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P48609

- CDK5_DROME

UniProt

P48609 - CDK5_DROME

Protein

Cyclin-dependent kinase 5 homolog

Gene

Cdk5

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 2 (01 Dec 2000)
      Previous versions | rss
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    Functioni

    Probably involved in the control of the cell cycle. Interacts with D1 and D3-type G1 cyclins. Possible regulator of neuronal differentiation and/or development By similarity.By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei33 – 331ATPPROSITE-ProRule annotation
    Active sitei126 – 1261Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 189ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cyclin-dependent protein serine/threonine kinase activity Source: FlyBase
    3. protein binding Source: IntAct
    4. protein serine/threonine kinase activity Source: FlyBase

    GO - Biological processi

    1. adult locomotory behavior Source: FlyBase
    2. axonogenesis Source: FlyBase
    3. cell division Source: UniProtKB-KW
    4. centrosome localization Source: FlyBase
    5. determination of adult lifespan Source: FlyBase
    6. flight behavior Source: FlyBase
    7. intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: FlyBase
    8. melanotic encapsulation of foreign target Source: FlyBase
    9. mitotic cell cycle Source: FlyBase
    10. motor neuron axon guidance Source: FlyBase
    11. protein phosphorylation Source: FlyBase
    12. regulation of cell cycle Source: GOC
    13. regulation of synaptic growth at neuromuscular junction Source: FlyBase

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Cell cycle, Cell division

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.11.22. 1994.
    ReactomeiREACT_180258. Factors involved in megakaryocyte development and platelet production.
    SignaLinkiP48609.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-dependent kinase 5 homolog (EC:2.7.11.22)
    Alternative name(s):
    Cell division protein kinase 5
    Gene namesi
    Name:Cdk5
    ORF Names:CG8203
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 2R

    Organism-specific databases

    FlyBaseiFBgn0013762. Cdk5.

    Subcellular locationi

    GO - Cellular componenti

    1. cyclin-dependent protein kinase 5 holoenzyme complex Source: FlyBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 294294Cyclin-dependent kinase 5 homologPRO_0000085788Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei14 – 141PhosphothreonineBy similarity
    Modified residuei15 – 151PhosphotyrosineBy similarity
    Modified residuei159 – 1591PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiP48609.

    Expressioni

    Tissue specificityi

    Abundantly expressed in all adult tissues. Lower levels found in larvae and early embryos. Barely detectable in late embryos.

    Gene expression databases

    BgeeiP48609.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CycCP250084EBI-94216,EBI-195485

    Protein-protein interaction databases

    BioGridi62461. 42 interactions.
    DIPiDIP-22131N.
    IntActiP48609. 41 interactions.
    MINTiMINT-775083.

    Structurei

    3D structure databases

    ProteinModelPortaliP48609.
    SMRiP48609. Positions 1-288.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 286283Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00600000083998.
    InParanoidiP48609.
    KOiK02090.
    OMAiPAITSWS.
    OrthoDBiEOG7966H8.
    PhylomeDBiP48609.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P48609-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQKYDKMEKI GEGTYGTVFK GRNRDTMEIV ALKRVRLDED DEGVPSSALR    50
    EICLLKELKH KNIVRLIDVL HSDKKLTLVF EHCDQDLKKY FDSLNGEIDM 100
    AVCRSFMLQL LRGLAFCHSH NVLHRDLKPQ NLLINKNGEL KLADFGLARA 150
    FGIPVKCYSA EVVTLWYRPP DVLFGAKLYT TSIDMWSAGC ILAELADAGR 200
    PLFPGSDVLD QLMKIFRVLG TPNEDSWPGV SHLSDYVALP SFPAITSWSQ 250
    LVPRLNSKGR DLLQKLLICR PNQRISAEAA MQHPYFTDSS SSGH 294
    Length:294
    Mass (Da):33,180
    Last modified:December 1, 2000 - v2
    Checksum:iE6B7B37B2410AA23
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti25 – 251D → A in AAA63754. (PubMed:7805863)Curated
    Sequence conflicti166 – 1661W → L in AAA63754. (PubMed:7805863)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U21552 Genomic DNA. Translation: AAA63754.1.
    X99511 mRNA. Translation: CAA67861.1.
    AE013599 Genomic DNA. Translation: AAF58119.1.
    AY061049 mRNA. Translation: AAL28597.1.
    PIRiS51008.
    RefSeqiNP_477080.1. NM_057732.3.
    UniGeneiDm.640.

    Genome annotation databases

    EnsemblMetazoaiFBtr0087350; FBpp0086483; FBgn0013762.
    GeneIDi36727.
    KEGGidme:Dmel_CG8203.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U21552 Genomic DNA. Translation: AAA63754.1 .
    X99511 mRNA. Translation: CAA67861.1 .
    AE013599 Genomic DNA. Translation: AAF58119.1 .
    AY061049 mRNA. Translation: AAL28597.1 .
    PIRi S51008.
    RefSeqi NP_477080.1. NM_057732.3.
    UniGenei Dm.640.

    3D structure databases

    ProteinModelPortali P48609.
    SMRi P48609. Positions 1-288.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 62461. 42 interactions.
    DIPi DIP-22131N.
    IntActi P48609. 41 interactions.
    MINTi MINT-775083.

    Proteomic databases

    PaxDbi P48609.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0087350 ; FBpp0086483 ; FBgn0013762 .
    GeneIDi 36727.
    KEGGi dme:Dmel_CG8203.

    Organism-specific databases

    CTDi 1020.
    FlyBasei FBgn0013762. Cdk5.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00600000083998.
    InParanoidi P48609.
    KOi K02090.
    OMAi PAITSWS.
    OrthoDBi EOG7966H8.
    PhylomeDBi P48609.

    Enzyme and pathway databases

    BRENDAi 2.7.11.22. 1994.
    Reactomei REACT_180258. Factors involved in megakaryocyte development and platelet production.
    SignaLinki P48609.

    Miscellaneous databases

    GenomeRNAii 36727.
    NextBioi 800081.
    PROi P48609.

    Gene expression databases

    Bgeei P48609.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of the Drosophila melanogaster CDK5 homolog."
      Hellmich M.R., Kennison J.A., Hampton L.L., Battey J.F.
      FEBS Lett. 356:317-321(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Oregon-R.
    2. "Novel members of the cdc2-related kinase family in Drosophila: cdk4/6, cdk5, PFTAIRE, and PITSLRE kinase."
      Sauer K., Weigmann K., Sigrist S., Lehner C.F.
      Mol. Biol. Cell 7:1759-1769(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    4. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Berkeley.
      Tissue: Embryo.

    Entry informationi

    Entry nameiCDK5_DROME
    AccessioniPrimary (citable) accession number: P48609
    Secondary accession number(s): Q94878, Q9V7D8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: December 1, 2000
    Last modified: October 1, 2014
    This is version 129 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3