Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P48559

- YPT11_YEAST

UniProt

P48559 - YPT11_YEAST

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

GTP-binding protein YPT11

Gene

YPT11

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved in the positive control of both endoplasmic reticulum (ER) and mitochondrion inheritance during cell divison. Required for the MYO2-dependent retention of newly inherited mitochondria at the bud tip in developing daughter cells.5 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi97 – 1048GTPSequence Analysis
Nucleotide bindingi228 – 2325GTPSequence Analysis
Nucleotide bindingi292 – 2954GTPSequence Analysis

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW

GO - Biological processi

  1. endoplasmic reticulum inheritance Source: SGD
  2. Golgi inheritance Source: SGD
  3. Golgi localization Source: SGD
  4. mitochondrion inheritance Source: SGD
  5. mitochondrion localization Source: SGD
  6. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-33291-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein YPT11
Alternative name(s):
Rab GTPase YPT11
Gene namesi
Name:YPT11
Ordered Locus Names:YNL304W
ORF Names:N0410
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIV

Organism-specific databases

SGDiS000005248. YPT11.

Subcellular locationi

Endoplasmic reticulum membrane 1 Publication; Lipid-anchor 1 Publication; Cytoplasmic side 1 Publication. Bud tip 1 Publication. Bud neck 1 Publication
Note: Enriched in the peripheral ER of small buds and daughter cells. Concentrates at the site of bud emergence, at the bud tip of the growing bud, and at the bud neck during M phase. Interaction with MYO2 is required for proper localization to the bud.

GO - Cellular componenti

  1. cellular bud neck Source: SGD
  2. cellular bud tip Source: SGD
  3. endoplasmic reticulum Source: SGD
  4. incipient cellular bud site Source: SGD
  5. membrane Source: UniProtKB-KW
  6. mitochondrion Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi102 – 1021G → D: Impairs interaction with MYO2. 1 Publication
Mutagenesisi206 – 2061I → N: Abolishes interaction with MYO2. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 417417GTP-binding protein YPT11PRO_0000121322Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi415 – 4151S-geranylgeranyl cysteineBy similarity
Lipidationi416 – 4161S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Prenylation

Proteomic databases

MaxQBiP48559.
PaxDbiP48559.

Expressioni

Gene expression databases

GenevestigatoriP48559.

Interactioni

Subunit structurei

Interacts with MYO2 (via C-terminal tail domain). Interacts with YIF1, YIP3, YIP4 and YIP5.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
YIP3P536332EBI-29362,EBI-25301
YIP4P530932EBI-29362,EBI-24124

Protein-protein interaction databases

BioGridi35535. 30 interactions.
DIPiDIP-7864N.
IntActiP48559. 8 interactions.
MINTiMINT-2492537.
STRINGi4932.YNL304W.

Structurei

3D structure databases

ProteinModelPortaliP48559.
SMRiP48559. Positions 90-144, 202-331.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00760000119288.
HOGENOMiHOG000141968.
InParanoidiP48559.
KOiK17977.
OMAiCMERWIV.
OrthoDBiEOG7KM64Z.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48559-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSQRKRYSLN VVTSPSIPSP TPSAPIRTNE SNWEAASPAS AASSFLPNVH
60 70 80 90 100
HGGTVLNPGL GIMRSPSLNK SGAFGRSGSS GSSTVIEPSN IKLLLIGDAN
110 120 130 140 150
VGKTAMILSY CRELLTRAEM SRSARLRHQQ QQQHKDLGLK KTVVNHRLSM
160 170 180 190 200
KEKRKRYSSN DFEKEFKDIN HFADETSDFG NPNIGDDNNH EMADPNEIVI
210 220 230 240 250
ETRSTIGIDI KTNLVNIDNR FFNVILWDTA GQERYQNAII PSLYKKTNAV
260 270 280 290 300
ILTYDITNAK SFQSCMERWI VQALENFSSQ DLLKARFFLV GNKIDLYKER
310 320 330 340 350
QVTHYDVVQM VQEMQLKHGI KISGNFEVSC KWVNVVERTM NMIILDLVEN
360 370 380 390 400
GCFENNDPCV SITTSDDVQG HEQEFHDTVE EPFNFTRQRQ HQLEKNNTVD
410
ITKPNDDIAN NQSICCV
Length:417
Mass (Da):47,116
Last modified:June 16, 2009 - v2
Checksum:i26055FCE32A64977
GO

Sequence cautioni

The sequence AAC49094.1 differs from that shown. Reason: Frameshift at position 36.
The sequence CAA96231.1 differs from that shown. Reason: Frameshift at position 36.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U23084 Genomic DNA. Translation: AAC49094.1. Frameshift.
Z71580 Genomic DNA. Translation: CAA96231.1. Frameshift.
BK006947 Genomic DNA. Translation: DAA10257.1.
PIRiS60396.
RefSeqiNP_014095.2. NM_001183142.1.

Genome annotation databases

EnsemblFungiiYNL304W; YNL304W; YNL304W.
GeneIDi855412.
KEGGisce:YNL304W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U23084 Genomic DNA. Translation: AAC49094.1 . Frameshift.
Z71580 Genomic DNA. Translation: CAA96231.1 . Frameshift.
BK006947 Genomic DNA. Translation: DAA10257.1 .
PIRi S60396.
RefSeqi NP_014095.2. NM_001183142.1.

3D structure databases

ProteinModelPortali P48559.
SMRi P48559. Positions 90-144, 202-331.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35535. 30 interactions.
DIPi DIP-7864N.
IntActi P48559. 8 interactions.
MINTi MINT-2492537.
STRINGi 4932.YNL304W.

Proteomic databases

MaxQBi P48559.
PaxDbi P48559.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YNL304W ; YNL304W ; YNL304W .
GeneIDi 855412.
KEGGi sce:YNL304W.

Organism-specific databases

SGDi S000005248. YPT11.

Phylogenomic databases

eggNOGi COG1100.
GeneTreei ENSGT00760000119288.
HOGENOMi HOG000141968.
InParanoidi P48559.
KOi K17977.
OMAi CMERWIV.
OrthoDBi EOG7KM64Z.

Enzyme and pathway databases

BioCyci YEAST:G3O-33291-MONOMER.

Miscellaneous databases

NextBioi 979259.

Gene expression databases

Genevestigatori P48559.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view ]
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51419. RAB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence analysis of a 30 kb DNA segment from yeast chromosome XIV carrying a ribosomal protein gene cluster, the genes encoding a plasma membrane protein and a subunit of replication factor C, and a novel putative serine/threonine protein kinase gene."
    Maurer K.C.T., Urbanus J.H.M., Planta R.J.
    Yeast 11:1303-1310(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 96604 / S288c / FY1679.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
    Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
    , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
    Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Saccharomyces cerevisiae Pra1p/Yip3p interacts with Yip1p and Rab proteins."
    Calero M., Collins R.N.
    Biochem. Biophys. Res. Commun. 290:676-681(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH YIP3.
  5. "Identification of the novel proteins Yip4p and Yip5p as Rab GTPase interacting factors."
    Calero M., Winand N.J., Collins R.N.
    FEBS Lett. 515:89-98(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH YIF1; YIP4 AND YIP5.
  6. "Complex formation with Ypt11p, a rab-type small GTPase, is essential to facilitate the function of Myo2p, a class V myosin, in mitochondrial distribution in Saccharomyces cerevisiae."
    Itoh T., Watabe A., Toh-e A., Matsui Y.
    Mol. Cell. Biol. 22:7744-7757(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH MYO2, MUTAGENESIS OF GLY-102 AND ILE-206.
  7. "Sequencing and comparison of yeast species to identify genes and regulatory elements."
    Kellis M., Patterson N., Endrizzi M., Birren B.W., Lander E.S.
    Nature 423:241-254(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION OF FRAMESHIFT.
  8. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  9. "Finding functional features in Saccharomyces genomes by phylogenetic footprinting."
    Cliften P.F., Sudarsanam P., Desikan A., Fulton L., Fulton B., Majors J., Waterston R., Cohen B.A., Johnston M.
    Science 301:71-76(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION OF FRAMESHIFT.
  10. "Mmr1p is a mitochondrial factor for Myo2p-dependent inheritance of mitochondria in the budding yeast."
    Itoh T., Toh-e A., Matsui Y.
    EMBO J. 23:2520-2530(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN MITOCHONDRION INHERITANCE.
  11. "A type V myosin (Myo2p) and a Rab-like G-protein (Ypt11p) are required for retention of newly inherited mitochondria in yeast cells during cell division."
    Boldogh I.R., Ramcharan S.L., Yang H.-C., Pon L.A.
    Mol. Biol. Cell 15:3994-4002(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN MITOCHONDRION INHERITANCE.
  12. "Bioinformatic and comparative localization of Rab proteins reveals functional insights into the uncharacterized GTPases Ypt10p and Ypt11p."
    Buvelot Frei S., Rahl P.B., Nussbaum M., Briggs B.J., Calero M., Janeczko S., Regan A.D., Chen C.Z., Barral Y., Whittaker G.R., Collins R.N.
    Mol. Cell. Biol. 26:7299-7317(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN ENDOPLASMIC RETICULUM INHERITANCE, SUBCELLULAR LOCATION.
  13. "Multiple pathways influence mitochondrial inheritance in budding yeast."
    Frederick R.L., Okamoto K., Shaw J.M.
    Genetics 178:825-837(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN ENDOPLASMIC RETICULUM AND MITOCHONDRION INHERITANCE.
  14. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiYPT11_YEAST
AccessioniPrimary (citable) accession number: P48559
Secondary accession number(s): D6W0P1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: June 16, 2009
Last modified: October 29, 2014
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2850 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

External Data

Dasty 3