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Protein

Protein MON2

Gene

MON2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for traffic between late Golgi and early endosomes. Required for endocytosis and maintenance of vacuolar structure.4 Publications

GO - Molecular functioni

  • guanyl-nucleotide exchange factor activity Source: SGD

GO - Biological processi

  • endocytosis Source: SGD
  • Golgi to endosome transport Source: HGNC
  • protein targeting to vacuole Source: SGD
  • transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-33285-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein MON2
Gene namesi
Name:MON2
Synonyms:YSL2
Ordered Locus Names:YNL297C
ORF Names:N0453
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL297C.
SGDiS000005241. MON2.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: GOC
  • early endosome membrane Source: SGD
  • endosome Source: SGD
  • extrinsic component of membrane Source: SGD
  • Golgi apparatus Source: UniProtKB
  • Golgi membrane Source: UniProtKB-SubCell
  • trans-Golgi network Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002033722 – 1636Protein MON2Add BLAST1635

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei564PhosphoserineCombined sources1
Modified residuei567PhosphoserineCombined sources1
Modified residuei571PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP48563.
PRIDEiP48563.

PTM databases

iPTMnetiP48563.

Interactioni

Subunit structurei

Homodimer. Interacts with DOP1, ARL1 and NEO1.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
DOP1Q039214EBI-28333,EBI-34442
GGA2P388173EBI-28333,EBI-7569

Protein-protein interaction databases

BioGridi35541. 217 interactors.
IntActiP48563. 8 interactors.
MINTiMINT-2787218.

Structurei

3D structure databases

ProteinModelPortaliP48563.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni60 – 410Golgi membrane targeting and interaction with ARL11 PublicationAdd BLAST351
Regioni1501 – 1636Required for function in membrane traffickingAdd BLAST136

Sequence similaritiesi

Belongs to the MON2 family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000013286.
HOGENOMiHOG000074721.
InParanoidiP48563.
OMAiNTGISTH.
OrthoDBiEOG092C04O3.

Family and domain databases

InterProiIPR032629. DCB_dom.
IPR032817. Mon2_C.
IPR032691. Sec7_N.
[Graphical view]
PfamiPF16213. DCB. 1 hit.
PF16206. Mon2_C. 1 hit.
PF12783. Sec7_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48563-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMNTGGFDS MQRQLEAELR SLSSESKRRN STIRHASDKS IEILKRVHSF
60 70 80 90 100
EELERHPDFA LPFVLACQSR NAKMTTLAMQ CLQGLSTVPS IPRSRLSEIL
110 120 130 140 150
DAFIEATHLA MEIQLKVLQV VPIFFKTYGK FIYGPLCKKL LLCCSNLLHV
160 170 180 190 200
PNKAPVVVGT ASATLQQLID EIFDRLSIES VVDDKQYEVL ISNSESIKVN
210 220 230 240 250
VYRYDANKLF DNICSLNEIS SNGAVSDEEM LLDIGDIPID YGLEILESIL
260 270 280 290 300
KNSQKNLLEC QDLQYLLRVK AIPLLLRCIS SSRHFSTAVR SCRCLKLLIR
310 320 330 340 350
KEYLSILELE LEVILSLLIH GISVESNLSG WQRVLSLELF KDLSQDPEIV
360 370 380 390 400
NTLYMDYDNY PDKKHVFKYL LKECIVLLNS PEYITFLAPS KVVEKMDSPL
410 420 430 440 450
ITTENSTVKT KFMHLLDKSN APSINITYII SLILTICNHL CEGLNKSALE
460 470 480 490 500
SSPLEKKIED KEREEGTGND STVVKVYSGL FSGLFELNKL FLYSTSLETS
510 520 530 540 550
IFHLVVRAFQ KLAHSAGVLS LKDKLRACMK LFSILITNNV TSSNQYSFND
560 570 580 590 600
TSKSAKNQHT RNISTSSVTT SPVESTKNPS RSIADSAQNK EMKRRLHPRN
610 620 630 640 650
ISSRQVSLLR ALISLSISLG PIFDSESWRY TFLTWQWITY YIYGPSADFK
660 670 680 690 700
ESFYSEDIPP PPILTKSDVT SIESSLTKFF ESTSSYSCST FHLVLTRLIL
710 720 730 740 750
DSKNTLTLEQ TNLNLNNDIG YHPLDAKDEI IPCIYNKAFF VNKIGELATY
760 770 780 790 800
NCKKFLFGKN GKELWSLIST YMIKLISNRE MDNDSLRLYT VRVFTDIIKK
810 820 830 840 850
ATNEVGNSDE QDNKVKQFGT LENLVIDSLM ATINSIKQLD IGKQEIYNGT
860 870 880 890 900
INVESDILFQ LLLTLKEILN EFGELLMNSW TNIFNIINSP FEWTVEDTDF
910 920 930 940 950
SVNEDIDDSS LFEGIVQKHK NMIQVSYDVF KLISDDFLQS LPMSVIKFVI
960 970 980 990 1000
DTLVNFVSQK RNLNISFSSI SQFWLVGDYL RVRFNPETLN LSDEKRRSLS
1010 1020 1030 1040 1050
EKINNQKLIE IITSSSSHDW ELYNGLWIYL LKNLINCTND DRVEVKNGAV
1060 1070 1080 1090 1100
QTFFRIIDSH SVCFPPWDLI FLEVIEPLLT KEWSTEELEN ETDFINVTLQ
1110 1120 1130 1140 1150
GLIKLYPEHF KDFKNNTTCA KEWSMLLDFL KRLLSSTSNN TKNAVILNYQ
1160 1170 1180 1190 1200
TLLKEIITIE DVPSDILKKC CEIFTDYNIT YSDLSTNASS KTEYDCIYEL
1210 1220 1230 1240 1250
ITGFPPLYQL ISKYDAMTDE FVEKVLLLFN SAIKYPLLPE FVQDKTKPSS
1260 1270 1280 1290 1300
MQKAILSGLD IFMTNDSKDT EILILLQLST ISILAFDTRE KITKKLGPKL
1310 1320 1330 1340 1350
PKASLNRLPT FEAISYMSCS NLRNRIAKID QFGISTLKAK HILRILKNLA
1360 1370 1380 1390 1400
EIIKRKSLIT GSESDEIPIW VLASNCFCDL SNKIFKSLQE DAENPLKDNF
1410 1420 1430 1440 1450
CDLFINVIVV TLQRINPELD NLTEIDDLNE YSKYREILLE NRIIDLFNER
1460 1470 1480 1490 1500
QLDTFIYAVW DCSFLYEFDE LENALMQDCG TFSELSQKLS SFDFSCIFGS
1510 1520 1530 1540 1550
TTNPRFQTKY KCSLECLQDL VNFMLNTNEK LRKLTAPYLS ARIALALRRY
1560 1570 1580 1590 1600
ISDEYLIGRA PIPKLRKTEL ATLLNGLCVI LRGVLDQNST LGNKQIGVEN
1610 1620 1630
LQTLSPLILR TIPVSHKMDG LQDKVLELSL GFTKLD
Length:1,636
Mass (Da):186,836
Last modified:February 1, 1996 - v1
Checksum:iF0B3D8E6B0D994D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U23084 Genomic DNA. Translation: AAC49101.1.
Z71573 Genomic DNA. Translation: CAA96214.1.
BK006947 Genomic DNA. Translation: DAA10263.1.
PIRiS60403.
RefSeqiNP_014102.1. NM_001183135.1.

Genome annotation databases

EnsemblFungiiYNL297C; YNL297C; YNL297C.
GeneIDi855420.
KEGGisce:YNL297C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U23084 Genomic DNA. Translation: AAC49101.1.
Z71573 Genomic DNA. Translation: CAA96214.1.
BK006947 Genomic DNA. Translation: DAA10263.1.
PIRiS60403.
RefSeqiNP_014102.1. NM_001183135.1.

3D structure databases

ProteinModelPortaliP48563.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35541. 217 interactors.
IntActiP48563. 8 interactors.
MINTiMINT-2787218.

PTM databases

iPTMnetiP48563.

Proteomic databases

MaxQBiP48563.
PRIDEiP48563.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYNL297C; YNL297C; YNL297C.
GeneIDi855420.
KEGGisce:YNL297C.

Organism-specific databases

EuPathDBiFungiDB:YNL297C.
SGDiS000005241. MON2.

Phylogenomic databases

GeneTreeiENSGT00390000013286.
HOGENOMiHOG000074721.
InParanoidiP48563.
OMAiNTGISTH.
OrthoDBiEOG092C04O3.

Enzyme and pathway databases

BioCyciYEAST:G3O-33285-MONOMER.

Miscellaneous databases

PROiP48563.

Family and domain databases

InterProiIPR032629. DCB_dom.
IPR032817. Mon2_C.
IPR032691. Sec7_N.
[Graphical view]
PfamiPF16213. DCB. 1 hit.
PF16206. Mon2_C. 1 hit.
PF12783. Sec7_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMON2_YEAST
AccessioniPrimary (citable) accession number: P48563
Secondary accession number(s): D6W0P7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 2, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2410 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.