Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P48614 (WN10B_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein Wnt-10b
Alternative name(s):
Protein Wnt-12
Gene names
Name:Wnt10b
Synonyms:Wnt-10b, Wnt10, Wnt12
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length389 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.

Subcellular location

Secretedextracellular spaceextracellular matrix.

Tissue specificity

Expressed in embryos and in the mammary gland of non-pregnant mice.

Sequence similarities

Belongs to the Wnt family.

Ontologies

Keywords
   Biological processWnt signaling pathway
   Cellular componentExtracellular matrix
Secreted
   Coding sequence diversityAlternative splicing
   DomainSignal
   Molecular functionDevelopmental protein
   PTMGlycoprotein
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG2/M transition of mitotic cell cycle

Inferred from genetic interaction PubMed 19056892. Source: MGI

Wnt signaling pathway

Inferred from genetic interaction PubMed 11092808. Source: MGI

bone trabecula formation

Inferred from mutant phenotype PubMed 15728361. Source: MGI

canonical Wnt signaling pathway

Inferred from direct assay PubMed 10937998. Source: MGI

cell cycle arrest

Inferred from direct assay PubMed 19056892. Source: MGI

cell fate commitment

Inferred from Biological aspect of Ancestor. Source: RefGenome

cell-cell signaling

Traceable author statement PubMed 9889131. Source: MGI

cellular response to cAMP

Inferred from direct assay PubMed 12055200. Source: MGI

cellular response to hydrostatic pressure

Inferred from electronic annotation. Source: Ensembl

cellular response to organic cyclic compound

Inferred from direct assay PubMed 19723499. Source: MGI

cellular response to organic substance

Inferred from direct assay PubMed 12055200. Source: MGI

cellular response to parathyroid hormone stimulus

Inferred from direct assay PubMed 19723499. Source: MGI

chondrocyte differentiation

Inferred from electronic annotation. Source: Ensembl

fungiform papilla development

Inferred from mutant phenotype PubMed 17284610. Source: MGI

hematopoietic stem cell proliferation

Inferred from direct assay PubMed 9160667. Source: MGI

lipid metabolic process

Inferred from mutant phenotype PubMed 15673614. Source: MGI

myoblast differentiation involved in skeletal muscle regeneration

Inferred from mutant phenotype PubMed 15673614. Source: MGI

negative regulation of epithelial cell proliferation

Inferred from direct assay PubMed 18155657. Source: MGI

negative regulation of fat cell differentiation

Inferred from direct assay PubMed 10937998PubMed 12055200PubMed 15728361. Source: MGI

negative regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 15673614PubMed 15728361. Source: MGI

neuron differentiation

Inferred from Biological aspect of Ancestor. Source: RefGenome

organ morphogenesis

Traceable author statement PubMed 9889131. Source: MGI

positive regulation of G2/M transition of mitotic cell cycle

Inferred from direct assay PubMed 19056892. Source: MGI

positive regulation of RNA polymerase II transcriptional preinitiation complex assembly

Inferred from direct assay PubMed 19056892. Source: MGI

positive regulation of anagen

Inferred from direct assay PubMed 18155657. Source: MGI

positive regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of bone mineralization

Inferred from direct assay PubMed 15728361. Source: MGI

positive regulation of canonical Wnt signaling pathway

Inferred from direct assay PubMed 19723499. Source: MGI

positive regulation of cell proliferation

Inferred from direct assay PubMed 9160667. Source: MGI

positive regulation of epithelial cell differentiation

Inferred from direct assay PubMed 18155657. Source: MGI

positive regulation of ossification

Inferred from mutant phenotype PubMed 15728361PubMed 17708715. Source: MGI

positive regulation of osteoblast differentiation

Inferred from direct assay PubMed 15728361PubMed 19723499. Source: MGI

positive regulation of sequence-specific DNA binding transcription factor activity

Inferred from direct assay PubMed 19056892. Source: MGI

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 15673614PubMed 15728361PubMed 19056892PubMed 9769173. Source: MGI

protein stabilization

Inferred from electronic annotation. Source: Ensembl

regulation of fat cell differentiation

Inferred from mutant phenotype PubMed 15673614. Source: MGI

regulation of proteasomal ubiquitin-dependent protein catabolic process

Inferred from direct assay PubMed 19056892. Source: MGI

regulation of protein metabolic process

Inferred from mutant phenotype PubMed 15728361PubMed 19056892. Source: MGI

regulation of skeletal muscle tissue development

Inferred from mutant phenotype PubMed 15673614. Source: MGI

regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 18155657. Source: MGI

sensory perception of taste

Inferred from mutant phenotype PubMed 17284610. Source: MGI

signal transduction

Traceable author statement PubMed 9889131. Source: MGI

skeletal muscle fiber development

Inferred from mutant phenotype PubMed 15673614. Source: MGI

skeletal muscle tissue regeneration

Inferred from mutant phenotype PubMed 15673614. Source: MGI

smoothened signaling pathway

Inferred from direct assay PubMed 17284610. Source: MGI

   Cellular_componentextracellular space

Inferred from Biological aspect of Ancestor. Source: RefGenome

proteinaceous extracellular matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionfrizzled binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

receptor binding

Traceable author statement PubMed 9889131. Source: MGI

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform Long (identifier: P48614-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform Short (identifier: P48614-2)

The sequence of this isoform differs from the canonical sequence as follows:
     143-238: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2828 Potential
Chain29 – 389361Protein Wnt-10b
PRO_0000041464

Amino acid modifications

Modified residue461Phosphothreonine By similarity
Glycosylation931N-linked (GlcNAc...) Potential
Glycosylation3351N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence143 – 23896Missing in isoform Short.
VSP_006796

Sequences

Sequence LengthMass (Da)Tools
Isoform Long [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: F990AB33B7C84633

FASTA38943,119
        10         20         30         40         50         60 
MLEEPRSRPP PLGLAGLLFL ALFSRALSNE ILGLKLPGEP PLTANTVCLT LSGLSKRQLG 

        70         80         90        100        110        120 
LCLRSPDVTA SALQGLHIAV HECQHQLRDQ RWNCSALEGG GRLPHHSAIL KRGFRESAFS 

       130        140        150        160        170        180 
FSMLAAGVMH AVATACSLGK LVSCGCGWKG SGEQDRLRAK LLQLQALSRG KTFPISQPSP 

       190        200        210        220        230        240 
VPGSVPSPGP QDTWEWGGCN HDMDFGEKFS RDFLDSREAP RDIQARMRIH NNRVGRQVVT 

       250        260        270        280        290        300 
ENLKRKCKCH GTSGSCQFKT CWRAAPEFRA IGAALRERLS RAIFIDTHNR NSGAFQPRLR 

       310        320        330        340        350        360 
PRRLSGELVY FEKSPDFCER DPTLGSPGTR GRACNKTSRL LDGCGSLCCG RGHNVLRQTR 

       370        380 
VERCHCRFHW CCYVLCDECK VTEWVNVCK 

« Hide

Isoform Short [UniParc].

Checksum: E2BB87BC40C40240
Show »

FASTA29332,400

References

[1]"Insertional mutagenesis identifies a member of the Wnt gene family as a candidate oncogene in the mammary epithelium of int-2/Fgf-3 transgenic mice."
Lee F.S., Lane T.F., Kuo A., Shackleford G.M., Leder P.
Proc. Natl. Acad. Sci. U.S.A. 92:2268-2272(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Swiss Webster.
Tissue: Embryo.
[2]"The mouse Wnt-10B gene isolated from helper T cells is widely expressed and a possible oncogene in BR6 mouse mammary tumorigenesis."
Hardiman G., Albright S., Tsunoda J., McClanahan T., Lee F.
Gene 172:199-205(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Murine Wnt10a and Wnt10b: cloning and expression in developing limbs, face and skin of embryos and in adults."
Wang J., Shackleford G.M.
Oncogene 13:1537-1544(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT).
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U20658 mRNA. Translation: AAA80110.1.
U30464 mRNA. Translation: AAA84399.1.
U61970 mRNA. Translation: AAB08086.1.
U61971 mRNA. Translation: AAB08087.1.
CCDSCCDS27806.1. [P48614-1]
PIRA59392. A59393.
I49263.
RefSeqNP_035848.1. NM_011718.2. [P48614-1]
XP_006520954.1. XM_006520891.1. [P48614-1]
XP_006520955.1. XM_006520892.1. [P48614-2]
UniGeneMm.4709.

3D structure databases

ProteinModelPortalP48614.
SMRP48614. Positions 69-380.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteP48614.

Proteomic databases

PRIDEP48614.

Protocols and materials databases

DNASU22410.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000023732; ENSMUSP00000023732; ENSMUSG00000022996. [P48614-1]
ENSMUST00000166022; ENSMUSP00000131056; ENSMUSG00000022996. [P48614-1]
GeneID22410.
KEGGmmu:22410.
UCSCuc007xns.2. mouse. [P48614-2]
uc007xnt.2. mouse. [P48614-1]

Organism-specific databases

CTD7480.
MGIMGI:108061. Wnt10b.

Phylogenomic databases

eggNOGNOG240772.
GeneTreeENSGT00690000101857.
HOGENOMHOG000039528.
HOVERGENHBG001595.
InParanoidP48614.
KOK01357.
OMASERCNCR.
OrthoDBEOG7C8GJ8.
PhylomeDBP48614.
TreeFamTF105310.

Gene expression databases

ArrayExpressP48614.
BgeeP48614.
CleanExMM_WNT10B.
GenevestigatorP48614.

Family and domain databases

InterProIPR005817. Wnt.
IPR013302. Wnt10.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERPTHR12027. PTHR12027. 1 hit.
PfamPF00110. wnt. 1 hit.
[Graphical view]
PRINTSPR01893. WNT10PROTEIN.
PR01349. WNTPROTEIN.
SMARTSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEPS00246. WNT1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio302809.
PROP48614.
SOURCESearch...

Entry information

Entry nameWN10B_MOUSE
AccessionPrimary (citable) accession number: P48614
Secondary accession number(s): P70702
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: July 9, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot