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Protein

Serine/threonine-protein phosphatase PP2A catalytic subunit

Gene

pph-1

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi75Manganese 1By similarity1
Metal bindingi77Manganese 1By similarity1
Metal bindingi103Manganese 1By similarity1
Metal bindingi103Manganese 2By similarity1
Metal bindingi135Manganese 2By similarity1
Active sitei136Proton donorBy similarity1
Metal bindingi185Manganese 2By similarity1
Metal bindingi259Manganese 2By similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP2A catalytic subunit (EC:3.1.3.16)
Gene namesi
Name:pph-1
ORF Names:NCU06630
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Chromosome 4, Linkage Group IV

Organism-specific databases

EuPathDBiFungiDB:NCU06630.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000588701 – 327Serine/threonine-protein phosphatase PP2A catalytic subunitAdd BLAST327

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei327Leucine methyl esterBy similarity1

Keywords - PTMi

Methylation

Proteomic databases

PRIDEiP48580.

Structurei

3D structure databases

ProteinModelPortaliP48580.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-2A subfamily.Curated

Phylogenomic databases

HOGENOMiHOG000172696.
InParanoidiP48580.
KOiK04382.
OMAiWIENLMA.
OrthoDBiEOG092C2R40.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48580-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTNMEDVGR VPAELTSSNF EPTTIPTLDG WIESLMNCKQ LAESDVQRLC
60 70 80 90 100
EKAREVLQDE SNVQPVKCPV TVCGDIHGQF HDLMELFKIG GSCPDTNYLF
110 120 130 140 150
MGDYVDRGYY SVETVTLLVA LKIRYPNRIT ILRGNHESRQ ITQVYGFYDE
160 170 180 190 200
CLRKYGNANV WKYFTDLFDY LPLTALIDNQ IFCLHGGLSP SIDTLDNIRA
210 220 230 240 250
LDRIQEVPHE GPMCDLLWSD PDDRCGWGIS PRGAGYTFGQ DISEAFNHNN
260 270 280 290 300
GLTLIARAHQ LVMEGYNWSQ DRNVVTIFSA PNYCYRCGNQ AAIMEIDEHL
310 320
KYTFLQFDPC PRAGEPMVSR RTPDYFL
Length:327
Mass (Da):37,291
Last modified:April 4, 2003 - v3
Checksum:i335603AEAB32392B
GO

Sequence cautioni

The sequence CAA58573 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83593 Genomic DNA. Translation: CAA58573.1. Sequence problems.
CM002239 Genomic DNA. Translation: EAA32582.2.
PIRiS60471.
RefSeqiXP_961818.2. XM_956725.3.

Genome annotation databases

EnsemblFungiiEAA32582; EAA32582; NCU06630.
GeneIDi3877966.
KEGGincr:NCU06630.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83593 Genomic DNA. Translation: CAA58573.1. Sequence problems.
CM002239 Genomic DNA. Translation: EAA32582.2.
PIRiS60471.
RefSeqiXP_961818.2. XM_956725.3.

3D structure databases

ProteinModelPortaliP48580.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP48580.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAA32582; EAA32582; NCU06630.
GeneIDi3877966.
KEGGincr:NCU06630.

Organism-specific databases

EuPathDBiFungiDB:NCU06630.

Phylogenomic databases

HOGENOMiHOG000172696.
InParanoidiP48580.
KOiK04382.
OMAiWIENLMA.
OrthoDBiEOG092C2R40.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPP2A1_NEUCR
AccessioniPrimary (citable) accession number: P48580
Secondary accession number(s): Q7RVE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: April 4, 2003
Last modified: November 30, 2016
This is version 109 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.