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P48595 (SPB10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serpin B10
Alternative name(s):
Bomapin
Peptidase inhibitor 10
Short name=PI-10
Gene names
Name:SERPINB10
Synonyms:PI10
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length397 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Protease inhibitor that may play a role in the regulation of protease activities during hematopoiesis and apoptosis induced by TNF. May regulate protease activities in the cytoplasm and in the nucleus. Ref.1 Ref.4

Subcellular location

Nucleus. Cytoplasm. Note: Mostly found in the nucleus. Ref.3 Ref.4 Ref.5

Tissue specificity

Expressed specifically in myeloid cells and the bone marrow. Ref.1 Ref.5

Sequence similarities

Belongs to the serpin family. Ov-serpin subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 397397Serpin B10
PRO_0000094114

Regions

Motif74 – 774Nuclear localization signal

Sites

Site362 – 3632Reactive bond By similarity

Amino acid modifications

Disulfide bond68 ↔ 395Redox-active Ref.5

Natural variations

Natural variant31S → A.
Corresponds to variant rs17072097 [ dbSNP | Ensembl ].
VAR_051949
Natural variant411I → M.
Corresponds to variant rs8097425 [ dbSNP | Ensembl ].
VAR_024353
Natural variant991I → T.
Corresponds to variant rs724558 [ dbSNP | Ensembl ].
VAR_024354
Natural variant1351G → D.
Corresponds to variant rs17072146 [ dbSNP | Ensembl ].
VAR_051950
Natural variant1401P → S.
Corresponds to variant rs9967382 [ dbSNP | Ensembl ].
VAR_024355
Natural variant2461R → C.
Corresponds to variant rs963075 [ dbSNP | Ensembl ].
VAR_022116
Natural variant3601D → N. Ref.2
Corresponds to variant rs35453062 [ dbSNP | Ensembl ].
VAR_051951

Experimental info

Mutagenesis74 – 774KKRK → AAAA: Abolishes nuclear localization.
Mutagenesis3951C → S: No effect on cell proliferation. Ref.5

Sequences

Sequence LengthMass (Da)Tools
P48595 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 8CE01246867154DF

FASTA39745,403
        10         20         30         40         50         60 
MDSLATSINQ FALELSKKLA ESAQGKNIFF SSWSISTSLT IVYLGAKGTT AAQMAQVLQF 

        70         80         90        100        110        120 
NRDQGVKCDP ESEKKRKMEF NLSNSEEIHS DFQTLISEIL KPNDDYLLKT ANAIYGEKTY 

       130        140        150        160        170        180 
AFHNKYLEDM KTYFGAEPQP VNFVEASDQI RKDINSWVER QTEGKIQNLL PDDSVDSTTR 

       190        200        210        220        230        240 
MILVNALYFK GIWEHQFLVQ NTTEKPFRIN ETTSKPVQMM FMKKKLHIFH IEKPKAVGLQ 

       250        260        270        280        290        300 
LYYKSRDLSL LILLPEDING LEQLEKAITY EKLNEWTSAD MMELYEVQLH LPKFKLEDSY 

       310        320        330        340        350        360 
DLKSTLSSMG MSDAFSQSKA DFSGMSSARN LFLSNVFHKA FVEINEQGTE AAAGSGSEID 

       370        380        390 
IRIRVPSIEF NANHPFLFFI RHNKTNTILF YGRLCSP 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of bomapin (protease inhibitor 10), a novel human serpin that is expressed specifically in the bone marrow."
Riewald M., Schleef R.R.
J. Biol. Chem. 270:26754-26757(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
Tissue: Bone marrow.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASN-360.
[3]"Identification of a nuclear targeting domain in the insertion between helices C and D in protease inhibitor-10."
Chuang T.L., Schleef R.R.
J. Biol. Chem. 274:11194-11198(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, MUTAGENESIS OF 74-LYS--LYS-78.
[4]"Protease inhibitor 10 inhibits tumor necrosis factor alpha -induced cell death. Evidence for the formation of intracellular high M(r) protease inhibitor 10-containing complexes."
Schleef R.R., Chuang T.L.
J. Biol. Chem. 275:26385-26389(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[5]"Bomapin is a redox-sensitive nuclear serpin that affects responsiveness of myeloid progenitor cells to growth environment."
Przygodzka P., Ramstedt B., Tengel T., Larsson G., Wilczynska M.
BMC Cell Biol. 11:30-30(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: DISULFIDE BOND, SUBCELLULAR LOCATION, MUTAGENESIS OF CYS-395, TISSUE SPECIFICITY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U35459 mRNA. Translation: AAC50282.1.
BC096217 mRNA. Translation: AAH96217.1.
BC096219 mRNA. Translation: AAH96219.1.
BC096220 mRNA. Translation: AAH96220.1.
CCDSCCDS11990.1.
PIRI39184.
RefSeqNP_005015.1. NM_005024.1.
UniGeneHs.158339.

3D structure databases

ProteinModelPortalP48595.
SMRP48595. Positions 1-397.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid111291. 1 interaction.
IntActP48595. 1 interaction.

Protein family/group databases

MEROPSI04.015.

PTM databases

PhosphoSiteP48595.

Polymorphism databases

DMDM1345616.

Proteomic databases

PaxDbP48595.
PRIDEP48595.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000238508; ENSP00000238508; ENSG00000242550.
GeneID5273.
KEGGhsa:5273.
UCSCuc010xev.2. human.

Organism-specific databases

CTD5273.
GeneCardsGC18P061556.
HGNCHGNC:8942. SERPINB10.
MIM602058. gene.
neXtProtNX_P48595.
PharmGKBPA35510.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG4826.
HOGENOMHOG000238519.
HOVERGENHBG005957.
InParanoidP48595.
KOK13963.
OMALYYESRD.
PhylomeDBP48595.
TreeFamTF352619.

Gene expression databases

BgeeP48595.
CleanExHS_SERPINB10.
GenevestigatorP48595.

Family and domain databases

InterProIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERPTHR11461. PTHR11461. 1 hit.
PfamPF00079. Serpin. 1 hit.
[Graphical view]
SMARTSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMSSF56574. SSF56574. 1 hit.
PROSITEPS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSERPINB10. human.
GenomeRNAi5273.
NextBio20376.
PROP48595.
SOURCESearch...

Entry information

Entry nameSPB10_HUMAN
AccessionPrimary (citable) accession number: P48595
Secondary accession number(s): Q4VAX4, Q4VAX7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: July 9, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 18

Human chromosome 18: entries, gene names and cross-references to MIM