P48558 (YN45_YEAST) Reviewed, UniProtKB/Swiss-Prot
Last modified
December 14, 2011.
Version 77.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Uncharacterized vacuolar membrane protein YNL305C | ||||
| Gene names |
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| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | ||||
| Taxonomic identifier | 559292 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces |
Protein attributes
| Sequence length | 297 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Subcellular location |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Membrane Vacuole |
| Domain | Transmembrane Transmembrane helix |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | apoptotic process Inferred from mutant phenotype. Source: SGD calcium-mediated signalingInferred from mutant phenotype. Source: SGD endoplasmic reticulum unfolded protein responseInferred from mutant phenotype. Source: SGD |
| Cellular component | endoplasmic reticulum Inferred from direct assay. Source: SGD fungal-type vacuoleInferred from direct assay Ref.5. Source: SGD integral to membraneInferred from electronic annotation. Source: UniProtKB-KW mitochondrionInferred from direct assay. Source: SGD vacuolar membraneInferred from electronic annotation. Source: UniProtKB-SubCell |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 297 | 297 | Uncharacterized vacuolar membrane protein YNL305C | PRO_0000203369 | |||||
Regions | |||||||||
| Topological domain | 1 – 53 | 53 | Vacuolar Potential | ||||||
| Transmembrane | 54 – 74 | 21 | Helical; Potential | ||||||
| Topological domain | 75 – 85 | 11 | Cytoplasmic Potential | ||||||
| Transmembrane | 86 – 106 | 21 | Helical; Potential | ||||||
| Topological domain | 107 – 146 | 40 | Vacuolar Potential | ||||||
| Transmembrane | 147 – 167 | 21 | Helical; Potential | ||||||
| Topological domain | 168 – 171 | 4 | Cytoplasmic Potential | ||||||
| Transmembrane | 172 – 192 | 21 | Helical; Potential | ||||||
| Topological domain | 193 – 208 | 16 | Vacuolar Potential | ||||||
| Transmembrane | 209 – 229 | 21 | Helical; Potential | ||||||
| Topological domain | 230 – 239 | 10 | Cytoplasmic Potential | ||||||
| Transmembrane | 240 – 260 | 21 | Helical; Potential | ||||||
| Topological domain | 261 – 270 | 10 | Vacuolar Potential | ||||||
| Transmembrane | 271 – 291 | 21 | Helical; Potential | ||||||
| Topological domain | 292 – 297 | 6 | Cytoplasmic Potential | ||||||
Experimental info | |||||||||
| Sequence conflict | 84 | 1 | S → A in AAT92698. Ref.4 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Sequence analysis of a 30 kb DNA segment from yeast chromosome XIV carrying a ribosomal protein gene cluster, the genes encoding a plasma membrane protein and a subunit of replication factor C, and a novel putative serine/threonine protein kinase gene." Maurer K.C.T., Urbanus J.H.M., Planta R.J. Yeast 11:1303-1310(1995) [PubMed: 8553702] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679. |
| [2] | "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications." Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J. Hani J.Nature 387:93-98(1997) [PubMed: 9169873] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679. |
| [3] | Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c. |
| [4] | "Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. LaBaer J.Genome Res. 17:536-543(2007) [PubMed: 17322287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c. |
| [5] | "Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed: 14562095] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]. |
| [6] | "A global topology map of the Saccharomyces cerevisiae membrane proteome." Kim H., Melen K., Oesterberg M., von Heijne G. Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed: 16847258] [Abstract] Cited for: TOPOLOGY [LARGE SCALE ANALYSIS]. Strain: ATCC 208353 / W303-1A. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | U23084 Genomic DNA. Translation: AAC49093.1. Z71581 Genomic DNA. Translation: CAA96233.1. AY692679 Genomic DNA. Translation: AAT92698.1. BK006947 Genomic DNA. Translation: DAA10256.1. |
| PIR | S63281. |
| RefSeq | NP_014094.1. NM_001183143.1. |
3D structure databases | |
| ProteinModelPortal | P48558. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P48558. 2 interactions. |
| STRING | P48558. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblFungi | YNL305C; YNL305C; YNL305C. |
| GeneID | 855411. |
| KEGG | sce:YNL305C. |
| NMPDR | fig|4932.3.peg.5156. |
Organism-specific databases | |
| CYGD | YNL305c. |
| SGD | S000005249. YNL305C. |
Phylogenomic databases | |
| eggNOG | fuNOG09808. |
| GeneTree | EFGT00050000005815. |
| HOGENOM | HBG595196. |
| OrthoDB | EOG418FXW. |
Gene expression databases | |
| ArrayExpress | P48558. |
| Genevestigator | P48558. |
| GermOnline | YNL305C. Saccharomyces cerevisiae. |
Family and domain databases | |
| InterPro | IPR006214. Inhibitor_apoptosis_Bax1. [Graphical view] |
| KO | K06890. |
| PANTHER | PTHR23291. UPF0005. 1 hit. |
| Pfam | PF01027. Bax1-I. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 979256. |
Entry information
| Entry name | YN45_YEAST | ||||||||
| Accession | Primary (citable) accession number: P48558 Secondary accession number(s): D6W0P0, Q6B2Q1 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Fungal Protein Annotation Program | ||||||||
Relevant documents
| Yeast Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD |
| Yeast chromosome XIV Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names |

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