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P48617

- EPO_BOVIN

UniProt

P48617 - EPO_BOVIN

Protein

Erythropoietin

Gene

EPO

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass.

    GO - Molecular functioni

    1. protein kinase activator activity Source: Ensembl

    GO - Biological processi

    1. apoptotic process Source: Ensembl
    2. cellular hyperosmotic response Source: Ensembl
    3. embryo implantation Source: Ensembl
    4. erythrocyte maturation Source: UniProtKB-KW
    5. hemoglobin biosynthetic process Source: Ensembl
    6. negative regulation of calcium ion transport into cytosol Source: Ensembl
    7. negative regulation of cation channel activity Source: Ensembl
    8. negative regulation of erythrocyte apoptotic process Source: Ensembl
    9. negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress Source: Ensembl
    10. peptidyl-serine phosphorylation Source: Ensembl
    11. positive regulation of cell proliferation Source: Ensembl
    12. positive regulation of DNA replication Source: Ensembl
    13. positive regulation of Ras protein signal transduction Source: Ensembl
    14. positive regulation of transcription, DNA-templated Source: Ensembl
    15. positive regulation of tyrosine phosphorylation of Stat5 protein Source: Ensembl
    16. regulation of transcription from RNA polymerase II promoter Source: Ensembl
    17. response to hypoxia Source: Ensembl

    Keywords - Molecular functioni

    Hormone

    Keywords - Biological processi

    Erythrocyte maturation

    Enzyme and pathway databases

    ReactomeiREACT_220950. Regulation of gene expression by Hypoxia-inducible Factor.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Erythropoietin
    Gene namesi
    Name:EPO
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 25

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. extracellular space Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 192167ErythropoietinPRO_0000008397Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi32 ↔ 187By similarity
    Glycosylationi49 – 491N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi54 ↔ 58By similarity
    Glycosylationi63 – 631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi108 – 1081N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Expressioni

    Tissue specificityi

    Produced by kidney or liver of adult mammals and by liver of fetal or neonatal mammals.

    Structurei

    3D structure databases

    ProteinModelPortaliP48617.
    SMRiP48617. Positions 26-192.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the EPO/TPO family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG43828.
    GeneTreeiENSGT00390000017226.
    HOGENOMiHOG000052505.
    HOVERGENiHBG003978.
    InParanoidiP48617.
    KOiK05437.
    OMAiNVTMGCA.
    OrthoDBiEOG7DVDCR.
    TreeFamiTF333413.

    Family and domain databases

    Gene3Di1.20.1250.10. 1 hit.
    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR019767. EPO/TPO_CS.
    IPR001323. EPO_TPO.
    IPR003013. Erythroptn.
    [Graphical view]
    PANTHERiPTHR10370. PTHR10370. 1 hit.
    PfamiPF00758. EPO_TPO. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001951. EPO. 1 hit.
    PRINTSiPR00272. ERYTHROPTN.
    SUPFAMiSSF47266. SSF47266. 1 hit.
    PROSITEiPS00817. EPO_TPO. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P48617-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGARDCTPLL MLSFLLFPLG FPVLGAPARL ICDSRVLERY ILEAREAENA    50
    TMGCAEGCSF NENITVPDTK VNFYAWKRME VQQQALEVWQ GLALLSEAIL 100
    RGQALLANAS QPCEALRLHV DKAVSGLRSL TSLLRALGAQ KEAISLPDAT 150
    PSAAPLRAFT VDALSKLFRI YSNFLRGKLT LYTGEACRRG DR 192
    Length:192
    Mass (Da):21,076
    Last modified:February 1, 1996 - v1
    Checksum:iDBC419022F7B483A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L41354 mRNA. Translation: AAB41268.1.
    U44762 mRNA. Translation: AAA86653.1.
    EF374049 Genomic DNA. Translation: ABN48309.1.
    RefSeqiNP_776334.1. NM_173909.2.
    UniGeneiBt.525.

    Genome annotation databases

    EnsembliENSBTAT00000004450; ENSBTAP00000004450; ENSBTAG00000003430.
    GeneIDi280784.
    KEGGibta:280784.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L41354 mRNA. Translation: AAB41268.1 .
    U44762 mRNA. Translation: AAA86653.1 .
    EF374049 Genomic DNA. Translation: ABN48309.1 .
    RefSeqi NP_776334.1. NM_173909.2.
    UniGenei Bt.525.

    3D structure databases

    ProteinModelPortali P48617.
    SMRi P48617. Positions 26-192.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000004450 ; ENSBTAP00000004450 ; ENSBTAG00000003430 .
    GeneIDi 280784.
    KEGGi bta:280784.

    Organism-specific databases

    CTDi 2056.

    Phylogenomic databases

    eggNOGi NOG43828.
    GeneTreei ENSGT00390000017226.
    HOGENOMi HOG000052505.
    HOVERGENi HBG003978.
    InParanoidi P48617.
    KOi K05437.
    OMAi NVTMGCA.
    OrthoDBi EOG7DVDCR.
    TreeFami TF333413.

    Enzyme and pathway databases

    Reactomei REACT_220950. Regulation of gene expression by Hypoxia-inducible Factor.

    Miscellaneous databases

    NextBioi 20804945.

    Family and domain databases

    Gene3Di 1.20.1250.10. 1 hit.
    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR019767. EPO/TPO_CS.
    IPR001323. EPO_TPO.
    IPR003013. Erythroptn.
    [Graphical view ]
    PANTHERi PTHR10370. PTHR10370. 1 hit.
    Pfami PF00758. EPO_TPO. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001951. EPO. 1 hit.
    PRINTSi PR00272. ERYTHROPTN.
    SUPFAMi SSF47266. SSF47266. 1 hit.
    PROSITEi PS00817. EPO_TPO. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of a cDNA encoding bovine erythropoietin and analysis of its transcription in selected tissues."
      Suliman H.B., Majiwa P.A.O., Feldman B.F., Mertens B., Logan-Henfrey L.L.
      Gene 171:275-280(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Boran.
      Tissue: Kidney.
    2. "Cloning and sequence analysis on erythropoietin (EPO) gene of Bos taurus (San Jiang yellow cattle)."
      Jin S., Zhong J.C., Chen Z.H., Ma Z.J.
      Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiEPO_BOVIN
    AccessioniPrimary (citable) accession number: P48617
    Secondary accession number(s): A3FFT0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3