Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P48577

- PP2A_ACEPE

UniProt

P48577 - PP2A_ACEPE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Serine/threonine-protein phosphatase PP2A-1 catalytic subunit

Gene
N/A
Organism
Acetabularia peniculus (Green alga) (Polyphysa peniculus)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi54 – 541Manganese 1By similarity
Metal bindingi56 – 561Manganese 1By similarity
Metal bindingi82 – 821Manganese 1By similarity
Metal bindingi82 – 821Manganese 2By similarity
Metal bindingi114 – 1141Manganese 2By similarity
Active sitei115 – 1151Proton donorBy similarity
Metal bindingi164 – 1641Manganese 2By similarity
Metal bindingi238 – 2381Manganese 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP2A-1 catalytic subunit (EC:3.1.3.16)
OrganismiAcetabularia peniculus (Green alga) (Polyphysa peniculus)
Taxonomic identifieri35862 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeChlorophytaUlvophyceaeDasycladalesPolyphysaceaeAcetabularia

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 307307Serine/threonine-protein phosphatase PP2A-1 catalytic subunitPRO_0000058851Add
BLAST

Proteomic databases

PRIDEiP48577.

Structurei

3D structure databases

ProteinModelPortaliP48577.
SMRiP48577. Positions 2-307.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-2A subfamily.Curated

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48577-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVVYKQLDEW IEHLMQCKPL PEENVKELVA KAREVFSNEK NVQPVKMPVT
60 70 80 90 100
VCGDIHGQFH DMVELFKIGG TCPDTNYLFM GDYVDRGYNS VETVTLLVSL
110 120 130 140 150
KVRYPERITI LRGNHESRQI TQVYGFYDEC LRKYGNANVW QLFTDLFDFL
160 170 180 190 200
PLTGLIENEV FCLHGGLSPA LDTLDQIREL DRIQEVPHEG PMCDLLWSDP
210 220 230 240 250
DERLGWGISP RGAGYTFGQD ISEQFNVRNS LKLVARAHQL VMEGYNWSHE
260 270 280 290 300
KNVVTIFSAP NYCYRCGNMA AIMEVAEGMD KGFQQFEPAP RRGAEGEVNR

RTPDYFL
Length:307
Mass (Da):35,246
Last modified:February 1, 1996 - v1
Checksum:iAA021D16540EDA98
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z26654 mRNA. Translation: CAA81395.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z26654 mRNA. Translation: CAA81395.1 .

3D structure databases

ProteinModelPortali P48577.
SMRi P48577. Positions 2-307.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P48577.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
PRINTSi PR00114. STPHPHTASE.
SMARTi SM00156. PP2Ac. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Protein phosphatase 2A, a potential regulator of actin dynamics and actin-based organelle motility in the green alga Acetabularia."
    Menzel D., Vugrek O., Frank S., Elsner-Menzel C.
    Eur. J. Cell Biol. 67:179-187(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiPP2A_ACEPE
AccessioniPrimary (citable) accession number: P48577
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 1, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3