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P48583

- ERD2_CAEEL

UniProt

P48583 - ERD2_CAEEL

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Protein
ER lumen protein-retaining receptor
Gene
erd-2, erd2, F09B9.3
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi By similarity.

GO - Molecular functioni

  1. ER retention sequence binding Source: InterPro

GO - Biological processi

  1. protein retention in ER lumen Source: InterPro
  2. protein transport Source: UniProtKB-KW
  3. vesicle-mediated transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
ER lumen protein-retaining receptor
Gene namesi
Name:erd-2
Synonyms:erd2
ORF Names:F09B9.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome X

Organism-specific databases

WormBaseiF09B9.3; CE23635; WBGene00001331; erd-2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 22Lumenal Reviewed prediction
Transmembranei3 – 2119Helical; Reviewed prediction
Add
BLAST
Topological domaini22 – 3514Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei36 – 5318Helical; Reviewed prediction
Add
BLAST
Topological domaini54 – 618Lumenal Reviewed prediction
Transmembranei62 – 8019Helical; Reviewed prediction
Add
BLAST
Topological domaini81 – 9616Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei97 – 11014Helical; Reviewed prediction
Add
BLAST
Topological domaini111 – 1177Lumenal Reviewed prediction
Transmembranei118 – 13720Helical; Reviewed prediction
Add
BLAST
Topological domaini138 – 14912Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei150 – 16819Helical; Reviewed prediction
Add
BLAST
Topological domaini169 – 17810Lumenal Reviewed prediction
Transmembranei179 – 19921Helical; Reviewed prediction
Add
BLAST
Topological domaini200 – 21314Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 213213ER lumen protein-retaining receptor
PRO_0000194161Add
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the ERD2 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5196.
GeneTreeiENSGT00390000004010.
HOGENOMiHOG000231400.
InParanoidiP48583.
KOiK10949.
OMAiLAIVWCM.
OrthoDBiEOG761BW0.
PhylomeDBiP48583.

Family and domain databases

InterProiIPR000133. ER_ret_rcpt.
[Graphical view]
PANTHERiPTHR10585. PTHR10585. 1 hit.
PfamiPF00810. ER_lumen_recept. 1 hit.
[Graphical view]
PRINTSiPR00660. ERLUMENR.
PROSITEiPS00951. ER_LUMEN_RECEPTOR_1. 1 hit.
PS00952. ER_LUMEN_RECEPTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48583-1 [UniParc]FASTAAdd to Basket

« Hide

MNLFRFTADV AHAIAIVVLL LKIWKSRSCE GISGRSQLLF ALVFVTRYLD    50
LFTNFFSFYN TAMKIFYLVA SFGTVYLMWA KFKATYDRNN DSFRIEFLVI 100
PSMILALLIN HEFIFMEVMW TFSIYLEAVA IMPQLFMLSR TGNAETITAH 150
YLFALGSYRF LYILNWVYRY YTESFFDPIS VVAGIVQTVL YADFFYLYIT 200
RVIQSNRQFE MSA 213
Length:213
Mass (Da):25,060
Last modified:May 30, 2000 - v2
Checksum:i9A9D61C99012E48A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF081125 Genomic DNA. Translation: AAC31954.1.
Z49887 Genomic DNA. Translation: CAA90056.2.
PIRiC89623.
T20636.
RefSeqiNP_509703.1. NM_077302.5.
UniGeneiCel.6385.

Genome annotation databases

EnsemblMetazoaiF09B9.3; F09B9.3; WBGene00001331.
GeneIDi181228.
KEGGicel:CELE_F09B9.3.
UCSCiF09B9.3. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF081125 Genomic DNA. Translation: AAC31954.1 .
Z49887 Genomic DNA. Translation: CAA90056.2 .
PIRi C89623.
T20636.
RefSeqi NP_509703.1. NM_077302.5.
UniGenei Cel.6385.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai F09B9.3 ; F09B9.3 ; WBGene00001331 .
GeneIDi 181228.
KEGGi cel:CELE_F09B9.3.
UCSCi F09B9.3. c. elegans.

Organism-specific databases

CTDi 181228.
WormBasei F09B9.3 ; CE23635 ; WBGene00001331 ; erd-2.

Phylogenomic databases

eggNOGi COG5196.
GeneTreei ENSGT00390000004010.
HOGENOMi HOG000231400.
InParanoidi P48583.
KOi K10949.
OMAi LAIVWCM.
OrthoDBi EOG761BW0.
PhylomeDBi P48583.

Miscellaneous databases

NextBioi 913000.

Family and domain databases

InterProi IPR000133. ER_ret_rcpt.
[Graphical view ]
PANTHERi PTHR10585. PTHR10585. 1 hit.
Pfami PF00810. ER_lumen_recept. 1 hit.
[Graphical view ]
PRINTSi PR00660. ERLUMENR.
PROSITEi PS00951. ER_LUMEN_RECEPTOR_1. 1 hit.
PS00952. ER_LUMEN_RECEPTOR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A C. elegans gene encoding a homologue of the ER lumen protein receptor ERD2."
    Banfield D.K., Pelham H.R.B.
    Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiERD2_CAEEL
AccessioniPrimary (citable) accession number: P48583
Secondary accession number(s): O76766
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: May 30, 2000
Last modified: June 11, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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