Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

ER lumen protein-retaining receptor

Gene

erd-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi (By similarity).By similarity

GO - Molecular functioni

  1. ER retention sequence binding Source: InterPro

GO - Biological processi

  1. protein retention in ER lumen Source: InterPro
  2. protein transport Source: UniProtKB-KW
  3. vesicle-mediated transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
ER lumen protein-retaining receptor
Gene namesi
Name:erd-2
Synonyms:erd2
ORF Names:F09B9.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiF09B9.3; CE23635; WBGene00001331; erd-2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 22LumenalSequence Analysis
Transmembranei3 – 2119HelicalSequence AnalysisAdd
BLAST
Topological domaini22 – 3514CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei36 – 5318HelicalSequence AnalysisAdd
BLAST
Topological domaini54 – 618LumenalSequence Analysis
Transmembranei62 – 8019HelicalSequence AnalysisAdd
BLAST
Topological domaini81 – 9616CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei97 – 11014HelicalSequence AnalysisAdd
BLAST
Topological domaini111 – 1177LumenalSequence Analysis
Transmembranei118 – 13720HelicalSequence AnalysisAdd
BLAST
Topological domaini138 – 14912CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei150 – 16819HelicalSequence AnalysisAdd
BLAST
Topological domaini169 – 17810LumenalSequence Analysis
Transmembranei179 – 19921HelicalSequence AnalysisAdd
BLAST
Topological domaini200 – 21314CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 213213ER lumen protein-retaining receptorPRO_0000194161Add
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the ERD2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5196.
GeneTreeiENSGT00390000004010.
HOGENOMiHOG000231400.
InParanoidiP48583.
KOiK10949.
OMAiDMTHLIS.
OrthoDBiEOG761BW0.
PhylomeDBiP48583.

Family and domain databases

InterProiIPR000133. ER_ret_rcpt.
[Graphical view]
PANTHERiPTHR10585. PTHR10585. 1 hit.
PfamiPF00810. ER_lumen_recept. 1 hit.
[Graphical view]
PRINTSiPR00660. ERLUMENR.
PROSITEiPS00951. ER_LUMEN_RECEPTOR_1. 1 hit.
PS00952. ER_LUMEN_RECEPTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48583-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLFRFTADV AHAIAIVVLL LKIWKSRSCE GISGRSQLLF ALVFVTRYLD
60 70 80 90 100
LFTNFFSFYN TAMKIFYLVA SFGTVYLMWA KFKATYDRNN DSFRIEFLVI
110 120 130 140 150
PSMILALLIN HEFIFMEVMW TFSIYLEAVA IMPQLFMLSR TGNAETITAH
160 170 180 190 200
YLFALGSYRF LYILNWVYRY YTESFFDPIS VVAGIVQTVL YADFFYLYIT
210
RVIQSNRQFE MSA
Length:213
Mass (Da):25,060
Last modified:May 29, 2000 - v2
Checksum:i9A9D61C99012E48A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF081125 Genomic DNA. Translation: AAC31954.1.
Z49887 Genomic DNA. Translation: CAA90056.2.
PIRiC89623.
T20636.
RefSeqiNP_509703.1. NM_077302.5.
UniGeneiCel.6385.

Genome annotation databases

EnsemblMetazoaiF09B9.3; F09B9.3; WBGene00001331.
GeneIDi181228.
KEGGicel:CELE_F09B9.3.
UCSCiF09B9.3. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF081125 Genomic DNA. Translation: AAC31954.1.
Z49887 Genomic DNA. Translation: CAA90056.2.
PIRiC89623.
T20636.
RefSeqiNP_509703.1. NM_077302.5.
UniGeneiCel.6385.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF09B9.3; F09B9.3; WBGene00001331.
GeneIDi181228.
KEGGicel:CELE_F09B9.3.
UCSCiF09B9.3. c. elegans.

Organism-specific databases

CTDi181228.
WormBaseiF09B9.3; CE23635; WBGene00001331; erd-2.

Phylogenomic databases

eggNOGiCOG5196.
GeneTreeiENSGT00390000004010.
HOGENOMiHOG000231400.
InParanoidiP48583.
KOiK10949.
OMAiDMTHLIS.
OrthoDBiEOG761BW0.
PhylomeDBiP48583.

Miscellaneous databases

NextBioi913000.

Family and domain databases

InterProiIPR000133. ER_ret_rcpt.
[Graphical view]
PANTHERiPTHR10585. PTHR10585. 1 hit.
PfamiPF00810. ER_lumen_recept. 1 hit.
[Graphical view]
PRINTSiPR00660. ERLUMENR.
PROSITEiPS00951. ER_LUMEN_RECEPTOR_1. 1 hit.
PS00952. ER_LUMEN_RECEPTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A C. elegans gene encoding a homologue of the ER lumen protein receptor ERD2."
    Banfield D.K., Pelham H.R.B.
    Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiERD2_CAEEL
AccessioniPrimary (citable) accession number: P48583
Secondary accession number(s): O76766
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 1996
Last sequence update: May 29, 2000
Last modified: March 31, 2015
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.