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P48615

- WNT11_MOUSE

UniProt

P48615 - WNT11_MOUSE

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Protein
Protein Wnt-11
Gene
Wnt11, Wnt-11
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.

GO - Molecular functioni

  1. Ras GTPase activator activity Source: UniProtKB
  2. frizzled binding Source: RefGenome
  3. protein binding Source: MGI
  4. protein kinase activator activity Source: UniProtKB
  5. receptor binding Source: MGI
  6. transcription regulatory region DNA binding Source: UniProtKB

GO - Biological processi

  1. adrenal gland development Source: Ensembl
  2. artery morphogenesis Source: MGI
  3. bone mineralization Source: MGI
  4. canonical Wnt signaling pathway Source: MGI
  5. cell fate commitment Source: RefGenome
  6. cell-cell signaling Source: MGI
  7. cloacal septation Source: Ensembl
  8. embryonic skeletal system development Source: Ensembl
  9. kidney development Source: MGI
  10. lung-associated mesenchyme development Source: Ensembl
  11. mesonephric duct development Source: Ensembl
  12. negative regulation of apoptotic process Source: UniProtKB
  13. negative regulation of canonical Wnt signaling pathway Source: UniProtKB
  14. negative regulation of cell death Source: UniProtKB
  15. negative regulation of cell growth Source: UniProtKB
  16. negative regulation of cell migration Source: UniProtKB
  17. negative regulation of fibroblast growth factor production Source: MGI
  18. negative regulation of mesenchymal cell proliferation Source: MGI
  19. negative regulation of transcription, DNA-templated Source: UniProtKB
  20. neuroendocrine cell differentiation Source: UniProtKB
  21. neuron differentiation Source: RefGenome
  22. non-canonical Wnt signaling pathway Source: MGI
  23. organ morphogenesis Source: MGI
  24. osteoblast differentiation Source: MGI
  25. outflow tract morphogenesis Source: MGI
  26. palate development Source: UniProtKB
  27. positive regulation of Ras GTPase activity Source: UniProtKB
  28. positive regulation of apoptotic process Source: MGI
  29. positive regulation of cell migration Source: UniProtKB
  30. positive regulation of gene expression Source: UniProtKB
  31. positive regulation of protein kinase C signaling Source: UniProtKB
  32. positive regulation of stress fiber assembly Source: UniProtKB
  33. positive regulation of transcription, DNA-templated Source: UniProtKB
  34. positive regulation of transforming growth factor beta2 production Source: MGI
  35. protein localization to cell surface Source: UniProtKB
  36. protein phosphorylation Source: UniProtKB
  37. response to nutrient levels Source: Ensembl
  38. signal transduction Source: MGI
  39. tight junction assembly Source: MGI
  40. ureteric bud morphogenesis Source: Ensembl
  41. ventricular septum morphogenesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_213918. WNT ligand biogenesis and trafficking.
REACT_214043. PCP/CE pathway.
REACT_221970. Ca2+ pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-11
Gene namesi
Name:Wnt11
Synonyms:Wnt-11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:101948. Wnt11.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. extracellular matrix Source: MGI
  3. extracellular region Source: MGI
  4. extracellular space Source: RefGenome
  5. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 Reviewed prediction
Add
BLAST
Chaini25 – 354330Protein Wnt-11
PRO_0000041466Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi40 – 401N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi80 ↔ 91 By similarity
Glycosylationi90 – 901N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi130 ↔ 138 By similarity
Disulfide bondi140 ↔ 157 By similarity
Glycosylationi160 – 1601N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi209 ↔ 223 By similarity
Disulfide bondi211 ↔ 218 By similarity
Lipidationi215 – 2151O-palmitoyl serine; by PORCN By similarity
Disulfide bondi299 ↔ 314 By similarity
Glycosylationi300 – 3001N-linked (GlcNAc...) Reviewed prediction
Glycosylationi304 – 3041N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi329 ↔ 344 By similarity
Disulfide bondi331 ↔ 341 By similarity
Disulfide bondi336 ↔ 337 By similarity

Post-translational modificationi

Palmitoylation at Ser-215 is required for efficient binding to frizzled receptors. Palmitoylation is necessary for proper trafficking to cell surface By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PRIDEiP48615.

PTM databases

PhosphoSiteiP48615.

Expressioni

Developmental stagei

Expressed during embryogenesis.

Gene expression databases

ArrayExpressiP48615.
BgeeiP48615.
CleanExiMM_WNT11.
GenevestigatoriP48615.

Interactioni

Protein-protein interaction databases

BioGridi204570. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliP48615.
SMRiP48615. Positions 74-283.

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG273917.
HOGENOMiHOG000039529.
HOVERGENiHBG001595.
InParanoidiP48615.
KOiK01384.
OMAiELIYLQS.
PhylomeDBiP48615.
TreeFamiTF105310.

Family and domain databases

InterProiIPR005817. Wnt.
IPR026536. Wnt-11.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PTHR12027:SF7. PTHR12027:SF7. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48615-1 [UniParc]FASTAAdd to Basket

« Hide

MRARPQVCEA LLFALALHTG VCYGIKWLAL SKTPAALALN QTQHCKQLEG    50
LVSAQVQLCR SNLELMRTIV HAARGAMKAC RRAFADMRWN CSSIELAPNY 100
LLDLERGTRE SAFVYALSAA TISHTIARAC TSGDLPGCSC GPVPGEPPGP 150
GNRWGGCADN LSYGLLMGAK FSDAPMKVKK TGSQANKLMR LHNSEVGRQA 200
LRASLETKCK CHGVSGSCSI RTCWKGLQEL QDVAADLKTR YLSATKVVHR 250
PMGTRKHLVP KDLDIRPVKD SELVYLQSSP DFCMKNEKVG SHGTQDRQCN 300
KTSNGSDSCD LMCCGRGYNP YTDRVVERCH CKYHWCCYVT CRRCERTVER 350
YVCK 354
Length:354
Mass (Da):39,135
Last modified:February 1, 1996 - v1
Checksum:iED582FDD8427D37E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X70800 mRNA. Translation: CAA50070.1.
CCDSiCCDS21475.1.
PIRiS34378.
RefSeqiNP_001272721.1. NM_001285792.1.
NP_033545.1. NM_009519.2.
XP_006507649.1. XM_006507586.1.
UniGeneiMm.22182.

Genome annotation databases

EnsembliENSMUST00000067495; ENSMUSP00000064333; ENSMUSG00000015957.
ENSMUST00000167303; ENSMUSP00000132166; ENSMUSG00000015957.
GeneIDi22411.
KEGGimmu:22411.
UCSCiuc009ikv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X70800 mRNA. Translation: CAA50070.1 .
CCDSi CCDS21475.1.
PIRi S34378.
RefSeqi NP_001272721.1. NM_001285792.1.
NP_033545.1. NM_009519.2.
XP_006507649.1. XM_006507586.1.
UniGenei Mm.22182.

3D structure databases

ProteinModelPortali P48615.
SMRi P48615. Positions 74-283.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 204570. 2 interactions.

PTM databases

PhosphoSitei P48615.

Proteomic databases

PRIDEi P48615.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000067495 ; ENSMUSP00000064333 ; ENSMUSG00000015957 .
ENSMUST00000167303 ; ENSMUSP00000132166 ; ENSMUSG00000015957 .
GeneIDi 22411.
KEGGi mmu:22411.
UCSCi uc009ikv.2. mouse.

Organism-specific databases

CTDi 7481.
MGIi MGI:101948. Wnt11.

Phylogenomic databases

eggNOGi NOG273917.
HOGENOMi HOG000039529.
HOVERGENi HBG001595.
InParanoidi P48615.
KOi K01384.
OMAi ELIYLQS.
PhylomeDBi P48615.
TreeFami TF105310.

Enzyme and pathway databases

Reactomei REACT_213918. WNT ligand biogenesis and trafficking.
REACT_214043. PCP/CE pathway.
REACT_221970. Ca2+ pathway.

Miscellaneous databases

NextBioi 302813.
PROi P48615.
SOURCEi Search...

Gene expression databases

ArrayExpressi P48615.
Bgeei P48615.
CleanExi MM_WNT11.
Genevestigatori P48615.

Family and domain databases

InterProi IPR005817. Wnt.
IPR026536. Wnt-11.
IPR018161. Wnt_CS.
[Graphical view ]
PANTHERi PTHR12027. PTHR12027. 1 hit.
PTHR12027:SF7. PTHR12027:SF7. 1 hit.
Pfami PF00110. wnt. 1 hit.
[Graphical view ]
PRINTSi PR01349. WNTPROTEIN.
SMARTi SM00097. WNT1. 1 hit.
[Graphical view ]
PROSITEi PS00246. WNT1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Murine Wnt-11 and Wnt-12 have temporally and spatially restricted expression patterns during embryonic development."
    Christiansen J.H., Dennis C.L., Wicking C.A., Monkley S.J., Wilkinson D.G., Wainwright B.J.
    Mech. Dev. 51:341-350(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Swiss.

Entry informationi

Entry nameiWNT11_MOUSE
AccessioniPrimary (citable) accession number: P48615
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 3, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi