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P48577 (PP2A_ACEPE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein phosphatase PP2A-1 catalytic subunit

EC=3.1.3.16
OrganismAcetabularia peniculus (Green alga) (Polyphysa peniculus)
Taxonomic identifier35862 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeChlorophytaUlvophyceaeDasycladalesPolyphysaceaeAcetabularia

Protein attributes

Sequence length307 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactor

Binds 1 iron ion per subunit By similarity.

Binds 1 manganese ion per subunit By similarity.

Sequence similarities

Belongs to the PPP phosphatase family. PP-2A subfamily.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 307307Serine/threonine-protein phosphatase PP2A-1 catalytic subunit
PRO_0000058851

Sites

Active site1151Proton donor By similarity
Metal binding541Iron By similarity
Metal binding561Iron By similarity
Metal binding821Iron By similarity
Metal binding821Manganese By similarity
Metal binding1141Manganese By similarity
Metal binding1641Manganese By similarity
Metal binding2381Manganese By similarity

Sequences

Sequence LengthMass (Da)Tools
P48577 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: AA021D16540EDA98

FASTA30735,246
        10         20         30         40         50         60 
MVVYKQLDEW IEHLMQCKPL PEENVKELVA KAREVFSNEK NVQPVKMPVT VCGDIHGQFH 

        70         80         90        100        110        120 
DMVELFKIGG TCPDTNYLFM GDYVDRGYNS VETVTLLVSL KVRYPERITI LRGNHESRQI 

       130        140        150        160        170        180 
TQVYGFYDEC LRKYGNANVW QLFTDLFDFL PLTGLIENEV FCLHGGLSPA LDTLDQIREL 

       190        200        210        220        230        240 
DRIQEVPHEG PMCDLLWSDP DERLGWGISP RGAGYTFGQD ISEQFNVRNS LKLVARAHQL 

       250        260        270        280        290        300 
VMEGYNWSHE KNVVTIFSAP NYCYRCGNMA AIMEVAEGMD KGFQQFEPAP RRGAEGEVNR 


RTPDYFL 

« Hide

References

[1]"Protein phosphatase 2A, a potential regulator of actin dynamics and actin-based organelle motility in the green alga Acetabularia."
Menzel D., Vugrek O., Frank S., Elsner-Menzel C.
Eur. J. Cell Biol. 67:179-187(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z26654 mRNA. Translation: CAA81395.1.

3D structure databases

ProteinModelPortalP48577.
SMRP48577. Positions 2-307.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP48577.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR004843. Calcineurin-like_PHP_apaH.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSPR00114. STPHPHTASE.
SMARTSM00156. PP2Ac. 1 hit.
[Graphical view]
PROSITEPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePP2A_ACEPE
AccessionPrimary (citable) accession number: P48577
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: April 16, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families