPrimary (citable) accession number: P48617
Secondary accession number(s): A3FFT0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 24, 2015
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.