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P48580

- PP2A1_NEUCR

UniProt

P48580 - PP2A1_NEUCR

Protein

Serine/threonine-protein phosphatase PP2A catalytic subunit

Gene

pph-1

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 3 (04 Apr 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi75 – 751Manganese 1By similarity
    Metal bindingi77 – 771Manganese 1By similarity
    Metal bindingi103 – 1031Manganese 1By similarity
    Metal bindingi103 – 1031Manganese 2By similarity
    Metal bindingi135 – 1351Manganese 2By similarity
    Active sitei136 – 1361Proton donorBy similarity
    Metal bindingi185 – 1851Manganese 2By similarity
    Metal bindingi259 – 2591Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. phosphoprotein phosphatase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein phosphatase PP2A catalytic subunit (EC:3.1.3.16)
    Gene namesi
    Name:pph-1
    ORF Names:NCU06630
    OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
    Taxonomic identifieri367110 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
    ProteomesiUP000001805: Chromosome 4, Linkage Group IV

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 327327Serine/threonine-protein phosphatase PP2A catalytic subunitPRO_0000058870Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei327 – 3271Leucine methyl esterBy similarity

    Keywords - PTMi

    Methylation

    Proteomic databases

    PRIDEiP48580.

    Interactioni

    Protein-protein interaction databases

    STRINGi5141.NCU06630.1.

    Structurei

    3D structure databases

    ProteinModelPortaliP48580.
    SMRiP48580. Positions 28-327.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PPP phosphatase family. PP-2A subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG0639.
    HOGENOMiHOG000172696.
    KOiK04382.
    OMAiQVKTLCD.
    OrthoDBiEOG7FFN29.

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    PRINTSiPR00114. STPHPHTASE.
    SMARTiSM00156. PP2Ac. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 1 hit.
    PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P48580-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDTNMEDVGR VPAELTSSNF EPTTIPTLDG WIESLMNCKQ LAESDVQRLC    50
    EKAREVLQDE SNVQPVKCPV TVCGDIHGQF HDLMELFKIG GSCPDTNYLF 100
    MGDYVDRGYY SVETVTLLVA LKIRYPNRIT ILRGNHESRQ ITQVYGFYDE 150
    CLRKYGNANV WKYFTDLFDY LPLTALIDNQ IFCLHGGLSP SIDTLDNIRA 200
    LDRIQEVPHE GPMCDLLWSD PDDRCGWGIS PRGAGYTFGQ DISEAFNHNN 250
    GLTLIARAHQ LVMEGYNWSQ DRNVVTIFSA PNYCYRCGNQ AAIMEIDEHL 300
    KYTFLQFDPC PRAGEPMVSR RTPDYFL 327
    Length:327
    Mass (Da):37,291
    Last modified:April 4, 2003 - v3
    Checksum:i335603AEAB32392B
    GO

    Sequence cautioni

    The sequence CAA58573.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X83593 Genomic DNA. Translation: CAA58573.1. Sequence problems.
    CM002239 Genomic DNA. Translation: EAA32582.2.
    PIRiS60471.
    RefSeqiXP_961818.2. XM_956725.2.
    UniGeneiNcr.10651.

    Genome annotation databases

    EnsemblFungiiEFNCRT00000006359; EFNCRP00000006351; EFNCRG00000006348.
    GeneIDi3877966.
    KEGGincr:NCU06630.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X83593 Genomic DNA. Translation: CAA58573.1 . Sequence problems.
    CM002239 Genomic DNA. Translation: EAA32582.2 .
    PIRi S60471.
    RefSeqi XP_961818.2. XM_956725.2.
    UniGenei Ncr.10651.

    3D structure databases

    ProteinModelPortali P48580.
    SMRi P48580. Positions 28-327.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5141.NCU06630.1.

    Proteomic databases

    PRIDEi P48580.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii EFNCRT00000006359 ; EFNCRP00000006351 ; EFNCRG00000006348 .
    GeneIDi 3877966.
    KEGGi ncr:NCU06630.

    Phylogenomic databases

    eggNOGi COG0639.
    HOGENOMi HOG000172696.
    KOi K04382.
    OMAi QVKTLCD.
    OrthoDBi EOG7FFN29.

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    PRINTSi PR00114. STPHPHTASE.
    SMARTi SM00156. PP2Ac. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Inactivation of a single-2A phosphoprotein phosphatase is lethal in Neurospora crassa."
      Yatzkan E., Yarden O.
      Curr. Genet. 28:458-466(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
    2. Yarden O.
      Submitted (APR-2003) to UniProtKB
      Cited for: SEQUENCE REVISION TO C-TERMINUS.
    3. "The genome sequence of the filamentous fungus Neurospora crassa."
      Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
      , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
      Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

    Entry informationi

    Entry nameiPP2A1_NEUCR
    AccessioniPrimary (citable) accession number: P48580
    Secondary accession number(s): Q7RVE8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: April 4, 2003
    Last modified: October 1, 2014
    This is version 95 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3