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P48609

- CDK5_DROME

UniProt

P48609 - CDK5_DROME

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Protein
Cyclin-dependent kinase 5 homolog
Gene
Cdk5, CG8203
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Probably involved in the control of the cell cycle. Interacts with D1 and D3-type G1 cyclins. Possible regulator of neuronal differentiation and/or development By similarity.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331ATP By similarity
Active sitei126 – 1261Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 189ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: FlyBase
  3. protein binding Source: IntAct
  4. protein serine/threonine kinase activity Source: FlyBase

GO - Biological processi

  1. adult locomotory behavior Source: FlyBase
  2. axonogenesis Source: FlyBase
  3. cell division Source: UniProtKB-KW
  4. centrosome localization Source: FlyBase
  5. determination of adult lifespan Source: FlyBase
  6. flight behavior Source: FlyBase
  7. intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: FlyBase
  8. melanotic encapsulation of foreign target Source: FlyBase
  9. mitotic cell cycle Source: FlyBase
  10. motor neuron axon guidance Source: FlyBase
  11. protein phosphorylation Source: FlyBase
  12. regulation of synaptic growth at neuromuscular junction Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Cell cycle, Cell division

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.22. 1994.
ReactomeiREACT_180258. Factors involved in megakaryocyte development and platelet production.
SignaLinkiP48609.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 5 homolog (EC:2.7.11.22)
Alternative name(s):
Cell division protein kinase 5
Gene namesi
Name:Cdk5
ORF Names:CG8203
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0013762. Cdk5.

Subcellular locationi

GO - Cellular componenti

  1. cyclin-dependent protein kinase 5 holoenzyme complex Source: FlyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 294294Cyclin-dependent kinase 5 homolog
PRO_0000085788Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei14 – 141Phosphothreonine By similarity
Modified residuei15 – 151Phosphotyrosine By similarity
Modified residuei159 – 1591Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP48609.

Expressioni

Tissue specificityi

Abundantly expressed in all adult tissues. Lower levels found in larvae and early embryos. Barely detectable in late embryos.

Gene expression databases

BgeeiP48609.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CycCP250084EBI-94216,EBI-195485

Protein-protein interaction databases

BioGridi62461. 42 interactions.
DIPiDIP-22131N.
IntActiP48609. 41 interactions.
MINTiMINT-775083.

Structurei

3D structure databases

ProteinModelPortaliP48609.
SMRiP48609. Positions 1-288.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 286283Protein kinase
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00600000083998.
InParanoidiP48609.
KOiK02090.
OMAiPAITSWS.
OrthoDBiEOG7966H8.
PhylomeDBiP48609.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48609-1 [UniParc]FASTAAdd to Basket

« Hide

MQKYDKMEKI GEGTYGTVFK GRNRDTMEIV ALKRVRLDED DEGVPSSALR    50
EICLLKELKH KNIVRLIDVL HSDKKLTLVF EHCDQDLKKY FDSLNGEIDM 100
AVCRSFMLQL LRGLAFCHSH NVLHRDLKPQ NLLINKNGEL KLADFGLARA 150
FGIPVKCYSA EVVTLWYRPP DVLFGAKLYT TSIDMWSAGC ILAELADAGR 200
PLFPGSDVLD QLMKIFRVLG TPNEDSWPGV SHLSDYVALP SFPAITSWSQ 250
LVPRLNSKGR DLLQKLLICR PNQRISAEAA MQHPYFTDSS SSGH 294
Length:294
Mass (Da):33,180
Last modified:December 1, 2000 - v2
Checksum:iE6B7B37B2410AA23
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti25 – 251D → A in AAA63754. 1 Publication
Sequence conflicti166 – 1661W → L in AAA63754. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U21552 Genomic DNA. Translation: AAA63754.1.
X99511 mRNA. Translation: CAA67861.1.
AE013599 Genomic DNA. Translation: AAF58119.1.
AY061049 mRNA. Translation: AAL28597.1.
PIRiS51008.
RefSeqiNP_477080.1. NM_057732.3.
UniGeneiDm.640.

Genome annotation databases

EnsemblMetazoaiFBtr0087350; FBpp0086483; FBgn0013762.
GeneIDi36727.
KEGGidme:Dmel_CG8203.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U21552 Genomic DNA. Translation: AAA63754.1 .
X99511 mRNA. Translation: CAA67861.1 .
AE013599 Genomic DNA. Translation: AAF58119.1 .
AY061049 mRNA. Translation: AAL28597.1 .
PIRi S51008.
RefSeqi NP_477080.1. NM_057732.3.
UniGenei Dm.640.

3D structure databases

ProteinModelPortali P48609.
SMRi P48609. Positions 1-288.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 62461. 42 interactions.
DIPi DIP-22131N.
IntActi P48609. 41 interactions.
MINTi MINT-775083.

Proteomic databases

PaxDbi P48609.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0087350 ; FBpp0086483 ; FBgn0013762 .
GeneIDi 36727.
KEGGi dme:Dmel_CG8203.

Organism-specific databases

CTDi 1020.
FlyBasei FBgn0013762. Cdk5.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00600000083998.
InParanoidi P48609.
KOi K02090.
OMAi PAITSWS.
OrthoDBi EOG7966H8.
PhylomeDBi P48609.

Enzyme and pathway databases

BRENDAi 2.7.11.22. 1994.
Reactomei REACT_180258. Factors involved in megakaryocyte development and platelet production.
SignaLinki P48609.

Miscellaneous databases

GenomeRNAii 36727.
NextBioi 800081.
PROi P48609.

Gene expression databases

Bgeei P48609.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of the Drosophila melanogaster CDK5 homolog."
    Hellmich M.R., Kennison J.A., Hampton L.L., Battey J.F.
    FEBS Lett. 356:317-321(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Oregon-R.
  2. "Novel members of the cdc2-related kinase family in Drosophila: cdk4/6, cdk5, PFTAIRE, and PITSLRE kinase."
    Sauer K., Weigmann K., Sigrist S., Lehner C.F.
    Mol. Biol. Cell 7:1759-1769(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  4. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Embryo.

Entry informationi

Entry nameiCDK5_DROME
AccessioniPrimary (citable) accession number: P48609
Secondary accession number(s): Q94878, Q9V7D8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: December 1, 2000
Last modified: September 3, 2014
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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