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P48615 (WNT11_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein Wnt-11
Gene names
Name:Wnt11
Synonyms:Wnt-11
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length354 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.

Subcellular location

Secretedextracellular spaceextracellular matrix.

Developmental stage

Expressed during embryogenesis.

Post-translational modification

Palmitoylation at Ser-215 is required for efficient binding to frizzled receptors. It is also required for subsequent palmitoylation at Cys-80. Palmitoylation is necessary for proper trafficking to cell surface By similarity.

Sequence similarities

Belongs to the Wnt family.

Ontologies

Keywords
   Biological processWnt signaling pathway
   Cellular componentExtracellular matrix
Secreted
   DomainSignal
   Molecular functionDevelopmental protein
   PTMGlycoprotein
Lipoprotein
Palmitate
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processadrenal gland development

Inferred from electronic annotation. Source: Ensembl

artery morphogenesis

Inferred from mutant phenotype PubMed 17767158. Source: MGI

bone mineralization

Inferred from genetic interaction PubMed 19213727. Source: MGI

canonical Wnt signaling pathway

Inferred from direct assay PubMed 19213727. Source: MGI

cell fate commitment

Inferred from Biological aspect of Ancestor. Source: RefGenome

cell-cell signaling

Traceable author statement PubMed 9889131. Source: MGI

cloacal septation

Inferred from electronic annotation. Source: Ensembl

embryonic skeletal system development

Inferred from electronic annotation. Source: Ensembl

kidney development

Inferred from direct assay PubMed 21281623. Source: MGI

lung-associated mesenchyme development

Inferred from electronic annotation. Source: Ensembl

mesonephric duct development

Inferred from electronic annotation. Source: Ensembl

negative regulation of apoptotic process

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of canonical Wnt signaling pathway

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of cell death

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of cell growth

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of cell migration

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of fibroblast growth factor production

Inferred from mutant phenotype PubMed 18191119. Source: MGI

negative regulation of mesenchymal cell proliferation

Inferred from mutant phenotype PubMed 18191119. Source: MGI

negative regulation of transcription, DNA-templated

Inferred from sequence or structural similarity. Source: UniProtKB

neuroendocrine cell differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

neuron differentiation

Inferred from Biological aspect of Ancestor. Source: RefGenome

non-canonical Wnt signaling pathway

Inferred from mutant phenotype PubMed 17767158. Source: MGI

organ morphogenesis

Traceable author statement PubMed 9889131. Source: MGI

osteoblast differentiation

Inferred from genetic interaction PubMed 19213727. Source: MGI

outflow tract morphogenesis

Inferred from mutant phenotype PubMed 17767158. Source: MGI

palate development

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of Ras GTPase activity

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of apoptotic process

Inferred from mutant phenotype PubMed 18191119. Source: MGI

positive regulation of cell migration

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of gene expression

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of protein kinase C signaling

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of stress fiber assembly

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of transcription, DNA-templated

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of transforming growth factor beta2 production

Inferred from mutant phenotype PubMed 17767158. Source: MGI

protein localization to cell surface

Inferred from sequence or structural similarity. Source: UniProtKB

protein phosphorylation

Inferred from sequence or structural similarity. Source: UniProtKB

response to nutrient levels

Inferred from electronic annotation. Source: Ensembl

signal transduction

Traceable author statement PubMed 9889131. Source: MGI

tight junction assembly

Inferred from mutant phenotype PubMed 17767158. Source: MGI

ureteric bud morphogenesis

Inferred from electronic annotation. Source: Ensembl

ventricular septum morphogenesis

Inferred from mutant phenotype PubMed 17767158. Source: MGI

   Cellular_componentcytoplasm

Inferred from sequence or structural similarity. Source: UniProtKB

extracellular matrix

Inferred from direct assay PubMed 8700530. Source: MGI

extracellular region

Inferred from direct assay PubMed 18155657. Source: MGI

extracellular space

Inferred from Biological aspect of Ancestor. Source: RefGenome

proteinaceous extracellular matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionRas GTPase activator activity

Inferred from sequence or structural similarity. Source: UniProtKB

frizzled binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

protein kinase activator activity

Inferred from sequence or structural similarity. Source: UniProtKB

receptor binding

Traceable author statement PubMed 9889131. Source: MGI

transcription regulatory region DNA binding

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 354330Protein Wnt-11
PRO_0000041466

Amino acid modifications

Lipidation801S-palmitoyl cysteine By similarity
Lipidation2151O-palmitoyl serine; by PORCN By similarity
Glycosylation401N-linked (GlcNAc...) Potential
Glycosylation901N-linked (GlcNAc...) Potential
Glycosylation1601N-linked (GlcNAc...) Potential
Glycosylation3001N-linked (GlcNAc...) Potential
Glycosylation3041N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P48615 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: ED582FDD8427D37E

FASTA35439,135
        10         20         30         40         50         60 
MRARPQVCEA LLFALALHTG VCYGIKWLAL SKTPAALALN QTQHCKQLEG LVSAQVQLCR 

        70         80         90        100        110        120 
SNLELMRTIV HAARGAMKAC RRAFADMRWN CSSIELAPNY LLDLERGTRE SAFVYALSAA 

       130        140        150        160        170        180 
TISHTIARAC TSGDLPGCSC GPVPGEPPGP GNRWGGCADN LSYGLLMGAK FSDAPMKVKK 

       190        200        210        220        230        240 
TGSQANKLMR LHNSEVGRQA LRASLETKCK CHGVSGSCSI RTCWKGLQEL QDVAADLKTR 

       250        260        270        280        290        300 
YLSATKVVHR PMGTRKHLVP KDLDIRPVKD SELVYLQSSP DFCMKNEKVG SHGTQDRQCN 

       310        320        330        340        350 
KTSNGSDSCD LMCCGRGYNP YTDRVVERCH CKYHWCCYVT CRRCERTVER YVCK 

« Hide

References

[1]"Murine Wnt-11 and Wnt-12 have temporally and spatially restricted expression patterns during embryonic development."
Christiansen J.H., Dennis C.L., Wicking C.A., Monkley S.J., Wilkinson D.G., Wainwright B.J.
Mech. Dev. 51:341-350(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Swiss.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X70800 mRNA. Translation: CAA50070.1.
PIRS34378.
RefSeqNP_001272721.1. NM_001285792.1.
NP_033545.1. NM_009519.2.
XP_006507649.1. XM_006507586.1.
UniGeneMm.22182.

3D structure databases

ProteinModelPortalP48615.
SMRP48615. Positions 74-283.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid204570. 2 interactions.

PTM databases

PhosphoSiteP48615.

Proteomic databases

PRIDEP48615.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000067495; ENSMUSP00000064333; ENSMUSG00000015957.
ENSMUST00000167303; ENSMUSP00000132166; ENSMUSG00000015957.
GeneID22411.
KEGGmmu:22411.
UCSCuc009ikv.2. mouse.

Organism-specific databases

CTD7481.
MGIMGI:101948. Wnt11.

Phylogenomic databases

eggNOGNOG273917.
HOGENOMHOG000039529.
HOVERGENHBG001595.
InParanoidP48615.
KOK01384.
OMAMHTIVHA.
PhylomeDBP48615.
TreeFamTF105310.

Gene expression databases

ArrayExpressP48615.
BgeeP48615.
CleanExMM_WNT11.
GenevestigatorP48615.

Family and domain databases

InterProIPR005817. Wnt.
IPR026536. Wnt-11.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERPTHR12027. PTHR12027. 1 hit.
PTHR12027:SF7. PTHR12027:SF7. 1 hit.
PfamPF00110. wnt. 1 hit.
[Graphical view]
PRINTSPR01349. WNTPROTEIN.
SMARTSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEPS00246. WNT1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio302813.
PROP48615.
SOURCESearch...

Entry information

Entry nameWNT11_MOUSE
AccessionPrimary (citable) accession number: P48615
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: April 16, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot