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Protein

V-type proton ATPase catalytic subunit A isoform 1

Gene

Vha68-1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

Catalytic activityi

ATP + H2O + H+(In) = ADP + phosphate + H+(Out).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi247 – 254ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

  • ATP hydrolysis coupled proton transport Source: InterPro
  • ATP metabolic process Source: InterPro
  • cellular response to hypoxia Source: FlyBase
  • regulation of Notch signaling pathway Source: FlyBase
  • vacuolar acidification Source: UniProtKB

Keywordsi

Molecular functionHydrolase
Biological processHydrogen ion transport, Ion transport, Transport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-1222556 ROS, RNS production in phagocytes
R-DME-77387 Insulin receptor recycling
R-DME-917977 Transferrin endocytosis and recycling
R-DME-983712 Ion channel transport

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase catalytic subunit A isoform 1 (EC:3.6.3.14)
Short name:
V-ATPase subunit A 1
Alternative name(s):
V-ATPase 69 kDa subunit 1
Vacuolar proton pump subunit alpha 1
Gene namesi
Name:Vha68-1
Synonyms:Vha68, VhaA, Vhaa1
ORF Names:CG12403
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0265262 Vha68-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001445661 – 614V-type proton ATPase catalytic subunit A isoform 1Add BLAST614

Proteomic databases

PaxDbiP48602
PRIDEiP48602

Expressioni

Gene expression databases

BgeeiFBgn0265262
ExpressionAtlasiP48602 differential
GenevisibleiP48602 DM

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (main components: subunits A, B, C, D, E, and F) attached to an integral membrane V0 proton pore complex (main component: the proteolipid protein).

Protein-protein interaction databases

BioGridi69803, 8 interactors
DIPiDIP-20617N
IntActiP48602, 2 interactors
STRINGi7227.FBpp0080010

Structurei

3D structure databases

ProteinModelPortaliP48602
SMRiP48602
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase alpha/beta chains family.Curated

Phylogenomic databases

eggNOGiKOG1352 Eukaryota
COG1155 LUCA
GeneTreeiENSGT00550000074787
InParanoidiP48602
KOiK02145
OMAiEGYPPYL
OrthoDBiEOG091G03SR
PhylomeDBiP48602

Family and domain databases

Gene3Di1.10.1140.10, 1 hit
2.40.30.20, 1 hit
HAMAPiMF_00309 ATP_synth_A_arch, 1 hit
InterProiView protein in InterPro
IPR031686 ATP-synth_a_Xtn
IPR023366 ATP_synth_asu-like_sf
IPR020003 ATPase_a/bsu_AS
IPR004100 ATPase_F1/V1/A1_a/bsu_N
IPR036121 ATPase_F1/V1/A1_a/bsu_N_sf
IPR000194 ATPase_F1/V1/A1_a/bsu_nucl-bd
IPR024034 ATPase_F1/V1_b/a_C
IPR005725 ATPase_V1-cplx_asu
IPR027417 P-loop_NTPase
IPR022878 V-ATPase_asu
PANTHERiPTHR43607 PTHR43607, 1 hit
PfamiView protein in Pfam
PF00006 ATP-synt_ab, 1 hit
PF02874 ATP-synt_ab_N, 1 hit
PF16886 ATP-synt_ab_Xtn, 1 hit
SUPFAMiSSF50615 SSF50615, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR01042 V-ATPase_V1_A, 1 hit
PROSITEiView protein in PROSITE
PS00152 ATPASE_ALPHA_BETA, 1 hit

Sequencei

Sequence statusi: Complete.

P48602-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNLRKFKDE ERESEYGRVY AVSGPVVTAE AMSGSAMYEL VRVGYYELVG
60 70 80 90 100
EIIRLEGDMA TIQVYEETSG VTVGDPVLRT GKPLSVELGP GIMGSIFDGI
110 120 130 140 150
QRPLRDIGVM TNSIYIPKGV NTTALSRSEM WEFNPLNVRV GSHITGGDLY
160 170 180 190 200
GVVHENTLVK QRMIVAPRAK GTVRYIAPAG NYNLEDIVLE TEFDGEITKH
210 220 230 240 250
TMLQVWPVRQ PRPVTEKLPA NHPLFTGQRV LDSLFPCVQG GTTAIPGAFG
260 270 280 290 300
CGKTVISQAL SKYSNSDVII YVGCGERGNE MSEVLRDFPE LTCEIDGVTE
310 320 330 340 350
SIMKRTALVA NTSNMPVAAR EASIYTGITL SEYFRDMGYN VAMMADSTSR
360 370 380 390 400
WAEALREISG RLAEMPADSG YPAYLGARLA TFYERAGRVK CLGNPEREGS
410 420 430 440 450
VSIVGAVSPP GGDFSDPVTS ATLGIVQVFW GLDKKLAQRK HFPSINWLIS
460 470 480 490 500
YSKYMRALDE YYDKNYPEFV PLRTKVKEIL QEEEDLSEIV QLVGKASLAE
510 520 530 540 550
TDKVTLEVAK LLKDDFLQQN SYSPYDRVCP FYKTVGMLRN IMAFYETARH
560 570 580 590 600
AVESTAQSDN KITWNTIRES MGGIMYQLSS MKFKDPVKDG EQKIKADYDQ
610
LYEDLQQAFR NLED
Length:614
Mass (Da):68,376
Last modified:January 24, 2001 - v2
Checksum:i9E3B340722041542
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19745 mRNA Translation: AAA61761.2
AF185049 Genomic DNA Translation: AAF00515.1
AE014134 Genomic DNA Translation: AAF53236.1
AY089512 mRNA Translation: AAL90250.1
RefSeqiNP_001260426.1, NM_001273497.1
NP_523560.2, NM_078836.3
UniGeneiDm.3079

Genome annotation databases

EnsemblMetazoaiFBtr0080429; FBpp0080010; FBgn0265262
FBtr0336618; FBpp0307601; FBgn0265262
GeneIDi45668
KEGGidme:Dmel_CG12403
UCSCiCG12403-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiVATA1_DROME
AccessioniPrimary (citable) accession number: P48602
Secondary accession number(s): Q541D0, Q9V3M7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 24, 2001
Last modified: March 28, 2018
This is version 155 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health