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P48577

- PP2A_ACEPE

UniProt

P48577 - PP2A_ACEPE

Protein

Serine/threonine-protein phosphatase PP2A-1 catalytic subunit

Gene
N/A
Organism
Acetabularia peniculus (Green alga) (Polyphysa peniculus)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi54 – 541Manganese 1By similarity
    Metal bindingi56 – 561Manganese 1By similarity
    Metal bindingi82 – 821Manganese 1By similarity
    Metal bindingi82 – 821Manganese 2By similarity
    Metal bindingi114 – 1141Manganese 2By similarity
    Active sitei115 – 1151Proton donorBy similarity
    Metal bindingi164 – 1641Manganese 2By similarity
    Metal bindingi238 – 2381Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. phosphoprotein phosphatase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein phosphatase PP2A-1 catalytic subunit (EC:3.1.3.16)
    OrganismiAcetabularia peniculus (Green alga) (Polyphysa peniculus)
    Taxonomic identifieri35862 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeChlorophytaUlvophyceaeDasycladalesPolyphysaceaeAcetabularia

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 307307Serine/threonine-protein phosphatase PP2A-1 catalytic subunitPRO_0000058851Add
    BLAST

    Proteomic databases

    PRIDEiP48577.

    Structurei

    3D structure databases

    ProteinModelPortaliP48577.
    SMRiP48577. Positions 2-307.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PPP phosphatase family. PP-2A subfamily.Curated

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    PRINTSiPR00114. STPHPHTASE.
    SMARTiSM00156. PP2Ac. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 1 hit.
    PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P48577-1 [UniParc]FASTAAdd to Basket

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    MVVYKQLDEW IEHLMQCKPL PEENVKELVA KAREVFSNEK NVQPVKMPVT    50
    VCGDIHGQFH DMVELFKIGG TCPDTNYLFM GDYVDRGYNS VETVTLLVSL 100
    KVRYPERITI LRGNHESRQI TQVYGFYDEC LRKYGNANVW QLFTDLFDFL 150
    PLTGLIENEV FCLHGGLSPA LDTLDQIREL DRIQEVPHEG PMCDLLWSDP 200
    DERLGWGISP RGAGYTFGQD ISEQFNVRNS LKLVARAHQL VMEGYNWSHE 250
    KNVVTIFSAP NYCYRCGNMA AIMEVAEGMD KGFQQFEPAP RRGAEGEVNR 300
    RTPDYFL 307
    Length:307
    Mass (Da):35,246
    Last modified:February 1, 1996 - v1
    Checksum:iAA021D16540EDA98
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z26654 mRNA. Translation: CAA81395.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z26654 mRNA. Translation: CAA81395.1 .

    3D structure databases

    ProteinModelPortali P48577.
    SMRi P48577. Positions 2-307.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P48577.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    PRINTSi PR00114. STPHPHTASE.
    SMARTi SM00156. PP2Ac. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Protein phosphatase 2A, a potential regulator of actin dynamics and actin-based organelle motility in the green alga Acetabularia."
      Menzel D., Vugrek O., Frank S., Elsner-Menzel C.
      Eur. J. Cell Biol. 67:179-187(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiPP2A_ACEPE
    AccessioniPrimary (citable) accession number: P48577
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3