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P48579 (PP2A_HELAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein phosphatase PP2A catalytic subunit

EC=3.1.3.16
OrganismHelianthus annuus (Common sunflower)
Taxonomic identifier4232 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridscampanulidsAsteralesAsteraceaeAsteroideaeHeliantheae allianceHeliantheaeHelianthus

Protein attributes

Sequence length305 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactor

Binds 1 iron ion per subunit By similarity.

Binds 1 manganese ion per subunit By similarity.

Sequence similarities

Belongs to the PPP phosphatase family. PP-2A subfamily.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 305305Serine/threonine-protein phosphatase PP2A catalytic subunit
PRO_0000058858

Sites

Active site1141Proton donor By similarity
Metal binding531Iron By similarity
Metal binding551Iron By similarity
Metal binding811Iron By similarity
Metal binding811Manganese By similarity
Metal binding1131Manganese By similarity
Metal binding1631Manganese By similarity
Metal binding2371Manganese By similarity

Sequences

Sequence LengthMass (Da)Tools
P48579 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 0B9D14F3DDD0E950

FASTA30534,865
        10         20         30         40         50         60 
MPSQSDLDRQ IEHLMDCKPL PEEVRTLCDQ ARTILVEEWN VQPVKCPVTV CGDIHGQFHD 

        70         80         90        100        110        120 
LLELFRIGGS APDTNYLFMG DYVDRGYYSV ETVTLLVALK VRYRDRITIL RGNHESRQIT 

       130        140        150        160        170        180 
QVYGFFDECL RKYGNANVWK HFTDLFDYLP LTALIESQIF CLHGGLSPSL DTLDNIRALD 

       190        200        210        220        230        240 
RIQEVPHEGP MCDLLWSDPD DRCGWGISPR GAGYTFGQDI AAQFNHTNGL SLISRAHQLV 

       250        260        270        280        290        300 
MEGYNWSQEN NVVTIFSAPN YCYRCGNMAA ILEVGENMDQ NFLQFDPAPR QVEPDVARRT 


PDYFL 

« Hide

References

[1]"Protein phosphatase 2A, a potential regulator of actin dynamics and actin-based organelle motility in the green alga Acetabularia."
Menzel D., Vugrek O., Frank S., Elsner-Menzel C.
Eur. J. Cell Biol. 67:179-187(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Root meristem.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z26041 mRNA. Translation: CAA81126.1.
PIRS37086.

3D structure databases

ProteinModelPortalP48579.
SMRP48579. Positions 6-305.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR004843. Calcineurin-like_PHP_apaH.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSPR00114. STPHPHTASE.
SMARTSM00156. PP2Ac. 1 hit.
[Graphical view]
PROSITEPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePP2A_HELAN
AccessionPrimary (citable) accession number: P48579
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: April 16, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families