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P48606 (TBCA_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Tubulin-specific chaperone A
Alternative name(s):
Tubulin-folding cofactor A
Short name=CFA
Gene names
Name:RBL2
Ordered Locus Names:YOR265W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length106 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Tubulin-folding protein; involved in the early step of the tubulin folding pathway.

Subcellular location

Cytoplasmcytoskeleton.

Miscellaneous

Present with 1760 molecules/cell in log phase SD medium. Ref.6

Sequence similarities

Belongs to the TBCA family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

TUB2P025572EBI-18991,EBI-18986

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 106106Tubulin-specific chaperone A
PRO_0000080045

Amino acid modifications

Modified residue941Phosphoserine Ref.7 Ref.8 Ref.9

Secondary structure

......... 106
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P48606 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 3F649CCB78AB3EF3

FASTA10612,379
        10         20         30         40         50         60 
MAPTQLDIKV KALKRLTKEE GYYQQELKDQ EAHVAKLKED KSVDPYDLKK QEEVLDDTKR 

        70         80         90        100 
LLPTLYEKIR EFKEDLEQFL KTYQGTEDVS DARSAITSAQ ELLDSK 

« Hide

References

« Hide 'large scale' references
[1]"Rbl2p, a yeast protein that binds to beta-tubulin and participates in microtubule function in vivo."
Archer J.E., Vega L.R., Solomon F.
Cell 82:425-434(1995) [PubMed: 7634332] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Sequencing analysis of a 36.8 kb fragment of yeast chromosome XV reveals 26 open reading frames including SEC63, CDC31, SUG2, GCD1, RBL2, PNT1, PAC1 and VPH1."
Poirey R., Jauniaux J.-C.
Yeast 13:483-487(1997) [PubMed: 9153759] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 96604 / S288c / FY1679.
[3]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D. expand/collapse author list , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
Nature 387:98-102(1997) [PubMed: 9169874] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 96604 / S288c / FY1679.
[4]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[5]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed: 17322287] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[6]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed: 14562106] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[7]"Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway."
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J., Mann M., Jensen O.N.
Mol. Cell. Proteomics 4:310-327(2005) [PubMed: 15665377] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-94, MASS SPECTROMETRY.
Strain: YAL6B.
[8]"Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases."
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007) [PubMed: 17563356] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-94, MASS SPECTROMETRY.
[9]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed: 18407956] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-94, MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U30184 Genomic DNA. Translation: AAB08525.1.
Z75173 Genomic DNA. Translation: CAA99488.1.
AY692767 Genomic DNA. Translation: AAT92786.1.
BK006948 Genomic DNA. Translation: DAA11031.1.
PIRS64649.
RefSeqNP_014908.1. NM_001183684.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1QSDX-ray2.20A/B1-106[»]
ProteinModelPortalP48606.
SMRP48606. Positions 4-105.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-4101N.
IntActP48606. 4 interactions.
MINTMINT-558997.
STRINGP48606.

Proteomic databases

PeptideAtlasP48606.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYOR265W; YOR265W; YOR265W.
GeneID854439.
KEGGsce:YOR265W.
NMPDRfig|4932.3.peg.6020.

Organism-specific databases

CYGDYOR265w.
SGDS000005791. RBL2.

Phylogenomic databases

eggNOGfuNOG11801.
GeneTreeEFGT00050000006091.
HOGENOMHBG398009.
OMAEESQRMV.
OrthoDBEOG42593M.

Gene expression databases

ArrayExpressP48606.
GenevestigatorP48606.
GermOnlineYOR265W. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR004226. CofA_tubulin-bd.
[Graphical view]
PANTHERPTHR21500. CofA_tubulin_bd. 1 hit.
PfamPF02970. TBCA. 1 hit.
[Graphical view]
ProDomPD010430. CofA_tubulin_bd. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF46988. Tub_bind_cof_A. 1 hit.
ProtoNetSearch...

Other

NextBio976679.

Entry information

Entry nameTBCA_YEAST
AccessionPrimary (citable) accession number: P48606
Secondary accession number(s): D6W2W5
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: December 14, 2011
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families