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Protein

Trafficking protein particle complex subunit 10

Gene

TRAPPC10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in vesicular transport from endoplasmic reticulum to Golgi.

GO - Molecular functioni

  • sodium ion transmembrane transporter activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Trafficking protein particle complex subunit 10
Alternative name(s):
Epilepsy holoprosencephaly candidate 1 protein
Short name:
EHOC-1
Protein GT334
Trafficking protein particle complex subunit TMEM1
Transport protein particle subunit TMEM1
Short name:
TRAPP subunit TMEM1
Gene namesi
Name:TRAPPC10
Synonyms:EHOC1, TMEM1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:11868. TRAPPC10.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • Golgi membrane Source: GOC
  • integral component of membrane Source: ProtInc
  • TRAPPII protein complex Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162406870.

Polymorphism and mutation databases

BioMutaiTRAPPC10.
DMDMi12644285.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12591259Trafficking protein particle complex subunit 10PRO_0000193509Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei708 – 7081PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP48553.
MaxQBiP48553.
PaxDbiP48553.
PeptideAtlasiP48553.
PRIDEiP48553.

PTM databases

iPTMnetiP48553.
PhosphoSiteiP48553.

Expressioni

Tissue specificityi

Expressed in all tissues examined.

Gene expression databases

BgeeiP48553.
CleanExiHS_TRAPPC10.
ExpressionAtlasiP48553. baseline and differential.
GenevisibleiP48553. HS.

Interactioni

Subunit structurei

Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
RAB3IPQ96QF06EBI-6160572,EBI-747844

Protein-protein interaction databases

BioGridi112964. 31 interactions.
DIPiDIP-48281N.
IntActiP48553. 2 interactions.
STRINGi9606.ENSP00000291574.

Structurei

3D structure databases

ProteinModelPortaliP48553.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM1 family.Curated

Phylogenomic databases

eggNOGiKOG1931. Eukaryota.
ENOG410XNVF. LUCA.
GeneTreeiENSGT00390000003873.
HOGENOMiHOG000046007.
HOVERGENiHBG108593.
InParanoidiP48553.
OMAiLDCWVFL.
OrthoDBiEOG73V6JD.
PhylomeDBiP48553.
TreeFamiTF320954.

Family and domain databases

InterProiIPR022233. TRAPP_II_complex_TRAPPC10.
[Graphical view]
PfamiPF12584. TRAPPC10. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P48553-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDASEEPLPP VIYTMENKPI VTCAGDQNLF TSVYPTLSQQ LPREPMEWRR
60 70 80 90 100
SYGRAPKMIH LESNFVQFKE ELLPKEGNKA LLTFPFLHIY WTECCDTEVY
110 120 130 140 150
KATVKDDLTK WQNVLKAHSS VDWLIVIVEN DAKKKNKTNI LPRTSIVDKI
160 170 180 190 200
RNDFCNKQSD RCVVLSDPLK DSSRTQESWN AFLTKLRTLL LMSFTKNLGK
210 220 230 240 250
FEDDMRTLRE KRTEPGWSFC EYFMVQEELA FVFEMLQQFE DALVQYDELD
260 270 280 290 300
ALFSQYVVNF GAGDGANWLT FFCQPVKSWN GLILRKPIDM EKRESIQRRE
310 320 330 340 350
ATLLDLRSYL FSRQCTLLLF LQRPWEVAQR ALELLHNCVQ ELKLLEVSVP
360 370 380 390 400
PGALDCWVFL SCLEVLQRIE GCCDRAQIDS NIAHTVGLWS YATEKLKSLG
410 420 430 440 450
YLCGLVSEKG PNSEDLNRTV DLLAGLGAER PETANTAQSP YKKLKEALSS
460 470 480 490 500
VEAFEKHYLD LSHATIEMYT SIGRIRSAKF VGKDLAEFYM RKKAPQKAEI
510 520 530 540 550
YLQGALKNYL AEGWALPITH TRKQLAECQK HLGQIENYLQ TSSLLASDHH
560 570 580 590 600
LTEEERKHFC QEILDFASQP SDSPGHKIVL PMHSFAQLRD LHFDPSNAVV
610 620 630 640 650
HVGGVLCVEI TMYSQMPVPV HVEQIVVNVH FSIEKNSYRK TAEWLTKHKT
660 670 680 690 700
SNGIINFPPE TAPFPVSQNS LPALELYEMF ERSPSDNSLN TTGIICRNVH
710 720 730 740 750
MLLRRQESSS SLEMPSGVAL EEGAHVLRCS HVTLEPGANQ ITFRTQAKEP
760 770 780 790 800
GTYTLRQLCA SVGSVWFVLP HIYPIVQYDV YSQEPQLHVE PLADSLLAGI
810 820 830 840 850
PQRVKFTVTT GHYTIKNGDS LQLSNAEAML ILCQAESRAV VYSNTREQSS
860 870 880 890 900
EAALRIQSSD KVTSISLPVA PAYHVIEFEL EVLSLPSAPA LGGESDMLGM
910 920 930 940 950
AEPHRKHKDK QRTGRCMVTT DHKVSIDCPW SIYSTVIALT FSVPFRTTHS
960 970 980 990 1000
LLSSGTRKYV QVCVQNLSEL DFQLSDSYLV DTGDSTDLQL VPLNTQSQQP
1010 1020 1030 1040 1050
IYSKQSVFFV WELKWTEEPP PSLHCRFSVG FSPASEEQLS ISLKPYTYEF
1060 1070 1080 1090 1100
KVENFFTLYN VKAEIFPPSG MEYCRTGSLC SLEVLITRLS DLLEVDKDEA
1110 1120 1130 1140 1150
LTESDEHFST KLMYEVVDNS SNWAVCGKSC GVISMPVAAR ATHRVHMEVM
1160 1170 1180 1190 1200
PLFAGYLPLP DVRLFKYLPH HSAHSSQLDA DSWIENDSLS VDKHGDDQPD
1210 1220 1230 1240 1250
SSSLKSRGSV HSACSSEHKG LPMPRLQALP AGQVFNSSSG TQVLVIPSQD

DHVLEVSVT
Length:1,259
Mass (Da):142,189
Last modified:December 1, 2000 - v2
Checksum:iE8AB6847C9C6FE0C
GO
Isoform 2 (identifier: P48553-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     264-276: DGANWLTFFCQPV → GIKCPFHNSVACW
     277-1259: Missing.

Note: No experimental confirmation available.
Show »
Length:276
Mass (Da):32,173
Checksum:i33730891ECCDACE7
GO

Sequence cautioni

The sequence AAC50134.1 differs from that shown. Reason: Frameshift at position 1187. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti114 – 1141V → A in AAB58468 (PubMed:9370297).Curated
Sequence conflicti121 – 1211V → A in AAB58468 (PubMed:9370297).Curated
Sequence conflicti813 – 8131Y → D in AAC50134 (PubMed:7633421).Curated
Sequence conflicti910 – 9101K → Q in AAC51826 (PubMed:9370297).Curated
Sequence conflicti910 – 9101K → Q in AAB58468 (PubMed:9370297).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti257 – 2571V → E.1 Publication
VAR_009514
Natural varianti633 – 6331I → M.1 Publication
Corresponds to variant rs915877 [ dbSNP | Ensembl ].
VAR_009515
Natural varianti726 – 7261V → M Common polymorphism. 1 Publication
Corresponds to variant rs2071152 [ dbSNP | Ensembl ].
VAR_009516

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei264 – 27613DGANW…FCQPV → GIKCPFHNSVACW in isoform 2. 1 PublicationVSP_056589Add
BLAST
Alternative sequencei277 – 1259983Missing in isoform 2. 1 PublicationVSP_056590Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19252 mRNA. Translation: AAC50134.1. Frameshift.
AB001523 Genomic DNA. Translation: BAA21099.1.
U61500 mRNA. Translation: AAC51826.1.
U61520
, U61501, U61502, U61503, U61504, U61505, U61506, U61507, U61508, U61509, U61510, U61511, U61512, U61513, U61514, U61515, U61516, U61517, U61518, U61519 Genomic DNA. Translation: AAB58468.1.
AB001517 Genomic DNA. No translation available.
BC046241 mRNA. Translation: AAH46241.1.
BC052247 mRNA. Translation: AAH52247.1.
BC094823 mRNA. Translation: AAH94823.1.
BC101728 mRNA. Translation: AAI01729.1.
CCDSiCCDS13704.1. [P48553-1]
PIRiJC5523.
RefSeqiNP_003265.3. NM_003274.4. [P48553-1]
UniGeneiHs.126221.

Genome annotation databases

EnsembliENST00000291574; ENSP00000291574; ENSG00000160218. [P48553-1]
ENST00000380221; ENSP00000369570; ENSG00000160218. [P48553-2]
GeneIDi7109.
KEGGihsa:7109.
UCSCiuc002zdz.4. human. [P48553-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19252 mRNA. Translation: AAC50134.1. Frameshift.
AB001523 Genomic DNA. Translation: BAA21099.1.
U61500 mRNA. Translation: AAC51826.1.
U61520
, U61501, U61502, U61503, U61504, U61505, U61506, U61507, U61508, U61509, U61510, U61511, U61512, U61513, U61514, U61515, U61516, U61517, U61518, U61519 Genomic DNA. Translation: AAB58468.1.
AB001517 Genomic DNA. No translation available.
BC046241 mRNA. Translation: AAH46241.1.
BC052247 mRNA. Translation: AAH52247.1.
BC094823 mRNA. Translation: AAH94823.1.
BC101728 mRNA. Translation: AAI01729.1.
CCDSiCCDS13704.1. [P48553-1]
PIRiJC5523.
RefSeqiNP_003265.3. NM_003274.4. [P48553-1]
UniGeneiHs.126221.

3D structure databases

ProteinModelPortaliP48553.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112964. 31 interactions.
DIPiDIP-48281N.
IntActiP48553. 2 interactions.
STRINGi9606.ENSP00000291574.

PTM databases

iPTMnetiP48553.
PhosphoSiteiP48553.

Polymorphism and mutation databases

BioMutaiTRAPPC10.
DMDMi12644285.

Proteomic databases

EPDiP48553.
MaxQBiP48553.
PaxDbiP48553.
PeptideAtlasiP48553.
PRIDEiP48553.

Protocols and materials databases

DNASUi7109.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000291574; ENSP00000291574; ENSG00000160218. [P48553-1]
ENST00000380221; ENSP00000369570; ENSG00000160218. [P48553-2]
GeneIDi7109.
KEGGihsa:7109.
UCSCiuc002zdz.4. human. [P48553-1]

Organism-specific databases

CTDi7109.
GeneCardsiTRAPPC10.
HGNCiHGNC:11868. TRAPPC10.
MIMi602103. gene.
neXtProtiNX_P48553.
PharmGKBiPA162406870.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1931. Eukaryota.
ENOG410XNVF. LUCA.
GeneTreeiENSGT00390000003873.
HOGENOMiHOG000046007.
HOVERGENiHBG108593.
InParanoidiP48553.
OMAiLDCWVFL.
OrthoDBiEOG73V6JD.
PhylomeDBiP48553.
TreeFamiTF320954.

Enzyme and pathway databases

ReactomeiR-HSA-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.

Miscellaneous databases

ChiTaRSiTRAPPC10. human.
GeneWikiiTMEM1.
GenomeRNAii7109.
PROiP48553.
SOURCEiSearch...

Gene expression databases

BgeeiP48553.
CleanExiHS_TRAPPC10.
ExpressionAtlasiP48553. baseline and differential.
GenevisibleiP48553. HS.

Family and domain databases

InterProiIPR022233. TRAPP_II_complex_TRAPPC10.
[Graphical view]
PfamiPF12584. TRAPPC10. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of a candidate gene for progressive myoclonus epilepsy on 21q22.3."
    Yamakawa K., Mitchell S., Hubert R., Chen X.-N., Colbern S., Huo Y.-K., Gadomski C., Kim U.-J., Korenberg J.R.
    Hum. Mol. Genet. 4:709-716(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "Genomic organization and complete nucleotide sequence of the TMEM1 gene on human chromosome 21q22.3."
    Nagamine K., Kudoh J., Kawasaki K., Minoshima S., Asakawa S., Ito F., Shimizu N.
    Biochem. Biophys. Res. Commun. 235:185-190(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), VARIANTS GLU-257; MET-633 AND MET-726.
  4. "The DNA sequence of human chromosome 21."
    Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
    , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
    Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Lymph.
  6. Cited for: IDENTIFICATION IN TRAPP COMPLEX.
  7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking."
    Scrivens P.J., Noueihed B., Shahrzad N., Hul S., Brunet S., Sacher M.
    Mol. Biol. Cell 22:2083-2093(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN TRAPP COMPLEX.
  9. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-708, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma and Erythroleukemia.
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiTPC10_HUMAN
AccessioniPrimary (citable) accession number: P48553
Secondary accession number(s): Q3MIR2
, Q86SI7, Q9UMD4, Q9Y4L3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: December 1, 2000
Last modified: July 6, 2016
This is version 148 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.