P48583 (ERD2_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ER lumen protein retaining receptor

Gene names

Name:	erd-2
Synonyms:	erd2
ORF Names:	F09B9.3

Organism

Caenorhabditis elegans [Reference proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	213 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi By similarity.
Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the ERD2 family.

Ontologies

Keywords
Biological process	ER-Golgi transport Protein transport Transport
Cellular component	Endoplasmic reticulum Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Receptor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein retention in ER lumen Inferred from electronic annotation. Source: InterPro protein transport Inferred from electronic annotation. Source: UniProtKB-KW vesicle-mediated transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ER retention sequence binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 213	213	ER lumen protein retaining receptor		PRO_0000194161
Regions
	Topological domain	1 – 2	2	Lumenal Potential
	Transmembrane	3 – 21	19	Helical; Potential
	Topological domain	22 – 35	14	Cytoplasmic Potential
	Transmembrane	36 – 53	18	Helical; Potential
	Topological domain	54 – 61	8	Lumenal Potential
	Transmembrane	62 – 80	19	Helical; Potential
	Topological domain	81 – 96	16	Cytoplasmic Potential
	Transmembrane	97 – 110	14	Helical; Potential
	Topological domain	111 – 117	7	Lumenal Potential
	Transmembrane	118 – 137	20	Helical; Potential
	Topological domain	138 – 149	12	Cytoplasmic Potential
	Transmembrane	150 – 168	19	Helical; Potential
	Topological domain	169 – 178	10	Lumenal Potential
	Transmembrane	179 – 199	21	Helical; Potential
	Topological domain	200 – 213	14	Cytoplasmic Potential

Sequences

	Sequence		Length	Mass (Da)
	P48583 [UniParc]. Last modified May 30, 2000. Version 2. Checksum: 9A9D61C99012E48A	FASTA	213	25,060
	10 20 30 40 50 60 MNLFRFTADV AHAIAIVVLL LKIWKSRSCE GISGRSQLLF ALVFVTRYLD LFTNFFSFYN 70 80 90 100 110 120 TAMKIFYLVA SFGTVYLMWA KFKATYDRNN DSFRIEFLVI PSMILALLIN HEFIFMEVMW 130 140 150 160 170 180 TFSIYLEAVA IMPQLFMLSR TGNAETITAH YLFALGSYRF LYILNWVYRY YTESFFDPIS 190 200 210 VVAGIVQTVL YADFFYLYIT RVIQSNRQFE MSA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A C. elegans gene encoding a homologue of the ER lumen protein receptor ERD2." Banfield D.K., Pelham H.R.B. Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF081125 Genomic DNA. Translation: AAC31954.1. Z49887 Genomic DNA. Translation: CAA90056.2.
PIR	C89623. T20636.
RefSeq	NP_509703.1. NM_077302.5.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	F09B9.3; F09B9.3; F09B9.3.
GeneID	181228.
KEGG	cel:CELE_F09B9.3.
UCSC	F09B9.3. c. elegans.
Organism-specific databases
CTD	181228.
WormBase	F09B9.3; CE23635; WBGene00001331; erd-2.
Phylogenomic databases
eggNOG	COG5196.
GeneTree	ENSGT00390000004010.
HOGENOM	HOG000231400.
InParanoid	P48583.
KO	K10949.
OMA	FMEILWT.
Family and domain databases
InterPro	IPR000133. ER_ret_rcpt. [Graphical view]
PANTHER	PTHR10585. PTHR10585. 1 hit.
Pfam	PF00810. ER_lumen_recept. 1 hit. [Graphical view]
PRINTS	PR00660. ERLUMENR.
PROSITE	PS00951. ER_LUMEN_RECEPTOR_1. 1 hit. PS00952. ER_LUMEN_RECEPTOR_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	913000.

Entry information

Entry name

ERD2_CAEEL

Accession

Primary (citable) accession number: P48583
Secondary accession number(s): O76766

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	May 30, 2000
Last modified:	May 1, 2013
This is version 94 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project