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Protein

T-complex protein 1 subunit gamma

Gene

Cctgamma

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.

GO - Molecular functioni

  • ATPase activity, coupled Source: FlyBase
  • ATP binding Source: UniProtKB-KW
  • protein binding involved in protein folding Source: GO_Central
  • unfolded protein binding Source: GO_Central

GO - Biological processi

  • 'de novo' protein folding Source: GO_Central
  • chaperone-mediated protein folding Source: GO_Central
  • open tracheal system development Source: FlyBase
  • protein folding Source: FlyBase
  • terminal branching, open tracheal system Source: FlyBase

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-390471. Association of TriC/CCT with target proteins during biosynthesis.
R-DME-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 1 subunit gamma
Short name:
TCP-1-gamma
Alternative name(s):
CCT-gamma
Gene namesi
Name:Cctgamma
Synonyms:CCT-3, Cctg
ORF Names:CG8977
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0015019. Cctgamma.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001283271 – 544T-complex protein 1 subunit gammaAdd BLAST544

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi368 ↔ 374By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP48605.
PRIDEiP48605.

Expressioni

Gene expression databases

BgeeiFBgn0015019.
ExpressionAtlasiP48605. differential.
GenevisibleiP48605. DM.

Interactioni

Subunit structurei

Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi67074. 91 interactors.
DIPiDIP-20434N.
IntActiP48605. 16 interactors.
MINTiMINT-855241.
STRINGi7227.FBpp0082787.

Structurei

3D structure databases

ProteinModelPortaliP48605.
SMRiP48605.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

eggNOGiKOG0364. Eukaryota.
COG0459. LUCA.
GeneTreeiENSGT00570000079224.
InParanoidiP48605.
KOiK09495.
OMAiHFLLKAG.
OrthoDBiEOG091G0677.
PhylomeDBiP48605.

Family and domain databases

CDDicd03337. TCP1_gamma. 1 hit.
Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
InterProiView protein in InterPro
IPR012719. Chap_CCT_gamma.
IPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
PANTHERiPTHR11353. PTHR11353. 1 hit.
PfamiView protein in Pfam
PF00118. Cpn60_TCP1. 1 hit.
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF48592. SSF48592. 2 hits.
SSF52029. SSF52029. 1 hit.
SSF54849. SSF54849. 2 hits.
TIGRFAMsiTIGR02344. chap_CCT_gamma. 1 hit.
PROSITEiView protein in PROSITE
PS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.

Sequencei

Sequence statusi: Complete.

P48605-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFGGQQPILV LSQNTKRESG RKVQLENIQA GKAIADVIRT CLGPQAMLKM
60 70 80 90 100
LMDPMGGIVM TNDGNAILRE ITVQHPAAKS MIEIARTQDE EVGDGTTSVI
110 120 130 140 150
VLAGEMLAAA EPFLQQQIHP TVIIRAYREA LEDIVGHLQS QLSIQLDVKD
160 170 180 190 200
KAKMADVVKA CVGTKFIGKW SDLAVKIALD AVETVTLSEN GRLEVDIKRY
210 220 230 240 250
AKVEKIPGGA IEESCVLKGV MINKDVTHPK MRRLIENPRI VLLDCSLEYK
260 270 280 290 300
KGESQTNVEI IGEQDFTRML QIEEEFVQRI CADIIAVKPD LVFTEKGVSD
310 320 330 340 350
LAQHYLLKAG ITAIRRLRKT DNLRIARACG ATIVNRTEEL TEKDVGTGAG
360 370 380 390 400
LFEVKKIGDE YFTFVTECKE PKACTILLRG ASKDILNETE RNLQDALHVA
410 420 430 440 450
RNLVLEPRLV AGGGAVEMAA SQLLTRKQVK GPYTAVAHAL EIIPRTLAQN
460 470 480 490 500
CGANTIRALT ALRAKHASHT GDGVCAWGID GESGEIVDMN VKNIWEPLAV
510 520 530 540
KLQTYKTAVE TAILLLRIDD IVSGSKKRGG NEPTNPAAMA QGQE
Length:544
Mass (Da):59,395
Last modified:October 1, 1996 - v2
Checksum:iDD5E635809B322C2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12S → SD in CAA64860 (PubMed:8666276).Curated1
Sequence conflicti35 – 47Missing in AAA84416 (PubMed:7667301).CuratedAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31961 Genomic DNA. Translation: AAA84416.1.
X95602 Genomic DNA. Translation: CAA64860.1.
AE014297 Genomic DNA. Translation: AAF55350.1.
AY089543 mRNA. Translation: AAL90281.1.
RefSeqiNP_001189236.1. NM_001202307.2.
NP_001189237.1. NM_001202308.2.
NP_650572.2. NM_142315.4.
NP_732167.1. NM_169727.2.
UniGeneiDm.6927.

Genome annotation databases

EnsemblMetazoaiFBtr0083337; FBpp0082787; FBgn0015019.
FBtr0083338; FBpp0082788; FBgn0015019.
FBtr0302370; FBpp0291565; FBgn0015019.
FBtr0302371; FBpp0291566; FBgn0015019.
GeneIDi42029.
KEGGidme:Dmel_CG8977.

Similar proteinsi

Entry informationi

Entry nameiTCPG_DROME
AccessioniPrimary (citable) accession number: P48605
Secondary accession number(s): Q9VER9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: October 1, 1996
Last modified: October 25, 2017
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families