Skip Header

 
Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot P48606 (TBCA_YEAST)

Last modified November 24, 2009. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Tubulin-specific chaperone A
Alternative name(s):
    Tubulin-folding cofactor A
      Short name=CFA
Gene names
Name: RBL2
Ordered Locus Names: YOR265W
OrganismSaccharomyces cerevisiae (Baker's yeast) [Complete proteome]
Taxonomic identifier4932 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length106 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Tubulin-folding protein; involved in the early step of the tubulin folding pathway.

Subcellular location

Cytoplasmcytoskeleton.

Miscellaneous

Present with 1760 molecules/cell in log phase SD medium. Ref.5

Sequence similarities

Belongs to the TBCA family.

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 106106Tubulin-specific chaperone A
PRO_0000080045

Amino acid modifications

Modified residue941Phosphoserine Ref.6 Ref.7 Ref.8

Secondary structure

......... 106
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P48606-1 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 3F649CCB78AB3EF3

FASTA10612,379
        10         20         30         40         50         60 
MAPTQLDIKV KALKRLTKEE GYYQQELKDQ EAHVAKLKED KSVDPYDLKK QEEVLDDTKR 

        70         80         90        100 
LLPTLYEKIR EFKEDLEQFL KTYQGTEDVS DARSAITSAQ ELLDSK 

« Hide

References

« Hide 'large scale' references
[1]"Rbl2p, a yeast protein that binds to beta-tubulin and participates in microtubule function in vivo."
Archer J.E., Vega L.R., Solomon F.
Cell 82:425-434(1995) [PubMed: 7634332] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Sequencing analysis of a 36.8 kb fragment of yeast chromosome XV reveals 26 open reading frames including SEC63, CDC31, SUG2, GCD1, RBL2, PNT1, PAC1 and VPH1."
Poirey R., Jauniaux J.-C.
Yeast 13:483-487(1997) [PubMed: 9153759] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 96604 / S288c / FY1679.
[3]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D. expand/collapse author list , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
Nature 387:98-102(1997) [PubMed: 9169874] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 96604 / S288c / FY1679.
[4]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed: 17322287] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[5]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed: 14562106] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[6]"Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway."
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J., Mann M., Jensen O.N.
Mol. Cell. Proteomics 4:310-327(2005) [PubMed: 15665377] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-94, MASS SPECTROMETRY.
[7]"Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases."
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007) [PubMed: 17563356] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-94, MASS SPECTROMETRY.
[8]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed: 18407956] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-94, MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

U30184 Genomic DNA. Translation: AAB08525.1.
Z75173 Genomic DNA. Translation: CAA99488.1.
AY692767 Genomic DNA. Translation: AAT92786.1.
PIRS64649.
RefSeqNP_014908.1.

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
1QSDX-ray2.20A/B1-106[»]
ModBaseSearch...

Protein-protein interaction databases

DIPDIP:4101N.
IntActP48606. 4 interactions.
STRINGP48606.

Proteomic databases

PeptideAtlasP48606.

Genome annotation databases

EnsemblYOR265W; YOR265W; YOR265W; Saccharomyces cerevisiae. [Genome view]
GeneID854439.
KEGGsce:YOR265W.
NMPDRfig|4932.3.peg.6020.

Organism-specific databases

CYGDYOR265w.
SGDS000005791. RBL2.

Phylogenomic databases

HOGENOMP48606.
OMAEESQRMV
OrthoDBEOG912NNH

Gene expression databases

ArrayExpressP48606.
GenevestigatorP48606.
GermOnlineYOR265W. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR004226. CofA_tubulin_bd.
[Graphical view]
PANTHERPTHR21500. CofA_tubulin_bd. 1 hit.
PfamPF02970. TBCA. 1 hit.
[Graphical view]
ProDomPD010430. CofA_tubulin_bd. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Other Resources

NextBio976679.

Entry information

Entry nameTBCA_YEAST
AccessionPrimary (citable) accession number: P48606
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 24, 2009
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents