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Protein

Serine/threonine-protein phosphatase PP2A-3 catalytic subunit

Gene

PP2A3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi61Manganese 1By similarity1
Metal bindingi63Manganese 1By similarity1
Metal bindingi89Manganese 1By similarity1
Metal bindingi89Manganese 2By similarity1
Metal bindingi121Manganese 2By similarity1
Active sitei122Proton donorBy similarity1
Metal bindingi171Manganese 2By similarity1
Metal bindingi245Manganese 2By similarity1

GO - Molecular functioni

GO - Biological processi

  • protein dephosphorylation Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP2A-3 catalytic subunit (EC:3.1.3.16)
Alternative name(s):
Protein phosphatase 2A isoform 3
Gene namesi
Name:PP2A3
Synonyms:EP7, PP2A4
Ordered Locus Names:At3g58500
ORF Names:F14P22.90
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G58500.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: TAIR
  • cytosol Source: TAIR
  • nucleolus Source: TAIR
  • nucleus Source: TAIR
  • protein phosphatase type 2A complex Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000588551 – 313Serine/threonine-protein phosphatase PP2A-3 catalytic subunitAdd BLAST313

Proteomic databases

PaxDbiP48578.
PRIDEiP48578.

Expressioni

Gene expression databases

GenevisibleiP48578. AT.

Interactioni

Subunit structurei

PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (subunit A), that associates with a variety of regulatory subunits such as subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families).By similarity

Protein-protein interaction databases

BioGridi10334. 2 interactors.
IntActiP48578. 1 interactor.
STRINGi3702.AT3G58500.1.

Structurei

3D structure databases

ProteinModelPortaliP48578.
SMRiP48578.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-2A subfamily.Curated

Phylogenomic databases

eggNOGiKOG0371. Eukaryota.
COG0639. LUCA.
HOGENOMiHOG000172696.
KOiK04382.
OMAiGHEHKVV.
OrthoDBiEOG09360EXD.
PhylomeDBiP48578.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48578-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGANSLPTDA TLDLDEQISQ LMQCKPLSEQ QVRALCEKAK EILMDESNVQ
60 70 80 90 100
PVKSPVTICG DIHGQFHDLA ELFRIGGKCP DTNYLFMGDY VDRGYYSVET
110 120 130 140 150
VTLLVGLKVR YPQRITILRG NHESRQITQV YGFYDECLRK YGNANVWKIF
160 170 180 190 200
TDLFDYFPLT ALVESEIFCL HGGLSPSIET LDNIRNFDRV QEVPHEGPMC
210 220 230 240 250
DLLWSDPDDR CGWGISPRGA GYTFGQDISE QFNHTNNLKL IARAHQLVMD
260 270 280 290 300
GFNWAHEQKV VTIFSAPNYC YRCGNMASIL EVDDCRNHTF IQFEPAPRRG
310
EPDVTRRTPD YFL
Length:313
Mass (Da):35,767
Last modified:February 1, 1996 - v1
Checksum:i0636FF10832B1B00
GO

Sequence cautioni

The sequence CAB68188 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U08047 mRNA. Translation: AAA64941.1.
U60136 Genomic DNA. Translation: AAD10855.1.
AL137082 Genomic DNA. Translation: CAB68188.1. Sequence problems.
CP002686 Genomic DNA. Translation: AEE79790.1.
AY057604 mRNA. Translation: AAL14399.1.
AY056222 mRNA. Translation: AAL07071.1.
AY113023 mRNA. Translation: AAM47331.1.
PIRiS52660.
RefSeqiNP_567066.1. NM_115712.4.
UniGeneiAt.25267.

Genome annotation databases

EnsemblPlantsiAT3G58500.1; AT3G58500.1; AT3G58500.
GeneIDi825019.
GrameneiAT3G58500.1; AT3G58500.1; AT3G58500.
KEGGiath:AT3G58500.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U08047 mRNA. Translation: AAA64941.1.
U60136 Genomic DNA. Translation: AAD10855.1.
AL137082 Genomic DNA. Translation: CAB68188.1. Sequence problems.
CP002686 Genomic DNA. Translation: AEE79790.1.
AY057604 mRNA. Translation: AAL14399.1.
AY056222 mRNA. Translation: AAL07071.1.
AY113023 mRNA. Translation: AAM47331.1.
PIRiS52660.
RefSeqiNP_567066.1. NM_115712.4.
UniGeneiAt.25267.

3D structure databases

ProteinModelPortaliP48578.
SMRiP48578.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi10334. 2 interactors.
IntActiP48578. 1 interactor.
STRINGi3702.AT3G58500.1.

Proteomic databases

PaxDbiP48578.
PRIDEiP48578.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G58500.1; AT3G58500.1; AT3G58500.
GeneIDi825019.
GrameneiAT3G58500.1; AT3G58500.1; AT3G58500.
KEGGiath:AT3G58500.

Organism-specific databases

TAIRiAT3G58500.

Phylogenomic databases

eggNOGiKOG0371. Eukaryota.
COG0639. LUCA.
HOGENOMiHOG000172696.
KOiK04382.
OMAiGHEHKVV.
OrthoDBiEOG09360EXD.
PhylomeDBiP48578.

Miscellaneous databases

PROiP48578.

Gene expression databases

GenevisibleiP48578. AT.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPP2A3_ARATH
AccessioniPrimary (citable) accession number: P48578
Secondary accession number(s): Q9M2G6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 30, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.