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P48565 (PALH_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
pH-response regulator protein palH/RIM21
Alternative name(s):
Regulator of IME2 protein 21
Gene names
Name:RIM21
Synonyms:PAL2
Ordered Locus Names:YNL294C
ORF Names:N0466
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length533 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH By similarity. Required for growth at alkaline pH. Ref.4

Subcellular location

Cell membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the palH/RIM21 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 533533pH-response regulator protein palH/RIM21
PRO_0000058205

Regions

Topological domain1 – 9494Extracellular Potential
Transmembrane95 – 11521Helical; Potential
Topological domain116 – 12712Cytoplasmic Potential
Transmembrane128 – 14821Helical; Potential
Topological domain149 – 17830Extracellular Potential
Transmembrane179 – 19921Helical; Potential
Topological domain200 – 20910Cytoplasmic Potential
Transmembrane210 – 23021Helical; Potential
Topological domain231 – 24717Extracellular Potential
Transmembrane248 – 26821Helical; Potential
Topological domain269 – 28012Cytoplasmic Potential
Transmembrane281 – 30121Helical; Potential
Topological domain302 – 3076Extracellular Potential
Transmembrane308 – 32821Helical; Potential
Topological domain329 – 533205Cytoplasmic Potential

Amino acid modifications

Modified residue4091Phosphoserine Ref.6

Sequences

Sequence LengthMass (Da)Tools
P48565 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 9492A18512F399CC

FASTA53361,532
        10         20         30         40         50         60 
MNLWRHSPEE LAAYNSCHPM KLGSGVLIQL PLYDNSAVYA EDITFRSFCC ERVPVYVSTV 

        70         80         90        100        110        120 
LRNSSPYRYL DEVINDWQKF IQVSDYVGGS AEYAIYAVIL SITSNFVITV FLTVICCINI 

       130        140        150        160        170        180 
SGRAYKRILQ LLRIASLLAS LNLTIFITKV LRRLEKEHNV YGVVRAHSIM HIFSDDMTFV 

       190        200        210        220        230        240 
VLDFLATLMF QFCQVGIVIR LFQRAQEKRI IFFIGVILTI TANILWVIPP FANHTTKHRN 

       250        260        270        280        290        300 
DWQILRPFVY LFRIAIATSY ASIVIYHIWQ KKKLWFKFNQ MGLLTLLTIL VVLLLPGFFL 

       310        320        330        340        350        360 
ADVSNLWISE LGEVFNTTCY VTSTVITWEW LDRLNVLERK EEAQSILGRP IFEEEQQDYR 

       370        380        390        400        410        420 
FAKYALRVQN ALTRRESQDA STDRHDTSSN SEVCDLQTIS RYDPEDQISV GRSIDRMHFN 

       430        440        450        460        470        480 
DRGTYKDVAL KKLGYARDKI LYFTDQIVQK SVGHNNSSSS KNEKTKQRKA MVRKRLGLDK 

       490        500        510        520        530 
PGIYIYSTKD VVFNSDEDDD ENAEDEDDDE YEVGSEGNNN SSATFTSDHI GHI 

« Hide

References

« Hide 'large scale' references
[1]"Sequence analysis of a 30 kb DNA segment from yeast chromosome XIV carrying a ribosomal protein gene cluster, the genes encoding a plasma membrane protein and a subunit of replication factor C, and a novel putative serine/threonine protein kinase gene."
Maurer K.C.T., Urbanus J.H.M., Planta R.J.
Yeast 11:1303-1310(1995) [PubMed: 8553702] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 96604 / S288c / FY1679.
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J. expand/collapse author list , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
Nature 387:93-98(1997) [PubMed: 9169873] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Ambient pH signalling in ascomycetous yeasts involves homologues of the Aspergillus nidulans genes palF and palH."
Treton B., Blanchin-Roland S., Lambert M., Lepingle A., Gaillardin C.
Mol. Gen. Genet. 263:505-513(2000) [PubMed: 10821185] [Abstract]
Cited for: FUNCTION.
[5]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed: 16847258] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
[6]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed: 18407956] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-409, MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U23084 Genomic DNA. Translation: AAC49105.1.
Z71570 Genomic DNA. Translation: CAA96212.1.
BK006947 Genomic DNA. Translation: DAA10265.1.
PIRS63270.
RefSeqNP_014105.1. NM_001183132.1.

3D structure databases

ProteinModelPortalP48565.
ModBaseSearch...

Protein-protein interaction databases

MINTMINT-2784389.
STRINGP48565.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYNL294C; YNL294C; YNL294C.
GeneID855422.
KEGGsce:YNL294C.
NMPDRfig|4932.3.peg.5167.

Organism-specific databases

CYGDYNL294c.
SGDS000005238. RIM21.

Phylogenomic databases

eggNOGfuNOG08240.
GeneTreeEFGT00050000003323.
HOGENOMHBG202740.
OMAQSILGRP.
OrthoDBEOG4PG98P.

Gene expression databases

ArrayExpressP48565.
GenevestigatorP48565.
GermOnlineYNL294C. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR014844. PalH.
[Graphical view]
PfamPF08733. PalH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio979283.

Entry information

Entry namePALH_YEAST
AccessionPrimary (citable) accession number: P48565
Secondary accession number(s): D6W0P9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: January 25, 2012
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome XIV

Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

SIMILARITY comments

Index of protein domains and families