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P48595

- SPB10_HUMAN

UniProt

P48595 - SPB10_HUMAN

Protein

Serpin B10

Gene

SERPINB10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Protease inhibitor that may play a role in the regulation of protease activities during hematopoiesis and apoptosis induced by TNF. May regulate protease activities in the cytoplasm and in the nucleus.2 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei362 – 3632Reactive bondBy similarity

    GO - Molecular functioni

    1. serine-type endopeptidase inhibitor activity Source: RefGenome

    GO - Biological processi

    1. negative regulation of endopeptidase activity Source: RefGenome
    2. regulation of proteolysis Source: RefGenome

    Keywords - Molecular functioni

    Protease inhibitor, Serine protease inhibitor

    Protein family/group databases

    MEROPSiI04.015.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serpin B10
    Alternative name(s):
    Bomapin
    Peptidase inhibitor 10
    Short name:
    PI-10
    Gene namesi
    Name:SERPINB10
    Synonyms:PI10
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 18

    Organism-specific databases

    HGNCiHGNC:8942. SERPINB10.

    Subcellular locationi

    Nucleus. Cytoplasm
    Note: Mostly found in the nucleus.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. extracellular space Source: InterPro
    3. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi74 – 774KKRK → AAAA: Abolishes nuclear localization. 1 Publication
    Mutagenesisi395 – 3951C → S: No effect on cell proliferation. 2 Publications

    Organism-specific databases

    PharmGKBiPA35510.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 397397Serpin B10PRO_0000094114Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi68 ↔ 395Redox-active1 Publication

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiP48595.
    PRIDEiP48595.

    PTM databases

    PhosphoSiteiP48595.

    Expressioni

    Tissue specificityi

    Expressed specifically in myeloid cells and the bone marrow.2 Publications

    Gene expression databases

    BgeeiP48595.
    CleanExiHS_SERPINB10.
    GenevestigatoriP48595.

    Interactioni

    Protein-protein interaction databases

    BioGridi111291. 1 interaction.
    IntActiP48595. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP48595.
    SMRiP48595. Positions 1-397.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi74 – 774Nuclear localization signal

    Sequence similaritiesi

    Belongs to the serpin family. Ov-serpin subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG4826.
    HOGENOMiHOG000238519.
    HOVERGENiHBG005957.
    InParanoidiP48595.
    KOiK13963.
    OMAiLYYESRD.
    PhylomeDBiP48595.
    TreeFamiTF352619.

    Family and domain databases

    InterProiIPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view]
    PANTHERiPTHR11461. PTHR11461. 1 hit.
    PfamiPF00079. Serpin. 1 hit.
    [Graphical view]
    SMARTiSM00093. SERPIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF56574. SSF56574. 1 hit.
    PROSITEiPS00284. SERPIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P48595-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDSLATSINQ FALELSKKLA ESAQGKNIFF SSWSISTSLT IVYLGAKGTT    50
    AAQMAQVLQF NRDQGVKCDP ESEKKRKMEF NLSNSEEIHS DFQTLISEIL 100
    KPNDDYLLKT ANAIYGEKTY AFHNKYLEDM KTYFGAEPQP VNFVEASDQI 150
    RKDINSWVER QTEGKIQNLL PDDSVDSTTR MILVNALYFK GIWEHQFLVQ 200
    NTTEKPFRIN ETTSKPVQMM FMKKKLHIFH IEKPKAVGLQ LYYKSRDLSL 250
    LILLPEDING LEQLEKAITY EKLNEWTSAD MMELYEVQLH LPKFKLEDSY 300
    DLKSTLSSMG MSDAFSQSKA DFSGMSSARN LFLSNVFHKA FVEINEQGTE 350
    AAAGSGSEID IRIRVPSIEF NANHPFLFFI RHNKTNTILF YGRLCSP 397
    Length:397
    Mass (Da):45,403
    Last modified:February 1, 1996 - v1
    Checksum:i8CE01246867154DF
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti3 – 31S → A.
    Corresponds to variant rs17072097 [ dbSNP | Ensembl ].
    VAR_051949
    Natural varianti41 – 411I → M.
    Corresponds to variant rs8097425 [ dbSNP | Ensembl ].
    VAR_024353
    Natural varianti99 – 991I → T.
    Corresponds to variant rs724558 [ dbSNP | Ensembl ].
    VAR_024354
    Natural varianti135 – 1351G → D.
    Corresponds to variant rs17072146 [ dbSNP | Ensembl ].
    VAR_051950
    Natural varianti140 – 1401P → S.
    Corresponds to variant rs9967382 [ dbSNP | Ensembl ].
    VAR_024355
    Natural varianti246 – 2461R → C.
    Corresponds to variant rs963075 [ dbSNP | Ensembl ].
    VAR_022116
    Natural varianti360 – 3601D → N.1 Publication
    Corresponds to variant rs35453062 [ dbSNP | Ensembl ].
    VAR_051951

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U35459 mRNA. Translation: AAC50282.1.
    BC096217 mRNA. Translation: AAH96217.1.
    BC096219 mRNA. Translation: AAH96219.1.
    BC096220 mRNA. Translation: AAH96220.1.
    CCDSiCCDS11990.1.
    PIRiI39184.
    RefSeqiNP_005015.1. NM_005024.1.
    UniGeneiHs.158339.

    Genome annotation databases

    EnsembliENST00000238508; ENSP00000238508; ENSG00000242550.
    GeneIDi5273.
    KEGGihsa:5273.
    UCSCiuc010xev.2. human.

    Polymorphism databases

    DMDMi1345616.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U35459 mRNA. Translation: AAC50282.1 .
    BC096217 mRNA. Translation: AAH96217.1 .
    BC096219 mRNA. Translation: AAH96219.1 .
    BC096220 mRNA. Translation: AAH96220.1 .
    CCDSi CCDS11990.1.
    PIRi I39184.
    RefSeqi NP_005015.1. NM_005024.1.
    UniGenei Hs.158339.

    3D structure databases

    ProteinModelPortali P48595.
    SMRi P48595. Positions 1-397.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111291. 1 interaction.
    IntActi P48595. 1 interaction.

    Protein family/group databases

    MEROPSi I04.015.

    PTM databases

    PhosphoSitei P48595.

    Polymorphism databases

    DMDMi 1345616.

    Proteomic databases

    PaxDbi P48595.
    PRIDEi P48595.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000238508 ; ENSP00000238508 ; ENSG00000242550 .
    GeneIDi 5273.
    KEGGi hsa:5273.
    UCSCi uc010xev.2. human.

    Organism-specific databases

    CTDi 5273.
    GeneCardsi GC18P061556.
    HGNCi HGNC:8942. SERPINB10.
    MIMi 602058. gene.
    neXtProti NX_P48595.
    PharmGKBi PA35510.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG4826.
    HOGENOMi HOG000238519.
    HOVERGENi HBG005957.
    InParanoidi P48595.
    KOi K13963.
    OMAi LYYESRD.
    PhylomeDBi P48595.
    TreeFami TF352619.

    Miscellaneous databases

    ChiTaRSi SERPINB10. human.
    GenomeRNAii 5273.
    NextBioi 20376.
    PROi P48595.
    SOURCEi Search...

    Gene expression databases

    Bgeei P48595.
    CleanExi HS_SERPINB10.
    Genevestigatori P48595.

    Family and domain databases

    InterProi IPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view ]
    PANTHERi PTHR11461. PTHR11461. 1 hit.
    Pfami PF00079. Serpin. 1 hit.
    [Graphical view ]
    SMARTi SM00093. SERPIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56574. SSF56574. 1 hit.
    PROSITEi PS00284. SERPIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of bomapin (protease inhibitor 10), a novel human serpin that is expressed specifically in the bone marrow."
      Riewald M., Schleef R.R.
      J. Biol. Chem. 270:26754-26757(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
      Tissue: Bone marrow.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASN-360.
    3. "Identification of a nuclear targeting domain in the insertion between helices C and D in protease inhibitor-10."
      Chuang T.L., Schleef R.R.
      J. Biol. Chem. 274:11194-11198(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, MUTAGENESIS OF 74-LYS--LYS-78.
    4. "Protease inhibitor 10 inhibits tumor necrosis factor alpha -induced cell death. Evidence for the formation of intracellular high M(r) protease inhibitor 10-containing complexes."
      Schleef R.R., Chuang T.L.
      J. Biol. Chem. 275:26385-26389(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    5. "Bomapin is a redox-sensitive nuclear serpin that affects responsiveness of myeloid progenitor cells to growth environment."
      Przygodzka P., Ramstedt B., Tengel T., Larsson G., Wilczynska M.
      BMC Cell Biol. 11:30-30(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISULFIDE BOND, SUBCELLULAR LOCATION, MUTAGENESIS OF CYS-395, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiSPB10_HUMAN
    AccessioniPrimary (citable) accession number: P48595
    Secondary accession number(s): Q4VAX4, Q4VAX7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 121 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 18
      Human chromosome 18: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3