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Protein

ER lumen protein-retaining receptor

Gene

erd-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-CEL-6807878. COPI-mediated anterograde transport.
R-CEL-6811434. COPI-dependent Golgi-to-ER retrograde traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
ER lumen protein-retaining receptor
Gene namesi
Name:erd-2
Synonyms:erd2
ORF Names:F09B9.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiF09B9.3; CE23635; WBGene00001331; erd-2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 2LumenalSequence analysis2
Transmembranei3 – 21HelicalSequence analysisAdd BLAST19
Topological domaini22 – 35CytoplasmicSequence analysisAdd BLAST14
Transmembranei36 – 53HelicalSequence analysisAdd BLAST18
Topological domaini54 – 61LumenalSequence analysis8
Transmembranei62 – 80HelicalSequence analysisAdd BLAST19
Topological domaini81 – 96CytoplasmicSequence analysisAdd BLAST16
Transmembranei97 – 110HelicalSequence analysisAdd BLAST14
Topological domaini111 – 117LumenalSequence analysis7
Transmembranei118 – 137HelicalSequence analysisAdd BLAST20
Topological domaini138 – 149CytoplasmicSequence analysisAdd BLAST12
Transmembranei150 – 168HelicalSequence analysisAdd BLAST19
Topological domaini169 – 178LumenalSequence analysis10
Transmembranei179 – 199HelicalSequence analysisAdd BLAST21
Topological domaini200 – 213CytoplasmicSequence analysisAdd BLAST14

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001941611 – 213ER lumen protein-retaining receptorAdd BLAST213

Proteomic databases

PaxDbiP48583.

Expressioni

Gene expression databases

BgeeiWBGene00001331.

Interactioni

Protein-protein interaction databases

STRINGi6239.F09B9.3.

Structurei

3D structure databases

ProteinModelPortaliP48583.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ERD2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3106. Eukaryota.
COG5196. LUCA.
GeneTreeiENSGT00390000004010.
HOGENOMiHOG000231400.
InParanoidiP48583.
KOiK10949.
OMAiINHDFSP.
OrthoDBiEOG091G0Q1H.
PhylomeDBiP48583.

Family and domain databases

InterProiIPR000133. ER_ret_rcpt.
[Graphical view]
PANTHERiPTHR10585. PTHR10585. 1 hit.
PfamiPF00810. ER_lumen_recept. 1 hit.
[Graphical view]
PRINTSiPR00660. ERLUMENR.
PROSITEiPS00951. ER_LUMEN_RECEPTOR_1. 1 hit.
PS00952. ER_LUMEN_RECEPTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48583-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLFRFTADV AHAIAIVVLL LKIWKSRSCE GISGRSQLLF ALVFVTRYLD
60 70 80 90 100
LFTNFFSFYN TAMKIFYLVA SFGTVYLMWA KFKATYDRNN DSFRIEFLVI
110 120 130 140 150
PSMILALLIN HEFIFMEVMW TFSIYLEAVA IMPQLFMLSR TGNAETITAH
160 170 180 190 200
YLFALGSYRF LYILNWVYRY YTESFFDPIS VVAGIVQTVL YADFFYLYIT
210
RVIQSNRQFE MSA
Length:213
Mass (Da):25,060
Last modified:May 30, 2000 - v2
Checksum:i9A9D61C99012E48A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF081125 Genomic DNA. Translation: AAC31954.1.
Z49887 Genomic DNA. Translation: CAA90056.2.
PIRiC89623.
T20636.
RefSeqiNP_509703.1. NM_077302.5.
UniGeneiCel.6385.

Genome annotation databases

EnsemblMetazoaiF09B9.3; F09B9.3; WBGene00001331.
GeneIDi181228.
KEGGicel:CELE_F09B9.3.
UCSCiF09B9.3. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF081125 Genomic DNA. Translation: AAC31954.1.
Z49887 Genomic DNA. Translation: CAA90056.2.
PIRiC89623.
T20636.
RefSeqiNP_509703.1. NM_077302.5.
UniGeneiCel.6385.

3D structure databases

ProteinModelPortaliP48583.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F09B9.3.

Proteomic databases

PaxDbiP48583.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF09B9.3; F09B9.3; WBGene00001331.
GeneIDi181228.
KEGGicel:CELE_F09B9.3.
UCSCiF09B9.3. c. elegans.

Organism-specific databases

CTDi181228.
WormBaseiF09B9.3; CE23635; WBGene00001331; erd-2.

Phylogenomic databases

eggNOGiKOG3106. Eukaryota.
COG5196. LUCA.
GeneTreeiENSGT00390000004010.
HOGENOMiHOG000231400.
InParanoidiP48583.
KOiK10949.
OMAiINHDFSP.
OrthoDBiEOG091G0Q1H.
PhylomeDBiP48583.

Enzyme and pathway databases

ReactomeiR-CEL-6807878. COPI-mediated anterograde transport.
R-CEL-6811434. COPI-dependent Golgi-to-ER retrograde traffic.

Miscellaneous databases

PROiP48583.

Gene expression databases

BgeeiWBGene00001331.

Family and domain databases

InterProiIPR000133. ER_ret_rcpt.
[Graphical view]
PANTHERiPTHR10585. PTHR10585. 1 hit.
PfamiPF00810. ER_lumen_recept. 1 hit.
[Graphical view]
PRINTSiPR00660. ERLUMENR.
PROSITEiPS00951. ER_LUMEN_RECEPTOR_1. 1 hit.
PS00952. ER_LUMEN_RECEPTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiERD2_CAEEL
AccessioniPrimary (citable) accession number: P48583
Secondary accession number(s): O76766
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: May 30, 2000
Last modified: November 2, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.