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Protein

Protein Wnt-11

Gene

Wnt11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.

GO - Molecular functioni

GO - Biological processi

  • adrenal gland development Source: Ensembl
  • animal organ morphogenesis Source: MGI
  • artery morphogenesis Source: MGI
  • bicellular tight junction assembly Source: MGI
  • bone mineralization Source: MGI
  • canonical Wnt signaling pathway Source: MGI
  • cell-cell signaling Source: MGI
  • cell fate commitment Source: GO_Central
  • cellular response to mechanical stimulus Source: MGI
  • cloacal septation Source: Ensembl
  • convergent extension involved in axis elongation Source: MGI
  • embryonic skeletal system development Source: Ensembl
  • epithelial to mesenchymal transition Source: MGI
  • kidney development Source: MGI
  • lung-associated mesenchyme development Source: Ensembl
  • maintenance of epithelial cell apical/basal polarity Source: MGI
  • mesonephric duct development Source: Ensembl
  • negative regulation of apoptotic process Source: UniProtKB
  • negative regulation of canonical Wnt signaling pathway Source: MGI
  • negative regulation of cell death Source: UniProtKB
  • negative regulation of cell growth Source: UniProtKB
  • negative regulation of cell migration Source: UniProtKB
  • negative regulation of fibroblast growth factor production Source: MGI
  • negative regulation of mesenchymal cell proliferation Source: MGI
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • neuroendocrine cell differentiation Source: UniProtKB
  • neuron differentiation Source: GO_Central
  • non-canonical Wnt signaling pathway Source: MGI
  • notochord morphogenesis Source: MGI
  • osteoblast differentiation Source: MGI
  • outflow tract morphogenesis Source: MGI
  • paraxial mesoderm formation Source: MGI
  • planar cell polarity pathway involved in axis elongation Source: MGI
  • planar cell polarity pathway involved in gastrula mediolateral intercalation Source: MGI
  • positive regulation of apoptotic process Source: MGI
  • positive regulation of cell migration Source: UniProtKB
  • positive regulation of gene expression Source: UniProtKB
  • positive regulation of GTPase activity Source: UniProtKB
  • positive regulation of protein kinase C signaling Source: UniProtKB
  • positive regulation of stress fiber assembly Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transforming growth factor beta2 production Source: MGI
  • protein localization to cell surface Source: UniProtKB
  • protein phosphorylation Source: UniProtKB
  • response to nutrient levels Source: Ensembl
  • roof of mouth development Source: MGI
  • secondary palate development Source: BHF-UCL
  • signal transduction Source: MGI
  • somite development Source: MGI
  • ureteric bud morphogenesis Source: Ensembl
  • ventricular septum morphogenesis Source: MGI

Keywordsi

Molecular functionDevelopmental protein
Biological processWnt signaling pathway

Enzyme and pathway databases

ReactomeiR-MMU-3238698 WNT ligand biogenesis and trafficking
R-MMU-4086398 Ca2+ pathway
R-MMU-4086400 PCP/CE pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-11
Gene namesi
Name:Wnt11
Synonyms:Wnt-11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:101948 Wnt11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000004146625 – 354Protein Wnt-11Add BLAST330

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi40N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi80 ↔ 91By similarity
Glycosylationi90N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi130 ↔ 138By similarity
Disulfide bondi140 ↔ 157By similarity
Glycosylationi160N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi209 ↔ 223By similarity
Disulfide bondi211 ↔ 218By similarity
Lipidationi215O-palmitoleoyl serine; by PORCNBy similarity1
Disulfide bondi299 ↔ 314By similarity
Glycosylationi300N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi304N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi329 ↔ 344By similarity
Disulfide bondi331 ↔ 341By similarity
Disulfide bondi336 ↔ 337By similarity

Post-translational modificationi

Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein

Proteomic databases

PaxDbiP48615
PRIDEiP48615

PTM databases

PhosphoSitePlusiP48615

Expressioni

Developmental stagei

Expressed during embryogenesis.

Gene expression databases

BgeeiENSMUSG00000015957
CleanExiMM_WNT11
ExpressionAtlasiP48615 baseline and differential
GenevisibleiP48615 MM

Interactioni

GO - Molecular functioni

  • frizzled binding Source: GO_Central
  • signaling receptor binding Source: MGI

Protein-protein interaction databases

BioGridi204570, 2 interactors
STRINGi10090.ENSMUSP00000064333

Structurei

3D structure databases

ProteinModelPortaliP48615
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3913 Eukaryota
ENOG410XQZ1 LUCA
GeneTreeiENSGT00760000118943
HOGENOMiHOG000039529
HOVERGENiHBG001595
InParanoidiP48615
KOiK01384
OMAiQCNKTSH
OrthoDBiEOG091G0OFF
PhylomeDBiP48615
TreeFamiTF105310

Family and domain databases

InterProiView protein in InterPro
IPR005817 Wnt
IPR026536 Wnt-11
IPR018161 Wnt_CS
PANTHERiPTHR12027 PTHR12027, 1 hit
PTHR12027:SF7 PTHR12027:SF7, 1 hit
PfamiView protein in Pfam
PF00110 wnt, 1 hit
PRINTSiPR01349 WNTPROTEIN
SMARTiView protein in SMART
SM00097 WNT1, 1 hit
PROSITEiView protein in PROSITE
PS00246 WNT1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48615-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRARPQVCEA LLFALALHTG VCYGIKWLAL SKTPAALALN QTQHCKQLEG
60 70 80 90 100
LVSAQVQLCR SNLELMRTIV HAARGAMKAC RRAFADMRWN CSSIELAPNY
110 120 130 140 150
LLDLERGTRE SAFVYALSAA TISHTIARAC TSGDLPGCSC GPVPGEPPGP
160 170 180 190 200
GNRWGGCADN LSYGLLMGAK FSDAPMKVKK TGSQANKLMR LHNSEVGRQA
210 220 230 240 250
LRASLETKCK CHGVSGSCSI RTCWKGLQEL QDVAADLKTR YLSATKVVHR
260 270 280 290 300
PMGTRKHLVP KDLDIRPVKD SELVYLQSSP DFCMKNEKVG SHGTQDRQCN
310 320 330 340 350
KTSNGSDSCD LMCCGRGYNP YTDRVVERCH CKYHWCCYVT CRRCERTVER

YVCK
Length:354
Mass (Da):39,135
Last modified:February 1, 1996 - v1
Checksum:iED582FDD8427D37E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70800 mRNA Translation: CAA50070.1
CCDSiCCDS21475.1
PIRiS34378
RefSeqiNP_001272721.1, NM_001285792.1
NP_033545.1, NM_009519.2
XP_006507649.1, XM_006507586.3
UniGeneiMm.22182

Genome annotation databases

EnsembliENSMUST00000067495; ENSMUSP00000064333; ENSMUSG00000015957
ENSMUST00000167303; ENSMUSP00000132166; ENSMUSG00000015957
GeneIDi22411
KEGGimmu:22411
UCSCiuc009ikv.3 mouse

Similar proteinsi

Entry informationi

Entry nameiWNT11_MOUSE
AccessioniPrimary (citable) accession number: P48615
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 23, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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