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Protein

Ras-related protein Rac2

Gene

Rac2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in integrin alpha-PS3/beta-nu-mediated phagocytosis of Gram-positive S.aureus by hemocytes.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 17GTPBy similarity8
Nucleotide bindingi57 – 61GTPBy similarity5
Nucleotide bindingi115 – 118GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: FlyBase
  • GTP binding Source: UniProtKB-KW
  • protein kinase binding Source: FlyBase

GO - Biological processi

  • actin cytoskeleton reorganization Source: FlyBase
  • actin filament bundle assembly Source: FlyBase
  • adherens junction maintenance Source: FlyBase
  • aggressive behavior Source: FlyBase
  • cell morphogenesis Source: FlyBase
  • defense response to bacterium Source: FlyBase
  • dorsal appendage formation Source: FlyBase
  • dorsal closure Source: FlyBase
  • dorsal closure, elongation of leading edge cells Source: FlyBase
  • encapsulation of foreign target Source: FlyBase
  • feeding behavior Source: FlyBase
  • germ-band shortening Source: FlyBase
  • head involution Source: FlyBase
  • hemocyte migration Source: FlyBase
  • immune response-regulating cell surface receptor signaling pathway involved in phagocytosis Source: FlyBase
  • JNK cascade Source: FlyBase
  • lamellipodium assembly Source: FlyBase
  • lateral inhibition Source: FlyBase
  • mating behavior Source: FlyBase
  • melanotic encapsulation of foreign target Source: FlyBase
  • morphogenesis of an epithelium Source: FlyBase
  • muscle attachment Source: FlyBase
  • myoblast fusion Source: FlyBase
  • open tracheal system development Source: FlyBase
  • phagocytosis Source: FlyBase
  • positive regulation of wound healing Source: FlyBase
  • regulation of axonogenesis Source: FlyBase
  • regulation of lipid storage Source: FlyBase
  • Rho protein signal transduction Source: FlyBase
  • salivary gland morphogenesis Source: FlyBase
  • tracheal outgrowth, open tracheal system Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Phagocytosis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-114604. GPVI-mediated activation cascade.
R-DME-1433557. Signaling by SCF-KIT.
R-DME-193648. NRAGE signals death through JNK.
R-DME-194840. Rho GTPase cycle.
R-DME-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-DME-376172. DSCAM interactions.
R-DME-389359. CD28 dependent Vav1 pathway.
R-DME-3928662. EPHB-mediated forward signaling.
R-DME-3928664. Ephrin signaling.
R-DME-3928665. EPH-ephrin mediated repulsion of cells.
R-DME-4086400. PCP/CE pathway.
R-DME-416482. G alpha (12/13) signalling events.
R-DME-418885. DCC mediated attractive signaling.
R-DME-4420097. VEGFA-VEGFR2 Pathway.
R-DME-445144. Signal transduction by L1.
R-DME-5218920. VEGFR2 mediated vascular permeability.
R-DME-5627123. RHO GTPases activate PAKs.
R-DME-5663213. RHO GTPases Activate WASPs and WAVEs.
R-DME-5687128. MAPK6/MAPK4 signaling.
R-DME-6798695. Neutrophil degranulation.
R-DME-8849471. PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases.
R-DME-8875555. MET activates RAP1 and RAC1.
R-DME-983231. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rac2
Gene namesi
Name:Rac2
Synonyms:RacB
ORF Names:CG8556
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0014011. Rac2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001988941 – 189Ras-related protein Rac2Add BLAST189
PropeptideiPRO_0000281245190 – 192Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei189Cysteine methyl esterBy similarity1
Lipidationi189S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiP48554.
PRIDEiP48554.

Expressioni

Gene expression databases

BgeeiFBgn0014011.
ExpressionAtlasiP48554. baseline.
GenevisibleiP48554. DM.

Interactioni

Subunit structurei

Interacts with Pkn (via N-terminus).1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PakQ242133EBI-74869,EBI-74826

GO - Molecular functioni

  • protein kinase binding Source: FlyBase

Protein-protein interaction databases

BioGridi64269. 12 interactors.
DIPiDIP-18225N.
IntActiP48554. 6 interactors.
MINTiMINT-299240.
STRINGi7227.FBpp0305023.

Structurei

3D structure databases

ProteinModelPortaliP48554.
SMRiP48554.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi32 – 40Effector regionSequence analysis9

Phylogenomic databases

eggNOGiKOG0393. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00760000118978.
InParanoidiP48554.
KOiK04392.
OMAiSPRRHKC.
OrthoDBiEOG091G0KCM.
PhylomeDBiP48554.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51420. RHO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48554-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQAIKCVVVG DGAVGKTCLL ISYTTNAFPG EYIPTVFDNY SANVMVDAKP
60 70 80 90 100
INLGLWDTAG QEDYDRLRPL SYPQTDVFLI CFSLVNPASF ENVRAKWFPE
110 120 130 140 150
VRHHCPSVPI ILVGTKLDLR DDKQTIEKLK DKKLTPITYP QGLAMAKEIA
160 170 180 190
AVKYLECSAL TQKGLKTVFD EAIRSVLCPV VRGPKRHKCA LL
Length:192
Mass (Da):21,359
Last modified:February 1, 1996 - v1
Checksum:i06AE11CC18019982
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L38310 mRNA. Translation: AAA67041.1.
Z35643 mRNA. Translation: CAA84710.1.
AE014296 Genomic DNA. Translation: AAF50559.1.
AY118845 mRNA. Translation: AAM50705.1.
PIRiS54296.
RefSeqiNP_001261517.1. NM_001274588.2.
NP_648121.1. NM_139864.3.
UniGeneiDm.3545.

Genome annotation databases

EnsemblMetazoaiFBtr0076867; FBpp0076577; FBgn0014011.
FBtr0332800; FBpp0305023; FBgn0014011.
GeneIDi38831.
KEGGidme:Dmel_CG8556.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L38310 mRNA. Translation: AAA67041.1.
Z35643 mRNA. Translation: CAA84710.1.
AE014296 Genomic DNA. Translation: AAF50559.1.
AY118845 mRNA. Translation: AAM50705.1.
PIRiS54296.
RefSeqiNP_001261517.1. NM_001274588.2.
NP_648121.1. NM_139864.3.
UniGeneiDm.3545.

3D structure databases

ProteinModelPortaliP48554.
SMRiP48554.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi64269. 12 interactors.
DIPiDIP-18225N.
IntActiP48554. 6 interactors.
MINTiMINT-299240.
STRINGi7227.FBpp0305023.

Proteomic databases

PaxDbiP48554.
PRIDEiP48554.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0076867; FBpp0076577; FBgn0014011.
FBtr0332800; FBpp0305023; FBgn0014011.
GeneIDi38831.
KEGGidme:Dmel_CG8556.

Organism-specific databases

CTDi5880.
FlyBaseiFBgn0014011. Rac2.

Phylogenomic databases

eggNOGiKOG0393. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00760000118978.
InParanoidiP48554.
KOiK04392.
OMAiSPRRHKC.
OrthoDBiEOG091G0KCM.
PhylomeDBiP48554.

Enzyme and pathway databases

ReactomeiR-DME-114604. GPVI-mediated activation cascade.
R-DME-1433557. Signaling by SCF-KIT.
R-DME-193648. NRAGE signals death through JNK.
R-DME-194840. Rho GTPase cycle.
R-DME-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-DME-376172. DSCAM interactions.
R-DME-389359. CD28 dependent Vav1 pathway.
R-DME-3928662. EPHB-mediated forward signaling.
R-DME-3928664. Ephrin signaling.
R-DME-3928665. EPH-ephrin mediated repulsion of cells.
R-DME-4086400. PCP/CE pathway.
R-DME-416482. G alpha (12/13) signalling events.
R-DME-418885. DCC mediated attractive signaling.
R-DME-4420097. VEGFA-VEGFR2 Pathway.
R-DME-445144. Signal transduction by L1.
R-DME-5218920. VEGFR2 mediated vascular permeability.
R-DME-5627123. RHO GTPases activate PAKs.
R-DME-5663213. RHO GTPases Activate WASPs and WAVEs.
R-DME-5687128. MAPK6/MAPK4 signaling.
R-DME-6798695. Neutrophil degranulation.
R-DME-8849471. PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases.
R-DME-8875555. MET activates RAP1 and RAC1.
R-DME-983231. Factors involved in megakaryocyte development and platelet production.

Miscellaneous databases

GenomeRNAii38831.
PROiP48554.

Gene expression databases

BgeeiFBgn0014011.
ExpressionAtlasiP48554. baseline.
GenevisibleiP48554. DM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51420. RHO. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRAC2_DROME
AccessioniPrimary (citable) accession number: P48554
Secondary accession number(s): Q540X5, Q9VS69
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 30, 2016
This is version 147 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.