ID WNT11_MOUSE Reviewed; 354 AA. AC P48615; DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot. DT 01-FEB-1996, sequence version 1. DT 24-JAN-2024, entry version 168. DE RecName: Full=Protein Wnt-11; DE Flags: Precursor; GN Name=Wnt11; Synonyms=Wnt-11; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=SWR/J; RX PubMed=7547479; DOI=10.1016/0925-4773(95)00383-5; RA Christiansen J.H., Dennis C.L., Wicking C.A., Monkley S.J., Wilkinson D.G., RA Wainwright B.J.; RT "Murine Wnt-11 and Wnt-12 have temporally and spatially restricted RT expression patterns during embryonic development."; RL Mech. Dev. 51:341-350(1995). CC -!- FUNCTION: Ligand for members of the frizzled family of seven CC transmembrane receptors. Probable developmental protein. May be a CC signaling molecule which affects the development of discrete regions of CC tissues. Is likely to signal over only few cell diameters. CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular CC matrix. CC -!- DEVELOPMENTAL STAGE: Expressed during embryogenesis. CC -!- PTM: Palmitoleoylation is required for efficient binding to frizzled CC receptors. Depalmitoleoylation leads to Wnt signaling pathway CC inhibition. {ECO:0000250|UniProtKB:P27467, CC ECO:0000250|UniProtKB:P56704}. CC -!- SIMILARITY: Belongs to the Wnt family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X70800; CAA50070.1; -; mRNA. DR CCDS; CCDS21475.1; -. DR PIR; S34378; S34378. DR RefSeq; NP_001272721.1; NM_001285792.1. DR RefSeq; NP_033545.1; NM_009519.2. DR RefSeq; XP_006507649.1; XM_006507586.3. DR AlphaFoldDB; P48615; -. DR SMR; P48615; -. DR BioGRID; 204570; 3. DR STRING; 10090.ENSMUSP00000064333; -. DR GlyCosmos; P48615; 5 sites, No reported glycans. DR GlyGen; P48615; 5 sites. DR PhosphoSitePlus; P48615; -. DR PaxDb; 10090-ENSMUSP00000132166; -. DR ProteomicsDB; 297852; -. DR Antibodypedia; 31189; 157 antibodies from 31 providers. DR DNASU; 22411; -. DR Ensembl; ENSMUST00000067495.9; ENSMUSP00000064333.3; ENSMUSG00000015957.13. DR Ensembl; ENSMUST00000167303.8; ENSMUSP00000132166.2; ENSMUSG00000015957.13. DR GeneID; 22411; -. DR KEGG; mmu:22411; -. DR UCSC; uc009ikv.3; mouse. DR AGR; MGI:101948; -. DR CTD; 7481; -. DR MGI; MGI:101948; Wnt11. DR VEuPathDB; HostDB:ENSMUSG00000015957; -. DR eggNOG; KOG3913; Eukaryota. DR GeneTree; ENSGT00940000158413; -. DR HOGENOM; CLU_033039_1_0_1; -. DR InParanoid; P48615; -. DR OMA; CKLLPGM; -. DR OrthoDB; 2874082at2759; -. DR PhylomeDB; P48615; -. DR TreeFam; TF105310; -. DR Reactome; R-MMU-3238698; WNT ligand biogenesis and trafficking. DR Reactome; R-MMU-4086398; Ca2+ pathway. DR Reactome; R-MMU-4086400; PCP/CE pathway. DR BioGRID-ORCS; 22411; 1 hit in 79 CRISPR screens. DR PRO; PR:P48615; -. DR Proteomes; UP000000589; Chromosome 7. DR RNAct; P48615; Protein. DR Bgee; ENSMUSG00000015957; Expressed in mesenchyme from somatopleure and 223 other cell types or tissues. DR ExpressionAtlas; P48615; baseline and differential. DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB. DR GO; GO:0031012; C:extracellular matrix; IDA:MGI. DR GO; GO:0005576; C:extracellular region; IDA:MGI. DR GO; GO:0005615; C:extracellular space; IBA:GO_Central. DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central. DR GO; GO:0005109; F:frizzled binding; IBA:GO_Central. DR GO; GO:0005096; F:GTPase activator activity; ISS:UniProtKB. DR GO; GO:0030295; F:protein kinase activator activity; ISS:UniProtKB. DR GO; GO:0005102; F:signaling receptor binding; TAS:MGI. DR GO; GO:0030325; P:adrenal gland development; IEA:Ensembl. DR GO; GO:0009887; P:animal organ morphogenesis; TAS:MGI. DR GO; GO:0006915; P:apoptotic process; IMP:MGI. DR GO; GO:0048844; P:artery morphogenesis; IMP:MGI. DR GO; GO:0003283; P:atrial septum development; IGI:CACAO. DR GO; GO:0070830; P:bicellular tight junction assembly; IMP:MGI. DR GO; GO:0030282; P:bone mineralization; IGI:MGI. DR GO; GO:0060070; P:canonical Wnt signaling pathway; IDA:MGI. DR GO; GO:0045165; P:cell fate commitment; IBA:GO_Central. DR GO; GO:0007267; P:cell-cell signaling; TAS:MGI. DR GO; GO:0071260; P:cellular response to mechanical stimulus; IDA:MGI. DR GO; GO:0060197; P:cloacal septation; IEA:Ensembl. DR GO; GO:0060028; P:convergent extension involved in axis elongation; IGI:MGI. DR GO; GO:0048706; P:embryonic skeletal system development; IEA:Ensembl. DR GO; GO:1904019; P:epithelial cell apoptotic process; IMP:MGI. DR GO; GO:0001837; P:epithelial to mesenchymal transition; IGI:MGI. DR GO; GO:0001822; P:kidney development; IDA:MGI. DR GO; GO:0060484; P:lung-associated mesenchyme development; IEA:Ensembl. DR GO; GO:0045199; P:maintenance of epithelial cell apical/basal polarity; IGI:MGI. DR GO; GO:0010463; P:mesenchymal cell proliferation; IMP:MGI. DR GO; GO:0072177; P:mesonephric duct development; IEA:Ensembl. DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IDA:MGI. DR GO; GO:0030308; P:negative regulation of cell growth; ISS:UniProtKB. DR GO; GO:0030336; P:negative regulation of cell migration; ISS:UniProtKB. DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; ISS:UniProtKB. DR GO; GO:0090272; P:negative regulation of fibroblast growth factor production; IMP:MGI. DR GO; GO:0072201; P:negative regulation of mesenchymal cell proliferation; IMP:MGI. DR GO; GO:2000647; P:negative regulation of stem cell proliferation; IMP:MGI. DR GO; GO:0061101; P:neuroendocrine cell differentiation; ISS:UniProtKB. DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central. DR GO; GO:0035567; P:non-canonical Wnt signaling pathway; IMP:MGI. DR GO; GO:0048570; P:notochord morphogenesis; IGI:MGI. DR GO; GO:0001649; P:osteoblast differentiation; IGI:MGI. DR GO; GO:0003151; P:outflow tract morphogenesis; IMP:MGI. DR GO; GO:0048341; P:paraxial mesoderm formation; IGI:MGI. DR GO; GO:0003402; P:planar cell polarity pathway involved in axis elongation; IGI:MGI. DR GO; GO:0060775; P:planar cell polarity pathway involved in gastrula mediolateral intercalation; IGI:MGI. DR GO; GO:0043065; P:positive regulation of apoptotic process; IMP:MGI. DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; ISS:UniProtKB. DR GO; GO:1904037; P:positive regulation of epithelial cell apoptotic process; IMP:MGI. DR GO; GO:0043547; P:positive regulation of GTPase activity; ISS:UniProtKB. DR GO; GO:0090082; P:positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway; IGI:CACAO. DR GO; GO:0090037; P:positive regulation of protein kinase C signaling; ISS:UniProtKB. DR GO; GO:0051496; P:positive regulation of stress fiber assembly; ISS:UniProtKB. DR GO; GO:0032915; P:positive regulation of transforming growth factor beta2 production; IMP:MGI. DR GO; GO:0003138; P:primary heart field specification; IGI:CACAO. DR GO; GO:0034394; P:protein localization to cell surface; ISS:UniProtKB. DR GO; GO:0006468; P:protein phosphorylation; ISS:UniProtKB. DR GO; GO:0031667; P:response to nutrient levels; IEA:Ensembl. DR GO; GO:0060021; P:roof of mouth development; IMP:MGI. DR GO; GO:0003139; P:secondary heart field specification; IGI:CACAO. DR GO; GO:0062009; P:secondary palate development; ISS:UniProtKB. DR GO; GO:0007165; P:signal transduction; ISS:UniProtKB. DR GO; GO:0061053; P:somite development; IGI:MGI. DR GO; GO:0072089; P:stem cell proliferation; IMP:MGI. DR GO; GO:0060675; P:ureteric bud morphogenesis; IEA:Ensembl. DR GO; GO:0003281; P:ventricular septum development; IGI:CACAO. DR GO; GO:0060412; P:ventricular septum morphogenesis; IMP:MGI. DR CDD; cd19343; Wnt_Wnt11; 1. DR Gene3D; 3.30.2460.20; -; 1. DR InterPro; IPR005817; Wnt. DR InterPro; IPR043158; Wnt_C. DR InterPro; IPR018161; Wnt_CS. DR PANTHER; PTHR12027:SF7; PROTEIN WNT-11; 1. DR PANTHER; PTHR12027; WNT RELATED; 1. DR Pfam; PF00110; wnt; 1. DR PRINTS; PR01349; WNTPROTEIN. DR SMART; SM00097; WNT1; 1. DR PROSITE; PS00246; WNT1; 1. DR Genevisible; P48615; MM. PE 2: Evidence at transcript level; KW Developmental protein; Disulfide bond; Extracellular matrix; Glycoprotein; KW Lipoprotein; Reference proteome; Secreted; Signal; Wnt signaling pathway. FT SIGNAL 1..24 FT /evidence="ECO:0000255" FT CHAIN 25..354 FT /note="Protein Wnt-11" FT /id="PRO_0000041466" FT LIPID 215 FT /note="O-palmitoleoyl serine; by PORCN" FT /evidence="ECO:0000250|UniProtKB:P56704" FT CARBOHYD 40 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 90 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 160 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 300 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 304 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT DISULFID 80..91 FT /evidence="ECO:0000250|UniProtKB:P28026" FT DISULFID 130..138 FT /evidence="ECO:0000250|UniProtKB:P28026" FT DISULFID 140..157 FT /evidence="ECO:0000250|UniProtKB:P28026" FT DISULFID 209..223 FT /evidence="ECO:0000250|UniProtKB:P28026" FT DISULFID 211..218 FT /evidence="ECO:0000250|UniProtKB:P28026" FT DISULFID 283..314 FT /evidence="ECO:0000250|UniProtKB:P28026" FT DISULFID 299..309 FT /evidence="ECO:0000250|UniProtKB:P28026" FT DISULFID 313..353 FT /evidence="ECO:0000250|UniProtKB:P28026" FT DISULFID 329..344 FT /evidence="ECO:0000250|UniProtKB:P28026" FT DISULFID 331..341 FT /evidence="ECO:0000250|UniProtKB:P28026" FT DISULFID 336..337 FT /evidence="ECO:0000250|UniProtKB:P28026" SQ SEQUENCE 354 AA; 39135 MW; ED582FDD8427D37E CRC64; MRARPQVCEA LLFALALHTG VCYGIKWLAL SKTPAALALN QTQHCKQLEG LVSAQVQLCR SNLELMRTIV HAARGAMKAC RRAFADMRWN CSSIELAPNY LLDLERGTRE SAFVYALSAA TISHTIARAC TSGDLPGCSC GPVPGEPPGP GNRWGGCADN LSYGLLMGAK FSDAPMKVKK TGSQANKLMR LHNSEVGRQA LRASLETKCK CHGVSGSCSI RTCWKGLQEL QDVAADLKTR YLSATKVVHR PMGTRKHLVP KDLDIRPVKD SELVYLQSSP DFCMKNEKVG SHGTQDRQCN KTSNGSDSCD LMCCGRGYNP YTDRVVERCH CKYHWCCYVT CRRCERTVER YVCK //