Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P48594 (SPB4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 128. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serpin B4
Alternative name(s):
Leupin
Peptidase inhibitor 11
Short name=PI-11
Squamous cell carcinoma antigen 2
Short name=SCCA-2
Gene names
Name:SERPINB4
Synonyms:PI11, SCCA2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length390 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May act as a protease inhibitor to modulate the host immune response against tumor cells.

Subcellular location

Cytoplasm. Note: Seems to also be secreted in plasma by cancerous cells but at a low level. Ref.7

Tissue specificity

Squamous cells.

Sequence similarities

Belongs to the serpin family. Ov-serpin subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 390390Serpin B4
PRO_0000094104

Sites

Site354 – 3552Reactive bond

Amino acid modifications

Modified residue11N-acetylmethionine Ref.6

Experimental info

Sequence conflict3531E → K in BAF84901. Ref.4

Sequences

Sequence LengthMass (Da)Tools
P48594 [UniParc].

Last modified October 1, 1996. Version 2.
Checksum: 04E213CD892587D5

FASTA39044,854
        10         20         30         40         50         60 
MNSLSEANTK FMFDLFQQFR KSKENNIFYS PISITSALGM VLLGAKDNTA QQISKVLHFD 

        70         80         90        100        110        120 
QVTENTTEKA ATYHVDRSGN VHHQFQKLLT EFNKSTDAYE LKIANKLFGE KTYQFLQEYL 

       130        140        150        160        170        180 
DAIKKFYQTS VESTDFANAP EESRKKINSW VESQTNEKIK NLFPDGTIGN DTTLVLVNAI 

       190        200        210        220        230        240 
YFKGQWENKF KKENTKEEKF WPNKNTYKSV QMMRQYNSFN FALLEDVQAK VLEIPYKGKD 

       250        260        270        280        290        300 
LSMIVLLPNE IDGLQKLEEK LTAEKLMEWT SLQNMRETCV DLHLPRFKME ESYDLKDTLR 

       310        320        330        340        350        360 
TMGMVNIFNG DADLSGMTWS HGLSVSKVLH KAFVEVTEEG VEAAAATAVV VVELSSPSTN 

       370        380        390 
EEFCCNHPFL FFIRQNKTNS ILFYGRFSSP 

« Hide

References

« Hide 'large scale' references
[1]"Identification of a novel human serpin gene; cloning sequencing and expression of leupin."
Barnes R.C., Worrall D.M.
FEBS Lett. 373:61-65(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene."
Schneider S.S., Schick C., Fish K.E., Miller E., Pena J.C., Treter S.D., Hui S.M., Silverman G.A.
Proc. Natl. Acad. Sci. U.S.A. 92:3147-3151(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[3]"Molecular cloning of human squamous cell carcinoma antigen 1 gene and characterization of its promoter."
Hamada K., Shinomiya H., Asano Y., Kihana T., Iwamoto M., Hanakawa Y., Hashimoto K., Hirose S., Kyo S., Ito M.
Biochim. Biophys. Acta 1518:124-131(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Esophagus.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Bone marrow.
[6]Bienvenut W.V., Bensaad K., Vousden K.H.
Submitted (FEB-2008) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 1-21; 56-69; 88-94; 147-160; 215-260; 266-276 AND 378-386, ACETYLATION AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY.
Tissue: Osteosarcoma.
[7]"Circulating serpin tumor markers SCCA1 and SCCA2 are not actively secreted but reside in the cytosol of squamous carcinoma cells."
Uemura Y., Pak S.C., Luke C., Cataltepe S., Tsu C., Schick C., Kamachi Y., Pomeroy S.L., Perlmutter D.H., Silverman G.A.
Int. J. Cancer 89:368-377(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X89015 mRNA. Translation: CAA61420.1.
U19557 mRNA. Translation: AAA97553.1.
U19576 expand/collapse EMBL AC list , U19570, U19571, U19572, U19574, U19575 Genomic DNA. Translation: AAA92602.1.
AB035089 Genomic DNA. Translation: BAB21525.1.
AK292212 mRNA. Translation: BAF84901.1.
BC017401 mRNA. Translation: AAH17401.1.
CCDSCCDS11986.1.
PIRI38202.
RefSeqNP_002965.1. NM_002974.2.
UniGeneHs.123035.

3D structure databases

ProteinModelPortalP48594.
SMRP48594. Positions 2-390.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112224. 9 interactions.
IntActP48594. 6 interactions.
STRING9606.ENSP00000343445.

Protein family/group databases

MEROPSI04.008.

PTM databases

PhosphoSiteP48594.

Polymorphism databases

DMDM1710877.

2D gel databases

UCD-2DPAGEP48594.

Proteomic databases

MaxQBP48594.
PRIDEP48594.

Protocols and materials databases

DNASU6318.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000341074; ENSP00000343445; ENSG00000206073.
GeneID6318.
KEGGhsa:6318.
UCSCuc002ljf.3. human.

Organism-specific databases

CTD6318.
GeneCardsGC18M061277.
HGNCHGNC:10570. SERPINB4.
MIM600518. gene.
neXtProtNX_P48594.
PharmGKBPA35539.
GenAtlasSearch...

Phylogenomic databases

HOGENOMHOG000238519.
HOVERGENHBG005957.
InParanoidP48594.
KOK13963.
OMAKGEDLSM.
OrthoDBEOG7327PB.
PhylomeDBP48594.
TreeFamTF352619.

Gene expression databases

ArrayExpressP48594.
BgeeP48594.
CleanExHS_SERPINB4.
GenevestigatorP48594.

Family and domain databases

InterProIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERPTHR11461. PTHR11461. 1 hit.
PfamPF00079. Serpin. 1 hit.
[Graphical view]
SMARTSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMSSF56574. SSF56574. 1 hit.
PROSITEPS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSERPINB4. human.
GeneWikiSERPINB4.
GenomeRNAi6318.
NextBio24516.
PROP48594.
SOURCESearch...

Entry information

Entry nameSPB4_HUMAN
AccessionPrimary (citable) accession number: P48594
Secondary accession number(s): A8K847
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 18

Human chromosome 18: entries, gene names and cross-references to MIM