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P48617 (EPO_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Erythropoietin
Gene names
Name:EPO
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length192 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass.

Subcellular location

Secreted.

Tissue specificity

Produced by kidney or liver of adult mammals and by liver of fetal or neonatal mammals.

Sequence similarities

Belongs to the EPO/TPO family.

Ontologies

Keywords
   Biological processErythrocyte maturation
   Cellular componentSecreted
   DomainSignal
   Molecular functionHormone
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processapoptotic process

Inferred from electronic annotation. Source: Ensembl

cellular hyperosmotic response

Inferred from electronic annotation. Source: Ensembl

embryo implantation

Inferred from electronic annotation. Source: Ensembl

erythrocyte maturation

Inferred from electronic annotation. Source: UniProtKB-KW

hemoglobin biosynthetic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of calcium ion transport into cytosol

Inferred from electronic annotation. Source: Ensembl

negative regulation of cation channel activity

Inferred from electronic annotation. Source: Ensembl

negative regulation of erythrocyte apoptotic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

Inferred from electronic annotation. Source: Ensembl

peptidyl-serine phosphorylation

Inferred from electronic annotation. Source: Ensembl

positive regulation of DNA replication

Inferred from electronic annotation. Source: Ensembl

positive regulation of Ras protein signal transduction

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription, DNA-templated

Inferred from electronic annotation. Source: Ensembl

positive regulation of tyrosine phosphorylation of Stat5 protein

Inferred from electronic annotation. Source: Ensembl

regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

response to hypoxia

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcell surface

Inferred from electronic annotation. Source: Ensembl

extracellular space

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionprotein kinase activator activity

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 192167Erythropoietin
PRO_0000008397

Amino acid modifications

Glycosylation491N-linked (GlcNAc...) Potential
Glycosylation631N-linked (GlcNAc...) Potential
Glycosylation1081N-linked (GlcNAc...) Potential
Disulfide bond32 ↔ 187 By similarity
Disulfide bond54 ↔ 58 By similarity

Sequences

Sequence LengthMass (Da)Tools
P48617 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: DBC419022F7B483A

FASTA19221,076
        10         20         30         40         50         60 
MGARDCTPLL MLSFLLFPLG FPVLGAPARL ICDSRVLERY ILEAREAENA TMGCAEGCSF 

        70         80         90        100        110        120 
NENITVPDTK VNFYAWKRME VQQQALEVWQ GLALLSEAIL RGQALLANAS QPCEALRLHV 

       130        140        150        160        170        180 
DKAVSGLRSL TSLLRALGAQ KEAISLPDAT PSAAPLRAFT VDALSKLFRI YSNFLRGKLT 

       190 
LYTGEACRRG DR 

« Hide

References

[1]"Cloning of a cDNA encoding bovine erythropoietin and analysis of its transcription in selected tissues."
Suliman H.B., Majiwa P.A.O., Feldman B.F., Mertens B., Logan-Henfrey L.L.
Gene 171:275-280(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Boran.
Tissue: Kidney.
[2]"Cloning and sequence analysis on erythropoietin (EPO) gene of Bos taurus (San Jiang yellow cattle)."
Jin S., Zhong J.C., Chen Z.H., Ma Z.J.
Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L41354 mRNA. Translation: AAB41268.1.
U44762 mRNA. Translation: AAA86653.1.
EF374049 Genomic DNA. Translation: ABN48309.1.
RefSeqNP_776334.1. NM_173909.2.
UniGeneBt.525.

3D structure databases

ProteinModelPortalP48617.
SMRP48617. Positions 26-192.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000004450; ENSBTAP00000004450; ENSBTAG00000003430.
GeneID280784.
KEGGbta:280784.

Organism-specific databases

CTD2056.

Phylogenomic databases

eggNOGNOG43828.
GeneTreeENSGT00390000017226.
HOGENOMHOG000052505.
HOVERGENHBG003978.
InParanoidP48617.
KOK05437.
OMANVTMGCA.
OrthoDBEOG7DVDCR.
TreeFamTF333413.

Family and domain databases

Gene3D1.20.1250.10. 1 hit.
InterProIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR019767. EPO/TPO_CS.
IPR001323. EPO_TPO.
IPR003013. Erythroptn.
[Graphical view]
PANTHERPTHR10370. PTHR10370. 1 hit.
PfamPF00758. EPO_TPO. 1 hit.
[Graphical view]
PIRSFPIRSF001951. EPO. 1 hit.
PRINTSPR00272. ERYTHROPTN.
SUPFAMSSF47266. SSF47266. 1 hit.
PROSITEPS00817. EPO_TPO. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20804945.

Entry information

Entry nameEPO_BOVIN
AccessionPrimary (citable) accession number: P48617
Secondary accession number(s): A3FFT0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: February 19, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families