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P48579

- PP2A_HELAN

UniProt

P48579 - PP2A_HELAN

Protein

Serine/threonine-protein phosphatase PP2A catalytic subunit

Gene
N/A
Organism
Helianthus annuus (Common sunflower)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi53 – 531Manganese 1By similarity
    Metal bindingi55 – 551Manganese 1By similarity
    Metal bindingi81 – 811Manganese 1By similarity
    Metal bindingi81 – 811Manganese 2By similarity
    Metal bindingi113 – 1131Manganese 2By similarity
    Active sitei114 – 1141Proton donorBy similarity
    Metal bindingi163 – 1631Manganese 2By similarity
    Metal bindingi237 – 2371Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. phosphoprotein phosphatase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein phosphatase PP2A catalytic subunit (EC:3.1.3.16)
    OrganismiHelianthus annuus (Common sunflower)
    Taxonomic identifieri4232 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridscampanulidsAsteralesAsteraceaeAsteroideaeHeliantheae allianceHeliantheaeHelianthus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 305305Serine/threonine-protein phosphatase PP2A catalytic subunitPRO_0000058858Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP48579.
    SMRiP48579. Positions 6-305.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PPP phosphatase family. PP-2A subfamily.Curated

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    PRINTSiPR00114. STPHPHTASE.
    SMARTiSM00156. PP2Ac. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 1 hit.
    PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P48579-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPSQSDLDRQ IEHLMDCKPL PEEVRTLCDQ ARTILVEEWN VQPVKCPVTV    50
    CGDIHGQFHD LLELFRIGGS APDTNYLFMG DYVDRGYYSV ETVTLLVALK 100
    VRYRDRITIL RGNHESRQIT QVYGFFDECL RKYGNANVWK HFTDLFDYLP 150
    LTALIESQIF CLHGGLSPSL DTLDNIRALD RIQEVPHEGP MCDLLWSDPD 200
    DRCGWGISPR GAGYTFGQDI AAQFNHTNGL SLISRAHQLV MEGYNWSQEN 250
    NVVTIFSAPN YCYRCGNMAA ILEVGENMDQ NFLQFDPAPR QVEPDVARRT 300
    PDYFL 305
    Length:305
    Mass (Da):34,865
    Last modified:February 1, 1996 - v1
    Checksum:i0B9D14F3DDD0E950
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z26041 mRNA. Translation: CAA81126.1.
    PIRiS37086.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z26041 mRNA. Translation: CAA81126.1 .
    PIRi S37086.

    3D structure databases

    ProteinModelPortali P48579.
    SMRi P48579. Positions 6-305.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    PRINTSi PR00114. STPHPHTASE.
    SMARTi SM00156. PP2Ac. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Protein phosphatase 2A, a potential regulator of actin dynamics and actin-based organelle motility in the green alga Acetabularia."
      Menzel D., Vugrek O., Frank S., Elsner-Menzel C.
      Eur. J. Cell Biol. 67:179-187(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Root meristem.

    Entry informationi

    Entry nameiPP2A_HELAN
    AccessioniPrimary (citable) accession number: P48579
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3