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Protein

Ras-related protein Ral-a

Gene

Rala

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi18 – 25GTPBy similarity8
Nucleotide bindingi65 – 69GTPBy similarity5
Nucleotide bindingi124 – 127GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: FlyBase
  • GTP binding Source: UniProtKB-KW
  • PDZ domain binding Source: FlyBase

GO - Biological processi

  • border follicle cell migration Source: FlyBase
  • defense response to Gram-negative bacterium Source: FlyBase
  • dorsal closure Source: FlyBase
  • innate immune response Source: FlyBase
  • negative regulation of innate immune response Source: FlyBase
  • negative regulation of JNK cascade Source: FlyBase
  • R3/R4 cell fate commitment Source: FlyBase
  • Ras protein signal transduction Source: FlyBase
  • regulation of cell morphogenesis Source: FlyBase
  • regulation of Notch signaling pathway Source: FlyBase

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-1445148 Translocation of GLUT4 to the plasma membrane

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Ral-a
Gene namesi
Name:Rala
ORF Names:CG2849
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0015286 Rala

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000826971 – 198Ras-related protein Ral-aAdd BLAST198
PropeptideiPRO_0000281348199 – 201Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei198Cysteine methyl esterBy similarity1
Lipidationi198S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiP48555
PRIDEiP48555

Expressioni

Gene expression databases

BgeeiFBgn0015286
ExpressionAtlasiP48555 baseline and differential
GenevisibleiP48555 DM

Interactioni

GO - Molecular functioni

  • PDZ domain binding Source: FlyBase

Protein-protein interaction databases

BioGridi57853, 37 interactors
DIPiDIP-19199N
IntActiP48555, 3 interactors
STRINGi7227.FBpp0070558

Structurei

Secondary structure

1201
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi11 – 17Combined sources7
Helixi24 – 32Combined sources9
Turni45 – 48Combined sources4
Beta strandi49 – 54Combined sources6
Beta strandi57 – 65Combined sources9
Helixi75 – 80Combined sources6
Beta strandi84 – 90Combined sources7
Helixi96 – 99Combined sources4
Helixi101 – 109Combined sources9
Beta strandi118 – 123Combined sources6
Helixi136 – 143Combined sources8
Helixi144 – 146Combined sources3
Beta strandi150 – 152Combined sources3
Turni155 – 158Combined sources4
Helixi161 – 177Combined sources17

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5CM8X-ray2.60B1-201[»]
5CM9X-ray2.60C/D1-201[»]
ProteinModelPortaliP48555
SMRiP48555
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi40 – 48Effector region9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

eggNOGiKOG0395 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00860000133672
InParanoidiP48555
KOiK07834
OrthoDBiEOG091G0UAU
PhylomeDBiP48555

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type
PANTHERiPTHR24070 PTHR24070, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51421 RAS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48555-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKKPTAGPA LHKVIMVGSG GVGKSALTLQ FMYDEFVEDY EPTKADSYRK
60 70 80 90 100
KVVLDGEEVQ IDILDTAGQE DYAAIRDNYF RSGEGFLCVF SITDDESFQA
110 120 130 140 150
TQEFREQILR VKNDESIPFL LVGNKCDLND KRKVPLSECQ LRAQQWAVPY
160 170 180 190 200
VETSAKTREN VDKVFFDLMR EIRSRKTEDS KATSGRAKDR CKKRRLKCTL

L
Length:201
Mass (Da):22,938
Last modified:July 15, 1999 - v2
Checksum:i37F27FD84A813838
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U23800 mRNA Translation: AAC34902.1
AE014298 Genomic DNA Translation: AAF45889.1
AE014298 Genomic DNA Translation: AAF45890.1
AY118912 mRNA Translation: AAM50772.1
RefSeqiNP_525063.1, NM_080324.4
NP_726882.1, NM_166986.3
UniGeneiDm.1689

Genome annotation databases

EnsemblMetazoaiFBtr0070583; FBpp0070558; FBgn0015286
FBtr0070584; FBpp0070559; FBgn0015286
GeneIDi31332
KEGGidme:Dmel_CG2849

Similar proteinsi

Entry informationi

Entry nameiRALA_DROME
AccessioniPrimary (citable) accession number: P48555
Secondary accession number(s): Q540X1, Q9W4Q6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: July 15, 1999
Last modified: May 23, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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