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P48583

- ERD2_CAEEL

UniProt

P48583 - ERD2_CAEEL

Protein

ER lumen protein-retaining receptor

Gene

erd-2

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 2 (30 May 2000)
      Previous versions | rss
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    Functioni

    Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi By similarity.By similarity

    GO - Molecular functioni

    1. ER retention sequence binding Source: InterPro

    GO - Biological processi

    1. protein retention in ER lumen Source: InterPro
    2. protein transport Source: UniProtKB-KW
    3. vesicle-mediated transport Source: UniProtKB-KW

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    ER-Golgi transport, Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ER lumen protein-retaining receptor
    Gene namesi
    Name:erd-2
    Synonyms:erd2
    ORF Names:F09B9.3
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome X

    Organism-specific databases

    WormBaseiF09B9.3; CE23635; WBGene00001331; erd-2.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 213213ER lumen protein-retaining receptorPRO_0000194161Add
    BLAST

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 22LumenalSequence Analysis
    Topological domaini22 – 3514CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini54 – 618LumenalSequence Analysis
    Topological domaini81 – 9616CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini111 – 1177LumenalSequence Analysis
    Topological domaini138 – 14912CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini169 – 17810LumenalSequence Analysis
    Topological domaini200 – 21314CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei3 – 2119HelicalSequence AnalysisAdd
    BLAST
    Transmembranei36 – 5318HelicalSequence AnalysisAdd
    BLAST
    Transmembranei62 – 8019HelicalSequence AnalysisAdd
    BLAST
    Transmembranei97 – 11014HelicalSequence AnalysisAdd
    BLAST
    Transmembranei118 – 13720HelicalSequence AnalysisAdd
    BLAST
    Transmembranei150 – 16819HelicalSequence AnalysisAdd
    BLAST
    Transmembranei179 – 19921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ERD2 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5196.
    GeneTreeiENSGT00390000004010.
    HOGENOMiHOG000231400.
    InParanoidiP48583.
    KOiK10949.
    OMAiLAIVWCM.
    OrthoDBiEOG761BW0.
    PhylomeDBiP48583.

    Family and domain databases

    InterProiIPR000133. ER_ret_rcpt.
    [Graphical view]
    PANTHERiPTHR10585. PTHR10585. 1 hit.
    PfamiPF00810. ER_lumen_recept. 1 hit.
    [Graphical view]
    PRINTSiPR00660. ERLUMENR.
    PROSITEiPS00951. ER_LUMEN_RECEPTOR_1. 1 hit.
    PS00952. ER_LUMEN_RECEPTOR_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P48583-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNLFRFTADV AHAIAIVVLL LKIWKSRSCE GISGRSQLLF ALVFVTRYLD    50
    LFTNFFSFYN TAMKIFYLVA SFGTVYLMWA KFKATYDRNN DSFRIEFLVI 100
    PSMILALLIN HEFIFMEVMW TFSIYLEAVA IMPQLFMLSR TGNAETITAH 150
    YLFALGSYRF LYILNWVYRY YTESFFDPIS VVAGIVQTVL YADFFYLYIT 200
    RVIQSNRQFE MSA 213
    Length:213
    Mass (Da):25,060
    Last modified:May 30, 2000 - v2
    Checksum:i9A9D61C99012E48A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF081125 Genomic DNA. Translation: AAC31954.1.
    Z49887 Genomic DNA. Translation: CAA90056.2.
    PIRiC89623.
    T20636.
    RefSeqiNP_509703.1. NM_077302.5.
    UniGeneiCel.6385.

    Genome annotation databases

    EnsemblMetazoaiF09B9.3; F09B9.3; WBGene00001331.
    GeneIDi181228.
    KEGGicel:CELE_F09B9.3.
    UCSCiF09B9.3. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF081125 Genomic DNA. Translation: AAC31954.1 .
    Z49887 Genomic DNA. Translation: CAA90056.2 .
    PIRi C89623.
    T20636.
    RefSeqi NP_509703.1. NM_077302.5.
    UniGenei Cel.6385.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai F09B9.3 ; F09B9.3 ; WBGene00001331 .
    GeneIDi 181228.
    KEGGi cel:CELE_F09B9.3.
    UCSCi F09B9.3. c. elegans.

    Organism-specific databases

    CTDi 181228.
    WormBasei F09B9.3 ; CE23635 ; WBGene00001331 ; erd-2.

    Phylogenomic databases

    eggNOGi COG5196.
    GeneTreei ENSGT00390000004010.
    HOGENOMi HOG000231400.
    InParanoidi P48583.
    KOi K10949.
    OMAi LAIVWCM.
    OrthoDBi EOG761BW0.
    PhylomeDBi P48583.

    Miscellaneous databases

    NextBioi 913000.

    Family and domain databases

    InterProi IPR000133. ER_ret_rcpt.
    [Graphical view ]
    PANTHERi PTHR10585. PTHR10585. 1 hit.
    Pfami PF00810. ER_lumen_recept. 1 hit.
    [Graphical view ]
    PRINTSi PR00660. ERLUMENR.
    PROSITEi PS00951. ER_LUMEN_RECEPTOR_1. 1 hit.
    PS00952. ER_LUMEN_RECEPTOR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A C. elegans gene encoding a homologue of the ER lumen protein receptor ERD2."
      Banfield D.K., Pelham H.R.B.
      Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiERD2_CAEEL
    AccessioniPrimary (citable) accession number: P48583
    Secondary accession number(s): O76766
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: May 30, 2000
    Last modified: October 1, 2014
    This is version 102 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3