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Protein

Ras-related protein Ral-a

Gene

Rala

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi18 – 25GTPBy similarity8
Nucleotide bindingi65 – 69GTPBy similarity5
Nucleotide bindingi124 – 127GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: FlyBase
  • GTP binding Source: UniProtKB-KW
  • PDZ domain binding Source: FlyBase

GO - Biological processi

  • border follicle cell migration Source: FlyBase
  • defense response to Gram-negative bacterium Source: FlyBase
  • dorsal closure Source: FlyBase
  • innate immune response Source: FlyBase
  • negative regulation of innate immune response Source: FlyBase
  • negative regulation of JNK cascade Source: FlyBase
  • R3/R4 cell fate commitment Source: FlyBase
  • Ras protein signal transduction Source: FlyBase
  • regulation of cell morphogenesis Source: FlyBase
  • regulation of Notch signaling pathway Source: FlyBase
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-1445148. Translocation of GLUT4 to the plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Ral-a
Gene namesi
Name:Rala
ORF Names:CG2849
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0015286. Rala.

Subcellular locationi

GO - Cellular componenti

  • intracellular Source: GOC
  • plasma membrane Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000826971 – 198Ras-related protein Ral-aAdd BLAST198
PropeptideiPRO_0000281348199 – 201Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei198Cysteine methyl esterBy similarity1
Lipidationi198S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiP48555.
PRIDEiP48555.

Expressioni

Gene expression databases

BgeeiFBgn0015286.
ExpressionAtlasiP48555. baseline.
GenevisibleiP48555. DM.

Interactioni

GO - Molecular functioni

  • PDZ domain binding Source: FlyBase

Protein-protein interaction databases

BioGridi57853. 18 interactors.
DIPiDIP-19199N.
IntActiP48555. 3 interactors.
STRINGi7227.FBpp0070558.

Structurei

Secondary structure

1201
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi11 – 17Combined sources7
Helixi24 – 32Combined sources9
Turni45 – 48Combined sources4
Beta strandi49 – 54Combined sources6
Beta strandi57 – 65Combined sources9
Helixi75 – 80Combined sources6
Beta strandi84 – 90Combined sources7
Helixi96 – 99Combined sources4
Helixi101 – 109Combined sources9
Beta strandi118 – 123Combined sources6
Helixi136 – 143Combined sources8
Helixi144 – 146Combined sources3
Beta strandi150 – 152Combined sources3
Turni155 – 158Combined sources4
Helixi161 – 177Combined sources17

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5CM8X-ray2.60B1-201[»]
5CM9X-ray2.60C/D1-201[»]
ProteinModelPortaliP48555.
SMRiP48555.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi40 – 48Effector region9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00860000133672.
InParanoidiP48555.
KOiK07834.
OrthoDBiEOG091G0UAU.
PhylomeDBiP48555.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48555-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKKPTAGPA LHKVIMVGSG GVGKSALTLQ FMYDEFVEDY EPTKADSYRK
60 70 80 90 100
KVVLDGEEVQ IDILDTAGQE DYAAIRDNYF RSGEGFLCVF SITDDESFQA
110 120 130 140 150
TQEFREQILR VKNDESIPFL LVGNKCDLND KRKVPLSECQ LRAQQWAVPY
160 170 180 190 200
VETSAKTREN VDKVFFDLMR EIRSRKTEDS KATSGRAKDR CKKRRLKCTL

L
Length:201
Mass (Da):22,938
Last modified:July 15, 1999 - v2
Checksum:i37F27FD84A813838
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U23800 mRNA. Translation: AAC34902.1.
AE014298 Genomic DNA. Translation: AAF45889.1.
AE014298 Genomic DNA. Translation: AAF45890.1.
AY118912 mRNA. Translation: AAM50772.1.
RefSeqiNP_525063.1. NM_080324.4.
NP_726882.1. NM_166986.3.
UniGeneiDm.1689.

Genome annotation databases

EnsemblMetazoaiFBtr0070583; FBpp0070558; FBgn0015286.
FBtr0070584; FBpp0070559; FBgn0015286.
GeneIDi31332.
KEGGidme:Dmel_CG2849.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U23800 mRNA. Translation: AAC34902.1.
AE014298 Genomic DNA. Translation: AAF45889.1.
AE014298 Genomic DNA. Translation: AAF45890.1.
AY118912 mRNA. Translation: AAM50772.1.
RefSeqiNP_525063.1. NM_080324.4.
NP_726882.1. NM_166986.3.
UniGeneiDm.1689.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5CM8X-ray2.60B1-201[»]
5CM9X-ray2.60C/D1-201[»]
ProteinModelPortaliP48555.
SMRiP48555.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi57853. 18 interactors.
DIPiDIP-19199N.
IntActiP48555. 3 interactors.
STRINGi7227.FBpp0070558.

Proteomic databases

PaxDbiP48555.
PRIDEiP48555.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0070583; FBpp0070558; FBgn0015286.
FBtr0070584; FBpp0070559; FBgn0015286.
GeneIDi31332.
KEGGidme:Dmel_CG2849.

Organism-specific databases

CTDi5898.
FlyBaseiFBgn0015286. Rala.

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00860000133672.
InParanoidiP48555.
KOiK07834.
OrthoDBiEOG091G0UAU.
PhylomeDBiP48555.

Enzyme and pathway databases

ReactomeiR-DME-1445148. Translocation of GLUT4 to the plasma membrane.

Miscellaneous databases

GenomeRNAii31332.
PROiP48555.

Gene expression databases

BgeeiFBgn0015286.
ExpressionAtlasiP48555. baseline.
GenevisibleiP48555. DM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRALA_DROME
AccessioniPrimary (citable) accession number: P48555
Secondary accession number(s): Q540X1, Q9W4Q6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: July 15, 1999
Last modified: November 30, 2016
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.