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P48580

- PP2A1_NEUCR

UniProt

P48580 - PP2A1_NEUCR

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Protein

Serine/threonine-protein phosphatase PP2A catalytic subunit

Gene

pph-1

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi75 – 751Manganese 1By similarity
Metal bindingi77 – 771Manganese 1By similarity
Metal bindingi103 – 1031Manganese 1By similarity
Metal bindingi103 – 1031Manganese 2By similarity
Metal bindingi135 – 1351Manganese 2By similarity
Active sitei136 – 1361Proton donorBy similarity
Metal bindingi185 – 1851Manganese 2By similarity
Metal bindingi259 – 2591Manganese 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP2A catalytic subunit (EC:3.1.3.16)
Gene namesi
Name:pph-1
ORF Names:NCU06630
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
ProteomesiUP000001805: Chromosome 4, Linkage Group IV

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 327327Serine/threonine-protein phosphatase PP2A catalytic subunitPRO_0000058870Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei327 – 3271Leucine methyl esterBy similarity

Keywords - PTMi

Methylation

Proteomic databases

PRIDEiP48580.

Interactioni

Protein-protein interaction databases

STRINGi5141.NCU06630.1.

Structurei

3D structure databases

ProteinModelPortaliP48580.
SMRiP48580. Positions 28-327.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-2A subfamily.Curated

Phylogenomic databases

eggNOGiCOG0639.
HOGENOMiHOG000172696.
InParanoidiP48580.
KOiK04382.
OMAiQVKTLCD.
OrthoDBiEOG7FFN29.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48580-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDTNMEDVGR VPAELTSSNF EPTTIPTLDG WIESLMNCKQ LAESDVQRLC
60 70 80 90 100
EKAREVLQDE SNVQPVKCPV TVCGDIHGQF HDLMELFKIG GSCPDTNYLF
110 120 130 140 150
MGDYVDRGYY SVETVTLLVA LKIRYPNRIT ILRGNHESRQ ITQVYGFYDE
160 170 180 190 200
CLRKYGNANV WKYFTDLFDY LPLTALIDNQ IFCLHGGLSP SIDTLDNIRA
210 220 230 240 250
LDRIQEVPHE GPMCDLLWSD PDDRCGWGIS PRGAGYTFGQ DISEAFNHNN
260 270 280 290 300
GLTLIARAHQ LVMEGYNWSQ DRNVVTIFSA PNYCYRCGNQ AAIMEIDEHL
310 320
KYTFLQFDPC PRAGEPMVSR RTPDYFL
Length:327
Mass (Da):37,291
Last modified:April 4, 2003 - v3
Checksum:i335603AEAB32392B
GO

Sequence cautioni

The sequence CAA58573.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X83593 Genomic DNA. Translation: CAA58573.1. Sequence problems.
CM002239 Genomic DNA. Translation: EAA32582.2.
PIRiS60471.
RefSeqiXP_961818.2. XM_956725.2.
UniGeneiNcr.10651.

Genome annotation databases

EnsemblFungiiEFNCRT00000006359; EFNCRP00000006351; EFNCRG00000006348.
GeneIDi3877966.
KEGGincr:NCU06630.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X83593 Genomic DNA. Translation: CAA58573.1 . Sequence problems.
CM002239 Genomic DNA. Translation: EAA32582.2 .
PIRi S60471.
RefSeqi XP_961818.2. XM_956725.2.
UniGenei Ncr.10651.

3D structure databases

ProteinModelPortali P48580.
SMRi P48580. Positions 28-327.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5141.NCU06630.1.

Proteomic databases

PRIDEi P48580.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii EFNCRT00000006359 ; EFNCRP00000006351 ; EFNCRG00000006348 .
GeneIDi 3877966.
KEGGi ncr:NCU06630.

Phylogenomic databases

eggNOGi COG0639.
HOGENOMi HOG000172696.
InParanoidi P48580.
KOi K04382.
OMAi QVKTLCD.
OrthoDBi EOG7FFN29.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
PRINTSi PR00114. STPHPHTASE.
SMARTi SM00156. PP2Ac. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Inactivation of a single-2A phosphoprotein phosphatase is lethal in Neurospora crassa."
    Yatzkan E., Yarden O.
    Curr. Genet. 28:458-466(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
  2. Yarden O.
    Submitted (APR-2003) to UniProtKB
    Cited for: SEQUENCE REVISION TO C-TERMINUS.
  3. "The genome sequence of the filamentous fungus Neurospora crassa."
    Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
    , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
    Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Entry informationi

Entry nameiPP2A1_NEUCR
AccessioniPrimary (citable) accession number: P48580
Secondary accession number(s): Q7RVE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: April 4, 2003
Last modified: October 29, 2014
This is version 96 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3