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P48580 (PP2A1_NEUCR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein phosphatase PP2A catalytic subunit

EC=3.1.3.16
Gene names
Name:pph-1
ORF Names:NCU06630
OrganismNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) [Reference proteome]
Taxonomic identifier367110 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora

Protein attributes

Sequence length327 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactor

Binds 1 iron ion per subunit By similarity.

Binds 1 manganese ion per subunit By similarity.

Sequence similarities

Belongs to the PPP phosphatase family. PP-2A subfamily.

Sequence caution

The sequence CAA58573.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 327327Serine/threonine-protein phosphatase PP2A catalytic subunit
PRO_0000058870

Sites

Active site1361Proton donor By similarity
Metal binding751Iron By similarity
Metal binding771Iron By similarity
Metal binding1031Iron By similarity
Metal binding1031Manganese By similarity
Metal binding1351Manganese By similarity
Metal binding1851Manganese By similarity
Metal binding2591Manganese By similarity

Amino acid modifications

Modified residue3271Leucine methyl ester By similarity

Sequences

Sequence LengthMass (Da)Tools
P48580 [UniParc].

Last modified April 4, 2003. Version 3.
Checksum: 335603AEAB32392B

FASTA32737,291
        10         20         30         40         50         60 
MDTNMEDVGR VPAELTSSNF EPTTIPTLDG WIESLMNCKQ LAESDVQRLC EKAREVLQDE 

        70         80         90        100        110        120 
SNVQPVKCPV TVCGDIHGQF HDLMELFKIG GSCPDTNYLF MGDYVDRGYY SVETVTLLVA 

       130        140        150        160        170        180 
LKIRYPNRIT ILRGNHESRQ ITQVYGFYDE CLRKYGNANV WKYFTDLFDY LPLTALIDNQ 

       190        200        210        220        230        240 
IFCLHGGLSP SIDTLDNIRA LDRIQEVPHE GPMCDLLWSD PDDRCGWGIS PRGAGYTFGQ 

       250        260        270        280        290        300 
DISEAFNHNN GLTLIARAHQ LVMEGYNWSQ DRNVVTIFSA PNYCYRCGNQ AAIMEIDEHL 

       310        320 
KYTFLQFDPC PRAGEPMVSR RTPDYFL 

« Hide

References

« Hide 'large scale' references
[1]"Inactivation of a single-2A phosphoprotein phosphatase is lethal in Neurospora crassa."
Yatzkan E., Yarden O.
Curr. Genet. 28:458-466(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
[2]Yarden O.
Submitted (APR-2003) to UniProtKB
Cited for: SEQUENCE REVISION TO C-TERMINUS.
[3]"The genome sequence of the filamentous fungus Neurospora crassa."
Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D. expand/collapse author list , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X83593 Genomic DNA. Translation: CAA58573.1. Sequence problems.
CM002239 Genomic DNA. Translation: EAA32582.2.
PIRS60471.
RefSeqXP_961818.2. XM_956725.2.
UniGeneNcr.10651.

3D structure databases

ProteinModelPortalP48580.
SMRP48580. Positions 28-327.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5141.NCU06630.1.

Proteomic databases

PRIDEP48580.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiEFNCRT00000006359; EFNCRP00000006351; EFNCRG00000006348.
GeneID3877966.
KEGGncr:NCU06630.

Phylogenomic databases

eggNOGCOG0639.
HOGENOMHOG000172696.
KOK04382.
OMALMACKQL.
OrthoDBEOG7FFN29.

Family and domain databases

InterProIPR004843. Calcineurin-like_PHP_apaH.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSPR00114. STPHPHTASE.
SMARTSM00156. PP2Ac. 1 hit.
[Graphical view]
PROSITEPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePP2A1_NEUCR
AccessionPrimary (citable) accession number: P48580
Secondary accession number(s): Q7RVE8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: April 4, 2003
Last modified: April 16, 2014
This is version 92 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families