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Protein

GTP-binding protein YPT11

Gene

YPT11

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the positive control of both endoplasmic reticulum (ER) and mitochondrion inheritance during cell divison. Required for the MYO2-dependent retention of newly inherited mitochondria at the bud tip in developing daughter cells.5 Publications

Miscellaneous

Present with 2850 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi97 – 104GTPSequence analysis8
Nucleotide bindingi228 – 232GTPSequence analysis5
Nucleotide bindingi292 – 295GTPSequence analysis4

GO - Molecular functioni

GO - Biological processi

  • endoplasmic reticulum inheritance Source: SGD
  • Golgi inheritance Source: SGD
  • Golgi localization Source: SGD
  • mitochondrion inheritance Source: SGD
  • mitochondrion localization Source: SGD

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-33291-MONOMER
ReactomeiR-SCE-6798695 Neutrophil degranulation
R-SCE-8873719 RAB geranylgeranylation

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein YPT11
Alternative name(s):
Rab GTPase YPT11
Gene namesi
Name:YPT11
Ordered Locus Names:YNL304W
ORF Names:N0410
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL304W
SGDiS000005248 YPT11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi102G → D: Impairs interaction with MYO2. 1 Publication1
Mutagenesisi206I → N: Abolishes interaction with MYO2. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001213221 – 417GTP-binding protein YPT11Add BLAST417

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi415S-geranylgeranyl cysteineBy similarity1
Lipidationi416S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Prenylation

Proteomic databases

MaxQBiP48559
PaxDbiP48559
PRIDEiP48559

PTM databases

iPTMnetiP48559

Interactioni

Subunit structurei

Interacts with MYO2 (via C-terminal tail domain). Interacts with YIF1, YIP3, YIP4 and YIP5.3 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi35535, 191 interactors
DIPiDIP-7864N
IntActiP48559, 14 interactors
MINTiP48559
STRINGi4932.YNL304W

Structurei

3D structure databases

ProteinModelPortaliP48559
SMRiP48559
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

HOGENOMiHOG000141968
InParanoidiP48559
KOiK17977
OrthoDBiEOG092C2MXI

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequencei

Sequence statusi: Complete.

P48559-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQRKRYSLN VVTSPSIPSP TPSAPIRTNE SNWEAASPAS AASSFLPNVH
60 70 80 90 100
HGGTVLNPGL GIMRSPSLNK SGAFGRSGSS GSSTVIEPSN IKLLLIGDAN
110 120 130 140 150
VGKTAMILSY CRELLTRAEM SRSARLRHQQ QQQHKDLGLK KTVVNHRLSM
160 170 180 190 200
KEKRKRYSSN DFEKEFKDIN HFADETSDFG NPNIGDDNNH EMADPNEIVI
210 220 230 240 250
ETRSTIGIDI KTNLVNIDNR FFNVILWDTA GQERYQNAII PSLYKKTNAV
260 270 280 290 300
ILTYDITNAK SFQSCMERWI VQALENFSSQ DLLKARFFLV GNKIDLYKER
310 320 330 340 350
QVTHYDVVQM VQEMQLKHGI KISGNFEVSC KWVNVVERTM NMIILDLVEN
360 370 380 390 400
GCFENNDPCV SITTSDDVQG HEQEFHDTVE EPFNFTRQRQ HQLEKNNTVD
410
ITKPNDDIAN NQSICCV
Length:417
Mass (Da):47,116
Last modified:June 16, 2009 - v2
Checksum:i26055FCE32A64977
GO

Sequence cautioni

The sequence AAC49094 differs from that shown. Reason: Frameshift at position 36.Curated
The sequence CAA96231 differs from that shown. Reason: Frameshift at position 36.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U23084 Genomic DNA Translation: AAC49094.1 Frameshift.
Z71580 Genomic DNA Translation: CAA96231.1 Frameshift.
BK006947 Genomic DNA Translation: DAA10257.1
PIRiS60396
RefSeqiNP_014095.2, NM_001183142.1

Genome annotation databases

EnsemblFungiiYNL304W; YNL304W; YNL304W
GeneIDi855412
KEGGisce:YNL304W

Similar proteinsi

Entry informationi

Entry nameiYPT11_YEAST
AccessioniPrimary (citable) accession number: P48559
Secondary accession number(s): D6W0P1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: June 16, 2009
Last modified: March 28, 2018
This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health