##gff-version 3 P48552 UniProtKB Chain 1 1158 . . . ID=PRO_0000057951;Note=Nuclear receptor-interacting protein 1 P48552 UniProtKB Region 1 415 . . . Note=Interaction with ZNF366;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17085477;Dbxref=PMID:17085477 P48552 UniProtKB Region 33 56 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P48552 UniProtKB Region 78 333 . . . Note=Repression domain 1 P48552 UniProtKB Region 393 435 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P48552 UniProtKB Region 410 700 . . . Note=Repression domain 2 P48552 UniProtKB Region 431 472 . . . Note=Required for targeting to small nuclear foci P48552 UniProtKB Region 540 563 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P48552 UniProtKB Region 592 622 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P48552 UniProtKB Region 641 663 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P48552 UniProtKB Region 716 745 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P48552 UniProtKB Region 735 885 . . . Note=Repression domain 3 P48552 UniProtKB Region 753 1158 . . . Note=Interaction with ZNF366;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17085477;Dbxref=PMID:17085477 P48552 UniProtKB Region 950 974 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P48552 UniProtKB Region 1118 1158 . . . Note=Repression domain 4 P48552 UniProtKB Motif 21 25 . . . Note=LXXLL motif 1 P48552 UniProtKB Motif 133 137 . . . Note=LXXLL motif 2 P48552 UniProtKB Motif 185 189 . . . Note=LXXLL motif 3 P48552 UniProtKB Motif 266 270 . . . Note=LXXLL motif 4 P48552 UniProtKB Motif 380 384 . . . Note=LXXLL motif 5 P48552 UniProtKB Motif 440 446 . . . Note=CTBP-binding%3B principal site P48552 UniProtKB Motif 500 504 . . . Note=LXXLL motif 6 P48552 UniProtKB Motif 565 569 . . . Note=CTBP-binding P48552 UniProtKB Motif 599 603 . . . Note=CTBP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255 P48552 UniProtKB Motif 713 717 . . . Note=LXXLL motif 7 P48552 UniProtKB Motif 819 823 . . . Note=LXXLL motif 8 P48552 UniProtKB Motif 936 940 . . . Note=LXXLL motif 9 P48552 UniProtKB Motif 946 950 . . . Note=CTBP-binding P48552 UniProtKB Motif 1061 1074 . . . Note=Ligand-dependent nuclear receptor binding;Ontology_term=ECO:0000250;evidence=ECO:0000250 P48552 UniProtKB Compositional bias 404 435 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P48552 UniProtKB Compositional bias 641 658 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P48552 UniProtKB Compositional bias 722 743 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P48552 UniProtKB Compositional bias 954 969 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P48552 UniProtKB Modified residue 104 104 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8CBD1 P48552 UniProtKB Modified residue 111 111 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8CBD1 P48552 UniProtKB Modified residue 158 158 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8CBD1 P48552 UniProtKB Modified residue 207 207 . . . Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8CBD1 P48552 UniProtKB Modified residue 218 218 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24275569;Dbxref=PMID:24275569 P48552 UniProtKB Modified residue 286 286 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8CBD1 P48552 UniProtKB Modified residue 310 310 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8CBD1 P48552 UniProtKB Modified residue 356 356 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8CBD1 P48552 UniProtKB Modified residue 378 378 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8CBD1 P48552 UniProtKB Modified residue 446 446 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11509661;Dbxref=PMID:11509661 P48552 UniProtKB Modified residue 481 481 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8CBD1 P48552 UniProtKB Modified residue 487 487 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8CBD1 P48552 UniProtKB Modified residue 518 518 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8CBD1 P48552 UniProtKB Modified residue 528 528 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8CBD1 P48552 UniProtKB Modified residue 542 542 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8CBD1 P48552 UniProtKB Modified residue 564 564 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 P48552 UniProtKB Modified residue 606 606 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8CBD1 P48552 UniProtKB Modified residue 671 671 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24275569;Dbxref=PMID:24275569 P48552 UniProtKB Modified residue 807 807 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:23186163,ECO:0007744|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569 P48552 UniProtKB Modified residue 931 931 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8CBD1 P48552 UniProtKB Modified residue 1001 1001 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8CBD1 P48552 UniProtKB Cross-link 111 111 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 P48552 UniProtKB Cross-link 170 170 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 P48552 UniProtKB Cross-link 195 195 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 P48552 UniProtKB Cross-link 198 198 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 P48552 UniProtKB Cross-link 372 372 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 P48552 UniProtKB Cross-link 508 508 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 P48552 UniProtKB Cross-link 756 756 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:25218447,ECO:0007744|PubMed:28112733;Dbxref=PMID:25218447,PMID:28112733 P48552 UniProtKB Cross-link 802 802 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 P48552 UniProtKB Cross-link 850 850 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 P48552 UniProtKB Cross-link 901 901 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 P48552 UniProtKB Cross-link 931 931 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 P48552 UniProtKB Cross-link 1105 1105 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:25218447,ECO:0007744|PubMed:28112733;Dbxref=PMID:25218447,PMID:28112733 P48552 UniProtKB Cross-link 1115 1115 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 P48552 UniProtKB Cross-link 1154 1154 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 P48552 UniProtKB Natural variant 37 37 . . . ID=VAR_051241;Note=V->I;Dbxref=dbSNP:rs9941840 P48552 UniProtKB Natural variant 221 221 . . . ID=VAR_023706;Note=H->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16131398;Dbxref=dbSNP:rs139263261,PMID:16131398 P48552 UniProtKB Natural variant 315 315 . . . ID=VAR_034142;Note=Y->F;Dbxref=dbSNP:rs2228507 P48552 UniProtKB Natural variant 441 441 . . . ID=VAR_023707;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16131398;Dbxref=dbSNP:rs150468995,PMID:16131398 P48552 UniProtKB Natural variant 448 448 . . . ID=VAR_023708;Note=R->G;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16131398,ECO:0000269|PubMed:7641693;Dbxref=dbSNP:rs2229742,PMID:16131398,PMID:7641693 P48552 UniProtKB Natural variant 567 567 . . . ID=VAR_051242;Note=N->S;Dbxref=dbSNP:rs9975169 P48552 UniProtKB Natural variant 803 803 . . . ID=VAR_023709;Note=S->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16131398;Dbxref=dbSNP:rs61750208,PMID:16131398 P48552 UniProtKB Natural variant 1079 1079 . . . ID=VAR_023710;Note=V->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16131398;Dbxref=dbSNP:rs140803495,PMID:16131398 P48552 UniProtKB Mutagenesis 440 443 . . . Note=Abolishes interaction with CTBP1. PIDL->AAAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11509661;Dbxref=PMID:11509661 P48552 UniProtKB Mutagenesis 440 442 . . . Note=Abolishes interaction with CTBP1 and attenuates nuclear hormone receptor-dependent transcription repression. PID->AIA P48552 UniProtKB Mutagenesis 442 443 . . . Note=Reduces%2C but does not completely abolish%2C interaction with CTBP. Reduces transcriptional repression. DL->AA;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14736873,ECO:0000269|PubMed:15060175;Dbxref=PMID:14736873,PMID:15060175 P48552 UniProtKB Mutagenesis 442 443 . . . Note=Disrupts interaction with CTBP1%2C and CTBP2 to a lesser extent. Disrupts transcriptional repression%3B when associated with 567-AS-568. DL->AS;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14736873,ECO:0000269|PubMed:15060175;Dbxref=PMID:14736873,PMID:15060175 P48552 UniProtKB Mutagenesis 446 446 . . . Note=Disrupts interaction with CTBP1. Decreases lysine acetylation. Disrupts nuclear hormone receptor-dependent transcription repression. K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11509661;Dbxref=PMID:11509661 P48552 UniProtKB Mutagenesis 446 446 . . . Note=Does not disrupt nuclear hormone receptor-dependent transcription repression. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11509661;Dbxref=PMID:11509661 P48552 UniProtKB Mutagenesis 567 568 . . . Note=Disrupts transcriptional repression. NL->AA;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14736873,ECO:0000269|PubMed:15060175;Dbxref=PMID:14736873,PMID:15060175 P48552 UniProtKB Mutagenesis 567 568 . . . Note=Disrupts interaction with CTBP1 and CTBP2. Disrupts transcriptional repression%3B when associated with 442-AS-443. NL->AS;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14736873,ECO:0000269|PubMed:15060175;Dbxref=PMID:14736873,PMID:15060175 P48552 UniProtKB Mutagenesis 599 603 . . . Note=Does not further disrupt transcriptional repression%3B when associated with 442-AA-443 and 567-AA-568. SMDLT->PIAAS P48552 UniProtKB Mutagenesis 948 949 . . . Note=Abolishes CTBP binding but retains transcriptional repressor activity. DL->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14736873;Dbxref=PMID:14736873 P48552 UniProtKB Sequence conflict 124 124 . . . Note=P->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 P48552 UniProtKB Sequence conflict 721 726 . . . Note=NKGKSE->TKGRVK;Ontology_term=ECO:0000305;evidence=ECO:0000305 P48552 UniProtKB Sequence conflict 954 954 . . . Note=S->I;Ontology_term=ECO:0000305;evidence=ECO:0000305 P48552 UniProtKB Sequence conflict 1080 1080 . . . Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 P48552 UniProtKB Helix 379 385 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2GPO P48552 UniProtKB Helix 500 505 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5NTW