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Protein

Serine/threonine-protein phosphatase PP2A catalytic subunit

Gene
N/A
Organism
Helianthus annuus (Common sunflower)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi53Manganese 1By similarity1
Metal bindingi55Manganese 1By similarity1
Metal bindingi81Manganese 1By similarity1
Metal bindingi81Manganese 2By similarity1
Metal bindingi113Manganese 2By similarity1
Active sitei114Proton donorBy similarity1
Metal bindingi163Manganese 2By similarity1
Metal bindingi237Manganese 2By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandManganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP2A catalytic subunit (EC:3.1.3.16)
OrganismiHelianthus annuus (Common sunflower)
Taxonomic identifieri4232 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridscampanulidsAsteralesAsteraceaeAsteroideaeHeliantheae allianceHeliantheaeHelianthus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000588581 – 305Serine/threonine-protein phosphatase PP2A catalytic subunitAdd BLAST305

Proteomic databases

PRIDEiP48579

Structurei

3D structure databases

ProteinModelPortaliP48579
SMRiP48579
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-2A subfamily.Curated

Family and domain databases

Gene3Di3.60.21.10, 1 hit
InterProiView protein in InterPro
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like
IPR006186 Ser/Thr-sp_prot-phosphatase
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit
PRINTSiPR00114 STPHPHTASE
SMARTiView protein in SMART
SM00156 PP2Ac, 1 hit
PROSITEiView protein in PROSITE
PS00125 SER_THR_PHOSPHATASE, 1 hit

Sequencei

Sequence statusi: Complete.

P48579-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSQSDLDRQ IEHLMDCKPL PEEVRTLCDQ ARTILVEEWN VQPVKCPVTV
60 70 80 90 100
CGDIHGQFHD LLELFRIGGS APDTNYLFMG DYVDRGYYSV ETVTLLVALK
110 120 130 140 150
VRYRDRITIL RGNHESRQIT QVYGFFDECL RKYGNANVWK HFTDLFDYLP
160 170 180 190 200
LTALIESQIF CLHGGLSPSL DTLDNIRALD RIQEVPHEGP MCDLLWSDPD
210 220 230 240 250
DRCGWGISPR GAGYTFGQDI AAQFNHTNGL SLISRAHQLV MEGYNWSQEN
260 270 280 290 300
NVVTIFSAPN YCYRCGNMAA ILEVGENMDQ NFLQFDPAPR QVEPDVARRT

PDYFL
Length:305
Mass (Da):34,865
Last modified:February 1, 1996 - v1
Checksum:i0B9D14F3DDD0E950
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z26041 mRNA Translation: CAA81126.1
PIRiS37086
UniGeneiHan.194

Similar proteinsi

Entry informationi

Entry nameiPP2A_HELAN
AccessioniPrimary (citable) accession number: P48579
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 23, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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