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Protein

Protein Wnt-11

Gene

Wnt11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.

GO - Molecular functioni

  1. frizzled binding Source: GO_Central
  2. protein kinase activator activity Source: UniProtKB
  3. Ras GTPase activator activity Source: UniProtKB
  4. receptor binding Source: MGI
  5. transcription regulatory region DNA binding Source: UniProtKB

GO - Biological processi

  1. adrenal gland development Source: Ensembl
  2. artery morphogenesis Source: MGI
  3. bone mineralization Source: MGI
  4. canonical Wnt signaling pathway Source: MGI
  5. cell-cell signaling Source: MGI
  6. cell fate commitment Source: GO_Central
  7. cloacal septation Source: Ensembl
  8. embryonic skeletal system development Source: Ensembl
  9. kidney development Source: MGI
  10. lung-associated mesenchyme development Source: Ensembl
  11. mesonephric duct development Source: Ensembl
  12. negative regulation of apoptotic process Source: UniProtKB
  13. negative regulation of canonical Wnt signaling pathway Source: UniProtKB
  14. negative regulation of cell death Source: UniProtKB
  15. negative regulation of cell growth Source: UniProtKB
  16. negative regulation of cell migration Source: UniProtKB
  17. negative regulation of fibroblast growth factor production Source: MGI
  18. negative regulation of mesenchymal cell proliferation Source: MGI
  19. negative regulation of transcription, DNA-templated Source: UniProtKB
  20. neuroendocrine cell differentiation Source: UniProtKB
  21. neuron differentiation Source: GO_Central
  22. non-canonical Wnt signaling pathway Source: MGI
  23. organ morphogenesis Source: MGI
  24. osteoblast differentiation Source: MGI
  25. outflow tract morphogenesis Source: MGI
  26. palate development Source: UniProtKB
  27. positive regulation of apoptotic process Source: MGI
  28. positive regulation of cell migration Source: UniProtKB
  29. positive regulation of gene expression Source: UniProtKB
  30. positive regulation of protein kinase activity Source: MGI
  31. positive regulation of protein kinase C signaling Source: UniProtKB
  32. positive regulation of Ras GTPase activity Source: UniProtKB
  33. positive regulation of stress fiber assembly Source: UniProtKB
  34. positive regulation of transcription, DNA-templated Source: UniProtKB
  35. positive regulation of transforming growth factor beta2 production Source: MGI
  36. protein localization to cell surface Source: UniProtKB
  37. protein phosphorylation Source: UniProtKB
  38. response to nutrient levels Source: Ensembl
  39. signal transduction Source: MGI
  40. tight junction assembly Source: MGI
  41. ureteric bud morphogenesis Source: Ensembl
  42. ventricular septum morphogenesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_213918. WNT ligand biogenesis and trafficking.
REACT_214043. PCP/CE pathway.
REACT_221970. Ca2+ pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-11
Gene namesi
Name:Wnt11
Synonyms:Wnt-11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:101948. Wnt11.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. extracellular matrix Source: MGI
  3. extracellular region Source: MGI
  4. extracellular space Source: GO_Central
  5. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 354330Protein Wnt-11PRO_0000041466Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi40 – 401N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi80 ↔ 91By similarity
Glycosylationi90 – 901N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi130 ↔ 138By similarity
Disulfide bondi140 ↔ 157By similarity
Glycosylationi160 – 1601N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi209 ↔ 223By similarity
Disulfide bondi211 ↔ 218By similarity
Lipidationi215 – 2151O-palmitoyl serine; by PORCNBy similarity
Disulfide bondi299 ↔ 314By similarity
Glycosylationi300 – 3001N-linked (GlcNAc...)Sequence Analysis
Glycosylationi304 – 3041N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi329 ↔ 344By similarity
Disulfide bondi331 ↔ 341By similarity
Disulfide bondi336 ↔ 337By similarity

Post-translational modificationi

Palmitoylation at Ser-215 is required for efficient binding to frizzled receptors. Palmitoylation is necessary for proper trafficking to cell surface (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PRIDEiP48615.

PTM databases

PhosphoSiteiP48615.

Expressioni

Developmental stagei

Expressed during embryogenesis.

Gene expression databases

BgeeiP48615.
CleanExiMM_WNT11.
ExpressionAtlasiP48615. baseline and differential.
GenevestigatoriP48615.

Interactioni

Protein-protein interaction databases

BioGridi204570. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliP48615.
SMRiP48615. Positions 74-283.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG273917.
HOGENOMiHOG000039529.
HOVERGENiHBG001595.
InParanoidiP48615.
KOiK01384.
OMAiELIYLQS.
PhylomeDBiP48615.
TreeFamiTF105310.

Family and domain databases

InterProiIPR005817. Wnt.
IPR026536. Wnt-11.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PTHR12027:SF7. PTHR12027:SF7. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48615-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRARPQVCEA LLFALALHTG VCYGIKWLAL SKTPAALALN QTQHCKQLEG
60 70 80 90 100
LVSAQVQLCR SNLELMRTIV HAARGAMKAC RRAFADMRWN CSSIELAPNY
110 120 130 140 150
LLDLERGTRE SAFVYALSAA TISHTIARAC TSGDLPGCSC GPVPGEPPGP
160 170 180 190 200
GNRWGGCADN LSYGLLMGAK FSDAPMKVKK TGSQANKLMR LHNSEVGRQA
210 220 230 240 250
LRASLETKCK CHGVSGSCSI RTCWKGLQEL QDVAADLKTR YLSATKVVHR
260 270 280 290 300
PMGTRKHLVP KDLDIRPVKD SELVYLQSSP DFCMKNEKVG SHGTQDRQCN
310 320 330 340 350
KTSNGSDSCD LMCCGRGYNP YTDRVVERCH CKYHWCCYVT CRRCERTVER

YVCK
Length:354
Mass (Da):39,135
Last modified:February 1, 1996 - v1
Checksum:iED582FDD8427D37E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70800 mRNA. Translation: CAA50070.1.
CCDSiCCDS21475.1.
PIRiS34378.
RefSeqiNP_001272721.1. NM_001285792.1.
NP_033545.1. NM_009519.2.
XP_006507649.1. XM_006507586.1.
UniGeneiMm.22182.

Genome annotation databases

EnsembliENSMUST00000067495; ENSMUSP00000064333; ENSMUSG00000015957.
ENSMUST00000167303; ENSMUSP00000132166; ENSMUSG00000015957.
GeneIDi22411.
KEGGimmu:22411.
UCSCiuc009ikv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70800 mRNA. Translation: CAA50070.1.
CCDSiCCDS21475.1.
PIRiS34378.
RefSeqiNP_001272721.1. NM_001285792.1.
NP_033545.1. NM_009519.2.
XP_006507649.1. XM_006507586.1.
UniGeneiMm.22182.

3D structure databases

ProteinModelPortaliP48615.
SMRiP48615. Positions 74-283.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204570. 2 interactions.

PTM databases

PhosphoSiteiP48615.

Proteomic databases

PRIDEiP48615.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000067495; ENSMUSP00000064333; ENSMUSG00000015957.
ENSMUST00000167303; ENSMUSP00000132166; ENSMUSG00000015957.
GeneIDi22411.
KEGGimmu:22411.
UCSCiuc009ikv.2. mouse.

Organism-specific databases

CTDi7481.
MGIiMGI:101948. Wnt11.

Phylogenomic databases

eggNOGiNOG273917.
HOGENOMiHOG000039529.
HOVERGENiHBG001595.
InParanoidiP48615.
KOiK01384.
OMAiELIYLQS.
PhylomeDBiP48615.
TreeFamiTF105310.

Enzyme and pathway databases

ReactomeiREACT_213918. WNT ligand biogenesis and trafficking.
REACT_214043. PCP/CE pathway.
REACT_221970. Ca2+ pathway.

Miscellaneous databases

NextBioi302813.
PROiP48615.
SOURCEiSearch...

Gene expression databases

BgeeiP48615.
CleanExiMM_WNT11.
ExpressionAtlasiP48615. baseline and differential.
GenevestigatoriP48615.

Family and domain databases

InterProiIPR005817. Wnt.
IPR026536. Wnt-11.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PTHR12027:SF7. PTHR12027:SF7. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Murine Wnt-11 and Wnt-12 have temporally and spatially restricted expression patterns during embryonic development."
    Christiansen J.H., Dennis C.L., Wicking C.A., Monkley S.J., Wilkinson D.G., Wainwright B.J.
    Mech. Dev. 51:341-350(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Swiss.

Entry informationi

Entry nameiWNT11_MOUSE
AccessioniPrimary (citable) accession number: P48615
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: February 4, 2015
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.