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P48583 (ERD2_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ER lumen protein retaining receptor
Gene names
Name:erd-2
Synonyms:erd2
ORF Names:F09B9.3
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length213 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi By similarity.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the ERD2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 213213ER lumen protein retaining receptor
PRO_0000194161

Regions

Topological domain1 – 22Lumenal Potential
Transmembrane3 – 2119Helical; Potential
Topological domain22 – 3514Cytoplasmic Potential
Transmembrane36 – 5318Helical; Potential
Topological domain54 – 618Lumenal Potential
Transmembrane62 – 8019Helical; Potential
Topological domain81 – 9616Cytoplasmic Potential
Transmembrane97 – 11014Helical; Potential
Topological domain111 – 1177Lumenal Potential
Transmembrane118 – 13720Helical; Potential
Topological domain138 – 14912Cytoplasmic Potential
Transmembrane150 – 16819Helical; Potential
Topological domain169 – 17810Lumenal Potential
Transmembrane179 – 19921Helical; Potential
Topological domain200 – 21314Cytoplasmic Potential

Sequences

Sequence LengthMass (Da)Tools
P48583 [UniParc].

Last modified May 30, 2000. Version 2.
Checksum: 9A9D61C99012E48A

FASTA21325,060
        10         20         30         40         50         60 
MNLFRFTADV AHAIAIVVLL LKIWKSRSCE GISGRSQLLF ALVFVTRYLD LFTNFFSFYN 

        70         80         90        100        110        120 
TAMKIFYLVA SFGTVYLMWA KFKATYDRNN DSFRIEFLVI PSMILALLIN HEFIFMEVMW 

       130        140        150        160        170        180 
TFSIYLEAVA IMPQLFMLSR TGNAETITAH YLFALGSYRF LYILNWVYRY YTESFFDPIS 

       190        200        210 
VVAGIVQTVL YADFFYLYIT RVIQSNRQFE MSA 

« Hide

References

« Hide 'large scale' references
[1]"A C. elegans gene encoding a homologue of the ER lumen protein receptor ERD2."
Banfield D.K., Pelham H.R.B.
Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF081125 Genomic DNA. Translation: AAC31954.1.
Z49887 Genomic DNA. Translation: CAA90056.2.
PIRC89623.
T20636.
RefSeqNP_509703.1. NM_077302.5.
UniGeneCel.6385.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaF09B9.3; F09B9.3; F09B9.3.
GeneID181228.
KEGGcel:CELE_F09B9.3.
UCSCF09B9.3. c. elegans.

Organism-specific databases

CTD181228.
WormBaseF09B9.3; CE23635; WBGene00001331; erd-2.

Phylogenomic databases

eggNOGCOG5196.
HOGENOMHOG000231400.
InParanoidP48583.
KOK10949.
OMAFTRWIAC.
OrthoDBEOG761BW0.
PhylomeDBP48583.

Family and domain databases

InterProIPR000133. ER_ret_rcpt.
[Graphical view]
PANTHERPTHR10585. PTHR10585. 1 hit.
PfamPF00810. ER_lumen_recept. 1 hit.
[Graphical view]
PRINTSPR00660. ERLUMENR.
PROSITEPS00951. ER_LUMEN_RECEPTOR_1. 1 hit.
PS00952. ER_LUMEN_RECEPTOR_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio913000.

Entry information

Entry nameERD2_CAEEL
AccessionPrimary (citable) accession number: P48583
Secondary accession number(s): O76766
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: May 30, 2000
Last modified: April 16, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase