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P48617

- EPO_BOVIN

UniProt

P48617 - EPO_BOVIN

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Protein

Erythropoietin

Gene

EPO

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass.

GO - Molecular functioni

  1. protein kinase activator activity Source: Ensembl

GO - Biological processi

  1. apoptotic process Source: Ensembl
  2. cellular hyperosmotic response Source: Ensembl
  3. embryo implantation Source: Ensembl
  4. erythrocyte maturation Source: UniProtKB-KW
  5. hemoglobin biosynthetic process Source: Ensembl
  6. negative regulation of calcium ion transport into cytosol Source: Ensembl
  7. negative regulation of cation channel activity Source: Ensembl
  8. negative regulation of erythrocyte apoptotic process Source: Ensembl
  9. negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress Source: Ensembl
  10. peptidyl-serine phosphorylation Source: Ensembl
  11. positive regulation of cell proliferation Source: Ensembl
  12. positive regulation of DNA replication Source: Ensembl
  13. positive regulation of Ras protein signal transduction Source: Ensembl
  14. positive regulation of transcription, DNA-templated Source: Ensembl
  15. positive regulation of tyrosine phosphorylation of Stat5 protein Source: Ensembl
  16. regulation of transcription from RNA polymerase II promoter Source: Ensembl
  17. response to hypoxia Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Keywords - Biological processi

Erythrocyte maturation

Enzyme and pathway databases

ReactomeiREACT_220950. Regulation of gene expression by Hypoxia-inducible Factor.

Names & Taxonomyi

Protein namesi
Recommended name:
Erythropoietin
Gene namesi
Name:EPO
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 25

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: Ensembl
  2. extracellular space Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 192167ErythropoietinPRO_0000008397Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi32 ↔ 187By similarity
Glycosylationi49 – 491N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi54 ↔ 58By similarity
Glycosylationi63 – 631N-linked (GlcNAc...)Sequence Analysis
Glycosylationi108 – 1081N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Produced by kidney or liver of adult mammals and by liver of fetal or neonatal mammals.

Structurei

3D structure databases

ProteinModelPortaliP48617.
SMRiP48617. Positions 26-192.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the EPO/TPO family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG43828.
GeneTreeiENSGT00390000017226.
HOGENOMiHOG000052505.
HOVERGENiHBG003978.
InParanoidiP48617.
KOiK05437.
OMAiNVTMGCA.
OrthoDBiEOG7DVDCR.
TreeFamiTF333413.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR019767. EPO/TPO_CS.
IPR001323. EPO_TPO.
IPR003013. Erythroptn.
[Graphical view]
PANTHERiPTHR10370. PTHR10370. 1 hit.
PfamiPF00758. EPO_TPO. 1 hit.
[Graphical view]
PIRSFiPIRSF001951. EPO. 1 hit.
PRINTSiPR00272. ERYTHROPTN.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00817. EPO_TPO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48617-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGARDCTPLL MLSFLLFPLG FPVLGAPARL ICDSRVLERY ILEAREAENA
60 70 80 90 100
TMGCAEGCSF NENITVPDTK VNFYAWKRME VQQQALEVWQ GLALLSEAIL
110 120 130 140 150
RGQALLANAS QPCEALRLHV DKAVSGLRSL TSLLRALGAQ KEAISLPDAT
160 170 180 190
PSAAPLRAFT VDALSKLFRI YSNFLRGKLT LYTGEACRRG DR
Length:192
Mass (Da):21,076
Last modified:February 1, 1996 - v1
Checksum:iDBC419022F7B483A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41354 mRNA. Translation: AAB41268.1.
U44762 mRNA. Translation: AAA86653.1.
EF374049 Genomic DNA. Translation: ABN48309.1.
RefSeqiNP_776334.1. NM_173909.2.
UniGeneiBt.525.

Genome annotation databases

EnsembliENSBTAT00000004450; ENSBTAP00000004450; ENSBTAG00000003430.
GeneIDi280784.
KEGGibta:280784.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41354 mRNA. Translation: AAB41268.1 .
U44762 mRNA. Translation: AAA86653.1 .
EF374049 Genomic DNA. Translation: ABN48309.1 .
RefSeqi NP_776334.1. NM_173909.2.
UniGenei Bt.525.

3D structure databases

ProteinModelPortali P48617.
SMRi P48617. Positions 26-192.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000004450 ; ENSBTAP00000004450 ; ENSBTAG00000003430 .
GeneIDi 280784.
KEGGi bta:280784.

Organism-specific databases

CTDi 2056.

Phylogenomic databases

eggNOGi NOG43828.
GeneTreei ENSGT00390000017226.
HOGENOMi HOG000052505.
HOVERGENi HBG003978.
InParanoidi P48617.
KOi K05437.
OMAi NVTMGCA.
OrthoDBi EOG7DVDCR.
TreeFami TF333413.

Enzyme and pathway databases

Reactomei REACT_220950. Regulation of gene expression by Hypoxia-inducible Factor.

Miscellaneous databases

NextBioi 20804945.

Family and domain databases

Gene3Di 1.20.1250.10. 1 hit.
InterProi IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR019767. EPO/TPO_CS.
IPR001323. EPO_TPO.
IPR003013. Erythroptn.
[Graphical view ]
PANTHERi PTHR10370. PTHR10370. 1 hit.
Pfami PF00758. EPO_TPO. 1 hit.
[Graphical view ]
PIRSFi PIRSF001951. EPO. 1 hit.
PRINTSi PR00272. ERYTHROPTN.
SUPFAMi SSF47266. SSF47266. 1 hit.
PROSITEi PS00817. EPO_TPO. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning of a cDNA encoding bovine erythropoietin and analysis of its transcription in selected tissues."
    Suliman H.B., Majiwa P.A.O., Feldman B.F., Mertens B., Logan-Henfrey L.L.
    Gene 171:275-280(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Boran.
    Tissue: Kidney.
  2. "Cloning and sequence analysis on erythropoietin (EPO) gene of Bos taurus (San Jiang yellow cattle)."
    Jin S., Zhong J.C., Chen Z.H., Ma Z.J.
    Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiEPO_BOVIN
AccessioniPrimary (citable) accession number: P48617
Secondary accession number(s): A3FFT0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 1, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3