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P48615

- WNT11_MOUSE

UniProt

P48615 - WNT11_MOUSE

Protein

Protein Wnt-11

Gene

Wnt11

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.

    GO - Molecular functioni

    1. frizzled binding Source: RefGenome
    2. protein binding Source: MGI
    3. protein kinase activator activity Source: UniProtKB
    4. Ras GTPase activator activity Source: UniProtKB
    5. receptor binding Source: MGI
    6. transcription regulatory region DNA binding Source: UniProtKB

    GO - Biological processi

    1. adrenal gland development Source: Ensembl
    2. artery morphogenesis Source: MGI
    3. bone mineralization Source: MGI
    4. canonical Wnt signaling pathway Source: MGI
    5. cell-cell signaling Source: MGI
    6. cell fate commitment Source: RefGenome
    7. cloacal septation Source: Ensembl
    8. embryonic skeletal system development Source: Ensembl
    9. kidney development Source: MGI
    10. lung-associated mesenchyme development Source: Ensembl
    11. mesonephric duct development Source: Ensembl
    12. negative regulation of apoptotic process Source: UniProtKB
    13. negative regulation of canonical Wnt signaling pathway Source: UniProtKB
    14. negative regulation of cell death Source: UniProtKB
    15. negative regulation of cell growth Source: UniProtKB
    16. negative regulation of cell migration Source: UniProtKB
    17. negative regulation of fibroblast growth factor production Source: MGI
    18. negative regulation of mesenchymal cell proliferation Source: MGI
    19. negative regulation of transcription, DNA-templated Source: UniProtKB
    20. neuroendocrine cell differentiation Source: UniProtKB
    21. neuron differentiation Source: RefGenome
    22. non-canonical Wnt signaling pathway Source: MGI
    23. organ morphogenesis Source: MGI
    24. osteoblast differentiation Source: MGI
    25. outflow tract morphogenesis Source: MGI
    26. palate development Source: UniProtKB
    27. positive regulation of apoptotic process Source: MGI
    28. positive regulation of cell migration Source: UniProtKB
    29. positive regulation of gene expression Source: UniProtKB
    30. positive regulation of protein kinase C signaling Source: UniProtKB
    31. positive regulation of Ras GTPase activity Source: UniProtKB
    32. positive regulation of stress fiber assembly Source: UniProtKB
    33. positive regulation of transcription, DNA-templated Source: UniProtKB
    34. positive regulation of transforming growth factor beta2 production Source: MGI
    35. protein localization to cell surface Source: UniProtKB
    36. protein phosphorylation Source: UniProtKB
    37. response to nutrient levels Source: Ensembl
    38. signal transduction Source: MGI
    39. tight junction assembly Source: MGI
    40. ureteric bud morphogenesis Source: Ensembl
    41. ventricular septum morphogenesis Source: MGI

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Wnt signaling pathway

    Enzyme and pathway databases

    ReactomeiREACT_213918. WNT ligand biogenesis and trafficking.
    REACT_214043. PCP/CE pathway.
    REACT_221970. Ca2+ pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein Wnt-11
    Gene namesi
    Name:Wnt11
    Synonyms:Wnt-11
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:101948. Wnt11.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. extracellular matrix Source: MGI
    3. extracellular region Source: MGI
    4. extracellular space Source: RefGenome
    5. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 354330Protein Wnt-11PRO_0000041466Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi40 – 401N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi80 ↔ 91By similarity
    Glycosylationi90 – 901N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi130 ↔ 138By similarity
    Disulfide bondi140 ↔ 157By similarity
    Glycosylationi160 – 1601N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi209 ↔ 223By similarity
    Disulfide bondi211 ↔ 218By similarity
    Lipidationi215 – 2151O-palmitoyl serine; by PORCNBy similarity
    Disulfide bondi299 ↔ 314By similarity
    Glycosylationi300 – 3001N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi304 – 3041N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi329 ↔ 344By similarity
    Disulfide bondi331 ↔ 341By similarity
    Disulfide bondi336 ↔ 337By similarity

    Post-translational modificationi

    Palmitoylation at Ser-215 is required for efficient binding to frizzled receptors. Palmitoylation is necessary for proper trafficking to cell surface By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PRIDEiP48615.

    PTM databases

    PhosphoSiteiP48615.

    Expressioni

    Developmental stagei

    Expressed during embryogenesis.

    Gene expression databases

    ArrayExpressiP48615.
    BgeeiP48615.
    CleanExiMM_WNT11.
    GenevestigatoriP48615.

    Interactioni

    Protein-protein interaction databases

    BioGridi204570. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP48615.
    SMRiP48615. Positions 74-283.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Wnt family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG273917.
    HOGENOMiHOG000039529.
    HOVERGENiHBG001595.
    InParanoidiP48615.
    KOiK01384.
    OMAiELIYLQS.
    PhylomeDBiP48615.
    TreeFamiTF105310.

    Family and domain databases

    InterProiIPR005817. Wnt.
    IPR026536. Wnt-11.
    IPR018161. Wnt_CS.
    [Graphical view]
    PANTHERiPTHR12027. PTHR12027. 1 hit.
    PTHR12027:SF7. PTHR12027:SF7. 1 hit.
    PfamiPF00110. wnt. 1 hit.
    [Graphical view]
    PRINTSiPR01349. WNTPROTEIN.
    SMARTiSM00097. WNT1. 1 hit.
    [Graphical view]
    PROSITEiPS00246. WNT1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P48615-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRARPQVCEA LLFALALHTG VCYGIKWLAL SKTPAALALN QTQHCKQLEG    50
    LVSAQVQLCR SNLELMRTIV HAARGAMKAC RRAFADMRWN CSSIELAPNY 100
    LLDLERGTRE SAFVYALSAA TISHTIARAC TSGDLPGCSC GPVPGEPPGP 150
    GNRWGGCADN LSYGLLMGAK FSDAPMKVKK TGSQANKLMR LHNSEVGRQA 200
    LRASLETKCK CHGVSGSCSI RTCWKGLQEL QDVAADLKTR YLSATKVVHR 250
    PMGTRKHLVP KDLDIRPVKD SELVYLQSSP DFCMKNEKVG SHGTQDRQCN 300
    KTSNGSDSCD LMCCGRGYNP YTDRVVERCH CKYHWCCYVT CRRCERTVER 350
    YVCK 354
    Length:354
    Mass (Da):39,135
    Last modified:February 1, 1996 - v1
    Checksum:iED582FDD8427D37E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X70800 mRNA. Translation: CAA50070.1.
    CCDSiCCDS21475.1.
    PIRiS34378.
    RefSeqiNP_001272721.1. NM_001285792.1.
    NP_033545.1. NM_009519.2.
    XP_006507649.1. XM_006507586.1.
    UniGeneiMm.22182.

    Genome annotation databases

    EnsembliENSMUST00000067495; ENSMUSP00000064333; ENSMUSG00000015957.
    ENSMUST00000167303; ENSMUSP00000132166; ENSMUSG00000015957.
    GeneIDi22411.
    KEGGimmu:22411.
    UCSCiuc009ikv.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X70800 mRNA. Translation: CAA50070.1 .
    CCDSi CCDS21475.1.
    PIRi S34378.
    RefSeqi NP_001272721.1. NM_001285792.1.
    NP_033545.1. NM_009519.2.
    XP_006507649.1. XM_006507586.1.
    UniGenei Mm.22182.

    3D structure databases

    ProteinModelPortali P48615.
    SMRi P48615. Positions 74-283.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 204570. 2 interactions.

    PTM databases

    PhosphoSitei P48615.

    Proteomic databases

    PRIDEi P48615.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000067495 ; ENSMUSP00000064333 ; ENSMUSG00000015957 .
    ENSMUST00000167303 ; ENSMUSP00000132166 ; ENSMUSG00000015957 .
    GeneIDi 22411.
    KEGGi mmu:22411.
    UCSCi uc009ikv.2. mouse.

    Organism-specific databases

    CTDi 7481.
    MGIi MGI:101948. Wnt11.

    Phylogenomic databases

    eggNOGi NOG273917.
    HOGENOMi HOG000039529.
    HOVERGENi HBG001595.
    InParanoidi P48615.
    KOi K01384.
    OMAi ELIYLQS.
    PhylomeDBi P48615.
    TreeFami TF105310.

    Enzyme and pathway databases

    Reactomei REACT_213918. WNT ligand biogenesis and trafficking.
    REACT_214043. PCP/CE pathway.
    REACT_221970. Ca2+ pathway.

    Miscellaneous databases

    NextBioi 302813.
    PROi P48615.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P48615.
    Bgeei P48615.
    CleanExi MM_WNT11.
    Genevestigatori P48615.

    Family and domain databases

    InterProi IPR005817. Wnt.
    IPR026536. Wnt-11.
    IPR018161. Wnt_CS.
    [Graphical view ]
    PANTHERi PTHR12027. PTHR12027. 1 hit.
    PTHR12027:SF7. PTHR12027:SF7. 1 hit.
    Pfami PF00110. wnt. 1 hit.
    [Graphical view ]
    PRINTSi PR01349. WNTPROTEIN.
    SMARTi SM00097. WNT1. 1 hit.
    [Graphical view ]
    PROSITEi PS00246. WNT1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Murine Wnt-11 and Wnt-12 have temporally and spatially restricted expression patterns during embryonic development."
      Christiansen J.H., Dennis C.L., Wicking C.A., Monkley S.J., Wilkinson D.G., Wainwright B.J.
      Mech. Dev. 51:341-350(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Swiss.

    Entry informationi

    Entry nameiWNT11_MOUSE
    AccessioniPrimary (citable) accession number: P48615
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3