ID   ERD21_CAEEL             Reviewed;         213 AA.
AC   P48583; O76766;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 2.
DT   27-MAR-2024, entry version 143.
DE   RecName: Full=ER lumen protein-retaining receptor erd-2.1 {ECO:0000305};
GN   Name=erd-2.1 {ECO:0000312|WormBase:F09B9.3};
GN   Synonyms=erd-2 {ECO:0000312|WormBase:F09B9.3};
GN   ORFNames=F09B9.3 {ECO:0000312|WormBase:F09B9.3};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Banfield D.K., Pelham H.R.B.;
RT   "A C. elegans gene encoding a homologue of the ER lumen protein receptor
RT   ERD2.";
RL   Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Required for the retention of luminal endoplasmic reticulum
CC       proteins. Determines the specificity of the luminal ER protein
CC       retention system. Also required for normal vesicular traffic through
CC       the Golgi (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass
CC       membrane protein.
CC   -!- SIMILARITY: Belongs to the ERD2 family. {ECO:0000305}.
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DR   EMBL; AF081125; AAC31954.1; -; Genomic_DNA.
DR   EMBL; BX284606; CAA90056.2; -; Genomic_DNA.
DR   PIR; C89623; C89623.
DR   PIR; T20636; T20636.
DR   RefSeq; NP_509703.1; NM_077302.5.
DR   AlphaFoldDB; P48583; -.
DR   SMR; P48583; -.
DR   STRING; 6239.F09B9.3.1; -.
DR   TCDB; 9.B.191.1.10; the endoplasmic reticulum retention receptor (kdelr) family.
DR   PaxDb; 6239-F09B9-3; -.
DR   EnsemblMetazoa; F09B9.3.1; F09B9.3.1; WBGene00001331.
DR   UCSC; F09B9.3; c. elegans.
DR   AGR; WB:WBGene00001331; -.
DR   WormBase; F09B9.3; CE23635; WBGene00001331; erd-2.1.
DR   eggNOG; KOG3106; Eukaryota.
DR   GeneTree; ENSGT00390000004010; -.
DR   HOGENOM; CLU_057784_0_0_1; -.
DR   InParanoid; P48583; -.
DR   OMA; WKSRSCE; -.
DR   OrthoDB; 5258269at2759; -.
DR   PhylomeDB; P48583; -.
DR   Reactome; R-CEL-6807878; COPI-mediated anterograde transport.
DR   Reactome; R-CEL-6811434; COPI-dependent Golgi-to-ER retrograde traffic.
DR   PRO; PR:P48583; -.
DR   Proteomes; UP000001940; Chromosome X.
DR   Bgee; WBGene00001331; Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues.
DR   GO; GO:0005801; C:cis-Golgi network; IBA:GO_Central.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046923; F:ER retention sequence binding; IBA:GO_Central.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR   GO; GO:0006621; P:protein retention in ER lumen; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR000133; ER_ret_rcpt.
DR   PANTHER; PTHR10585; ER LUMEN PROTEIN RETAINING RECEPTOR; 1.
DR   PANTHER; PTHR10585:SF91; ER LUMEN PROTEIN-RETAINING RECEPTOR ERD-2.1; 1.
DR   Pfam; PF00810; ER_lumen_recept; 1.
DR   PRINTS; PR00660; ERLUMENR.
DR   PROSITE; PS00951; ER_LUMEN_RECEPTOR_1; 1.
DR   PROSITE; PS00952; ER_LUMEN_RECEPTOR_2; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; ER-Golgi transport; Membrane; Protein transport;
KW   Receptor; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..213
FT                   /note="ER lumen protein-retaining receptor erd-2.1"
FT                   /id="PRO_0000194161"
FT   TOPO_DOM        1..2
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        3..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        22..35
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        36..53
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        54..61
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        62..80
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        81..96
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        97..110
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        111..117
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        118..137
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        138..149
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        150..168
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        169..178
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        179..199
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        200..213
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   213 AA;  25060 MW;  9A9D61C99012E48A CRC64;
     MNLFRFTADV AHAIAIVVLL LKIWKSRSCE GISGRSQLLF ALVFVTRYLD LFTNFFSFYN
     TAMKIFYLVA SFGTVYLMWA KFKATYDRNN DSFRIEFLVI PSMILALLIN HEFIFMEVMW
     TFSIYLEAVA IMPQLFMLSR TGNAETITAH YLFALGSYRF LYILNWVYRY YTESFFDPIS
     VVAGIVQTVL YADFFYLYIT RVIQSNRQFE MSA
//