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P48614

- WN10B_MOUSE

UniProt

P48614 - WN10B_MOUSE

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Protein

Protein Wnt-10b

Gene

Wnt10b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.

GO - Molecular functioni

  1. frizzled binding Source: RefGenome
  2. receptor binding Source: MGI

GO - Biological processi

  1. bone trabecula formation Source: MGI
  2. canonical Wnt signaling pathway Source: MGI
  3. cell-cell signaling Source: MGI
  4. cell cycle arrest Source: MGI
  5. cell fate commitment Source: RefGenome
  6. cellular response to cAMP Source: MGI
  7. cellular response to hydrostatic pressure Source: Ensembl
  8. cellular response to organic cyclic compound Source: MGI
  9. cellular response to organic substance Source: MGI
  10. cellular response to parathyroid hormone stimulus Source: MGI
  11. chondrocyte differentiation Source: Ensembl
  12. fungiform papilla development Source: MGI
  13. G2/M transition of mitotic cell cycle Source: MGI
  14. hematopoietic stem cell proliferation Source: MGI
  15. lipid metabolic process Source: MGI
  16. myoblast differentiation involved in skeletal muscle regeneration Source: MGI
  17. negative regulation of epithelial cell proliferation Source: MGI
  18. negative regulation of fat cell differentiation Source: MGI
  19. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  20. neuron differentiation Source: RefGenome
  21. organ morphogenesis Source: MGI
  22. positive regulation of anagen Source: MGI
  23. positive regulation of apoptotic process Source: Ensembl
  24. positive regulation of bone mineralization Source: MGI
  25. positive regulation of canonical Wnt signaling pathway Source: MGI
  26. positive regulation of cell proliferation Source: MGI
  27. positive regulation of epithelial cell differentiation Source: MGI
  28. positive regulation of G2/M transition of mitotic cell cycle Source: MGI
  29. positive regulation of ossification Source: MGI
  30. positive regulation of osteoblast differentiation Source: MGI
  31. positive regulation of RNA polymerase II transcriptional preinitiation complex assembly Source: MGI
  32. positive regulation of sequence-specific DNA binding transcription factor activity Source: MGI
  33. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  34. protein stabilization Source: Ensembl
  35. regulation of fat cell differentiation Source: MGI
  36. regulation of proteasomal ubiquitin-dependent protein catabolic process Source: MGI
  37. regulation of protein metabolic process Source: MGI
  38. regulation of skeletal muscle tissue development Source: MGI
  39. regulation of transcription from RNA polymerase II promoter Source: MGI
  40. sensory perception of taste Source: MGI
  41. signal transduction Source: MGI
  42. skeletal muscle fiber development Source: MGI
  43. skeletal muscle tissue regeneration Source: MGI
  44. smoothened signaling pathway Source: MGI
  45. Wnt signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_213918. WNT ligand biogenesis and trafficking.
REACT_252217. Transcriptional regulation of white adipocyte differentiation.
REACT_27166. Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-10b
Alternative name(s):
Protein Wnt-12
Gene namesi
Name:Wnt10b
Synonyms:Wnt-10b, Wnt10, Wnt12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:108061. Wnt10b.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: RefGenome
  2. proteinaceous extracellular matrix Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence AnalysisAdd
BLAST
Chaini29 – 389361Protein Wnt-10bPRO_0000041464Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei46 – 461PhosphothreonineBy similarity
Disulfide bondi83 ↔ 94By similarity
Glycosylationi93 – 931N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi136 ↔ 144By similarity
Disulfide bondi146 ↔ 199By similarity
Disulfide bondi247 ↔ 261By similarity
Disulfide bondi249 ↔ 256By similarity
Disulfide bondi334 ↔ 349By similarity
Glycosylationi335 – 3351N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi364 ↔ 379By similarity
Disulfide bondi366 ↔ 376By similarity
Disulfide bondi371 ↔ 372By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiP48614.

PTM databases

PhosphoSiteiP48614.

Expressioni

Tissue specificityi

Expressed in embryos and in the mammary gland of non-pregnant mice.

Gene expression databases

BgeeiP48614.
CleanExiMM_WNT10B.
ExpressionAtlasiP48614. baseline and differential.
GenevestigatoriP48614.

Structurei

3D structure databases

ProteinModelPortaliP48614.
SMRiP48614. Positions 69-380.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG240772.
GeneTreeiENSGT00690000101857.
HOGENOMiHOG000039528.
HOVERGENiHBG001595.
InParanoidiP48614.
KOiK01357.
OMAiSERCNCR.
OrthoDBiEOG7C8GJ8.
PhylomeDBiP48614.
TreeFamiTF105310.

Family and domain databases

InterProiIPR005817. Wnt.
IPR013302. Wnt10.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01893. WNT10PROTEIN.
PR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform Long (identifier: P48614-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLEEPRSRPP PLGLAGLLFL ALFSRALSNE ILGLKLPGEP PLTANTVCLT
60 70 80 90 100
LSGLSKRQLG LCLRSPDVTA SALQGLHIAV HECQHQLRDQ RWNCSALEGG
110 120 130 140 150
GRLPHHSAIL KRGFRESAFS FSMLAAGVMH AVATACSLGK LVSCGCGWKG
160 170 180 190 200
SGEQDRLRAK LLQLQALSRG KTFPISQPSP VPGSVPSPGP QDTWEWGGCN
210 220 230 240 250
HDMDFGEKFS RDFLDSREAP RDIQARMRIH NNRVGRQVVT ENLKRKCKCH
260 270 280 290 300
GTSGSCQFKT CWRAAPEFRA IGAALRERLS RAIFIDTHNR NSGAFQPRLR
310 320 330 340 350
PRRLSGELVY FEKSPDFCER DPTLGSPGTR GRACNKTSRL LDGCGSLCCG
360 370 380
RGHNVLRQTR VERCHCRFHW CCYVLCDECK VTEWVNVCK
Length:389
Mass (Da):43,119
Last modified:February 1, 1996 - v1
Checksum:iF990AB33B7C84633
GO
Isoform Short (identifier: P48614-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     143-238: Missing.

Show »
Length:293
Mass (Da):32,400
Checksum:iE2BB87BC40C40240
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei143 – 23896Missing in isoform Short. 1 PublicationVSP_006796Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20658 mRNA. Translation: AAA80110.1.
U30464 mRNA. Translation: AAA84399.1.
U61970 mRNA. Translation: AAB08086.1.
U61971 mRNA. Translation: AAB08087.1.
CCDSiCCDS27806.1. [P48614-1]
PIRiA59393. A59392.
I49263.
RefSeqiNP_035848.1. NM_011718.2. [P48614-1]
XP_006520954.1. XM_006520891.1. [P48614-1]
XP_006520955.1. XM_006520892.1. [P48614-2]
UniGeneiMm.4709.

Genome annotation databases

EnsembliENSMUST00000023732; ENSMUSP00000023732; ENSMUSG00000022996. [P48614-1]
ENSMUST00000166022; ENSMUSP00000131056; ENSMUSG00000022996. [P48614-1]
GeneIDi22410.
KEGGimmu:22410.
UCSCiuc007xns.2. mouse. [P48614-2]
uc007xnt.2. mouse. [P48614-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20658 mRNA. Translation: AAA80110.1 .
U30464 mRNA. Translation: AAA84399.1 .
U61970 mRNA. Translation: AAB08086.1 .
U61971 mRNA. Translation: AAB08087.1 .
CCDSi CCDS27806.1. [P48614-1 ]
PIRi A59393. A59392.
I49263.
RefSeqi NP_035848.1. NM_011718.2. [P48614-1 ]
XP_006520954.1. XM_006520891.1. [P48614-1 ]
XP_006520955.1. XM_006520892.1. [P48614-2 ]
UniGenei Mm.4709.

3D structure databases

ProteinModelPortali P48614.
SMRi P48614. Positions 69-380.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei P48614.

Proteomic databases

PRIDEi P48614.

Protocols and materials databases

DNASUi 22410.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000023732 ; ENSMUSP00000023732 ; ENSMUSG00000022996 . [P48614-1 ]
ENSMUST00000166022 ; ENSMUSP00000131056 ; ENSMUSG00000022996 . [P48614-1 ]
GeneIDi 22410.
KEGGi mmu:22410.
UCSCi uc007xns.2. mouse. [P48614-2 ]
uc007xnt.2. mouse. [P48614-1 ]

Organism-specific databases

CTDi 7480.
MGIi MGI:108061. Wnt10b.

Phylogenomic databases

eggNOGi NOG240772.
GeneTreei ENSGT00690000101857.
HOGENOMi HOG000039528.
HOVERGENi HBG001595.
InParanoidi P48614.
KOi K01357.
OMAi SERCNCR.
OrthoDBi EOG7C8GJ8.
PhylomeDBi P48614.
TreeFami TF105310.

Enzyme and pathway databases

Reactomei REACT_213918. WNT ligand biogenesis and trafficking.
REACT_252217. Transcriptional regulation of white adipocyte differentiation.
REACT_27166. Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes.

Miscellaneous databases

NextBioi 302809.
PROi P48614.
SOURCEi Search...

Gene expression databases

Bgeei P48614.
CleanExi MM_WNT10B.
ExpressionAtlasi P48614. baseline and differential.
Genevestigatori P48614.

Family and domain databases

InterProi IPR005817. Wnt.
IPR013302. Wnt10.
IPR018161. Wnt_CS.
[Graphical view ]
PANTHERi PTHR12027. PTHR12027. 1 hit.
Pfami PF00110. wnt. 1 hit.
[Graphical view ]
PRINTSi PR01893. WNT10PROTEIN.
PR01349. WNTPROTEIN.
SMARTi SM00097. WNT1. 1 hit.
[Graphical view ]
PROSITEi PS00246. WNT1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Insertional mutagenesis identifies a member of the Wnt gene family as a candidate oncogene in the mammary epithelium of int-2/Fgf-3 transgenic mice."
    Lee F.S., Lane T.F., Kuo A., Shackleford G.M., Leder P.
    Proc. Natl. Acad. Sci. U.S.A. 92:2268-2272(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Swiss Webster.
    Tissue: Embryo.
  2. "The mouse Wnt-10B gene isolated from helper T cells is widely expressed and a possible oncogene in BR6 mouse mammary tumorigenesis."
    Hardiman G., Albright S., Tsunoda J., McClanahan T., Lee F.
    Gene 172:199-205(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Murine Wnt10a and Wnt10b: cloning and expression in developing limbs, face and skin of embryos and in adults."
    Wang J., Shackleford G.M.
    Oncogene 13:1537-1544(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT).
    Tissue: Brain.

Entry informationi

Entry nameiWN10B_MOUSE
AccessioniPrimary (citable) accession number: P48614
Secondary accession number(s): P70702
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 26, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3