Reviewed,
UniProtKB/Swiss-Prot P48565 (PALH_YEAST)
Last modified
November 24, 2009.
Version 66.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: pH-response regulator protein palH/RIM21 Alternative name(s): Regulator of IME2 protein 21 | ||||||||
| Gene names |
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| Organism | Saccharomyces cerevisiae (Baker's yeast) [Complete proteome] | ||||||||
| Taxonomic identifier | 4932 [NCBI] | ||||||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces |
Protein attributes
| Sequence length | 533 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH By similarity. Required for growth at alkaline pH. |
| Subcellular location | Cell membrane; Multi-pass membrane protein Potential. |
| Sequence similarities | Belongs to the palH/RIM21 family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cell membrane Membrane |
| Domain | Transmembrane |
| PTM | Phosphoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | ascospore formation Ref.3 Inferred from mutant phenotype. Source: SGD fungal-type cell wall biogenesisInferred from genetic interaction. Source: SGD invasive growth in response to glucose limitation Ref.3Inferred from mutant phenotype. Source: SGD |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membraneInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 533 | 533 | pH-response regulator protein palH/RIM21 | PRO_0000058205 | |||||
Regions | |||||||||
| Topological domain | 1 – 94 | 94 | Extracellular Potential | ||||||
| Transmembrane | 95 – 115 | 21 | Potential | ||||||
| Topological domain | 116 – 127 | 12 | Cytoplasmic Potential | ||||||
| Transmembrane | 128 – 148 | 21 | Potential | ||||||
| Topological domain | 149 – 178 | 30 | Extracellular Potential | ||||||
| Transmembrane | 179 – 199 | 21 | Potential | ||||||
| Topological domain | 200 – 209 | 10 | Cytoplasmic Potential | ||||||
| Transmembrane | 210 – 230 | 21 | Potential | ||||||
| Topological domain | 231 – 247 | 17 | Extracellular Potential | ||||||
| Transmembrane | 248 – 268 | 21 | Potential | ||||||
| Topological domain | 269 – 280 | 12 | Cytoplasmic Potential | ||||||
| Transmembrane | 281 – 301 | 21 | Potential | ||||||
| Topological domain | 302 – 307 | 6 | Extracellular Potential | ||||||
| Transmembrane | 308 – 328 | 21 | Potential | ||||||
| Topological domain | 329 – 533 | 205 | Cytoplasmic Potential | ||||||
Amino acid modifications | |||||||||
| Modified residue | 409 | 1 | Phosphoserine Ref.5 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Sequence analysis of a 30 kb DNA segment from yeast chromosome XIV carrying a ribosomal protein gene cluster, the genes encoding a plasma membrane protein and a subunit of replication factor C, and a novel putative serine/threonine protein kinase gene." Maurer K.C.T., Urbanus J.H.M., Planta R.J. Yeast 11:1303-1310(1995) [PubMed: 8553702] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679. |
| [2] | "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications." Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J. Hani J.Nature 387:93-98(1997) [PubMed: 9169873] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c. |
| [3] | "Ambient pH signalling in ascomycetous yeasts involves homologues of the Aspergillus nidulans genes palF and palH." Treton B., Blanchin-Roland S., Lambert M., Lepingle A., Gaillardin C. Mol. Gen. Genet. 263:505-513(2000) [PubMed: 10821185] [Abstract] Cited for: FUNCTION. |
| [4] | "A global topology map of the Saccharomyces cerevisiae membrane proteome." Kim H., Melen K., Oesterberg M., von Heijne G. Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed: 16847258] [Abstract] Cited for: TOPOLOGY [LARGE SCALE ANALYSIS]. |
| [5] | "A multidimensional chromatography technology for in-depth phosphoproteome analysis." Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H. Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed: 18407956] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-409, MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| U23084 Genomic DNA. Translation: AAC49105.1. Z71570 Genomic DNA. Translation: CAA96212.1. | |
| PIR | S63270. |
| RefSeq | NP_014105.1. |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | P48565. |
Proteomic databases | |
| PRIDE | P48565. |
Genome annotation databases | |
| Ensembl | YNL294C; YNL294C; YNL294C; Saccharomyces cerevisiae. [Genome view] |
| GeneID | 855422. |
| KEGG | sce:YNL294C. |
| NMPDR | fig|4932.3.peg.5167. |
Organism-specific databases | |
| CYGD | YNL294c. |
| SGD | S000005238. RIM21. |
Phylogenomic databases | |
| HOGENOM | P48565. |
| OMA | QSILGRP |
| OrthoDB | EOG9ZW6TB |
Gene expression databases | |
| ArrayExpress | P48565. |
| Genevestigator | P48565. |
| GermOnline | YNL294C. Saccharomyces cerevisiae. |
Family and domain databases | |
| InterPro | IPR014844. PalH. [Graphical view] |
| Pfam | PF08733. PalH. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 979283. |
Entry information
| Entry name | PALH_YEAST | ||||||||
| Accession | Primary (citable) accession number: P48565 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |
| Yeast Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD |
| Yeast chromosome XIV Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names |

Clusters with


