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Protein

GrpE protein homolog, mitochondrial

Gene

Roe1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • neurogenesis Source: FlyBase
  • protein folding Source: InterPro
  • protein import into mitochondrial matrix Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Names & Taxonomyi

Protein namesi
Recommended name:
GrpE protein homolog, mitochondrial
Alternative name(s):
dRoe1
Gene namesi
Name:Roe1
ORF Names:CG6155
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0014877. Roe1.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial matrix Source: UniProtKB-SubCell
  • mitochondrion Source: FlyBase
  • presequence translocase-associated import motor Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000013048? – 213GrpE protein homolog, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

PaxDbiP48604.
PRIDEiP48604.

Expressioni

Gene expression databases

BgeeiFBgn0014877.
ExpressionAtlasiP48604. baseline.
GenevisibleiP48604. DM.

Interactioni

Subunit structurei

Probable component of the PAM complex at least composed of a mitochondrial HSP70 protein, Roe1, TIM44, blp/TIM16 and TIM14.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi62264. 2 interactors.
IntActiP48604. 5 interactors.
MINTiMINT-994948.
STRINGi7227.FBpp0086795.

Structurei

3D structure databases

ProteinModelPortaliP48604.
SMRiP48604.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GrpE family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3003. Eukaryota.
COG0576. LUCA.
GeneTreeiENSGT00390000005589.
InParanoidiP48604.
KOiK03687.
OMAiFANENIM.
OrthoDBiEOG091G0O5D.
PhylomeDBiP48604.

Family and domain databases

CDDicd00446. GrpE. 1 hit.
Gene3Di2.30.22.10. 1 hit.
3.90.20.20. 1 hit.
HAMAPiMF_01151. GrpE. 1 hit.
InterProiIPR000740. GrpE.
IPR013805. GrpE_coiled_coil.
IPR009012. GrpE_head.
[Graphical view]
PANTHERiPTHR21237. PTHR21237. 1 hit.
PfamiPF01025. GrpE. 1 hit.
[Graphical view]
PRINTSiPR00773. GRPEPROTEIN.
SUPFAMiSSF51064. SSF51064. 1 hit.
PROSITEiPS01071. GRPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48604-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAKAALPLQ MFGRRLVHLR SSVTSQNMSA LRLYSTEKQP EEATEQKATE
60 70 80 90 100
SSPEVEKLTK ELAAAKEQNA ELMDKYKRSL ADSENMRNRL NKQISDAKIF
110 120 130 140 150
GIQSFCKDLL EVADTLGHAT QAVPKDKLSG NADLKNLYEG LTMTRASLLQ
160 170 180 190 200
VFKRHGLEPL DPINQKFDPN QHEALFQKED KTVEPNTVVE VTKLGYKLHE
210
RCIRPALVGV SKC
Length:213
Mass (Da):23,926
Last modified:September 27, 2004 - v2
Checksum:i3418F8A23F31528D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti55V → L in AAA79044 (Ref. 1) Curated1
Sequence conflicti132A → T in AAA79044 (Ref. 1) Curated1
Sequence conflicti158E → K in AAM11242 (PubMed:12537569).Curated1
Sequence conflicti159P → S in AAA79044 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34903 mRNA. Translation: AAA79044.1.
AE013599 Genomic DNA. Translation: AAF58354.1.
AY094889 mRNA. Translation: AAM11242.1.
RefSeqiNP_610886.2. NM_137042.4.
UniGeneiDm.4119.

Genome annotation databases

EnsemblMetazoaiFBtr0087675; FBpp0086795; FBgn0014877.
GeneIDi36508.
KEGGidme:Dmel_CG6155.
UCSCiCG6155-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34903 mRNA. Translation: AAA79044.1.
AE013599 Genomic DNA. Translation: AAF58354.1.
AY094889 mRNA. Translation: AAM11242.1.
RefSeqiNP_610886.2. NM_137042.4.
UniGeneiDm.4119.

3D structure databases

ProteinModelPortaliP48604.
SMRiP48604.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi62264. 2 interactors.
IntActiP48604. 5 interactors.
MINTiMINT-994948.
STRINGi7227.FBpp0086795.

Proteomic databases

PaxDbiP48604.
PRIDEiP48604.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0087675; FBpp0086795; FBgn0014877.
GeneIDi36508.
KEGGidme:Dmel_CG6155.
UCSCiCG6155-RA. d. melanogaster.

Organism-specific databases

CTDi36508.
FlyBaseiFBgn0014877. Roe1.

Phylogenomic databases

eggNOGiKOG3003. Eukaryota.
COG0576. LUCA.
GeneTreeiENSGT00390000005589.
InParanoidiP48604.
KOiK03687.
OMAiFANENIM.
OrthoDBiEOG091G0O5D.
PhylomeDBiP48604.

Miscellaneous databases

GenomeRNAii36508.
PROiP48604.

Gene expression databases

BgeeiFBgn0014877.
ExpressionAtlasiP48604. baseline.
GenevisibleiP48604. DM.

Family and domain databases

CDDicd00446. GrpE. 1 hit.
Gene3Di2.30.22.10. 1 hit.
3.90.20.20. 1 hit.
HAMAPiMF_01151. GrpE. 1 hit.
InterProiIPR000740. GrpE.
IPR013805. GrpE_coiled_coil.
IPR009012. GrpE_head.
[Graphical view]
PANTHERiPTHR21237. PTHR21237. 1 hit.
PfamiPF01025. GrpE. 1 hit.
[Graphical view]
PRINTSiPR00773. GRPEPROTEIN.
SUPFAMiSSF51064. SSF51064. 1 hit.
PROSITEiPS01071. GRPE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGRPE_DROME
AccessioniPrimary (citable) accession number: P48604
Secondary accession number(s): Q8SX27, Q9V6R8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: September 27, 2004
Last modified: November 30, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.