Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Calcium-binding protein E63-1

Gene

Eip63F-1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi48 – 591PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi140 – 1512PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi176 – 1873PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • calcium ion binding Source: FlyBase

GO - Biological processi

  • autophagic cell death Source: FlyBase
  • salivary gland cell autophagic cell death Source: FlyBase

Keywordsi

LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-binding protein E63-1
Gene namesi
Name:Eip63F-1
Synonyms:E63-1
ORF Names:CG15855
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0004910. Eip63F-1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: FlyBase
  • nucleus Source: FlyBase
  • plasma membrane Source: FlyBase

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000738621 – 193Calcium-binding protein E63-1Add BLAST193

Proteomic databases

PaxDbiP48593.
PRIDEiP48593.

Expressioni

Inductioni

By ecdysone.

Gene expression databases

BgeeiFBgn0004910.
ExpressionAtlasiP48593. differential.

Interactioni

Protein-protein interaction databases

BioGridi71025. 5 interactors.
DIPiDIP-21826N.
IntActiP48593. 3 interactors.
MINTiMINT-809371.
STRINGi7227.FBpp0073031.

Structurei

3D structure databases

ProteinModelPortaliP48593.
SMRiP48593.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 70EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini71 – 106EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini127 – 162EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini163 – 193EF-hand 4PROSITE-ProRule annotationAdd BLAST31

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00670000097718.
InParanoidiP48593.
KOiK02183.
OMAiQHEDNAS.
OrthoDBiEOG091G0P0S.
PhylomeDBiP48593.

Family and domain databases

CDDicd00051. EFh. 1 hit.
InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
PfamiView protein in Pfam
PF13499. EF-hand_7. 2 hits.
SMARTiView protein in SMART
SM00054. EFh. 4 hits.
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiView protein in PROSITE
PS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.

Sequencei

Sequence statusi: Complete.

P48593-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPMSGLRQQ LKMLGTALLG KRATKSVKKK PFTEVEIKDL RTAFDLLDRN
60 70 80 90 100
RDGRVTANEL QFMLKNLGIN VSDELIHDLI REASHSGNGL INEAEFLQWV
110 120 130 140 150
GRIQALRDEQ HSHEDSKDSK PVDEADDVTE DLIAAFRVFD RDGNGFITRD
160 170 180 190
ELQTAMEMIG EPLNEQQLEQ LLVIADLDQD GRINYEEFTR LLL
Length:193
Mass (Da):21,995
Last modified:May 9, 2003 - v2
Checksum:i98C117B944727578
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti171L → M in AAB61120 (PubMed:7671827).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25882 mRNA. Translation: AAB61120.1.
AE014296 Genomic DNA. Translation: AAG22243.1.
RefSeqiNP_524902.2. NM_080163.4.
UniGeneiDm.36728.

Genome annotation databases

EnsemblMetazoaiFBtr0073174; FBpp0073031; FBgn0004910.
GeneIDi47878.
KEGGidme:Dmel_CG15855.

Similar proteinsi

Entry informationi

Entry nameiE631_DROME
AccessioniPrimary (citable) accession number: P48593
Secondary accession number(s): Q9I7T4, Q9VZL0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: May 9, 2003
Last modified: August 30, 2017
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase