Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P48614

- WN10B_MOUSE

UniProt

P48614 - WN10B_MOUSE

Protein

Protein Wnt-10b

Gene

Wnt10b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.

    GO - Molecular functioni

    1. frizzled binding Source: RefGenome
    2. receptor binding Source: MGI

    GO - Biological processi

    1. bone trabecula formation Source: MGI
    2. canonical Wnt signaling pathway Source: MGI
    3. cell-cell signaling Source: MGI
    4. cell cycle arrest Source: MGI
    5. cell fate commitment Source: RefGenome
    6. cellular response to cAMP Source: MGI
    7. cellular response to hydrostatic pressure Source: Ensembl
    8. cellular response to organic cyclic compound Source: MGI
    9. cellular response to organic substance Source: MGI
    10. cellular response to parathyroid hormone stimulus Source: MGI
    11. chondrocyte differentiation Source: Ensembl
    12. fungiform papilla development Source: MGI
    13. G2/M transition of mitotic cell cycle Source: MGI
    14. hematopoietic stem cell proliferation Source: MGI
    15. lipid metabolic process Source: MGI
    16. myoblast differentiation involved in skeletal muscle regeneration Source: MGI
    17. negative regulation of epithelial cell proliferation Source: MGI
    18. negative regulation of fat cell differentiation Source: MGI
    19. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    20. neuron differentiation Source: RefGenome
    21. organ morphogenesis Source: MGI
    22. positive regulation of anagen Source: MGI
    23. positive regulation of apoptotic process Source: Ensembl
    24. positive regulation of bone mineralization Source: MGI
    25. positive regulation of canonical Wnt signaling pathway Source: MGI
    26. positive regulation of cell proliferation Source: MGI
    27. positive regulation of epithelial cell differentiation Source: MGI
    28. positive regulation of G2/M transition of mitotic cell cycle Source: MGI
    29. positive regulation of ossification Source: MGI
    30. positive regulation of osteoblast differentiation Source: MGI
    31. positive regulation of RNA polymerase II transcriptional preinitiation complex assembly Source: MGI
    32. positive regulation of sequence-specific DNA binding transcription factor activity Source: MGI
    33. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    34. protein stabilization Source: Ensembl
    35. regulation of fat cell differentiation Source: MGI
    36. regulation of proteasomal ubiquitin-dependent protein catabolic process Source: MGI
    37. regulation of protein metabolic process Source: MGI
    38. regulation of skeletal muscle tissue development Source: MGI
    39. regulation of transcription from RNA polymerase II promoter Source: MGI
    40. sensory perception of taste Source: MGI
    41. signal transduction Source: MGI
    42. skeletal muscle fiber development Source: MGI
    43. skeletal muscle tissue regeneration Source: MGI
    44. smoothened signaling pathway Source: MGI
    45. Wnt signaling pathway Source: MGI

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Wnt signaling pathway

    Enzyme and pathway databases

    ReactomeiREACT_213918. WNT ligand biogenesis and trafficking.
    REACT_27166. Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein Wnt-10b
    Alternative name(s):
    Protein Wnt-12
    Gene namesi
    Name:Wnt10b
    Synonyms:Wnt-10b, Wnt10, Wnt12
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:108061. Wnt10b.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: RefGenome
    2. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2828Sequence AnalysisAdd
    BLAST
    Chaini29 – 389361Protein Wnt-10bPRO_0000041464Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei46 – 461PhosphothreonineBy similarity
    Disulfide bondi83 ↔ 94By similarity
    Glycosylationi93 – 931N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi136 ↔ 144By similarity
    Disulfide bondi146 ↔ 199By similarity
    Disulfide bondi247 ↔ 261By similarity
    Disulfide bondi249 ↔ 256By similarity
    Disulfide bondi334 ↔ 349By similarity
    Glycosylationi335 – 3351N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi364 ↔ 379By similarity
    Disulfide bondi366 ↔ 376By similarity
    Disulfide bondi371 ↔ 372By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PRIDEiP48614.

    PTM databases

    PhosphoSiteiP48614.

    Expressioni

    Tissue specificityi

    Expressed in embryos and in the mammary gland of non-pregnant mice.

    Gene expression databases

    ArrayExpressiP48614.
    BgeeiP48614.
    CleanExiMM_WNT10B.
    GenevestigatoriP48614.

    Structurei

    3D structure databases

    ProteinModelPortaliP48614.
    SMRiP48614. Positions 69-380.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Wnt family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG240772.
    GeneTreeiENSGT00690000101857.
    HOGENOMiHOG000039528.
    HOVERGENiHBG001595.
    InParanoidiP48614.
    KOiK01357.
    OMAiSERCNCR.
    OrthoDBiEOG7C8GJ8.
    PhylomeDBiP48614.
    TreeFamiTF105310.

    Family and domain databases

    InterProiIPR005817. Wnt.
    IPR013302. Wnt10.
    IPR018161. Wnt_CS.
    [Graphical view]
    PANTHERiPTHR12027. PTHR12027. 1 hit.
    PfamiPF00110. wnt. 1 hit.
    [Graphical view]
    PRINTSiPR01893. WNT10PROTEIN.
    PR01349. WNTPROTEIN.
    SMARTiSM00097. WNT1. 1 hit.
    [Graphical view]
    PROSITEiPS00246. WNT1. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform Long (identifier: P48614-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLEEPRSRPP PLGLAGLLFL ALFSRALSNE ILGLKLPGEP PLTANTVCLT    50
    LSGLSKRQLG LCLRSPDVTA SALQGLHIAV HECQHQLRDQ RWNCSALEGG 100
    GRLPHHSAIL KRGFRESAFS FSMLAAGVMH AVATACSLGK LVSCGCGWKG 150
    SGEQDRLRAK LLQLQALSRG KTFPISQPSP VPGSVPSPGP QDTWEWGGCN 200
    HDMDFGEKFS RDFLDSREAP RDIQARMRIH NNRVGRQVVT ENLKRKCKCH 250
    GTSGSCQFKT CWRAAPEFRA IGAALRERLS RAIFIDTHNR NSGAFQPRLR 300
    PRRLSGELVY FEKSPDFCER DPTLGSPGTR GRACNKTSRL LDGCGSLCCG 350
    RGHNVLRQTR VERCHCRFHW CCYVLCDECK VTEWVNVCK 389
    Length:389
    Mass (Da):43,119
    Last modified:February 1, 1996 - v1
    Checksum:iF990AB33B7C84633
    GO
    Isoform Short (identifier: P48614-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         143-238: Missing.

    Show »
    Length:293
    Mass (Da):32,400
    Checksum:iE2BB87BC40C40240
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei143 – 23896Missing in isoform Short. 1 PublicationVSP_006796Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U20658 mRNA. Translation: AAA80110.1.
    U30464 mRNA. Translation: AAA84399.1.
    U61970 mRNA. Translation: AAB08086.1.
    U61971 mRNA. Translation: AAB08087.1.
    CCDSiCCDS27806.1. [P48614-1]
    PIRiA59393. A59392.
    I49263.
    RefSeqiNP_035848.1. NM_011718.2. [P48614-1]
    XP_006520954.1. XM_006520891.1. [P48614-1]
    XP_006520955.1. XM_006520892.1. [P48614-2]
    UniGeneiMm.4709.

    Genome annotation databases

    EnsembliENSMUST00000023732; ENSMUSP00000023732; ENSMUSG00000022996. [P48614-1]
    ENSMUST00000166022; ENSMUSP00000131056; ENSMUSG00000022996. [P48614-1]
    GeneIDi22410.
    KEGGimmu:22410.
    UCSCiuc007xns.2. mouse. [P48614-2]
    uc007xnt.2. mouse. [P48614-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U20658 mRNA. Translation: AAA80110.1 .
    U30464 mRNA. Translation: AAA84399.1 .
    U61970 mRNA. Translation: AAB08086.1 .
    U61971 mRNA. Translation: AAB08087.1 .
    CCDSi CCDS27806.1. [P48614-1 ]
    PIRi A59393. A59392.
    I49263.
    RefSeqi NP_035848.1. NM_011718.2. [P48614-1 ]
    XP_006520954.1. XM_006520891.1. [P48614-1 ]
    XP_006520955.1. XM_006520892.1. [P48614-2 ]
    UniGenei Mm.4709.

    3D structure databases

    ProteinModelPortali P48614.
    SMRi P48614. Positions 69-380.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P48614.

    Proteomic databases

    PRIDEi P48614.

    Protocols and materials databases

    DNASUi 22410.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000023732 ; ENSMUSP00000023732 ; ENSMUSG00000022996 . [P48614-1 ]
    ENSMUST00000166022 ; ENSMUSP00000131056 ; ENSMUSG00000022996 . [P48614-1 ]
    GeneIDi 22410.
    KEGGi mmu:22410.
    UCSCi uc007xns.2. mouse. [P48614-2 ]
    uc007xnt.2. mouse. [P48614-1 ]

    Organism-specific databases

    CTDi 7480.
    MGIi MGI:108061. Wnt10b.

    Phylogenomic databases

    eggNOGi NOG240772.
    GeneTreei ENSGT00690000101857.
    HOGENOMi HOG000039528.
    HOVERGENi HBG001595.
    InParanoidi P48614.
    KOi K01357.
    OMAi SERCNCR.
    OrthoDBi EOG7C8GJ8.
    PhylomeDBi P48614.
    TreeFami TF105310.

    Enzyme and pathway databases

    Reactomei REACT_213918. WNT ligand biogenesis and trafficking.
    REACT_27166. Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes.

    Miscellaneous databases

    NextBioi 302809.
    PROi P48614.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P48614.
    Bgeei P48614.
    CleanExi MM_WNT10B.
    Genevestigatori P48614.

    Family and domain databases

    InterProi IPR005817. Wnt.
    IPR013302. Wnt10.
    IPR018161. Wnt_CS.
    [Graphical view ]
    PANTHERi PTHR12027. PTHR12027. 1 hit.
    Pfami PF00110. wnt. 1 hit.
    [Graphical view ]
    PRINTSi PR01893. WNT10PROTEIN.
    PR01349. WNTPROTEIN.
    SMARTi SM00097. WNT1. 1 hit.
    [Graphical view ]
    PROSITEi PS00246. WNT1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Insertional mutagenesis identifies a member of the Wnt gene family as a candidate oncogene in the mammary epithelium of int-2/Fgf-3 transgenic mice."
      Lee F.S., Lane T.F., Kuo A., Shackleford G.M., Leder P.
      Proc. Natl. Acad. Sci. U.S.A. 92:2268-2272(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Swiss Webster.
      Tissue: Embryo.
    2. "The mouse Wnt-10B gene isolated from helper T cells is widely expressed and a possible oncogene in BR6 mouse mammary tumorigenesis."
      Hardiman G., Albright S., Tsunoda J., McClanahan T., Lee F.
      Gene 172:199-205(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Murine Wnt10a and Wnt10b: cloning and expression in developing limbs, face and skin of embryos and in adults."
      Wang J., Shackleford G.M.
      Oncogene 13:1537-1544(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT).
      Tissue: Brain.

    Entry informationi

    Entry nameiWN10B_MOUSE
    AccessioniPrimary (citable) accession number: P48614
    Secondary accession number(s): P70702
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 120 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3