P48615 (WNT11_MOUSE) Reviewed, UniProtKB/Swiss-Prot
Last modified
April 3, 2013.
Version 96.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Protein Wnt-11 | ||||
| Gene names |
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| Organism | Mus musculus (Mouse) [Reference proteome] | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus![]() |
Protein attributes
| Sequence length | 354 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. |
| Subcellular location | |
| Developmental stage | Expressed during embryogenesis. |
| Post-translational modification | Palmitoylation at Ser-215 is required for efficient binding to frizzled receptors. It is also required for subsequent palmitoylation at Cys-80. Palmitoylation is necessary for proper trafficking to cell surface By similarity. |
| Sequence similarities | Belongs to the Wnt family. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 24 | 24 | Potential | ||||||
| Chain | 25 – 354 | 330 | Protein Wnt-11 | PRO_0000041466 | |||||
Amino acid modifications | |||||||||
| Lipidation | 80 | 1 | S-palmitoyl cysteine By similarity | ||||||
| Lipidation | 215 | 1 | O-palmitoyl serine; by PORCN By similarity | ||||||
| Glycosylation | 40 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 90 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 160 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 300 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 304 | 1 | N-linked (GlcNAc...) Potential | ||||||
Sequences
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References
| [1] | "Murine Wnt-11 and Wnt-12 have temporally and spatially restricted expression patterns during embryonic development." Christiansen J.H., Dennis C.L., Wicking C.A., Monkley S.J., Wilkinson D.G., Wainwright B.J. Mech. Dev. 51:341-350(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Swiss. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | X70800 mRNA. Translation: CAA50070.1. |
| IPI | IPI00113832. |
| PIR | S34378. |
| RefSeq | NP_033545.1. NM_009519.2. |
| UniGene | Mm.22182. |
3D structure databases | |
| ProteinModelPortal | P48615. |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | P48615. |
Proteomic databases | |
| PRIDE | P48615. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENSMUST00000067495; ENSMUSP00000064333; ENSMUSG00000015957. ENSMUST00000167303; ENSMUSP00000132166; ENSMUSG00000015957. |
| GeneID | 22411. |
| KEGG | mmu:22411. |
Organism-specific databases | |
| CTD | 7481. |
| MGI | MGI:101948. Wnt11. |
Phylogenomic databases | |
| eggNOG | NOG273917. |
| HOGENOM | HOG000039529. |
| HOVERGEN | HBG001595. |
| InParanoid | P48615. |
| KO | K01384. |
| OMA | ELIYLQS. |
| OrthoDB | EOG4FR0RT. |
Gene expression databases | |
| ArrayExpress | P48615. |
| Bgee | P48615. |
| CleanEx | MM_WNT11. |
| Genevestigator | P48615. |
| GermOnline | ENSMUSG00000015957. Mus musculus. |
Family and domain databases | |
| InterPro | IPR005817. Wnt. IPR026536. Wnt-11. IPR018161. Wnt_CS. [Graphical view] |
| PANTHER | PTHR12027. PTHR12027. 1 hit. PTHR12027:SF7. PTHR12027:SF7. 1 hit. |
| Pfam | PF00110. wnt. 1 hit. [Graphical view] |
| PRINTS | PR01349. WNTPROTEIN. |
| SMART | SM00097. WNT1. 1 hit. [Graphical view] |
| PROSITE | PS00246. WNT1. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 302813. |
| SOURCE | Search... |
Entry information
| Entry name | WNT11_MOUSE | ||||||||
| Accession | Primary (citable) accession number: P48615 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with
